research paper with synthesis

How to Synthesize Written Information from Multiple Sources

Shona McCombes

Content Manager

B.A., English Literature, University of Glasgow

Shona McCombes is the content manager at Scribbr, Netherlands.

Learn about our Editorial Process

Saul Mcleod, PhD

Editor-in-Chief for Simply Psychology

BSc (Hons) Psychology, MRes, PhD, University of Manchester

Saul Mcleod, PhD., is a qualified psychology teacher with over 18 years of experience in further and higher education. He has been published in peer-reviewed journals, including the Journal of Clinical Psychology.

On This Page:

When you write a literature review or essay, you have to go beyond just summarizing the articles you’ve read – you need to synthesize the literature to show how it all fits together (and how your own research fits in).

Synthesizing simply means combining. Instead of summarizing the main points of each source in turn, you put together the ideas and findings of multiple sources in order to make an overall point.

At the most basic level, this involves looking for similarities and differences between your sources. Your synthesis should show the reader where the sources overlap and where they diverge.

Unsynthesized Example

Franz (2008) studied undergraduate online students. He looked at 17 females and 18 males and found that none of them liked APA. According to Franz, the evidence suggested that all students are reluctant to learn citations style. Perez (2010) also studies undergraduate students. She looked at 42 females and 50 males and found that males were significantly more inclined to use citation software ( p < .05). Findings suggest that females might graduate sooner. Goldstein (2012) looked at British undergraduates. Among a sample of 50, all females, all confident in their abilities to cite and were eager to write their dissertations.

Synthesized Example

Studies of undergraduate students reveal conflicting conclusions regarding relationships between advanced scholarly study and citation efficacy. Although Franz (2008) found that no participants enjoyed learning citation style, Goldstein (2012) determined in a larger study that all participants watched felt comfortable citing sources, suggesting that variables among participant and control group populations must be examined more closely. Although Perez (2010) expanded on Franz’s original study with a larger, more diverse sample…

Step 1: Organize your sources

After collecting the relevant literature, you’ve got a lot of information to work through, and no clear idea of how it all fits together.

Before you can start writing, you need to organize your notes in a way that allows you to see the relationships between sources.

One way to begin synthesizing the literature is to put your notes into a table. Depending on your topic and the type of literature you’re dealing with, there are a couple of different ways you can organize this.

Summary table

A summary table collates the key points of each source under consistent headings. This is a good approach if your sources tend to have a similar structure – for instance, if they’re all empirical papers.

Each row in the table lists one source, and each column identifies a specific part of the source. You can decide which headings to include based on what’s most relevant to the literature you’re dealing with.

For example, you might include columns for things like aims, methods, variables, population, sample size, and conclusion.

For each study, you briefly summarize each of these aspects. You can also include columns for your own evaluation and analysis.

The summary table gives you a quick overview of the key points of each source. This allows you to group sources by relevant similarities, as well as noticing important differences or contradictions in their findings.

Synthesis matrix

A synthesis matrix is useful when your sources are more varied in their purpose and structure – for example, when you’re dealing with books and essays making various different arguments about a topic.

Each column in the table lists one source. Each row is labeled with a specific concept, topic or theme that recurs across all or most of the sources.

Then, for each source, you summarize the main points or arguments related to the theme.

The purposes of the table is to identify the common points that connect the sources, as well as identifying points where they diverge or disagree.

Step 2: Outline your structure

Now you should have a clear overview of the main connections and differences between the sources you’ve read. Next, you need to decide how you’ll group them together and the order in which you’ll discuss them.

For shorter papers, your outline can just identify the focus of each paragraph; for longer papers, you might want to divide it into sections with headings.

There are a few different approaches you can take to help you structure your synthesis.

If your sources cover a broad time period, and you found patterns in how researchers approached the topic over time, you can organize your discussion chronologically .

That doesn’t mean you just summarize each paper in chronological order; instead, you should group articles into time periods and identify what they have in common, as well as signalling important turning points or developments in the literature.

If the literature covers various different topics, you can organize it thematically .

That means that each paragraph or section focuses on a specific theme and explains how that theme is approached in the literature.

Source Used with Permission: The Chicago School

If you’re drawing on literature from various different fields or they use a wide variety of research methods, you can organize your sources methodologically .

That means grouping together studies based on the type of research they did and discussing the findings that emerged from each method.

If your topic involves a debate between different schools of thought, you can organize it theoretically .

That means comparing the different theories that have been developed and grouping together papers based on the position or perspective they take on the topic, as well as evaluating which arguments are most convincing.

Step 3: Write paragraphs with topic sentences

What sets a synthesis apart from a summary is that it combines various sources. The easiest way to think about this is that each paragraph should discuss a few different sources, and you should be able to condense the overall point of the paragraph into one sentence.

This is called a topic sentence , and it usually appears at the start of the paragraph. The topic sentence signals what the whole paragraph is about; every sentence in the paragraph should be clearly related to it.

A topic sentence can be a simple summary of the paragraph’s content:

“Early research on [x] focused heavily on [y].”

For an effective synthesis, you can use topic sentences to link back to the previous paragraph, highlighting a point of debate or critique:

“Several scholars have pointed out the flaws in this approach.” “While recent research has attempted to address the problem, many of these studies have methodological flaws that limit their validity.”

By using topic sentences, you can ensure that your paragraphs are coherent and clearly show the connections between the articles you are discussing.

As you write your paragraphs, avoid quoting directly from sources: use your own words to explain the commonalities and differences that you found in the literature.

Don’t try to cover every single point from every single source – the key to synthesizing is to extract the most important and relevant information and combine it to give your reader an overall picture of the state of knowledge on your topic.

Step 4: Revise, edit and proofread

Like any other piece of academic writing, synthesizing literature doesn’t happen all in one go – it involves redrafting, revising, editing and proofreading your work.

Checklist for Synthesis

•   Do I introduce the paragraph with a clear, focused topic sentence?
•   Do I discuss more than one source in the paragraph?
•   Do I mention only the most relevant findings, rather than describing every part of the studies?
•   Do I discuss the similarities or differences between the sources, rather than summarizing each source in turn?
•   Do I put the findings or arguments of the sources in my own words?
•   Is the paragraph organized around a single idea?
•   Is the paragraph directly relevant to my research question or topic?
•   Is there a logical transition from this paragraph to the next one?

Further Information

How to Synthesise: a Step-by-Step Approach

Help…I”ve Been Asked to Synthesize!

Learn how to Synthesise (combine information from sources)

How to write a Psychology Essay

Have a language expert improve your writing

Run a free plagiarism check in 10 minutes, generate accurate citations for free.

• Knowledge Base
• Working with sources
• Synthesizing Sources | Examples & Synthesis Matrix

Synthesizing Sources | Examples & Synthesis Matrix

Published on July 4, 2022 by Eoghan Ryan . Revised on May 31, 2023.

Synthesizing sources involves combining the work of other scholars to provide new insights. It’s a way of integrating sources that helps situate your work in relation to existing research.

Synthesizing sources involves more than just summarizing . You must emphasize how each source contributes to current debates, highlighting points of (dis)agreement and putting the sources in conversation with each other.

You might synthesize sources in your literature review to give an overview of the field or throughout your research paper when you want to position your work in relation to existing research.

Table of contents

Example of synthesizing sources, how to synthesize sources, synthesis matrix, other interesting articles, frequently asked questions about synthesizing sources.

Let’s take a look at an example where sources are not properly synthesized, and then see what can be done to improve it.

This paragraph provides no context for the information and does not explain the relationships between the sources described. It also doesn’t analyze the sources or consider gaps in existing research.

Research on the barriers to second language acquisition has primarily focused on age-related difficulties. Building on Lenneberg’s (1967) theory of a critical period of language acquisition, Johnson and Newport (1988) tested Lenneberg’s idea in the context of second language acquisition. Their research seemed to confirm that young learners acquire a second language more easily than older learners. Recent research has considered other potential barriers to language acquisition. Schepens, van Hout, and van der Slik (2022) have revealed that the difficulties of learning a second language at an older age are compounded by dissimilarity between a learner’s first language and the language they aim to acquire. Further research needs to be carried out to determine whether the difficulty faced by adult monoglot speakers is also faced by adults who acquired a second language during the “critical period.”

Scribbr Citation Checker New

The AI-powered Citation Checker helps you avoid common mistakes such as:

• Missing commas and periods
• Incorrect usage of “et al.”
• Ampersands (&) in narrative citations
• Missing reference entries

To synthesize sources, group them around a specific theme or point of contention.

As you read sources, ask:

• What questions or ideas recur? Do the sources focus on the same points, or do they look at the issue from different angles?
• How does each source relate to others? Does it confirm or challenge the findings of past research?
• Where do the sources agree or disagree?

Once you have a clear idea of how each source positions itself, put them in conversation with each other. Analyze and interpret their points of agreement and disagreement. This displays the relationships among sources and creates a sense of coherence.

Consider both implicit and explicit (dis)agreements. Whether one source specifically refutes another or just happens to come to different conclusions without specifically engaging with it, you can mention it in your synthesis either way.

Synthesize your sources using:

• Topic sentences to introduce the relationship between the sources
• Signal phrases to attribute ideas to their authors
• Transition words and phrases to link together different ideas

To more easily determine the similarities and dissimilarities among your sources, you can create a visual representation of their main ideas with a synthesis matrix . This is a tool that you can use when researching and writing your paper, not a part of the final text.

In a synthesis matrix, each column represents one source, and each row represents a common theme or idea among the sources. In the relevant rows, fill in a short summary of how the source treats each theme or topic.

This helps you to clearly see the commonalities or points of divergence among your sources. You can then synthesize these sources in your work by explaining their relationship.

If you want to know more about ChatGPT, AI tools , citation , and plagiarism , make sure to check out some of our other articles with explanations and examples.

• ChatGPT vs human editor
• ChatGPT citations
• Is ChatGPT trustworthy?
• Using ChatGPT for your studies
• What is ChatGPT?
• Chicago style
• Paraphrasing

 Plagiarism

• Types of plagiarism
• Self-plagiarism
• Avoiding plagiarism
• Academic integrity
• Consequences of plagiarism
• Common knowledge

Prevent plagiarism. Run a free check.

Synthesizing sources means comparing and contrasting the work of other scholars to provide new insights.

It involves analyzing and interpreting the points of agreement and disagreement among sources.

You might synthesize sources in your literature review to give an overview of the field of research or throughout your paper when you want to contribute something new to existing research.

A literature review is a survey of scholarly sources (such as books, journal articles, and theses) related to a specific topic or research question .

It is often written as part of a thesis, dissertation , or research paper , in order to situate your work in relation to existing knowledge.

Topic sentences help keep your writing focused and guide the reader through your argument.

In an essay or paper , each paragraph should focus on a single idea. By stating the main idea in the topic sentence, you clarify what the paragraph is about for both yourself and your reader.

At college level, you must properly cite your sources in all essays , research papers , and other academic texts (except exams and in-class exercises).

Add a citation whenever you quote , paraphrase , or summarize information or ideas from a source. You should also give full source details in a bibliography or reference list at the end of your text.

The exact format of your citations depends on which citation style you are instructed to use. The most common styles are APA , MLA , and Chicago .

Cite this Scribbr article

If you want to cite this source, you can copy and paste the citation or click the “Cite this Scribbr article” button to automatically add the citation to our free Citation Generator.

Ryan, E. (2023, May 31). Synthesizing Sources | Examples & Synthesis Matrix. Scribbr. Retrieved July 10, 2024, from https://www.scribbr.com/working-with-sources/synthesizing-sources/

Is this article helpful?

Eoghan Ryan

Other students also liked, signal phrases | definition, explanation & examples, how to write a literature review | guide, examples, & templates, how to find sources | scholarly articles, books, etc., get unlimited documents corrected.

✔ Free APA citation check included ✔ Unlimited document corrections ✔ Specialized in correcting academic texts

Purdue Online Writing Lab Purdue OWL® College of Liberal Arts

Synthesizing Sources

Welcome to the Purdue OWL

This page is brought to you by the OWL at Purdue University. When printing this page, you must include the entire legal notice.

Copyright ©1995-2018 by The Writing Lab & The OWL at Purdue and Purdue University. All rights reserved. This material may not be published, reproduced, broadcast, rewritten, or redistributed without permission. Use of this site constitutes acceptance of our terms and conditions of fair use.

When you look for areas where your sources agree or disagree and try to draw broader conclusions about your topic based on what your sources say, you are engaging in synthesis. Writing a research paper usually requires synthesizing the available sources in order to provide new insight or a different perspective into your particular topic (as opposed to simply restating what each individual source says about your research topic).

Note that synthesizing is not the same as summarizing.  

• A summary restates the information in one or more sources without providing new insight or reaching new conclusions.
• A synthesis draws on multiple sources to reach a broader conclusion.

There are two types of syntheses: explanatory syntheses and argumentative syntheses . Explanatory syntheses seek to bring sources together to explain a perspective and the reasoning behind it. Argumentative syntheses seek to bring sources together to make an argument. Both types of synthesis involve looking for relationships between sources and drawing conclusions.

In order to successfully synthesize your sources, you might begin by grouping your sources by topic and looking for connections. For example, if you were researching the pros and cons of encouraging healthy eating in children, you would want to separate your sources to find which ones agree with each other and which ones disagree.

After you have a good idea of what your sources are saying, you want to construct your body paragraphs in a way that acknowledges different sources and highlights where you can draw new conclusions.

As you continue synthesizing, here are a few points to remember:

• Don’t force a relationship between sources if there isn’t one. Not all of your sources have to complement one another.
• Do your best to highlight the relationships between sources in very clear ways.
• Don’t ignore any outliers in your research. It’s important to take note of every perspective (even those that disagree with your broader conclusions).

Example Syntheses

Below are two examples of synthesis: one where synthesis is NOT utilized well, and one where it is.

Parents are always trying to find ways to encourage healthy eating in their children. Elena Pearl Ben-Joseph, a doctor and writer for KidsHealth , encourages parents to be role models for their children by not dieting or vocalizing concerns about their body image. The first popular diet began in 1863. William Banting named it the “Banting” diet after himself, and it consisted of eating fruits, vegetables, meat, and dry wine. Despite the fact that dieting has been around for over a hundred and fifty years, parents should not diet because it hinders children’s understanding of healthy eating.

In this sample paragraph, the paragraph begins with one idea then drastically shifts to another. Rather than comparing the sources, the author simply describes their content. This leads the paragraph to veer in an different direction at the end, and it prevents the paragraph from expressing any strong arguments or conclusions.

An example of a stronger synthesis can be found below.

Parents are always trying to find ways to encourage healthy eating in their children. Different scientists and educators have different strategies for promoting a well-rounded diet while still encouraging body positivity in children. David R. Just and Joseph Price suggest in their article “Using Incentives to Encourage Healthy Eating in Children” that children are more likely to eat fruits and vegetables if they are given a reward (855-856). Similarly, Elena Pearl Ben-Joseph, a doctor and writer for Kids Health , encourages parents to be role models for their children. She states that “parents who are always dieting or complaining about their bodies may foster these same negative feelings in their kids. Try to keep a positive approach about food” (Ben-Joseph). Martha J. Nepper and Weiwen Chai support Ben-Joseph’s suggestions in their article “Parents’ Barriers and Strategies to Promote Healthy Eating among School-age Children.” Nepper and Chai note, “Parents felt that patience, consistency, educating themselves on proper nutrition, and having more healthy foods available in the home were important strategies when developing healthy eating habits for their children.” By following some of these ideas, parents can help their children develop healthy eating habits while still maintaining body positivity.

In this example, the author puts different sources in conversation with one another. Rather than simply describing the content of the sources in order, the author uses transitions (like "similarly") and makes the relationship between the sources evident.

Literature Syntheis 101

How To Synthesise The Existing Research (With Examples)

By: Derek Jansen (MBA) | Expert Reviewer: Eunice Rautenbach (DTech) | August 2023

One of the most common mistakes that students make when writing a literature review is that they err on the side of describing the existing literature rather than providing a critical synthesis of it. In this post, we’ll unpack what exactly synthesis means and show you how to craft a strong literature synthesis using practical examples.

This post is based on our popular online course, Literature Review Bootcamp . In the course, we walk you through the full process of developing a literature review, step by step. If it’s your first time writing a literature review, you definitely want to use this link to get 50% off the course (limited-time offer).

Overview: Literature Synthesis

• What exactly does “synthesis” mean?
• Aspect 1: Agreement
• Aspect 2: Disagreement
• Aspect 3: Key theories
• Aspect 4: Contexts
• Aspect 5: Methodologies
• Bringing it all together

What does “synthesis” actually mean?

As a starting point, let’s quickly define what exactly we mean when we use the term “synthesis” within the context of a literature review.

Simply put, literature synthesis means going beyond just describing what everyone has said and found. Instead, synthesis is about bringing together all the information from various sources to present a cohesive assessment of the current state of knowledge in relation to your study’s research aims and questions .

Put another way, a good synthesis tells the reader exactly where the current research is “at” in terms of the topic you’re interested in – specifically, what’s known , what’s not , and where there’s a need for more research .

So, how do you go about doing this?

Well, there’s no “one right way” when it comes to literature synthesis, but we’ve found that it’s particularly useful to ask yourself five key questions when you’re working on your literature review. Having done so,  you can then address them more articulately within your actual write up. So, let’s take a look at each of these questions.

1. Points Of Agreement

The first question that you need to ask yourself is: “Overall, what things seem to be agreed upon by the vast majority of the literature?”

For example, if your research aim is to identify which factors contribute toward job satisfaction, you’ll need to identify which factors are broadly agreed upon and “settled” within the literature. Naturally, there may at times be some lone contrarian that has a radical viewpoint , but, provided that the vast majority of researchers are in agreement, you can put these random outliers to the side. That is, of course, unless your research aims to explore a contrarian viewpoint and there’s a clear justification for doing so. 

Identifying what’s broadly agreed upon is an essential starting point for synthesising the literature, because you generally don’t want (or need) to reinvent the wheel or run down a road investigating something that is already well established . So, addressing this question first lays a foundation of “settled” knowledge.

Need a helping hand?

2. Points Of Disagreement

Related to the previous point, but on the other end of the spectrum, is the equally important question: “Where do the disagreements lie?” .

In other words, which things are not well agreed upon by current researchers? It’s important to clarify here that by disagreement, we don’t mean that researchers are (necessarily) fighting over it – just that there are relatively mixed findings within the empirical research , with no firm consensus amongst researchers.

This is a really important question to address as these “disagreements” will often set the stage for the research gap(s). In other words, they provide clues regarding potential opportunities for further research, which your study can then (hopefully) contribute toward filling. If you’re not familiar with the concept of a research gap, be sure to check out our explainer video covering exactly that .

3. Key Theories

The next question you need to ask yourself is: “Which key theories seem to be coming up repeatedly?” .

Within most research spaces, you’ll find that you keep running into a handful of key theories that are referred to over and over again. Apart from identifying these theories, you’ll also need to think about how they’re connected to each other. Specifically, you need to ask yourself:

• Are they all covering the same ground or do they have different focal points  or underlying assumptions ?
• Do some of them feed into each other and if so, is there an opportunity to integrate them into a more cohesive theory?
• Do some of them pull in different directions ? If so, why might this be?
• Do all of the theories define the key concepts and variables in the same way, or is there some disconnect? If so, what’s the impact of this ?

Simply put, you’ll need to pay careful attention to the key theories in your research area, as they will need to feature within your theoretical framework , which will form a critical component within your final literature review. This will set the foundation for your entire study, so it’s essential that you be critical in this area of your literature synthesis.

If this sounds a bit fluffy, don’t worry. We deep dive into the theoretical framework (as well as the conceptual framework) and look at practical examples in Literature Review Bootcamp . If you’d like to learn more, take advantage of our limited-time offer to get 60% off the standard price.

4. Contexts

The next question that you need to address in your literature synthesis is an important one, and that is: “Which contexts have (and have not) been covered by the existing research?” .

For example, sticking with our earlier hypothetical topic (factors that impact job satisfaction), you may find that most of the research has focused on white-collar , management-level staff within a primarily Western context, but little has been done on blue-collar workers in an Eastern context. Given the significant socio-cultural differences between these two groups, this is an important observation, as it could present a contextual research gap .

In practical terms, this means that you’ll need to carefully assess the context of each piece of literature that you’re engaging with, especially the empirical research (i.e., studies that have collected and analysed real-world data). Ideally, you should keep notes regarding the context of each study in some sort of catalogue or sheet, so that you can easily make sense of this before you start the writing phase. If you’d like, our free literature catalogue worksheet is a great tool for this task.

5. Methodological Approaches

Last but certainly not least, you need to ask yourself the question: “What types of research methodologies have (and haven’t) been used?”

For example, you might find that most studies have approached the topic using qualitative methods such as interviews and thematic analysis. Alternatively, you might find that most studies have used quantitative methods such as online surveys and statistical analysis.

But why does this matter?

Well, it can run in one of two potential directions . If you find that the vast majority of studies use a specific methodological approach, this could provide you with a firm foundation on which to base your own study’s methodology . In other words, you can use the methodologies of similar studies to inform (and justify) your own study’s research design .

On the other hand, you might argue that the lack of diverse methodological approaches presents a research gap , and therefore your study could contribute toward filling that gap by taking a different approach. For example, taking a qualitative approach to a research area that is typically approached quantitatively. Of course, if you’re going to go against the methodological grain, you’ll need to provide a strong justification for why your proposed approach makes sense. Nevertheless, it is something worth at least considering.

Regardless of which route you opt for, you need to pay careful attention to the methodologies used in the relevant studies and provide at least some discussion about this in your write-up. Again, it’s useful to keep track of this on some sort of spreadsheet or catalogue as you digest each article, so consider grabbing a copy of our free literature catalogue if you don’t have anything in place.

Bringing It All Together

Alright, so we’ve looked at five important questions that you need to ask (and answer) to help you develop a strong synthesis within your literature review.  To recap, these are:

• Which things are broadly agreed upon within the current research?
• Which things are the subject of disagreement (or at least, present mixed findings)?
• Which theories seem to be central to your research topic and how do they relate or compare to each other?
• Which contexts have (and haven’t) been covered?
• Which methodological approaches are most common?

Importantly, you’re not just asking yourself these questions for the sake of asking them – they’re not just a reflection exercise. You need to weave your answers to them into your actual literature review when you write it up. How exactly you do this will vary from project to project depending on the structure you opt for, but you’ll still need to address them within your literature review, whichever route you go.

The best approach is to spend some time actually writing out your answers to these questions, as opposed to just thinking about them in your head. Putting your thoughts onto paper really helps you flesh out your thinking . As you do this, don’t just write down the answers – instead, think about what they mean in terms of the research gap you’ll present , as well as the methodological approach you’ll take . Your literature synthesis needs to lay the groundwork for these two things, so it’s essential that you link all of it together in your mind, and of course, on paper.

Psst… there’s more!

This post is an extract from our bestselling short course, Literature Review Bootcamp . If you want to work smart, you don't want to miss this .

excellent , thank you

Thank you for this significant piece of information.

Submit a Comment Cancel reply

Your email address will not be published. Required fields are marked *

Save my name, email, and website in this browser for the next time I comment.

• Print Friendly

Synthesizing Research

When combining another author’s ideas with your own, we have talked about how using the can help make sure your points are being adequately argued (if you have not read our handout on the  evidence cycle,  check it out!). Synthesis takes assertions (statements that describe your claim), evidence (facts and proof from outside sources), and commentary (your connections to why the evidence supports your claim), and blends these processes together to make a cohesive paragraph.

In other words, synthesis encompasses several aspects:

• It is the process of integrating support from more than one source for one idea/argument while also identifying how sources are related to each other and to your main idea.
• It is an acknowledgment of how the source material from several sources address the same question/research topic.
• It is the identification of how important factors (assumptions, interpretations of results, theories, hypothesis, speculations, etc.) relate between separate sources.

TIP: It’s a fruit smoothie!

Think of synthesis as a fruit smoothie that you are creating in your paper. You will have unique parts and flavors in your writing that you will need to blend together to make one tasty, unified drink!

Why Synthesis is Important

• Synthesis integrates information from multiple sources, which shows that you have done the necessary research to engage with a topic more fully.
• Research involves incorporating many sources to understand and/or answer a research question, and discovering these connections between the sources helps you better analyze and understand the conversations surrounding your topic.
• Successful synthesis creates links between your ideas helping your paper “flow” and connect better.
• Synthesis prevents your papers from looking like a list of copied and pasted sources from various authors.
• Synthesis is a higher order process in writing—this is the area where you as a writer get to shine and show your audience your reasoning.

Types of Synthesis

Demonstrates how two or more sources agree with one another.

The collaborative nature of writing tutorials has been discussed by scholars like Andrea Lunsford (1991) and Stephen North (1984). In these essays, they explore the usefulness and the complexities of collaboration between tutors and students in writing center contexts.

Demonstrates how two or more sources support a main point in different ways.

While some scholars like Berlin (1987) have primarily placed their focus on the histories of large, famous universities, other scholars like Yahner and Murdick (1991) have found value in connecting their local histories to contrast or highlight trends found in bigger-name universities.

Accumulation

Demonstrates how one source builds on the idea of another.

Although North’s (1984) essay is fundamental to many writing centers today, Lunsford (1991) takes his ideas a step further by identifying different writing center models and also expanding North’s ideas on how writing centers can help students become better writers.

Demonstrates how one source discusses the effects of another source’s ideas.

While Healy (2001) notes the concerns of having primarily email appointments in writing centers, he also notes that constraints like funding, resources, and time affect how online resources are formed. For writing centers, email is the most economical and practical option for those wanting to offer online services but cannot dedicate the time or money to other online tutoring methods. As a result, in Neaderheiser and Wolfe’s (2009) reveals that of all the online options available in higher education, over 91% of institutions utilize online tutoring through email, meaning these constraints significantly affect the types of services writing centers offer.

Discussing Specific Source Ideas/Arguments

To debate with clarity and precision, you may need to incorporate a quote into your statement. Using can help you to thoroughly introduce your quotes so that they fit in to your paragraph and your argument. Remember that you need to use the to bridge between your ideas and outside source material.

Berlin, J. (1987).  Rhetoric and reality: Writing instruction in American colleges, 1900-1985 . Carbondale: Southern Illinois University Press.

Boquet, E.H. (2001). “Our little secret”: A history of writing centers, pre- to open admissions. In R.W. Barnett & J.S. Blumner (Eds.),  The Allyn and Bacon guide to writing center theory and practice  (pp. 42-60). Boston: Allyn and Bacon.

Carino, P. (1995). Early writing centers: Toward a history.  The Writing Center Journal ,  15 (2), 103-15.

Healy, D. (2001). From place to space: Perceptual and administrative issues in the online writing center. In R.W. Barnett & J.S. Blumner (Eds.), T he Allyn and Bacon guide to writing center theory and practice  (pp. 541-554). Boston: Allyn and Bacon.

Lunsford, A. (1991). Collaboration, control, and the idea of the writing center.  The Writing Center Journal ,  12 (1), 310-75.

Neaderheiser, S. & Wolfe, J. (2009). Between technological endorsement and resistance: The state of online writing centers.  The Writing Center Journal .  29 (1), 49-75.

North, S. (1984). The idea of a writing center.  College English ,  45 (5), 433-446.

Yahner, W. & Murdick, W. (1991). The evolution of a writing center: 1972-1990.  Writing Center Journal ,  11 (2), 13-28.

Step-by-Step Synthesis

By  Jordan McNeill

You have / 5 articles left. Sign up for a free account or log in.

Jordan McNeill is a doctoral student in special education at the University of North Carolina at Chapel Hill. Follow her on Twitter at @jordanmcneill89 .

In January, I wrote my comprehensive exam for my doctoral program, which, in my department, involves a 50-page critical synthesis based on a specific claim of knowledge over a six-week period. It is a fairly daunting task, requiring the integration of literature across many methodologies, subdisciplines and underlying theories. The writer’s job is to somehow balance the big picture of their knowledge claim with the individual contributions of each included source, ultimately making a cohesive argument. Easy, right?

Unfortunately, the particular skill set required for this kind of synthesis is often not explicitly taught. Sure, we have all crafted five-paragraph essays since the fifth grade, and we have probably contributed to scientific research reports. But synthesizing other people's writing to make your own point takes a different thought process. Many graduate students find it hard to move beyond summarizing individual studies in a linear fashion. As the proverb goes, we struggle to see the forest for the trees, detailing specifics but failing to communicate the overall meaning effectively.

As I planned for writing my exam, I realized that the bulk of the work of finding patterns in my sources needed to happen before I started writing. Using ideas from the book Destination Dissertation: A Traveler’s Guide to a Done Dissertation and my own adaptations, I developed a step-by-step process for organizing my notes and ideas. This process assumes you’ve already conducted an exhaustive literature search and have a fairly set reference list; it’s difficult to piece together a synthesis without first establishing your sources. If you are tackling a literature review, comprehensive exam or other similar writing activity, this process can help you synthesize your information before even beginning a draft.

1. Read your sources several times

First, read every article, chapter or other source multiple times with different purposes for each read. On the first read, skim for the big ideas and start mentally categorizing them. After familiarizing yourself with the basics, read in-depth with highlighter in hand, marking the main constructs, findings or arguments relevant to your claim. The third read will be for in-depth note taking.

2. Take organized notes on every source

On this third read, each source gets a notes page labeled with the author and year at the top. I formatted my notes in two columns, with the left column including a word or phrase to capture the main concept and the right column with the details. For example, my knowledge claim addressed teachers’ subjective ideas and experiences related to using specific interventions in their classrooms. My notes included concepts like teachers’ use of interventions, contextual influences and training experiences. Avoid organizing your notes by steps in the research process -- labeling information as sample, methods or results won’t help you make connections later on. I chose to write all my notes by hand , but this could also be done in a typed document.

3. Identify relevant concepts and supporting sources

Once you have a stack of source notes, it’s time to identify the concepts that show up across them. These concepts might include specific research findings, definitions of terms, future implications or other ideas driven by the purpose of your paper. Not every source will address every concept. First, make a master list of all the concepts from the left sides of your source notes. Then, find all the sources that covered each specific concept in their article or chapter. Personally, I simply transferred each concept to an individual sticky note and listed the authors who addressed it underneath.

4. Restructure your notes by concept

Now, each of those concepts gets its own two-column notes page. This time, the authors will go on the left-hand column and you will transfer the notes from step two specific to that concept on the right side. Think of it as if you were cutting apart your article notes, categorizing them by concept and pasting them to a new page (which, conceivably, you could also do, but it might get messy). As you are transferring these notes, pay attention to which authors agree and which raise unique ideas related to the concept; this will help you make connections when you write. In the spirit of synthesis, once this step is completed, these concept notes will be your primary reference, not the individual source notes.

Pro tip: Include a concept notes page for your overarching argument or thesis . In my paper, I argued the necessity of understanding teachers’ subjective beliefs about interventions. This was broader than my other concepts, but it was the common thread that needed to weave throughout the synthesis. By maintaining a single page of the primary arguments made by others, including particularly effective quotations , I could pull ideas from here throughout the whole writing process to keep my claim at the forefront.

5. Organize concepts into an outline

Those concepts should now form the basis of an outline of the paper. Decide how the concepts can be meaningfully grouped under larger themes. In my case, I sorted 29 concepts into six major themes, which became the level-one headings in my draft. Physically sequence your concepts based on the structure of your paper so that as you draft, you can just flip through the notes in order.

Once all of your notes are organized, it’s time to draft! You will have already done most of the synthesis work before ever putting a sentence on the page. For reference, I tracked my time use on my exam and ended up spending almost half of my total working time in the prewriting stage. This saved me the frustration of sifting through my sources over and over again to draw parallels and integrate the information while drafting. If you’re looking to write a synthesis more effectively and efficiently, try integrating these five steps into your prewriting process. Let us know how it goes in the comments or on Twitter!

Image by author.

GOP Platform: ‘Make Our College Campuses Safe and Patriotic Again’

Share this article, more from gradhacker.

5 Productivity Practices That Helped Me Finish My Dissertation

Summer Planning Strategies

Holding Pattern

• Become a Member
• Sign up for Newsletters
• Learning & Assessment
• Diversity & Equity
• Career Development
• Labor & Unionization
• Shared Governance
• Academic Freedom
• Books & Publishing
• Financial Aid
• Residential Life
• Free Speech
• Physical & Mental Health
• Race & Ethnicity
• Sex & Gender
• Socioeconomics
• Traditional-Age
• Adult & Post-Traditional
• Teaching & Learning
• Artificial Intelligence
• Digital Publishing
• Data Analytics
• Administrative Tech
• Alternative Credentials
• Financial Health
• Cost-Cutting
• Revenue Strategies
• Academic Programs
• Physical Campuses
• Mergers & Collaboration
• Fundraising
• Research Universities
• Regional Public Universities
• Community Colleges
• Private Nonprofit Colleges
• Minority-Serving Institutions
• Religious Colleges
• Women's Colleges
• Specialized Colleges
• For-Profit Colleges
• Executive Leadership
• Trustees & Regents
• State Oversight
• Accreditation
• Politics & Elections
• Supreme Court
• Student Aid Policy
• Science & Research Policy
• State Policy
• Colleges & Localities
• Employee Satisfaction
• Remote & Flexible Work
• Staff Issues
• Study Abroad
• International Students in U.S.
• U.S. Colleges in the World
• Intellectual Affairs
• Seeking a Faculty Job
• Advancing in the Faculty
• Seeking an Administrative Job
• Advancing as an Administrator
• Beyond Transfer
• Call to Action
• Confessions of a Community College Dean
• Higher Ed Gamma
• Higher Ed Policy
• Just Explain It to Me!
• Just Visiting
• Law, Policy—and IT?
• Leadership & StratEDgy
• Leadership in Higher Education
• Learning Innovation
• Online: Trending Now
• Resident Scholar
• University of Venus
• Student Voice
• Academic Life
• Health & Wellness
• The College Experience
• Life After College
• Academic Minute
• Weekly Wisdom
• Reports & Data
• Quick Takes
• Advertising & Marketing
• Consulting Services
• Data & Insights
• Hiring & Jobs
• Event Partnerships

4 /5 Articles remaining this month.

Sign up for a free account or log in.

• Sign Up, It’s FREE

• University of Oregon Libraries
• Research Guides

How to Write a Literature Review

• 6. Synthesize
• Literature Reviews: A Recap
• Reading Journal Articles
• Does it Describe a Literature Review?
• 1. Identify the Question
• 2. Review Discipline Styles
• Searching Article Databases
• Finding Full-Text of an Article
• Citation Chaining
• When to Stop Searching
• 4. Manage Your References
• 5. Critically Analyze and Evaluate

Synthesis Visualization

Synthesis matrix example.

• 7. Write a Literature Review

• Synthesis Worksheet

About Synthesis

Approaches to Synthesis

You can sort the literature in various ways, for example:

How to Begin?

Read your sources carefully and find the main idea(s) of each source

Look for similarities in your sources – which sources are talking about the same main ideas? (for example, sources that discuss the historical background on your topic)

Use the worksheet (above) or synthesis matrix (below) to get organized

This work can be messy. Don't worry if you have to go through a few iterations of the worksheet or matrix as you work on your lit review!

Four Examples of Student Writing

In the four examples below, only ONE shows a good example of synthesis: the fourth column, or  Student D . For a web accessible version, click the link below the image.

Long description of "Four Examples of Student Writing" for web accessibility

• Download a copy of the "Four Examples of Student Writing" chart

Click on the example to view the pdf.

From Jennifer Lim

• << Previous: 5. Critically Analyze and Evaluate
• Next: 7. Write a Literature Review >>
• Last Updated: May 3, 2024 5:17 PM
• URL: https://researchguides.uoregon.edu/litreview

Contact Us Library Accessibility UO Libraries Privacy Notices and Procedures

1501 Kincaid Street Eugene, OR 97403 P: 541-346-3053 F: 541-346-3485

• Visit us on Facebook
• Visit us on Twitter
• Visit us on Youtube
• Visit us on Instagram
• Report a Concern
• Nondiscrimination and Title IX
• Accessibility
• Privacy Policy
• Find People

Writing Lab

Research papers.

• Research Paper Basics
• Credible Sources
• Reading Scholarly Articles
• Summarizing and Paraphrasing
• Paraphrasing and Student Voice
• Direct Quotations
• Synthesis in Writing
• Citing Sources

Scholarly writing requires the use of synthesis. Scholars take writhing beyond the analysis level to the level where synthesis is evident; they add their ideas, interpretations, and voices to existing sources of information and take it further (Efron & David, 2018).

Difference between Summarizing and Synthesis

Summarizing requires an understanding of the material and identification of the major themes. No new information is being added to the information; it’s just being summed up. Although summarizing is necessary for the process of synthesis, synthesis goes beyond summarizing into the addition of information like interpretations or new conclusions (Efron & Ravid, 2018). 

Summarizing to Synthesis

Approach this in a step-by-step manner, starting with a summary of each source. The next step is to look for patterns and themes within each summary. After noting those, compare and contrast those patterns and themes between all sources. Find the relationships between the sources (Efron & Ravid, 2018). 

Synthesis occurs at the paragraph level when writers connect individual pieces of evidence from multiple sources to support a paragraph’s main idea and advance a paper’s thesis statement. Your paragraph includes a main idea, evidence from multiple sources, and the analysis of those multiple sources together.

Use strong verbs to integrate sources:

• The author  affirms, states, mentions, warns, predicts, proposes, admits  that..
• Findings  emphasize, argue, and reject  the importance..
• Research  revealed, verified, suggests  that..
• Evidence  indicates, confirms, denies, demonstrates ...
• << Previous: Direct Quotations
• Next: Citing Sources >>
• Last Updated: Jun 18, 2024 4:44 PM
• URL: https://guides.rasmussen.edu/research-papers

• U.S. Locations
• UMGC Europe
• Learn Online
• Find Answers
• 855-655-8682
• Current Students

UMGC Effective Writing Center Write to Synthesize: The Research Essay

Explore more of umgc.

• Writing Resources

In a synthesis, you bring things together. This combination, integration, or merging creates something new--your synthesis. The action of synthesis is basic to our world. Take, for example, what happens when a single oxygen molecule is combined with two hydrogen molecules. Water is created or synthesized. Hard to get more basic than that.

You also use synthesis to make personal decisions. If two instructors are teaching a class you must take, you may synthesize your past experiences with the teachers to choose the best class for you.

Research Essays:

Thesis driven.

In school, when writing a synthesis from your research, your sources may come from the school's library, a textbook, or the Internet. Here are some important points to keep in mind:

First, regardless of where your sources come from or how many you have, what you write should be driven by a thesis that you devise. After reading and studying your sources, you should form a personal point of view, a slant to connect your sources.

Here's a quick example--Let's say you've read three folktales: Goldilocks and the Three Bears, Little Red Riding Hood, and the Pied Piper--and now you must write a synthesis of them. As you study the three sources, you think about links between them and come up with this thesis: 

Folktales use fear to teach children lessons.

Then you use this thesis to synthesize your three sources as you support your point of view. You combine elements from the three sources to prove and illustrate this thesis. Your support points could focus on the lessons for children:

• Lesson 1 : Never talk to strangers.
• Lesson 2 : Don't wander from home.
• Lesson 3 : Appearances can deceive us.

This step of outlining your thesis and main points is a crucial one when writing a synthesis. If your goal in writing a research essay is to provide readers a unified perspective based on sources, the unified perspective must be clear before the writing begins.

Once the writing begins, your point of view is then carried through to the paragraph and sentence levels. Let's examine some techniques for achieving the unity that a good synthesis requires. First, here’s an example of an unsuccessful attempt at synthesizing sources:

Many sources agree that capital punishment is not a crime deterrent. [This is the idea around which the sources should be unified. Now comes the sources] According to Judy Pennington in an interview with Helen Prejean, crime rates in New Orleans rise for at least eight weeks following executions (110). Jimmy Dunne notes that crime rates often go up in the first two or three months following an execution. “Death in the Americas” argues that America’s crime rate as a whole has increased drastically since the re-instatement of the death penalty in the 1960s. The article notes that 700 crimes are committed for every 100,000 Americans (2). Helen Prejean cites Ellis in her book to note that in 1980, 500,000 people were behind bars and in 1990 that figure rose to 1.1 million (112).

Sample student paragraph adapted from "Literature Review: Synthesizing Multiple Sources." Retrieved 2011 from https://scholarworks.iupui.edu/items/7dda80e7-b0b3-477c-a972-283b48cfdf5c

This paragraph certainly uses a number of sources. However, the sources are presented in a random, grocery list fashion. Besides the main point at the beginning, there is no further attempt to synthesize. The sources seem tossed in, like ingredients in a salad. Let's examine a possible revision of that paragraph and how an adequate synthesis might be achieved:

Major studies suggest that capital punishment fails to deter crime. Helen Prejean, in "Deadman Walking," reviews decades of statistics that indicate capital punishment does little to lower crime. [Key idea from  topic sentence—"capital punishment fails to deter crime"— echoed in sentence about source–"capital punishment does little to lower crime." Repetition links source to main idea.] Based on this evidence, Prejean concludes “Executions do not deter crime . . . the U.S. murder rate is no higher in states that do not have the death penalty than those who do” (110). ["Based on this evidence" forces  reader to refer back to "statistics" in previous sentence.] Prejean’s point is reiterated from a historical perspective in Dunne's article “Death in the Americas.”  [This sentence provides a thought bridge between two sources.] Dunne first points out that, despite the social and economic upheavals from 1930 to 1960, crime rates were unchanged (2). [Linking phrase:"Dunne first points out"] However, after the reinstatement of the death penalty in the 1960s, “crime rates soared” (2). [Linking phase "However, Dunne notes."]

The result is a matrix of connective devices that unifies the sources around a key idea stated at the beginning. Although this matrix seems complex, it is actually built on a simple three-point strategy.

• Stay in charge . You the writer must control the sources, using them to serve your purpose. In good synthesis writing, sources are used to support what you, the writer, have already said in your own words.
• Stay focused . Your main point is not merely stated once and left to wilt. Your main idea is repeated and echoed throughout as a way to link the sources, to weave them together into a strong fabric of meaning.
• Stay strategic . Notice the "source sandwich" strategy at work. First, the author sets up the source with its background and relevance to the point. After the source comes a follows up in his/her own words as a way to bridge or link to the next part. In other words, the writer's own words are used like two slices of bread, with the source in the middle.

Follow these simple principles when using sources in your writing and you will achieve the most important goal of synthesis writing--to create a whole greater than its parts.

Our helpful admissions advisors can help you choose an academic program to fit your career goals, estimate your transfer credits, and develop a plan for your education costs that fits your budget. If you’re a current UMGC student, please visit the Help Center .

Personal Information

Contact information, additional information.

By submitting this form, you acknowledge that you intend to sign this form electronically and that your electronic signature is the equivalent of a handwritten signature, with all the same legal and binding effect. You are giving your express written consent without obligation for UMGC to contact you regarding our educational programs and services using e-mail, phone, or text, including automated technology for calls and/or texts to the mobile number(s) provided. For more details, including how to opt out, read our privacy policy or contact an admissions advisor .

Please wait, your form is being submitted.

By using our website you agree to our use of cookies. Learn more about how we use cookies by reading our  Privacy Policy .

A Guide to Evidence Synthesis: What is Evidence Synthesis?

• Meet Our Team
• Our Published Reviews and Protocols
• What is Evidence Synthesis?
• Types of Evidence Synthesis
• Evidence Synthesis Across Disciplines
• Finding and Appraising Existing Systematic Reviews
• 0. Develop a Protocol
• 1. Draft your Research Question
• 2. Select Databases
• 3. Select Grey Literature Sources
• 4. Write a Search Strategy
• 5. Register a Protocol
• 6. Translate Search Strategies
• 7. Citation Management
• 8. Article Screening
• 9. Risk of Bias Assessment
• 10. Data Extraction
• 11. Synthesize, Map, or Describe the Results
• Evidence Synthesis Institute for Librarians
• Open Access Evidence Synthesis Resources

What are Evidence Syntheses?

What are evidence syntheses.

According to the Royal Society, 'evidence synthesis' refers to the process of bringing together information from a range of sources and disciplines to inform debates and decisions on specific issues. They generally include a methodical and comprehensive literature synthesis focused on a well-formulated research question.  Their aim is to identify and synthesize all  of the scholarly research on a particular topic, including both published and unpublished studies. Evidence syntheses are conducted in an unbiased, reproducible way to provide evidence for practice and policy-making, as well as to identify gaps in the research. Evidence syntheses may also include a meta-analysis, a more quantitative process of synthesizing and visualizing data retrieved from various studies. 

Evidence syntheses are much more time-intensive than traditional literature reviews and require a multi-person research team. See this PredicTER tool to get a sense of a systematic review timeline (one type of evidence synthesis). Before embarking on an evidence synthesis, it's important to clearly identify your reasons for conducting one. For a list of types of evidence synthesis projects, see the next tab.

How Does a Traditional Literature Review Differ From an Evidence Synthesis?

How does a systematic review differ from a traditional literature review.

One commonly used form of evidence synthesis is a systematic review.  This table compares a traditional literature review with a systematic review.

Video: Reproducibility and transparent methods (Video 3:25)

Reporting Standards

There are some reporting standards for evidence syntheses. These can serve as guidelines for protocol and manuscript preparation and journals may require that these standards are followed for the review type that is being employed (e.g. systematic review, scoping review, etc). ​

• PRISMA checklist Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) is an evidence-based minimum set of items for reporting in systematic reviews and meta-analyses.
• PRISMA-P Standards An updated version of the original PRISMA standards for protocol development.
• PRISMA - ScR Reporting guidelines for scoping reviews and evidence maps
• PRISMA-IPD Standards Extension of the original PRISMA standards for systematic reviews and meta-analyses of individual participant data.
• EQUATOR Network The EQUATOR (Enhancing the QUAlity and Transparency Of health Research) Network is an international initiative that seeks to improve the reliability and value of published health research literature by promoting transparent and accurate reporting and wider use of robust reporting guidelines. They provide a list of various standards for reporting in systematic reviews.

Video: Guidelines and reporting standards

PRISMA Flow Diagram

The  PRISMA  flow diagram depicts the flow of information through the different phases of an evidence synthesis. It maps the search (number of records identified), screening (number of records included and excluded), and selection (reasons for exclusion).  Many evidence syntheses include a PRISMA flow diagram in the published manuscript.

See below for resources to help you generate your own PRISMA flow diagram.

• PRISMA Flow Diagram Tool
• PRISMA Flow Diagram Word Template
• << Previous: Our Published Reviews and Protocols
• Next: Types of Evidence Synthesis >>
• Last Updated: Jul 2, 2024 12:50 PM
• URL: https://guides.library.cornell.edu/evidence-synthesis

• Walden University
• Faculty Portal

Using Evidence: Synthesis

Synthesis video playlist.

Note that these videos were created while APA 6 was the style guide edition in use. There may be some examples of writing that have not been updated to APA 7 guidelines.

Basics of Synthesis

As you incorporate published writing into your own writing, you should aim for synthesis of the material.

Synthesizing requires critical reading and thinking in order to compare different material, highlighting similarities, differences, and connections. When writers synthesize successfully, they present new ideas based on interpretations of other evidence or arguments. You can also think of synthesis as an extension of—or a more complicated form of—analysis. One main difference is that synthesis involves multiple sources, while analysis often focuses on one source.

Conceptually, it can be helpful to think about synthesis existing at both the local (or paragraph) level and the global (or paper) level.

Local Synthesis

Local synthesis occurs at the paragraph level when writers connect individual pieces of evidence from multiple sources to support a paragraph’s main idea and advance a paper’s thesis statement. A common example in academic writing is a scholarly paragraph that includes a main idea, evidence from multiple sources, and analysis of those multiple sources together.

Global Synthesis

Global synthesis occurs at the paper (or, sometimes, section) level when writers connect ideas across paragraphs or sections to create a new narrative whole. A literature review , which can either stand alone or be a section/chapter within a capstone, is a common example of a place where global synthesis is necessary. However, in almost all academic writing, global synthesis is created by and sometimes referred to as good cohesion and flow.

Synthesis in Literature Reviews

While any types of scholarly writing can include synthesis, it is most often discussed in the context of literature reviews. Visit our literature review pages for more information about synthesis in literature reviews.

Related Webinars

Didn't find what you need? Email us at [email protected] .

• Previous Page: Analysis
• Next Page: Citing Sources Properly
• Office of Student Disability Services

Walden Resources

Departments.

• Academic Residencies
• Academic Skills
• Career Planning and Development
• Customer Care Team
• Field Experience
• Military Services
• Student Success Advising
• Writing Skills

Centers and Offices

• Center for Social Change
• Office of Academic Support and Instructional Services
• Office of Degree Acceleration
• Office of Research and Doctoral Services
• Office of Student Affairs

Student Resources

• Doctoral Writing Assessment
• Form & Style Review
• Quick Answers
• ScholarWorks
• SKIL Courses and Workshops
• Walden Bookstore
• Walden Catalog & Student Handbook
• Student Safety/Title IX
• Legal & Consumer Information
• Website Terms and Conditions
• Cookie Policy
• Accessibility
• Accreditation
• State Authorization
• Net Price Calculator
• Contact Walden

Walden University is a member of Adtalem Global Education, Inc. www.adtalem.com Walden University is certified to operate by SCHEV © 2024 Walden University LLC. All rights reserved.

• USU Library

Synthesis: Home

Engaging in synthesis.

Synthesis requires you to make sense of all the relevant ideas in your sources and blend them together with your own thoughts and ideas. Watch this video to learn how to engage in synthesis in order to take research from multiple sources along with your own arguments and turn it into a research paper.

Synthesizing Your Research

Understanding your research.

1. Read through your sources carefully.

2. Identify common themes or sub-topics that keep appearing in the articles you’re reading.

The Research Matrix

• Blank Research Matrix Fill out this blank matrix.
• Blank Synthesis Matrix template (Google Docs)

The research matrix is a helpful tool you can use to synthesize your research along with your own voice. The blank research matrix above can help you organize your paper by main idea, identify connections between your sources, and add your own analysis.

Filling Out Your Matrix

1. Write your topic or research question above the matrix.

2. Write your main ideas for your paper on the left side of the matrix. Helpful Tip: Choose your main ideas AFTER you have read your sources!

3. Write the title, author, or citation of each source in the top row of the matrix.

4. Fill in the matrix boxes with a paraphrase or direct quote that represents how the source discussed that main idea. You do not need every source to address every main idea!

5. Don't forget to nclude your own analysis of the main idea and the sources in the last column on the matrix.

Identify Gaps in Your Research

1. There’s a high likelihood that you will have empty spaces on your research matrix and that’s okay! Small gaps show that there is room for your own voice to join the conversation.

2. Large gaps in your matrix are often a sign that you need to do more research on that main idea. As a rule of thumb you should have at least two sources for each main idea in order to create a meaningful dialogue. 

• Last Updated: Mar 13, 2023 1:12 PM
• URL: https://libguides.usu.edu/synthesizing_info

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License

Writing Resources

• Student Paper Template
• Grammar Guidelines
• Punctuation Guidelines
• Writing Guidelines
• Creating a Title
• Outlining and Annotating
• Using Generative AI (Chat GPT and others)
• Introduction, Thesis, and Conclusion
• Strategies for Citations
• Determining the Resource This link opens in a new window
• Citation Examples
• Paragraph Development
• Paraphrasing
• Inclusive Language
• International Center for Academic Integrity
• How to Synthesize and Analyze
• Synthesis and Analysis Practice
• Synthesis and Analysis Group Sessions
• Decoding the Assignment Prompt
• Annotated Bibliography
• Comparative Analysis
• Conducting an Interview
• Infographics
• Office Memo
• Policy Brief
• Poster Presentations
• PowerPoint Presentation
• White Paper
• Writing a Blog
• Research Writing: The 5 Step Approach
• Step 1: Seek Out Evidence
• Step 2: Explain
• Step 3: The Big Picture
• Step 4: Own It
• Step 5: Illustrate
• MLA Resources
• Time Management

ASC Chat Hours

ASC Chat is usually available at the following times ( Pacific Time):

If there is not a coach on duty, submit your question via one of the below methods:

  928-440-1325

  Ask a Coach

  [email protected]

Search our FAQs on the Academic Success Center's  Ask a Coach   page.

Learning about Synthesis Analysis

What D oes Synthesis and Analysis Mean?

Synthesis: the combination of ideas to

• show commonalities or patterns

Analysis: a detailed examination

• of elements, ideas, or the structure of something
• can be a basis for discussion or interpretation

Synthesis and Analysis: combine and examine ideas to

• show how commonalities, patterns, and elements fit together
• form a unified point for a theory, discussion, or interpretation
• develop an informed evaluation of the idea by presenting several different viewpoints and/or ideas

Key Resource: Synthesis Matrix

Synthesis Matrix

A synthesis matrix is an excellent tool to use to organize sources by theme and to be able to see the similarities and differences as well as any important patterns in the methodology and recommendations for future research. Using a synthesis matrix can assist you not only in synthesizing and analyzing,  but it can also aid you in finding a researchable problem and gaps in methodology and/or research.

Use the Synthesis Matrix Template attached below to organize your research by theme and look for patterns in your sources .Use the companion handout, "Types of Articles" to aid you in identifying the different article types for the sources you are using in your matrix. If you have any questions about how to use the synthesis matrix, sign up for the synthesis analysis group session to practice using them with Dr. Sara Northern!

Was this resource helpful?

• << Previous: International Center for Academic Integrity
• Next: How to Synthesize and Analyze >>
• Last Updated: Jun 11, 2024 10:55 AM
• URL: https://resources.nu.edu/writingresources

• How it works

How to Synthesise Sources – Steps and Examples

Published by Olive Robin at October 17th, 2023 , Revised On October 17, 2023

The ability to effectively incorporate multiple sources into one’s work is not just a skill, but a necessity. Whether we are talking about research papers, articles, or even simple blog posts, synthesising sources can elevate our content to a more nuanced, comprehensive, and insightful level. But what does it truly mean to synthesise sources, and how does it differ from the commonly understood techniques of summarising and paraphrasing?

Importance of Synthesising Sources in Research and Writing

When finding sources , it is imperative to distinguish between various available information types. Secondary sources , for example, provide interpretations and analyses based on primary sources. Synthesising goes beyond the mere gathering of information. It involves the complex task of interweaving multiple sources to generate a broader and richer perspective. When we synthesise, we are not just collecting; we are connecting. 

By merging various viewpoints and data, we provide our readers with a well-rounded understanding of the topic. This approach ensures that our work is grounded in credible sources  while also adding unique insights.

Summarising, Paraphrasing, and Synthesising

At first glance, these three techniques might seem similar, but they serve distinctly different purposes:

Summarising

Synthesis is the art of blending multiple sources to create a unified narrative or argument. It is essential to use signal phrases to introduce these sources naturally, helping the reader follow the information flow. Block quotes can also be used for direct quotations, especially if they’re longer.

Paraphrasing

Here, we restate the original content using different words. While the wording changes, the essence and core meaning remain intact. This method is useful for clarifying complex ideas or for tailoring content to a specific audience.

Synthesising

Synthesis is the art of blending multiple sources to create a unified narrative or argument. It is not about echoing what others have said; it is about drawing connections, identifying patterns, and building a cohesive piece that holds its own merit.

What is Synthesising Sources?

Synthesising sources is a method used in research and writing wherein the author combines, interprets, and analyses information from various sources to generate a unified perspective, narrative, or argument. It involves a process that we can call source evaluation . It is an intricate process that goes beyond simply collecting data or quoting authors. Instead, it involves evaluating, integrating, and constructing a new narrative based on a collective understanding of all the sources under consideration.

Imagine a quilt where each piece of fabric represents a different source. Synthesising would be the act of sewing these individual pieces together in such a way that they form a beautiful, cohesive blanket. Each piece retains its uniqueness but contributes to the larger design and purpose of the quilt.

Objective of Synthesising

• Synthesising allows writers to delve deeper into topics by using a multitude of perspectives. This offers a more robust and comprehensive view than any single source could provide.
• By integrating diverse sources, authors can identify trends, consistencies, or discrepancies within a field or topic. This can lead to new insights or highlight areas needing further exploration.
• By interlinking sources, writers can add layers of complexity to their arguments, making their content more engaging and thought-provoking.
• While the sources themselves might not be new, the way in which they are combined and interpreted can lead to fresh conclusions and unique standpoints.
• Relying on a single source or a few like-minded ones can inadvertently introduce biases. Synthesising encourages the consideration of diverse viewpoints, ensuring a more balanced representation of the topic.

Why is Synthesis Important?

The art of synthesis, while a nuanced aspect of research and writing, holds unparalleled significance in constructing meaningful, in-depth content. Here is a detailed exploration of why synthesis is pivotal:

Enhancing Comprehension and Knowledge Depth

• Depth Over Breadth: While a vast amount of information exists on nearly any topic, true understanding isn’t about skimming the surface. Synthesising allows you to dive deeper, connecting various pieces of information and seeing the bigger picture.
• Clarifying Complexity: Topics, especially those in research, can be multifaceted. By merging multiple sources, we can simplify and explain intricate subjects more effectively.
• Reinforcing Concepts: By revisiting a concept from various sources and angles, the repetition, in a way, strengthens our grasp on the subject. It’s like studying from multiple textbooks; the overlap in content solidifies understanding.

Avoiding Plagiarism

• Original Thought Generation: While synthesising, you are compelled to merge ideas, compare viewpoints, and draw unique conclusions. This process naturally leads to producing original content rather than merely reproducing what one source says.
• Skilful Integration: A well-synthesised piece does not heavily rely on long, verbatim quotes. Instead, it seamlessly integrates information from various sources, duly cited, minimising the chances of unintentional plagiarism.
• Reflecting Authentic Engagement: When you synthesise, it showcases your genuine engagement with the material. It’s evident that you have not just copied content but have wrestled with the information, pondered upon it, and made it your own.

Developing a Holistic Perspective on a Topic

• Seeing the Full Spectrum: Single sources can offer a limited or biased viewpoint. Synthesis, by its nature, compels you to consult multiple sources, allowing for a more balanced and comprehensive view.
• Connecting the Dots: Life, society, and most academic subjects are interconnected. Synthesis helps recognise patterns, draw parallels, and understand how various elements interplay in the grand scheme of things.
• Elevating Critical Thinking: The act of synthesis hones your critical thinking skills. You’re constantly evaluating the validity of sources, comparing arguments, and discerning the weight of different perspectives. This makes your current work stronger and sharpens your intellect for future projects.

Steps of Synthesizing a Source

Here is a step-by-step guide on how to synthesise sources. 

Step 1: Read and Understand

Before you can synthesise sources effectively, you must first understand them individually. A strong synthesis is built upon a clear understanding of each source’s content, context, and nuances.

Tips To Ensure Comprehension

• Annotations: Make notes in the margins as you read, highlighting key points and ideas.
• Summarisation: After reading a section or an article, write a brief summary in your own words.
• Discussion: Talk about the content with peers or mentors. This can help clarify any confusion and deepen your understanding.
• Questioning: Constantly ask questions as you read. If something is unclear, revisit the content or consult supplementary materials.

Step 2: Identify Common Themes

Sources will often touch upon similar themes, even if they approach them differently. Recognising these themes can act as a foundation for synthesis.

• Mind Mapping: Visualise the interconnectedness of topics and subtopics.
• Lists: Create lists of similar ideas or arguments from different sources.
• Highlighting: Use colour codes to highlight recurring themes across different documents.

Step 3: Analyse and Compare

Different sources might have diverging opinions or findings. Recognising these differences is crucial to produce a balanced synthesis.

• Side-by-Side Analysis: Put the information from various sources next to each other to see how they align or diverge.
• Critical Evaluation: Ask yourself why sources might have different perspectives. Consider the methodology, context, or biases that could contribute.

Determining the Relevance of Each Source

Not all sources will hold equal weight or relevance in your synthesis.

• Criteria Checklist: Establish criteria for relevance (e.g., publication date, author credentials) and evaluate each source against this.
• Priority Setting: Decide which sources offer primary insights and which offer supplementary information.

Step 4: Organise Information

A clear structure is essential to guide your readers through the synthesised narrative.

• Outlines: Create a traditional outline that sequences your main points and supports them with subpoints from your sources.
• Flowcharts: For more complex topics, flowcharts can visually demonstrate the progression of ideas and their interconnections.

Step 5: Craft Your Narrative

This step involves the actual writing, where you combine the insights, evidence, and analysis into a singular narrative.

• Transitional Phrasing: Use transitions to move between ideas and sources smoothly.
• Voice Consistency: Even though you integrate multiple sources, ensure that the narrative maintains a consistent voice and tone.

Step 6: Cite Appropriately

Always credit original authors and sources to maintain integrity in your work and avoid plagiarism. Knowing how to cite sources is crucial in this process.

• In-text Citations: Whenever you refer to, paraphrase, or quote a source, provide a citation.

Different Citation Styles and Choosing The Right One

There are multiple citation styles (e.g., APA, MLA, Chicago), and your choice will often depend on your discipline or the preference of your institution or publication.

• Guideline Review: Familiarise yourself with the preferred citation style’s guidelines.

Citation Tools: Consider using tools like Zotero, Mendeley, or EndNote to help streamline and manage your citations.

The research done by our experts have:

• Precision and Clarity
• Zero Plagiarism
• Authentic Sources

Examples of Source Synthesis

Let’s explore some examples of synthesising sources. 

Example 1: Synthesising sources on climate change

Scenario: You have sources that discuss the causes of climate change. Some sources argue for anthropogenic (human-caused) factors, while others emphasise natural cycles.

Synthesis Approach

• Begin with an overview of climate change, its impacts, and its significance.
• Introduce the anthropogenic viewpoint, citing research on the rise of CO2 from industrial processes, deforestation, etc.
• Present the natural cycle perspective, highlighting periods in Earth’s history where temperature fluctuations were observed.
• Discuss overlaps, such as how human activities might exacerbate natural cycles.
• Conclude by emphasising the consensus in the scientific community about human contributions to recent climate change, but acknowledge the existence of natural cycles as part of Earth’s climate history.

Example 2: Merging Historical Texts on a Particular Event

Scenario: You are examining the Battle of Waterloo from British, French, and Prussian primary sources.

• Provide background on the Battle of Waterloo, setting the stage.
• Introduce the British perspective, detailing their strategies, key figures, and their account of the battle’s progression.
• Shift to the French viewpoint, noting their strategic decisions, challenges, and Napoleon’s role.
• Explore the Prussian account, emphasising their contributions and coordination with the British.
• Highlight areas of agreement among the sources (e.g., timeline of events) and areas of discrepancy or unique insights (e.g., differing reasons for the outcome).
• Conclude with a comprehensive view of the battle, incorporating insights from all perspectives and its significance in European history.

Example 3: Synthesising Qualitative And Quantitative Research On A Social Issue

Scenario: You are researching the effects of remote learning on student performance and well-being during the pandemic.

• Start with an introduction to the sudden shift to remote learning due to COVID-19.
• Present quantitative data: statistics showcasing the drop or rise in student grades, attendance rates, and standardised test scores.
• Introduce qualitative insights, like interviews or case studies, highlighting student sentiments, challenges faced at home, or feelings of isolation.
• Discuss the interplay between numbers and narratives. For instance, a drop in grades (quantitative) could be related to a lack of motivation or home distractions (qualitative).
• Compare outcomes across different demographics, using both types of data to show how remote learning might affect diverse student populations differently.
• Conclude with a holistic understanding of the impacts of remote learning, noting areas that need further research or intervention.

Common Mistakes to Avoid when Synthesising Sources

• Relying heavily on a single source limits the depth and breadth of your understanding. It may also inadvertently introduce bias if that source isn’t comprehensive or neutral.
• How to Avoid: Ensure you consult various sources for a well-rounded view. This includes both primary and secondary sources, academic articles, and more accessible pieces like news articles or blogs, if relevant.
• Every source comes with its own perspective. Identifying these biases can lead to a skewed understanding of your topic.
• How to Avoid: Critical reading is key. Always consider who the author is, their potential motivations, the context in which they’re writing, and the methodologies they use.
• Simply presenting what each source says without drawing connections or highlighting contrasts misses the essence of synthesis.
• How to Avoid: As you research, actively look for common themes, conflicting viewpoints, and unique insights. Your goal is to weave a narrative that reflects a comprehensive understanding of all these elements.

Tools and Resources for Synthesising Sources

These are the different tools that can be used for synthesising sources. 

Citation Tools

Managing references can be cumbersome, especially when dealing with numerous sources. Citation tools can help organise, format, and insert citations with ease.

• Zotero: A free, open-source tool that helps you collect, organise, cite, and share research.
• Mendeley: A reference manager and academic social network that can help you organise your research, collaborate with others online, and discover the latest developments.

Mind-Mapping Software or Apps

Mind mapping helps visually organise and interlink ideas, making the synthesis process more intuitive.

• MindMeister: An online mind-mapping tool that lets you capture, develop, and share ideas visually.
• XMind: A popular mind mapping and brainstorming software with various templates to help structure your thoughts.

Note-Taking Apps and Strategies

Effective note-taking is fundamental to understanding and organising information from various sources. Digital note-taking apps often offer features like tagging, search functionalities, and integration with other tools.

• Evernote: A cross-platform app designed for note-taking, organising, and archiving.
• Microsoft OneNote: A digital notebook that allows you to gather drawings, handwritten or typed notes, and save web clippings.
• Cornell Note-taking System: A structured method of note-taking that divides the paper into sections, encouraging active engagement with the material.

Frequently Asked Questions

What is a literature review.

A literature review is a comprehensive survey of existing research on a particular topic, synthesising findings to provide an overview of key concepts, debates, and gaps in knowledge. It establishes a foundation for new research, highlighting relevant studies and contextualising them within the broader academic conversation.

How to synthesise a source?

To synthesise a source, thoroughly understand its content, and then integrate its insights with information from other sources. This involves comparing and contrasting viewpoints, identifying patterns, and constructing a cohesive narrative or argument that offers a broader perspective rather than merely echoing the original source’s content.

Why do I need to cite sources?

Citing sources acknowledges original authors, maintains academic integrity, and provides readers with a reference for verification. It prevents plagiarism by giving credit to the ideas and research of others, allowing readers to trace the evolution of thought and confirm the reliability and accuracy of the presented information.

What are topic sentences?

Topic sentences are the main statements that introduce and summarise a paragraph’s main idea or focus. They provide context and direction, helping readers follow the writer’s argument or narrative. Typically placed at the beginning of a paragraph, they act as signposts, guiding the flow of the discussion.

You May Also Like

A tertiary source is an information source that compiles, analyses, and synthesises both primary and secondary sources.

A credible source can be trusted to provide accurate, reliable, and unbiased information. Credible sources are essential for various purposes, including academic research, journalism, decision-making, and gaining knowledge on various topics.

Primary sources refer to original, unmediated documents or records that have not been altered or transformed by interpretation or commentary. They provide first-hand accounts, evidence, or direct testimony concerning a subject or event under investigation.

USEFUL LINKS

LEARNING RESOURCES

COMPANY DETAILS

• How It Works

Help | Advanced Search

Computer Science > Computation and Language

Title: scaling synthetic data creation with 1,000,000,000 personas.

Abstract: We propose a novel persona-driven data synthesis methodology that leverages various perspectives within a large language model (LLM) to create diverse synthetic data. To fully exploit this methodology at scale, we introduce Persona Hub -- a collection of 1 billion diverse personas automatically curated from web data. These 1 billion personas (~13% of the world's total population), acting as distributed carriers of world knowledge, can tap into almost every perspective encapsulated within the LLM, thereby facilitating the creation of diverse synthetic data at scale for various scenarios. By showcasing Persona Hub's use cases in synthesizing high-quality mathematical and logical reasoning problems, instructions (i.e., user prompts), knowledge-rich texts, game NPCs and tools (functions) at scale, we demonstrate persona-driven data synthesis is versatile, scalable, flexible, and easy to use, potentially driving a paradigm shift in synthetic data creation and applications in practice, which may have a profound impact on LLM research and development.

Submission history

Access paper:.

• HTML (experimental)
• Other Formats

References & Citations

• Google Scholar
• Semantic Scholar

BibTeX formatted citation

Bibliographic and Citation Tools

Code, data and media associated with this article, recommenders and search tools.

• Institution

arXivLabs: experimental projects with community collaborators

arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website.

Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them.

Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs .

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

• View all journals
• Explore content
• About the journal
• Publish with us
• Sign up for alerts
• Research Briefing
• Published: 02 July 2024

Enzymatic synthesis of peptide therapeutics

Nature Chemical Biology ( 2024 ) Cite this article

1139 Accesses

13 Altmetric

Metrics details

• Biocatalysis
• Biosynthesis

Peptides are fundamental in life and are widely used as therapeutic agents; however, they are problematic to produce by chemical synthesis. The discovery of unusual biosynthetic pathways that produce peptide natural products reveals an alternative approach for peptide synthesis that uses ‘standalone’ ligase enzymes rather than multimodular enzymes.

This is a preview of subscription content, access via your institution

Access options

Access Nature and 54 other Nature Portfolio journals

Get Nature+, our best-value online-access subscription

24,99 € / 30 days

cancel any time

Subscribe to this journal

Receive 12 print issues and online access

251,40 € per year

only 20,95 € per issue

Buy this article

• Purchase on Springer Link
• Instant access to full article PDF

Prices may be subject to local taxes which are calculated during checkout

Isidro-Llobet, A. et al. Sustainability challenges in peptide synthesis and purification: from R&D to production. J. Org. Chem. 84 , 4615–4628 (2019). A review article from ‘big pharma’ that discusses the problems with current peptide synthesis.

Article   CAS   PubMed   Google Scholar  

Montalbán-López, M. et al. New developments in RiPP discovery, enzymology and engineering. Nat. Prod. Rep. 38 , 130–239 (2020). This review article presents recent developments in the field of ribosomal peptide biosynthesis.

Article   PubMed   PubMed Central   Google Scholar  

Winn, M. et al. Recent advances in engineering nonribosomal peptide assembly lines. Nat. Prod. Rep. 33 , 317–347 (2016). Another review article summarizes approaches for engineering NRPSs for the in vivo production of peptides.

Winn, M. et al. Discovery, characterization and engineering of ligases for amide synthesis. Nature 593 , 391–398 (2021). An article from our laboratory on the discovery of ligase enzymes for amide synthesis, which points to future peptide targets.

Winn, M. et al. Harnessing and engineering amide bond forming ligases for the synthesis of amides. Curr. Opin. Chem. Biol. 55 , 77–85 (2020). A wider opinion on the development of ligase enzymes for amide synthesis.

Download references

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This is a summary of: Xu, G. et al. Cryptic enzymatic assembly of peptides armed with β-lactone warheads. Nat. Chem. Biol . https://doi.org/10.1038/s41589-024-01657-7 (2024).

Rights and permissions

Reprints and permissions

About this article

Cite this article.

Enzymatic synthesis of peptide therapeutics. Nat Chem Biol (2024). https://doi.org/10.1038/s41589-024-01658-6

Download citation

Published : 02 July 2024

DOI : https://doi.org/10.1038/s41589-024-01658-6

Share this article

Anyone you share the following link with will be able to read this content:

Sorry, a shareable link is not currently available for this article.

Provided by the Springer Nature SharedIt content-sharing initiative

Quick links

• Explore articles by subject
• Guide to authors
• Editorial policies

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

• DOI: 10.1016/j.ribaf.2024.102472
• Corpus ID: 271025265

Cryptocurrency Volatility: A Review, Synthesis, and Research Agenda

• Mohamed Shaker Ahmed , Ahmed A. El‐Masry , +1 author Satish Kumar
• Published in Research In International… 1 July 2024
• Business, Economics

228 References

Interdependence of clean energy and green markets with cryptocurrencies, which factors drive bitcoin volatility: macroeconomic, technical, or both, volatility interdependence between cryptocurrencies, equity, and bond markets, the differential influence of social media sentiment on cryptocurrency returns and volatility during covid-19, asymmetric volatility dynamics in cryptocurrency markets on multi-time scales, on the volatility of cryptocurrencies, do financial volatilities mitigate the risk of cryptocurrency indexes, asymmetric dynamic spillover effect between cryptocurrency and china's financial market: evidence from tvp-var based connectedness approach, dynamic volatility connectedness between thermal coal futures and major cryptocurrencies: evidence from china, leverage effect in cryptocurrency markets, related papers.

Showing 1 through 3 of 0 Related Papers

Addressing Hallucinations in Speech Synthesis LLMs with the NVIDIA NeMo T5-TTS Model

NVIDIA NeMo has released the T5-TTS model , a significant advancement in text-to-speech (TTS) technology. Based on large language models (LLMs) , T5-TTS produces more accurate and natural-sounding speech. By improving alignment between text and audio, T5-TTS eliminates hallucinations such as repeated spoken words and skipped text. Additionally, T5-TTS makes up to 2x fewer word pronunciation errors compared to other open-source models such as Bark and SpeechT5 . 

Listen to T5-TTS model audio samples.

NVIDIA NeMo is an end-to-end platform for developing multimodal generative AI models at scale anywhere—on-premises and on any cloud.

The role of LLMs in speech synthesis

LLMs have revolutionized natural language processing (NLP) with their remarkable ability to understand and generate coherent text. Recently, LLMs have been widely adopted in the speech domain, using vast amounts of data to capture the nuances of human speech patterns and intonations. LLM-based speech synthesis models produce speech that is not only more natural, but also more expressive, opening up a world of possibilities for applications in various industries.

However, similar to their use in text domain, speech LLMs face the hallucinations challenges, which can hinder their real-world deployment.

T5-TTS model overview

The T5-TTS model leverages an encoder-decoder transformer architecture for speech synthesis. The encoder processes text input, and the auto-regressive decoder takes a reference speech prompt from the target speaker. The auto-regressive decoder then generates speech tokens by attending to the encoder’s output through the transformer’s cross-attention heads. These cross-attention heads implicitly learn to align text and speech. However, their robustness can falter, especially when the input text contains repeated words.

Addressing the hallucination challenge

Hallucination in TTS occurs when the generated speech deviates from the intended text, causing errors ranging from minor mispronunciations to entirely incorrect words. These inaccuracies can compromise the reliability of TTS systems in critical applications like assistive technologies, customer service, and content creation.

The T5-TTS model addresses this issue by more efficiently aligning textual inputs with corresponding speech outputs, significantly reducing hallucinations. By applying monotonic alignment prior and connectionist temporal classification (CTC) loss , the generated speech closely matches the intended text, resulting in a more reliable and accurate TTS system. For word pronunciation, the T5-TTS model makes 2x fewer errors compared to Bark , 1.8x fewer errors compared to VALLE-X ( open-source implementation ), and 1.5x fewer errors compared to SpeechT5 (Figure 2).

Implications and future considerations for research

The release of the T5-TTS model by NVIDIA NeMo marks a significant advancement in TTS systems. By effectively addressing the hallucination problem, the model sets the stage for more reliable and high-quality speech synthesis, enhancing user experiences across a wide range of applications.

Looking forward, the NVIDIA NeMo team plans to further refine the T5-TTS model by expanding language support, improving its ability to capture diverse speech patterns, and integrating it into broader NLP frameworks.

Explore the NVIDIA NeMo T5-TTS model

The T5-TTS model represents a major breakthrough in achieving more accurate and natural text-to-speech synthesis. Its innovative approach to learning robust text and speech alignment sets a new benchmark in the field, promising to transform how we interact with and benefit from TTS technology. 

To access the T5-TTS model and start exploring its potential, visit NVIDIA/NeMo on GitHub. Whether you’re a researcher, developer, or enthusiast, this powerful tool offers countless possibilities for innovation and advancement in the realm of text-to-speech technology. To learn more, see Improving Robustness of LLM-based Speech Synthesis by Learning Monotonic Alignment .

Acknowledgments

We extend our gratitude to all the model authors and collaborators who contributed to this work, including Paarth Neekhara, Shehzeen Hussain, Subhankar Ghosh, Jason Li, Boris Ginsburg, Rafael Valle, and Rohan Badlani.

Related resources

• GTC session: Making Large Language Models and Retrieval-Augmented Generation Work With Ease (Presented by Softserve, Inc.)
• GTC session: Training Optimization for LLM with NVIDIA NeMo and AWS
• GTC session: Large Language Model Fine-Tuning using Parameter Efficient Fine-Tuning (PEFT)
• NGC Containers: NeMo Framework
• SDK: NeMo LLM Service
• SDK: NeMo Megatron

About the Authors

Related posts

Pushing the Boundaries of Speech Recognition with NVIDIA NeMo Parakeet ASR Models

NVIDIA Speech and Translation AI Models Set Records for Speed and Accuracy

Creating Robust Neural Speech Synthesis with ForwardTacotron

Getting a Real Time Factor Over 60 for Text-To-Speech Services Using NVIDIA Riva

Generate Natural Sounding Speech from Text in Real-Time

New Standard for Speech Recognition and Translation from the NVIDIA NeMo Canary Model

Turbocharge ASR Accuracy and Speed with NVIDIA NeMo Parakeet-TDT

Event: Speech and Generative AI Developer Day at NVIDIA GTC 2024

RSC Advances

Design, synthesis, and in vitro and in silico studies of morpholine derived thiazoles as bovine carbonic anhydrase-ii inhibitors †.

* Corresponding authors

a Institute of Chemical Sciences, Bahauddin Zakariya University, Multan-60800, Pakistan E-mail: [email protected]

b Natural and Medical Sciences Research Centre, University of Nizwa, P.O. Box 33, PC 616, Birkat Al Mauz, Nizwa, Sultanate of Oman E-mail: [email protected]

c School of Pharmacy, D. Y. Patil University (Deemed to be University), Sector 7, Nerul, Navi Mumbai 400706, India

d Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi 682041, India

e Department of Pharmaceutical & Medicinal Chemistry, An der Immenburg 4, D-53121 Bonn, Germany

f Chemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia

g Department of Pharmacy, University of Genoa, Viale Benedetto XV, 3, Genoa 16132, Italy

Carbonic anhydrase CA-II enzyme is essential for maintaining homeostasis in several processes, including respiration, lipogenesis, gluconeogenesis, calcification, bone resorption, and electrolyte balance due to its vital function within cellular processes. Herein, we screened 25 newly synthesized thiazole derivatives and assessed their inhibitory potential against the zinc-containing carbonic anhydrase CA-II enzyme. Intriguingly, derivatives of thiazole exhibited varying degrees of inhibitory action against CA-II. The distinctive attribute of these compounds is that they can attach to the CA-II binding site and block its action. Morpholine based thiazoles can be strategically modified to improve bovine CA-II inhibitor binding affinity, selectivity, and pharmacokinetics. Thiazole and morpholine moieties can boost inhibitory efficacy and selectivity over other calcium-binding proteins by interacting with target bovine CA-II binding sites. The derivatives 23–26 exhibited greater affinity when compared to the standard acetazolamide. Furthermore, kinetic study of the most potent compound 24 was performed, which exhibited concentration dependent inhibition with a K i value of 9.64 ± 0.007 μM. Molecular docking, MD simulation and QSAR analysis was also carried out to elucidate the interactions, orientation, and conformational changes of these compounds within the active site of the enzyme. Moreover, pharmacokinetic assessments showed that most of the compounds possess attributes conducive to potential drug development.

Supplementary files

• Supplementary information PDF (8591K)

Article information

Download Citation

Permissions.

Design, synthesis, and in vitro and in silico studies of morpholine derived thiazoles as bovine carbonic anhydrase-II inhibitors

M. Tasleem, S. Ullah, A. Khan, S. N. Mali, S. Kumar, B. Mathew, A. Oneto, F. Noreen, G. E. Eldesoky, S. Schenone, A. Al-Harrasi and Z. Shafiq, RSC Adv. , 2024,  14 , 21355 DOI: 10.1039/D4RA03385J

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence . You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication , please go to the Copyright Clearance Center request page .

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page .

Read more about how to correctly acknowledge RSC content .

Social activity

Search articles by author, advertisements.