list of relevant research papers

How to Find Relevant Papers for your Research Project

Keeping up to date with new literature and reviewing the existing literature helps you to build deep knowledge and understanding in your field. Developing effective reading strategies and systems to retain and evolve your knowledge over time is a key part of your research project. With millions of papers published every year in more than ten thousand different journals, the challenge lies in finding relevant papers for your work, deciding which ones to read in-depth and working out how to retain and build an expansive knowledge over a long time frame, while balancing this alongside all your other research activities.  

In this multi-part Academic Reading Series we’ll focus on systems for reading and learning from academic papers, pooling information from our experiences in academia and advice from current researchers. In this first part we’ll cover searching for papers.

Why read Academic Papers?

Academic papers share the details of recent developments and discoveries, and are the most up to date records of advances in a field.  When starting a new project, you’ll typically first spend a lot of time reading.  This reading helps you to build a solid working knowledge, and learn about current areas of investigation and interest from researchers in your field.  

Every paper you read can also help you to:

• learn standard techniques and methods for your project
• discover emerging or new techniques and theories 
• find and access relevant data sets for analysis
• identify other relevant papers in reference sections
• spot gaps for your exploration
• notice opportunities for new projects and collaborations
• save yourself time so you don’t repeat what’s already been done

Papers are an invaluable source of information that you can use to build your foundational knowledge, determine interesting directions and to generate novel ideas for your projects.

Papers and your Research Project

Publishing papers is the academic standard for disseminating ideas, discoveries and findings.  Through your research projects, you’ll add to the body of academic knowledge, ideally contributing something novel to your field.  Depending on your research stage your project may involve writing a thesis or dissertation or publishing a journal articles to share your ideas within the research community. 

Typically academic writing involves referring to previously conducted work in the field to provide the context for your own work and sharing the information and evidence that supports your approach or methodology, as well as your findings and interpretations.  So the papers you are reading not only form a critical part in shaping your research, they also needed to back up your work when you write.  

While reading, you can start to create a personal catalogue of information and ideas that you can refer to when writing. Depending on how you build your catalogue and organise notes from your reading, you can then save yourself time searching for relevant knowledge when you sit down to write or want to plan out an investigation in future.  

Finding Relevant Papers when starting a Project

When you first start a project, you’ll likely be pointed in the direction of some relevant literature by your supervisor or PI.  There are several ways to find other relevant literature to read and would strongly recommend speaking with the experts around you, such as asking other researchers within your group, (if you are joining a group) or looking at your PI’s other publications, and exploring the publications of any collaborators on those papers.  Your PI may have varied research interests so keep in mind not all of their publications will be relevant for your project.

If you are continuing a project from a previous researcher, then their thesis or publications can hold relevant information, as well as point you towards other relevant literature from their references and bibliography.  

Recommendations from your PI and other researchers may point you in the direction of Seminal papers – the work that initiated or presents key ideas and theories in your field. These are the papers synonymous with your field so as you are searching for relevant papers, don’t disregard some of the older papers in your searches. 

Another way to identify relevant literature is finding relevant conferences in the field and exploring the presentations, posters and keynote speakers listed on the websites.  Again asking other researchers in your group and your supervisors will help you find conferences and meetings.  

It’s tempting to go search and uncover everything through searching online, but don’t forget to take advantage of the specific knowledge and expertise available from the people around you.

Finding Relevant Papers Online

As you deepen your familiarity with your research, you’ll start to notice and identify the most relevant recurring keywords in the papers you’re finding.  Take note of them for use in your future searches.  These keywords and combinations of those keywords can be used to help you with finding further relevant literature through literature databases like Google Scholar, PubMed or Web of Science.  You could even use these keywords to set up notifications to alert you about newly published papers related to these keywords.

Literature databases operate on keyword searches and have additional filters available to apply further parameters to your search, such as publication date or publication type as well as citation count. Generally high citation counts, when you consider the publication date, can indicate key papers and researchers in the field.  These high citation papers, and their authors offer another avenue for finding relevant papers for your project, from the references section of the paper and looking at other publications from these authors.   

Review papers can be a particularly good source of other relevant papers.  Reviews assess and analyse the published work in a field to date, and also highlight potential areas for further investigation.  The references section of these papers can point you towards several further relevant papers for your project. 

You might have come across the idea of a ‘Seed Paper’ and this is a paper you find that is very relevant to your work, which can act to point you in the direction of other relevant work. Tools like LitMaps can be useful here, as they show you the prior and derivative work based on the references in the paper, and which papers have since cited the paper. 

Ongoing Literature Search

Searching the literature is an expansive and iterative activity.  Finding relevant papers to read should be a regular part of your research activities. As you identify your keywords, you can take advantage of automated notifications when new papers are published. You might also identify particular journals that publish relevant research and you can monitor RSS feeds, using tools like Feedly to see new publications.

There are also lots of AI tools to help with your academic research from identifying relevant papers, generating summaries and ‘talking’ with collections of your papers.  These tools can definitely speed up your search and reading process. Keep in mind AI can be an incredibly useful tool, but you’ll need to analyse, interpret and apply the knowledge to direct your project in new and interesting directions.

Literature Searches are an iterative process, you might need to try several different combinations of keywords to find the most relevant results.  And as your project evolves or you follow different lines of inquiry in your work, you should search with updated and/or new keywords to unearth relevant literature.

It can be beneficial to save these searches, as well as the papers you want to look at in more detail. Some tools keep a log of all your searches performed, others you might need to keep track using your own system.  

Organising Relevant Papers

As you start finding relevant papers, it’s beneficial to make use of Reference Managers.  These tools capture the important information about a paper and contain a link or copy of the paper for you to access in future.  Adding your papers in you’ll start to build your own personal literature library, which will be an invaluable resource as you continue your project.

With a growing literature collection, which will only get larger over time, Reference Managers are a much better option than having a load of open Tabs, saved bookmarks in your browser or a Folder of PDFs on your desktop.   These Managers let you develop organisational systems to group related papers together and help you to add references into your academic writing. Proper referencing is a critical part of all academic writing and is made much quicker with a reference manager.  You can use popular reference management tools like Mendeley and Zotero , and Protolyst also has built-in referencing .

In the next part of this series, we’ll cover deciding which papers to read and different approaches to reading papers. 

• There are many ways to identify relevant literature to build your knowledge and inform your research project direction.  You can search through literature databases, search using AI tools, and don’t forget to seek suggestions from your PI and other researchers in your group.
• Once you’ve identified a relevant paper, look at the references in that paper and explore other publications from the Authors.
• Reading papers is an ongoing activity, consider using systems to organise your searches and the papers you discover
• Keep track of the most relevant Keywords for your project to iterate on your searches for relevant Literature
• Make use of Reference Managers to keep track of all the papers you are discovering to read and refer to in future
• Keep track of all relevant papers, you can decide which ones you should read and how to read them later

This is not an exhaustive list of suggestions to find relevant papers for your research! What tips and advice would you add? We’d love it if you let us know !

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

Save my name, email, and website in this browser for the next time I comment.

You're wasting 1 day a week refinding the golden nuggets of info buried in your files and folders. Protolyst is a networked note taking web app where you can collect and categorise each individual highlight to find and use your most valuable info fast.

• Cookie Policy
• Privacy Policy
• Writing Referenced Articles Fast
• Writing a Literature Review
• Taking Notes on Research Papers
• Building a Literature Database
• Zettelkasten Notetaking System
• Connecting Cornell Notes

Privacy Overview

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

• View all journals
• Explore content
• About the journal
• Publish with us
• Sign up for alerts

Collection  12 March 2023

Journal Top 100 - 2022

This collection highlights our most downloaded* research papers published in 2022. Featuring authors from around the world, these papers highlight valuable research from an international community.

You can also check out the Top 100 across various subject areas here .

*Data obtained from SN Insights, which is based on Digital Science’s Dimensions.

mRNA vaccine-induced antibodies more effective than natural immunity in neutralizing SARS-CoV-2 and its high affinity variants

• Dominic Esposito

Cats learn the names of their friend cats in their daily lives

• Saho Takagi
• Atsuko Saito
• Hika Kuroshima

Metformin administration is associated with enhanced response to transarterial chemoembolization for hepatocellular carcinoma in type 2 diabetes patients

• Woo Jin Jung
• Sangmi Jang
• Jin-Wook Kim

The impact of digital media on children’s intelligence while controlling for genetic differences in cognition and socioeconomic background

• Bruno Sauce
• Magnus Liebherr
• Torkel Klingberg

Life tables of annual life expectancy and mortality for companion dogs in the United Kingdom

• Kendy Tzu-yun Teng
• Dave C. Brodbelt
• Dan G. O’Neill

Bioarchaeological and palaeogenomic portrait of two Pompeians that died during the eruption of Vesuvius in 79 AD

• Gabriele Scorrano
• Serena Viva
• Fabio Macciardi

Reading on a smartphone affects sigh generation, brain activity, and comprehension

• Motoyasu Honma
• Yuri Masaoka
• Masahiko Izumizaki

Principal Component Analyses (PCA)-based findings in population genetic studies are highly biased and must be reevaluated

• Eran Elhaik

The determinants of COVID-19 morbidity and mortality across countries

• Dianna Chang
• Kelvin Jui Keng Tan

Birdsongs alleviate anxiety and paranoia in healthy participants

• J. Sundermann

Identification of ADS024, a newly characterized strain of Bacillus velezensis with direct Clostridiodes difficile killing and toxin degradation bio-activities

• Michelle M. O’Donnell
• James W. Hegarty
• Laurent Chesnel

Multiple sclerosis genetic and non-genetic factors interact through the transient transcriptome

• Renato Umeton
• Gianmarco Bellucci
• Giovanni Ristori

The effect of metformin on the survival of colorectal cancer patients with type 2 diabetes mellitus

• Zeinab Tarhini
• Kamelia Manceur
• Niki Christou

Chemical characterisation of the vapour emitted by an e-cigarette using a ceramic wick-based technology

• M. Isabel Pinto

Large-magnitude (VEI ≥ 7) ‘wet’ explosive silicic eruption preserved a Lower Miocene habitat at the Ipolytarnóc Fossil Site, North Hungary

• Dávid Karátson
• Imre Szarvas

Far-UVC (222 nm) efficiently inactivates an airborne pathogen in a room-sized chamber

• Waseem Hiwar
• Kenneth Wood

Low dose aspirin associated with greater bone mineral density in older adults

• Hongzhan Liu
• Xungang Xiao

First direct evidence of adult European eels migrating to their breeding place in the Sargasso Sea

• Rosalind M. Wright
• Adam T. Piper
• David Righton

Infections with the SARS-CoV-2 Delta variant exhibit fourfold increased viral loads in the upper airways compared to Alpha or non-variants of concern

• Christian J. H. von Wintersdorff
• Jozef Dingemans
• Paul H. M. Savelkoul

Inappropriate sinus tachycardia in post-COVID-19 syndrome

• Júlia Aranyó
• Victor Bazan
• Roger Villuendas

The microstructure and the origin of the Venus from Willendorf

• Gerhard W. Weber
• Alexander Lukeneder

COVID-19 reinfections among naturally infected and vaccinated individuals

• Sezanur Rahman
• M. Mahfuzur Rahman
• Mustafizur Rahman

Lockdown measures during the COVID-19 pandemic strongly impacted the circulation of respiratory pathogens in Southern China

• Heping Wang
• Yuejie Zheng
• Wenjian Wang

Alzheimer’s disease large-scale gene expression portrait identifies exercise as the top theoretical treatment

• Mason A. Hill
• Stephen C. Gammie

COVID-19 symptoms are reduced by targeted hydration of the nose, larynx and trachea

• Carolin Elizabeth George
• Gerhard Scheuch
• David A. Edwards

SARS-CoV-2 spike protein induces cognitive deficit and anxiety-like behavior in mouse via non-cell autonomous hippocampal neuronal death

• Junyoung Oh
• Woo-Hyun Cho
• Sung Joong Lee

Abdominal pain patterns during COVID-19: an observational study

• Alexandre Balaphas
• Kyriaki Gkoufa
• Christian Toso

Detection of human pathogenic bacteria in rectal DNA samples from Zalophus californianus in the Gulf of California, Mexico

• Francesco Cicala
• David Ramírez-Delgado
• Alexei F. Licea-Navarro

Industrialised fishing nations largely contribute to floating plastic pollution in the North Pacific subtropical gyre

• Laurent Lebreton
• Sarah-Jeanne Royer
• Matthias Egger

Hypertension and diabetes including their earlier stage are associated with increased risk of sudden cardiac arrest

• Seung Young Roh
• Young-Hoon Kim

Utility of an artificial intelligence system for classification of esophageal lesions when simulating its clinical use

• Ayaka Tajiri
• Ryu Ishihara
• Tomohiro Tada

Prevalence, age of decision, and interpersonal warmth judgements of childfree adults

• Zachary P. Neal
• Jennifer Watling Neal

Acute and protracted abstinence from methamphetamine bidirectionally changes intrinsic excitability of indirect pathway spiny projection neurons in the dorsomedial striatum

• Sanghoon Choi
• Steven M. Graves

Indeterminacy of cannabis impairment and ∆ 9 -tetrahydrocannabinol (∆ 9 -THC) levels in blood and breath

• Gregory T. Wurz
• Michael W. DeGregorio

High rates of plasmid cotransformation in E. coli overturn the clonality myth and reveal colony development

• Delia Tomoiaga
• Jaclyn Bubnell
• Paul Feinstein

Metformin sensitizes leukemic cells to cytotoxic lymphocytes by increasing expression of intercellular adhesion molecule-1 (ICAM-1)

• Nerea Allende-Vega
• Joaquin Marco Brualla
• Martin Villalba

Incorporation of machine learning and deep neural network approaches into a remote sensing-integrated crop model for the simulation of rice growth

• Seungtaek Jeong
• Jong-min Yeom

Perceiving societal pressure to be happy is linked to poor well-being, especially in happy nations

• Egon Dejonckheere
• Joshua J. Rhee
• Brock Bastian

The earliest Pleistocene record of a large-bodied hominin from the Levant supports two out-of-Africa dispersal events

• Alon Barash
• Miriam Belmaker

Generation mechanism and prediction of an observed extreme rogue wave

• Johannes Gemmrich

Fitness tracking reveals task-specific associations between memory, mental health, and physical activity

• Jeremy R. Manning
• Gina M. Notaro
• Paxton C. Fitzpatrick

Domestic dogs ( Canis familiaris ) grieve over the loss of a conspecific

• Stefania Uccheddu
• Lucia Ronconi
• Federica Pirrone

Human transgenerational observations of regular smoking before puberty on fat mass in grandchildren and great-grandchildren

• Jean Golding
• Steve Gregory
• Matthew Suderman

Chlamydia pneumoniae can infect the central nervous system via the olfactory and trigeminal nerves and contributes to Alzheimer’s disease risk

• Jenny A. K. Ekberg

Oxycodone/naloxone versus tapentadol in real-world chronic non-cancer pain management: an observational and pharmacogenetic study

• Jordi Barrachina
• Cesar Margarit
• Ana M. Peiró

Cooking methods are associated with inflammatory factors, renal function, and other hormones and nutritional biomarkers in older adults

• Montserrat Rodríguez-Ayala
• José Ramón Banegas
• Pilar Guallar-Castillón

Classification of pig calls produced from birth to slaughter according to their emotional valence and context of production

• Elodie F. Briefer
• Ciara C.-R. Sypherd
• Céline Tallet

Higher emotional awareness is associated with greater domain-general reflective tendencies

• Michelle Persich
• William D. S. Killgore

A large Megaraptoridae (Theropoda: Coelurosauria) from Upper Cretaceous (Maastrichtian) of Patagonia, Argentina

• Alexis M. Aranciaga Rolando
• Matias J. Motta
• Fernando E. Novas

Long COVID occurrence in COVID-19 survivors

• Aya Sugiyama
• Junko Tanaka

Water activated disposable paper battery

• Alexandre Poulin
• Xavier Aeby
• Gustav Nyström

Intestinal preservation in a birdlike dinosaur supports conservatism in digestive canal evolution among theropods

• Yichuan Liu

Antiviral effect of cetylpyridinium chloride in mouthwash on SARS-CoV-2

• Hirofumi Sawa

Evidence of an oceanic impact and megatsunami sedimentation in Chryse Planitia, Mars

• J. Alexis P. Rodriguez
• Darrel K. Robertson
• Mario Zarroca

Curcumin and metformin synergistically modulate peripheral and central immune mechanisms of pain

• Peththa Wadu Dasuni Wasana
• Pasarapa Towiwat

The first occurrence of an avian-style respiratory infection in a non-avian dinosaur

• D. Cary Woodruff
• Ewan D. S. Wolff
• Lawrence M. Witmer

Optimal linear estimation models predict 1400–2900 years of overlap between Homo sapiens and Neandertals prior to their disappearance from France and northern Spain

• Igor Djakovic
• Alastair Key
• Marie Soressi

The influence of time on the sensitivity of SARS-CoV-2 serological testing

• Arturo Torres Ortiz
• Fernanda Fenn Torrente
• Louis Grandjean

Online misinformation is linked to early COVID-19 vaccination hesitancy and refusal

• Francesco Pierri
• Brea L. Perry
• John Bryden

A distinct symptom pattern emerges for COVID-19 long-haul: a nationwide study

• Melissa D. Pinto
• Charles A. Downs
• Natalie Lambert

SARS-CoV-2-reactive IFN-γ-producing CD4 + and CD8 + T cells in blood do not correlate with clinical severity in unvaccinated critically ill COVID-19 patients

• Beatriz Olea
• Eliseo Albert
• David Navarro

Classification of 74 facial emoji’s emotional states on the valence-arousal axes

• Gaku Kutsuzawa
• Hiroyuki Umemura
• Yoshiyuki Kobayashi

The emergence of a new sex-system (XX/XY 1 Y 2 ) suggests a species complex in the “monotypic” rodent Oecomys auyantepui (Rodentia, Sigmodontinae)

• Willam Oliveira da Silva
• Celina Coelho Rosa
• Cleusa Yoshiko Nagamachi

Detection of COVID-19 using multimodal data from a wearable device: results from the first TemPredict Study

• Ashley E. Mason
• Frederick M. Hecht
• Benjamin L. Smarr

Spinal degeneration is associated with lumbar multifidus morphology in secondary care patients with low back or leg pain

• Jeffrey R. Cooley
• Tue S. Jensen
• Jeffrey J. Hebert

Phenomenology and content of the inhaled N , N -dimethyltryptamine ( N , N -DMT) experience

• David Wyndham Lawrence
• Robin Carhart-Harris
• Christopher Timmermann

A gigantic bizarre marine turtle (Testudines: Chelonioidea) from the Middle Campanian (Late Cretaceous) of South-western Europe

• Oscar Castillo-Visa
• Àngel H. Luján
• Albert Sellés

The first experience with fully endoscopic posterior cervical foraminotomy and discectomy for radiculopathy performed in Viet Duc University Hospital

• Son Ngoc Dinh
• Hung The Dinh

Mapping the “catscape” formed by a population of pet cats with outdoor access

• Richard Bischof
• Nina Rosita Hansen
• Torbjørn Haugaasen

Investigation of humans individual differences as predictors of their animal interaction styles, focused on the domestic cat

• Lauren R. Finka
• Lucia Ripari
• Marnie L. Brennan

Genesis of fecal floatation is causally linked to gut microbial colonization in mice

• Syed Mohammed Musheer Aalam
• Daphne Norma Crasta
• Nagarajan Kannan

Young children’s screen time during the first COVID-19 lockdown in 12 countries

• Christina Bergmann
• Nevena Dimitrova
• Nivedita Mani

Cichlids and stingrays can add and subtract ‘one’ in the number space from one to five

• V. Schluessel

Elevated estradiol levels in frozen embryo transfer have different effects on pregnancy outcomes depending on the stage of transferred embryos

• Liming Ruan

Group VR experiences can produce ego attenuation and connectedness comparable to psychedelics

• David R. Glowacki
• Rhoslyn Roebuck Williams
• Mike Chatziapostolou

New therizinosaurid dinosaur from the marine Osoushinai Formation (Upper Cretaceous, Japan) provides insight for function and evolution of therizinosaur claws

• Yoshitsugu Kobayashi
• Ryuji Takasaki
• Yoshinori Hikida

Smartphone-based ecological momentary assessment reveals mental health benefits of birdlife

• Ryan Hammoud
• Stefania Tognin
• Andrea Mechelli

Long-term outcomes of cataract surgery with toric intraocular lens implantation by the type of preoperative astigmatism

• Tetsuro Oshika
• Shinichiro Nakano
• Tsutomu Kaneko

Forest fire detection system using wireless sensor networks and machine learning

• Udaya Dampage
• Lumini Bandaranayake
• Bathiya Jayasanka

Misinformation of COVID-19 vaccines and vaccine hesitancy

• Sun Kyong Lee
• Juhyung Sun
• Shane Connelly

Deep language algorithms predict semantic comprehension from brain activity

• Charlotte Caucheteux
• Alexandre Gramfort
• Jean-Rémi King

Children with autism spectrum disorder show atypical electroencephalographic response to processing contextual incongruencies

• Amparo V. Márquez-García
• Vasily A. Vakorin
• Sam M. Doesburg

A generalizable one health framework for the control of zoonotic diseases

• Ria R. Ghai
• Ryan M. Wallace
• Casey Barton Behravesh

HS3ST2 expression induces the cell autonomous aggregation of tau

• M. B. Huynh
• N. Rebergue
• D. Papy-Garcia

Exceptional warming over the Barents area

• Ketil Isaksen
• Øyvind Nordli
• Tatiana Karandasheva

A new Early Cretaceous lizard in Myanmar amber with exceptionally preserved integument

• Andrej Čerňanský
• Edward L. Stanley
• Susan E. Evans

Coffee consumption and diabetic retinopathy in adults with diabetes mellitus

• Hak Jun Lee
• Daniel Duck-Jin Hwang

Shifts in the foraging tactics of crocodiles following invasion by toxic prey

• Abhilasha Aiyer
• Richard Shine
• Georgia Ward-Fear

Production of high loading insulin nanoparticles suitable for oral delivery by spray drying and freeze drying techniques

• Alberto Baldelli
• Anubhav Pratap-Singh

Cable news and COVID-19 vaccine uptake

• Matteo Pinna
• Christoph Goessmann

Estimating the time of last drinking from blood ethyl glucuronide and ethyl sulphate concentrations

• Zhongyuan Guo

COVID-19 infections in infants

• Małgorzata Sobolewska-Pilarczyk
• Maria Pokorska-Śpiewak
• Małgorzata Pawłowska

COVID-19 increases the risk for the onset of atrial fibrillation in hospitalized patients

• Jakob Wollborn
• Sergey Karamnov
• Jochen D. Muehlschlegel

Childhood temperament and adulthood personality differentially predict life outcomes

• Amanda J. Wright
• Joshua J. Jackson

Antivirus applied to JAR malware detection based on runtime behaviors

• Ricardo P. Pinheiro
• Sidney M. L. Lima
• Wellington P. dos Santos

Therapeutic enzyme engineering using a generative neural network

• Andrew Giessel
• Athanasios Dousis
• Stuart Licht

Identification of genes associated with human-canine communication in canine evolution

• Akiko Tonoike
• Ken-ichi Otaki
• Miho Nagasawa

Breath chemical markers of sexual arousal in humans

• G. Pugliese
• J. Williams

A 5-km-thick reservoir with > 380,000 km 3 of magma within the ancient Earth's crust

• Rais Latypov
• Sofya Chistyakova
• Mauritz van der Merwe

Return of large fin whale feeding aggregations to historical whaling grounds in the Southern Ocean

• Helena Herr
• Sacha Viquerat
• Bettina Meyer

Quick links

• Explore articles by subject
• Guide to authors
• Editorial policies

Reference management. Clean and simple.

The top list of academic research databases

2. Web of Science

5. ieee xplore, 6. sciencedirect, 7. directory of open access journals (doaj), get the most out of your academic research database, frequently asked questions about academic research databases, related articles.

Whether you are writing a thesis , dissertation, or research paper it is a key task to survey prior literature and research findings. More likely than not, you will be looking for trusted resources, most likely peer-reviewed research articles.

Academic research databases make it easy to locate the literature you are looking for. We have compiled the top list of trusted academic resources to help you get started with your research:

Scopus is one of the two big commercial, bibliographic databases that cover scholarly literature from almost any discipline. Besides searching for research articles, Scopus also provides academic journal rankings, author profiles, and an h-index calculator .

• Coverage: 90.6 million core records
• References: N/A
• Discipline: Multidisciplinary
• Access options: Limited free preview, full access by institutional subscription only
• Provider: Elsevier

Web of Science also known as Web of Knowledge is the second big bibliographic database. Usually, academic institutions provide either access to Web of Science or Scopus on their campus network for free.

• Coverage: approx. 100 million items
• References: 1.4 billion
• Access options: institutional subscription only
• Provider: Clarivate (formerly Thomson Reuters)

PubMed is the number one resource for anyone looking for literature in medicine or biological sciences. PubMed stores abstracts and bibliographic details of more than 30 million papers and provides full text links to the publisher sites or links to the free PDF on PubMed Central (PMC) .

• Coverage: approx. 35 million items
• Discipline: Medicine and Biological Sciences
• Access options: free
• Provider: NIH

For education sciences, ERIC is the number one destination. ERIC stands for Education Resources Information Center, and is a database that specifically hosts education-related literature.

• Coverage: approx. 1.6 million items
• Discipline: Education
• Provider: U.S. Department of Education

IEEE Xplore is the leading academic database in the field of engineering and computer science. It's not only journal articles, but also conference papers, standards and books that can be search for.

• Coverage: approx. 6 million items
• Discipline: Engineering
• Provider: IEEE (Institute of Electrical and Electronics Engineers)

ScienceDirect is the gateway to the millions of academic articles published by Elsevier, 1.4 million of which are open access. Journals and books can be searched via a single interface.

• Coverage: approx. 19.5 million items

The DOAJ is an open-access academic database that can be accessed and searched for free.

• Coverage: over 8 million records
• Provider: DOAJ

JSTOR is another great resource to find research papers. Any article published before 1924 in the United States is available for free and JSTOR also offers scholarships for independent researchers.

• Coverage: more than 12 million items
• Provider: ITHAKA

Start using a reference manager like Paperpile to save, organize, and cite your references. Paperpile integrates with PubMed and many popular databases, so you can save references and PDFs directly to your library using the Paperpile buttons:

Scopus is one of the two big commercial, bibliographic databases that cover scholarly literature from almost any discipline. Beside searching for research articles, Scopus also provides academic journal rankings, author profiles, and an h-index calculator .

PubMed is the number one resource for anyone looking for literature in medicine or biological sciences. PubMed stores abstracts and bibliographic details of more than 30 million papers and provides full text links to the publisher sites or links to the free PDF on PubMed Central (PMC)

Find the right journal

If you know the name of the journal you want to submit to, view all journals .

If you would like us to recommend the journal/s that are best suited to publish your article, use our Journal Suggester . All you need is an abstract or description of your article to find matching journals.

Tips for finding the right journal

Submitting a manuscript to unsuitable journals is a common mistake, and can cause journal editors to reject the manuscript before peer review. Choosing a relevant journal makes it more likely that your manuscript will be accepted. Some factors to consider are:

• The topics the journal publishes. If your research is applied, target a journal that publishes applied science; if it is clinical, target a clinical journal; if it is basic research, target a journal that publishes basic research. You may find it easier to browse a list of journals by subject area.
• The journal's audience. Will researchers in related fields be interested in your study? If so, a journal that covers a broad range of topics may be best. If only researchers in your field are likely to want to read your study, then a field-specific journal would be best.
• The types of articles the journal publishes. If you are looking to publish a review, case study or a theorem, ensure that your target journal accepts theses type of manuscripts.
• The reputation of the journal. A journal's Impact Factor is one measure of its reputation, but not always the most important. You should consider the prestige of the authors that publish in the journal and whether your research is of a similar level.
• What are your personal requirements: Does the journal usually publish articles quickly; is the "time to publication" important for you?

When looking for suitable journals in which to publish your own results, start with what you have read. You should already be familiar with published studies that are similar to yours. Which journal were those studies published in? The same journals may be appropriate for your manuscript, so make a list of them. If you need more journals to consider, you can do literature searches for other published articles in your field that are similar in scope and impact on the field, and see where they were published.

When you have a list of potential target journals, visit and read the websites for these journals. Every journal should have a page that provides instructions for authors, including information on many of the factors listed above.

Journals on your list that are not a match for your manuscript based on the factors listed above should be eliminated from consideration. Among the remaining journals, it is likely that one or more will stand out as a very good candidate. Consider if any additional experiments will give you a better chance of achieving publication in your top choice. If you are in a hurry to publish, consider which of the remaining journals offers rapid publication; if none do, consider which has the highest publication frequency. If your main goal is to reach as many readers as possible, strongly consider candidate journals that provide an open access option. Open access allows anyone to read your article, free of charge, online, which can make your article more likely to be read and cited.

When you have chosen the journal you think is the best fit for your study and your goals, it is usually a good idea to also identify your second- and third-choice journals. That way, if your paper is rejected from your first-choice journal, you can quickly submit to your second-choice journal.

Choose Your Test

Sat / act prep online guides and tips, 113 great research paper topics.

General Education

One of the hardest parts of writing a research paper can be just finding a good topic to write about. Fortunately we've done the hard work for you and have compiled a list of 113 interesting research paper topics. They've been organized into ten categories and cover a wide range of subjects so you can easily find the best topic for you.

In addition to the list of good research topics, we've included advice on what makes a good research paper topic and how you can use your topic to start writing a great paper.

What Makes a Good Research Paper Topic?

Not all research paper topics are created equal, and you want to make sure you choose a great topic before you start writing. Below are the three most important factors to consider to make sure you choose the best research paper topics.

#1: It's Something You're Interested In

A paper is always easier to write if you're interested in the topic, and you'll be more motivated to do in-depth research and write a paper that really covers the entire subject. Even if a certain research paper topic is getting a lot of buzz right now or other people seem interested in writing about it, don't feel tempted to make it your topic unless you genuinely have some sort of interest in it as well.

#2: There's Enough Information to Write a Paper

Even if you come up with the absolute best research paper topic and you're so excited to write about it, you won't be able to produce a good paper if there isn't enough research about the topic. This can happen for very specific or specialized topics, as well as topics that are too new to have enough research done on them at the moment. Easy research paper topics will always be topics with enough information to write a full-length paper.

Trying to write a research paper on a topic that doesn't have much research on it is incredibly hard, so before you decide on a topic, do a bit of preliminary searching and make sure you'll have all the information you need to write your paper.

#3: It Fits Your Teacher's Guidelines

Don't get so carried away looking at lists of research paper topics that you forget any requirements or restrictions your teacher may have put on research topic ideas. If you're writing a research paper on a health-related topic, deciding to write about the impact of rap on the music scene probably won't be allowed, but there may be some sort of leeway. For example, if you're really interested in current events but your teacher wants you to write a research paper on a history topic, you may be able to choose a topic that fits both categories, like exploring the relationship between the US and North Korea. No matter what, always get your research paper topic approved by your teacher first before you begin writing.

113 Good Research Paper Topics

Below are 113 good research topics to help you get you started on your paper. We've organized them into ten categories to make it easier to find the type of research paper topics you're looking for.

Arts/Culture

• Discuss the main differences in art from the Italian Renaissance and the Northern Renaissance .
• Analyze the impact a famous artist had on the world.
• How is sexism portrayed in different types of media (music, film, video games, etc.)? Has the amount/type of sexism changed over the years?
• How has the music of slaves brought over from Africa shaped modern American music?
• How has rap music evolved in the past decade?
• How has the portrayal of minorities in the media changed?

Current Events

• What have been the impacts of China's one child policy?
• How have the goals of feminists changed over the decades?
• How has the Trump presidency changed international relations?
• Analyze the history of the relationship between the United States and North Korea.
• What factors contributed to the current decline in the rate of unemployment?
• What have been the impacts of states which have increased their minimum wage?
• How do US immigration laws compare to immigration laws of other countries?
• How have the US's immigration laws changed in the past few years/decades?
• How has the Black Lives Matter movement affected discussions and view about racism in the US?
• What impact has the Affordable Care Act had on healthcare in the US?
• What factors contributed to the UK deciding to leave the EU (Brexit)?
• What factors contributed to China becoming an economic power?
• Discuss the history of Bitcoin or other cryptocurrencies  (some of which tokenize the S&P 500 Index on the blockchain) .
• Do students in schools that eliminate grades do better in college and their careers?
• Do students from wealthier backgrounds score higher on standardized tests?
• Do students who receive free meals at school get higher grades compared to when they weren't receiving a free meal?
• Do students who attend charter schools score higher on standardized tests than students in public schools?
• Do students learn better in same-sex classrooms?
• How does giving each student access to an iPad or laptop affect their studies?
• What are the benefits and drawbacks of the Montessori Method ?
• Do children who attend preschool do better in school later on?
• What was the impact of the No Child Left Behind act?
• How does the US education system compare to education systems in other countries?
• What impact does mandatory physical education classes have on students' health?
• Which methods are most effective at reducing bullying in schools?
• Do homeschoolers who attend college do as well as students who attended traditional schools?
• Does offering tenure increase or decrease quality of teaching?
• How does college debt affect future life choices of students?
• Should graduate students be able to form unions?

• What are different ways to lower gun-related deaths in the US?
• How and why have divorce rates changed over time?
• Is affirmative action still necessary in education and/or the workplace?
• Should physician-assisted suicide be legal?
• How has stem cell research impacted the medical field?
• How can human trafficking be reduced in the United States/world?
• Should people be able to donate organs in exchange for money?
• Which types of juvenile punishment have proven most effective at preventing future crimes?
• Has the increase in US airport security made passengers safer?
• Analyze the immigration policies of certain countries and how they are similar and different from one another.
• Several states have legalized recreational marijuana. What positive and negative impacts have they experienced as a result?
• Do tariffs increase the number of domestic jobs?
• Which prison reforms have proven most effective?
• Should governments be able to censor certain information on the internet?
• Which methods/programs have been most effective at reducing teen pregnancy?
• What are the benefits and drawbacks of the Keto diet?
• How effective are different exercise regimes for losing weight and maintaining weight loss?
• How do the healthcare plans of various countries differ from each other?
• What are the most effective ways to treat depression ?
• What are the pros and cons of genetically modified foods?
• Which methods are most effective for improving memory?
• What can be done to lower healthcare costs in the US?
• What factors contributed to the current opioid crisis?
• Analyze the history and impact of the HIV/AIDS epidemic .
• Are low-carbohydrate or low-fat diets more effective for weight loss?
• How much exercise should the average adult be getting each week?
• Which methods are most effective to get parents to vaccinate their children?
• What are the pros and cons of clean needle programs?
• How does stress affect the body?
• Discuss the history of the conflict between Israel and the Palestinians.
• What were the causes and effects of the Salem Witch Trials?
• Who was responsible for the Iran-Contra situation?
• How has New Orleans and the government's response to natural disasters changed since Hurricane Katrina?
• What events led to the fall of the Roman Empire?
• What were the impacts of British rule in India ?
• Was the atomic bombing of Hiroshima and Nagasaki necessary?
• What were the successes and failures of the women's suffrage movement in the United States?
• What were the causes of the Civil War?
• How did Abraham Lincoln's assassination impact the country and reconstruction after the Civil War?
• Which factors contributed to the colonies winning the American Revolution?
• What caused Hitler's rise to power?
• Discuss how a specific invention impacted history.
• What led to Cleopatra's fall as ruler of Egypt?
• How has Japan changed and evolved over the centuries?
• What were the causes of the Rwandan genocide ?

• Why did Martin Luther decide to split with the Catholic Church?
• Analyze the history and impact of a well-known cult (Jonestown, Manson family, etc.)
• How did the sexual abuse scandal impact how people view the Catholic Church?
• How has the Catholic church's power changed over the past decades/centuries?
• What are the causes behind the rise in atheism/ agnosticism in the United States?
• What were the influences in Siddhartha's life resulted in him becoming the Buddha?
• How has media portrayal of Islam/Muslims changed since September 11th?

Science/Environment

• How has the earth's climate changed in the past few decades?
• How has the use and elimination of DDT affected bird populations in the US?
• Analyze how the number and severity of natural disasters have increased in the past few decades.
• Analyze deforestation rates in a certain area or globally over a period of time.
• How have past oil spills changed regulations and cleanup methods?
• How has the Flint water crisis changed water regulation safety?
• What are the pros and cons of fracking?
• What impact has the Paris Climate Agreement had so far?
• What have NASA's biggest successes and failures been?
• How can we improve access to clean water around the world?
• Does ecotourism actually have a positive impact on the environment?
• Should the US rely on nuclear energy more?
• What can be done to save amphibian species currently at risk of extinction?
• What impact has climate change had on coral reefs?
• How are black holes created?
• Are teens who spend more time on social media more likely to suffer anxiety and/or depression?
• How will the loss of net neutrality affect internet users?
• Analyze the history and progress of self-driving vehicles.
• How has the use of drones changed surveillance and warfare methods?
• Has social media made people more or less connected?
• What progress has currently been made with artificial intelligence ?
• Do smartphones increase or decrease workplace productivity?
• What are the most effective ways to use technology in the classroom?
• How is Google search affecting our intelligence?
• When is the best age for a child to begin owning a smartphone?
• Has frequent texting reduced teen literacy rates?

How to Write a Great Research Paper

Even great research paper topics won't give you a great research paper if you don't hone your topic before and during the writing process. Follow these three tips to turn good research paper topics into great papers.

#1: Figure Out Your Thesis Early

Before you start writing a single word of your paper, you first need to know what your thesis will be. Your thesis is a statement that explains what you intend to prove/show in your paper. Every sentence in your research paper will relate back to your thesis, so you don't want to start writing without it!

As some examples, if you're writing a research paper on if students learn better in same-sex classrooms, your thesis might be "Research has shown that elementary-age students in same-sex classrooms score higher on standardized tests and report feeling more comfortable in the classroom."

If you're writing a paper on the causes of the Civil War, your thesis might be "While the dispute between the North and South over slavery is the most well-known cause of the Civil War, other key causes include differences in the economies of the North and South, states' rights, and territorial expansion."

#2: Back Every Statement Up With Research

Remember, this is a research paper you're writing, so you'll need to use lots of research to make your points. Every statement you give must be backed up with research, properly cited the way your teacher requested. You're allowed to include opinions of your own, but they must also be supported by the research you give.

#3: Do Your Research Before You Begin Writing

You don't want to start writing your research paper and then learn that there isn't enough research to back up the points you're making, or, even worse, that the research contradicts the points you're trying to make!

Get most of your research on your good research topics done before you begin writing. Then use the research you've collected to create a rough outline of what your paper will cover and the key points you're going to make. This will help keep your paper clear and organized, and it'll ensure you have enough research to produce a strong paper.

What's Next?

Are you also learning about dynamic equilibrium in your science class? We break this sometimes tricky concept down so it's easy to understand in our complete guide to dynamic equilibrium .

Thinking about becoming a nurse practitioner? Nurse practitioners have one of the fastest growing careers in the country, and we have all the information you need to know about what to expect from nurse practitioner school .

Want to know the fastest and easiest ways to convert between Fahrenheit and Celsius? We've got you covered! Check out our guide to the best ways to convert Celsius to Fahrenheit (or vice versa).

These recommendations are based solely on our knowledge and experience. If you purchase an item through one of our links, PrepScholar may receive a commission.

Christine graduated from Michigan State University with degrees in Environmental Biology and Geography and received her Master's from Duke University. In high school she scored in the 99th percentile on the SAT and was named a National Merit Finalist. She has taught English and biology in several countries.

Ask a Question Below

Have any questions about this article or other topics? Ask below and we'll reply!

Improve With Our Famous Guides

• For All Students

The 5 Strategies You Must Be Using to Improve 160+ SAT Points

How to Get a Perfect 1600, by a Perfect Scorer

Series: How to Get 800 on Each SAT Section:

Score 800 on SAT Math

Score 800 on SAT Reading

Score 800 on SAT Writing

Series: How to Get to 600 on Each SAT Section:

Score 600 on SAT Math

Score 600 on SAT Reading

Score 600 on SAT Writing

Free Complete Official SAT Practice Tests

What SAT Target Score Should You Be Aiming For?

15 Strategies to Improve Your SAT Essay

The 5 Strategies You Must Be Using to Improve 4+ ACT Points

How to Get a Perfect 36 ACT, by a Perfect Scorer

Series: How to Get 36 on Each ACT Section:

36 on ACT English

36 on ACT Math

36 on ACT Reading

36 on ACT Science

Series: How to Get to 24 on Each ACT Section:

24 on ACT English

24 on ACT Math

24 on ACT Reading

24 on ACT Science

What ACT target score should you be aiming for?

ACT Vocabulary You Must Know

ACT Writing: 15 Tips to Raise Your Essay Score

How to Get Into Harvard and the Ivy League

How to Get a Perfect 4.0 GPA

How to Write an Amazing College Essay

What Exactly Are Colleges Looking For?

Is the ACT easier than the SAT? A Comprehensive Guide

Should you retake your SAT or ACT?

When should you take the SAT or ACT?

Stay Informed

Get the latest articles and test prep tips!

Looking for Graduate School Test Prep?

Check out our top-rated graduate blogs here:

GRE Online Prep Blog

GMAT Online Prep Blog

TOEFL Online Prep Blog

Holly R. "I am absolutely overjoyed and cannot thank you enough for helping me!”

An official website of the United States government

The .gov means it’s official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

• Publications
• Account settings

Preview improvements coming to the PMC website in October 2024. Learn More or Try it out now .

• Advanced Search
• Journal List
• J Med Libr Assoc
• v.106(4); 2018 Oct

A systematic approach to searching: an efficient and complete method to develop literature searches

Associated data.

Creating search strategies for systematic reviews, finding the best balance between sensitivity and specificity, and translating search strategies between databases is challenging. Several methods describe standards for systematic search strategies, but a consistent approach for creating an exhaustive search strategy has not yet been fully described in enough detail to be fully replicable. The authors have established a method that describes step by step the process of developing a systematic search strategy as needed in the systematic review. This method describes how single-line search strategies can be prepared in a text document by typing search syntax (such as field codes, parentheses, and Boolean operators) before copying and pasting search terms (keywords and free-text synonyms) that are found in the thesaurus. To help ensure term completeness, we developed a novel optimization technique that is mainly based on comparing the results retrieved by thesaurus terms with those retrieved by the free-text search words to identify potentially relevant candidate search terms. Macros in Microsoft Word have been developed to convert syntaxes between databases and interfaces almost automatically. This method helps information specialists in developing librarian-mediated searches for systematic reviews as well as medical and health care practitioners who are searching for evidence to answer clinical questions. The described method can be used to create complex and comprehensive search strategies for different databases and interfaces, such as those that are needed when searching for relevant references for systematic reviews, and will assist both information specialists and practitioners when they are searching the biomedical literature.

INTRODUCTION

Librarians and information specialists are often involved in the process of preparing and completing systematic reviews (SRs), where one of their main tasks is to identify relevant references to include in the review [ 1 ]. Although several recommendations for the process of searching have been published [ 2 – 6 ], none describe the development of a systematic search strategy from start to finish.

Traditional methods of SR search strategy development and execution are highly time consuming, reportedly requiring up to 100 hours or more [ 7 , 8 ]. The authors wanted to develop systematic and exhaustive search strategies more efficiently, while preserving the high sensitivity that SR search strategies necessitate. In this article, we describe the method developed at Erasmus University Medical Center (MC) and demonstrate its use through an example search. The efficiency of the search method and outcome of 73 searches that have resulted in published reviews are described in a separate article [ 9 ].

As we aimed to describe the creation of systematic searches in full detail, the method starts at a basic level with the analysis of the research question and the creation of search terms. Readers who are new to SR searching are advised to follow all steps described. More experienced searchers can consider the basic steps to be existing knowledge that will already be part of their normal workflow, although step 4 probably differs from general practice. Experienced searchers will gain the most from reading about the novelties in the method as described in steps 10–13 and comparing the examples given in the supplementary appendix to their own practice.

CREATING A SYSTEMATIC SEARCH STRATEGY

Our methodology for planning and creating a multi-database search strategy consists of the following steps:

• Determine a clear and focused question
• Describe the articles that can answer the question
• Decide which key concepts address the different elements of the question
• Decide which elements should be used for the best results
• Choose an appropriate database and interface to start with
• Document the search process in a text document
• Identify appropriate index terms in the thesaurus of the first database
• Identify synonyms in the thesaurus
• Add variations in search terms
• Use database-appropriate syntax, with parentheses, Boolean operators, and field codes
• Optimize the search
• Evaluate the initial results
• Check for errors
• Translate to other databases
• Test and reiterate

Each step in the process is reflected by an example search described in the supplementary appendix .

1. Determine a clear and focused question

A systematic search can best be applied to a well-defined and precise research or clinical question. Questions that are too broad or too vague cannot be answered easily in a systematic way and will generally result in an overwhelming number of search results. On the other hand, a question that is too specific will result into too few or even zero search results. Various papers describe this process in more detail [ 10 – 12 ].

2. Describe the articles that can answer the question

Although not all clinical or research questions can be answered in the literature, the next step is to presume that the answer can indeed be found in published studies. A good starting point for a search is hypothesizing what the research that can answer the question would look like. These hypothetical (when possible, combined with known) articles can be used as guidance for constructing the search strategy.

3. Decide which key concepts address the different elements of the question

Key concepts are the topics or components that the desired articles should address, such as diseases or conditions, actions, substances, settings, domains (e.g., therapy, diagnosis, etiology), or study types. Key concepts from the research question can be grouped to create elements in the search strategy.

Elements in a search strategy do not necessarily follow the patient, intervention, comparison, outcome (PICO) structure or any other related structure. Using the PICO or another similar framework as guidance can be helpful to consider, especially in the inclusion and exclusion review stage of the SR, but this is not necessary for good search strategy development [ 13 – 15 ]. Sometimes concepts from different parts of the PICO structure can be grouped together into one search element, such as when the desired outcome is frequently described in a certain study type.

4. Decide which elements should be used for the best results

Not all elements of a research question should necessarily be used in the search strategy. Some elements are less important than others or may unnecessarily complicate or restrict a search strategy. Adding an element to a search strategy increases the chance of missing relevant references. Therefore, the number of elements in a search strategy should remain as low as possible to optimize recall.

Using the schema in Figure 1 , elements can be ordered by their specificity and importance to determine the best search approach. Whether an element is more specific or more general can be measured objectively by the number of hits retrieved in a database when searching for a key term representing that element. Depending on the research question, certain elements are more important than others. If articles (hypothetically or known) exist that can answer the question but lack a certain element in their titles, abstracts, or keywords, that element is unimportant to the question. An element can also be unimportant because of expected bias or an overlap with another element.

Schema for determining the optimal order of elements

Bias in elements

The choice of elements in a search strategy can introduce bias through use of overly specific terminology or terms often associated with positive outcomes. For the question “does prolonged breastfeeding improve intelligence outcomes in children?,” searching specifically for the element of duration will introduce bias, as articles that find a positive effect of prolonged breastfeeding will be much more likely to mention time factors in their titles or abstracts.

Overlapping elements

Elements in a question sometimes overlap in their meaning. Sometimes certain therapies are interventions for one specific disease. The Lichtenstein technique, for example, is a repair method for inguinal hernias. There is no need to include an element of “inguinal hernias” to a search for the effectiveness of the Lichtenstein therapy. Likewise, sometimes certain diseases are only found in certain populations. Adding such an overlapping element could lead to missing relevant references.

The elements to use in a search strategy can be found in the plot of elements in Figure 1 , by following the top row from left to right. For this method, we recommend starting with the most important and specific elements. Then, continue with more general and important elements until the number of results is acceptable for screening. Determining how many results are acceptable for screening is often a matter of negotiation with the SR team.

5. Choose an appropriate database and interface to start with

Important factors for choosing databases to use are the coverage and the presence of a thesaurus. For medically oriented searches, the coverage and recall of Embase, which includes the MEDLINE database, are superior to those of MEDLINE [ 16 ]. Each of these two databases has its own thesaurus with its own unique definitions and structure. Because of the complexity of the Embase thesaurus, Emtree, which contains much more specific thesaurus terms than the MEDLINE Medical Subject Headings (MeSH) thesaurus, translation from Emtree to MeSH is easier than the other way around. Therefore, we recommend starting in Embase.

MEDLINE and Embase are available through many different vendors and interfaces. The choice of an interface and primary database is often determined by the searcher’s accessibility. For our method, an interface that allows searching with proximity operators is desirable, and full functionality of the thesaurus, including explosion of narrower terms, is crucial. We recommend developing a personal workflow that always starts with one specific database and interface.

6. Document the search process in a text document

We advise designing and creating the complete search strategies in a log document, instead of directly in the database itself, to register the steps taken and to make searches accountable and reproducible. The developed search strategies can be copied and pasted into the desired databases from the log document. This way, the searcher is in control of the whole process. Any change to the search strategy should be done in the log document, assuring that the search strategy in the log is always the most recent.

7. Identify appropriate index terms in the thesaurus of the first database

Searches should start by identifying appropriate thesaurus terms for the desired elements. The thesaurus of the database is searched for matching index terms for each key concept. We advise restricting the initial terms to the most important and most relevant terms. Later in the process, more general terms can be added in the optimization process, in which the effect on the number of hits, and thus the desirability of adding these terms, can be evaluated more easily.

Several factors can complicate the identification of thesaurus terms. Sometimes, one thesaurus term is found that exactly describes a specific element. In contrast, especially in more general elements, multiple thesaurus terms can be found to describe one element. If no relevant thesaurus terms have been found for an element, free-text terms can be used, and possible thesaurus terms found in the resulting references can be added later (step 11).

Sometimes, no distinct thesaurus term is available for a specific key concept that describes the concept in enough detail. In Emtree, one thesaurus term often combines two or more elements. The easiest solution for combining these terms for a sensitive search is to use such a thesaurus term in all elements where it is relevant. Examples are given in the supplementary appendix .

8. Identify synonyms in the thesaurus

Most thesauri offer a list of synonyms on their term details page (named Synonyms in Emtree and Entry Terms in MeSH). To create a sensitive search strategy for SRs, these terms need to be searched as free-text keywords in the title and abstract fields, in addition to searching their associated thesaurus terms.

The Emtree thesaurus contains more synonyms (300,000) than MeSH does (220,000) [ 17 ]. The difference in number of terms is even higher considering that many synonyms in MeSH are permuted terms (i.e., inversions of phrases using commas).

Thesaurus terms are ordered in a tree structure. When searching for a more general thesaurus term, the more specific (narrower) terms in the branches below that term will also be searched (this is frequently referred to as “exploding” a thesaurus term). However, to perform a sensitive search, all relevant variations of the narrower terms must be searched as free-text keywords in the title or abstract, in addition to relying on the exploded thesaurus term. Thus, all articles that describe a certain narrower topic in their titles and abstracts will already be retrieved before MeSH terms are added.

9. Add variations in search terms (e.g., truncation, spelling differences, abbreviations, opposites)

Truncation allows a searcher to search for words beginning with the same word stem. A search for therap* will, thus, retrieve therapy, therapies, therapeutic, and all other words starting with “therap.” Do not truncate a word stem that is too short. Also, limitations of interfaces should be taken into account, especially in PubMed, where the number of search term variations that can be found by truncation is limited to 600.

Databases contain references to articles using both standard British and American English spellings. Both need to be searched as free-text terms in the title and abstract. Alternatively, many interfaces offer a certain code to replace zero or one characters, allowing a search for “pediatric” or “paediatric” as “p?ediatric.” Table 1 provides a detailed description of the syntax for different interfaces.

Field codes in five most used interfaces for biomedical literature searching

Searching for abbreviations can identify extra, relevant references and retrieve more irrelevant ones. The search can be more focused by combining the abbreviation with an important word that is relevant to its meaning or by using the Boolean “NOT” to exclude frequently observed, clearly irrelevant results. We advise that searchers do not exclude all possible irrelevant meanings, as it is very time consuming to identify all the variations, it will result in unnecessarily complicated search strategies, and it may lead to erroneously narrowing the search and, thereby, reduce recall.

Searching partial abbreviations can be useful for retrieving relevant references. For example, it is very likely that an article would mention osteoarthritis (OA) early in the abstract, replacing all further occurrences of osteoarthritis with OA . Therefore, it may not contain the phrase “hip osteoarthritis” but only “hip oa.”

It is also important to search for the opposites of search terms to avoid bias. When searching for “disease recurrence,” articles about “disease free” may be relevant as well. When the desired outcome is survival , articles about mortality may be relevant.

10. Use database-appropriate syntax, with parentheses, Boolean operators, and field codes

Different interfaces require different syntaxes, the special set of rules and symbols unique to each database that define how a correctly constructed search operates. Common syntax components include the use of parentheses and Boolean operators such as “AND,” “OR,” and “NOT,” which are available in all major interfaces. An overview of different syntaxes for four major interfaces for bibliographic medical databases (PubMed, Ovid, EBSCOhost, Embase.com, and ProQuest) is shown in Table 1 .

Creating the appropriate syntax for each database, in combination with the selected terms as described in steps 7–9, can be challenging. Following the method outlined below simplifies the process:

• Create single-line queries in a text document (not combining multiple record sets), which allows immediate checking of the relevance of retrieved references and efficient optimization.
• Type the syntax (Boolean operators, parentheses, and field codes) before adding terms, which reduces the chance that errors are made in the syntax, especially in the number of parentheses.
• Use predefined proximity structures including parentheses, such as (() ADJ3 ()) in Ovid, that can be reused in the query when necessary.
• Use thesaurus terms separately from free-text terms of each element. Start an element with all thesaurus terms (using “OR”) and follow with the free-text terms. This allows the unique optimization methods as described in step 11.
• When adding terms to an existing search strategy, pay close attention to the position of the cursor. Make sure to place it appropriately either in the thesaurus terms section, in the title/abstract section, or as an addition (broadening) to an existing proximity search.

The supplementary appendix explains the method of building a query in more detail, step by step for different interfaces: PubMed, Ovid, EBSCOhost, Embase.com, and ProQuest. This method results in a basic search strategy designed to retrieve some relevant references upon which a more thorough search strategy can be built with optimization such as described in step 11.

11. Optimize the search

The most important question when performing a systematic search is whether all (or most) potentially relevant articles have been retrieved by the search strategy. This is also the most difficult question to answer, since it is unknown which and how many articles are relevant. It is, therefore, wise first to broaden the initial search strategy, making the search more sensitive, and then check if new relevant articles are found by comparing the set results (i.e., search for Strategy #2 NOT Strategy #1 to see the unique results).

A search strategy should be tested for completeness. Therefore, it is necessary to identify extra, possibly relevant search terms and add them to the test search in an OR relationship with the already used search terms. A good place to start, and a well-known strategy, is scanning the top retrieved articles when sorted by relevance, looking for additional relevant synonyms that could be added to the search strategy.

We have developed a unique optimization method that has not been described before in the literature. This method often adds valuable extra terms to our search strategy and, therefore, extra, relevant references to our search results. Extra synonyms can be found in articles that have been assigned a certain set of thesaurus terms but that lack synonyms in the title and/or abstract that are already present in the current search strategy. Searching for thesaurus terms NOT free-text terms will help identify missed free-text terms in the title or abstract. Searching for free-text terms NOT thesaurus terms will help identify missed thesaurus terms. If this is done repeatedly for each element, leaving the rest of the query unchanged, this method will help add numerous relevant terms to the query. These steps are explained in detail for five different search platforms in the supplementary appendix .

12. Evaluate the initial results

The results should now contain relevant references. If the interface allows relevance ranking, use that in the evaluation. If you know some relevant references that should be included in the research, search for those references specifically; for example, combine a specific (first) author name with a page number and the publication year. Check whether those references are retrieved by the search. If the known relevant references are not retrieved by the search, adapt the search so that they are. If it is unclear which element should be adapted to retrieve a certain article, combine that article with each element separately.

Different outcomes are desired for different types of research questions. For instance, in the case of clinical question answering, the researcher will not be satisfied with many references that contain a lot of irrelevant references. A clinical search should be rather specific and is allowed to miss a relevant reference. In the case of an SR, the researchers do not want to miss any relevant reference and are willing to handle many irrelevant references to do so. The search for references to include in an SR should be very sensitive: no included reference should be missed. A search that is too specific or too sensitive for the intended goal can be adapted to become more sensitive or specific. Steps to increase sensitivity or specificity of a search strategy can be found in the supplementary appendix .

13. Check for errors

Errors might not be easily detected. Sometimes clues can be found in the number of results, either when the number of results is much higher or lower than expected or when many retrieved references are not relevant. However, the number expected is often unknown, and very sensitive search strategies will always retrieve many irrelevant articles. Each query should, therefore, be checked for errors.

One of the most frequently occurring errors is missing the Boolean operator “OR.” When no “OR” is added between two search terms, many interfaces automatically add an “AND,” which unintentionally reduces the number of results and likely misses relevant references. One good strategy to identify missing “OR”s is to go to the web page containing the full search strategy, as translated by the database, and using Ctrl-F search for “AND.” Check whether the occurrences of the “AND” operator are deliberate.

Ideally, search strategies should be checked by other information specialists [ 18 ]. The Peer Review of Electronic Search Strategies (PRESS) checklist offers good guidance for this process [ 4 ]. Apart from the syntax (especially Boolean operators and field codes) of the search strategy, it is wise to have the search terms checked by the clinician or researcher familiar with the topic. At Erasmus MC, researchers and clinicians are involved during the complete process of structuring and optimizing the search strategy. Each word is added after the combined decision of the searcher and the researcher, with the possibility of directly comparing results with and without the new term.

14. Translate to other databases

To retrieve as many relevant references as possible, one has to search multiple databases. Translation of complex and exhaustive queries between different databases can be very time consuming and cumbersome. The single-line search strategy approach detailed above allows quick translations using the find and replace method in Microsoft Word (<Ctrl-H>).

At Erasmus MC, macros based on the find-and-replace method in Microsoft Word have been developed for easy and fast translation between the most used databases for biomedical and health sciences questions. The schema that is followed for the translation between databases is shown in Figure 2 . Most databases simply follow the structure set by the Embase.com search strategy. The translation from Emtree terms to MeSH terms for MEDLINE in Ovid often identifies new terms that need to be added to the Embase.com search strategy before the translation to other databases.

Schematic representation of translation between databases used at Erasmus University Medical Center

Dotted lines represent databases that are used in less than 80% of the searches.

Using five different macros, a thoroughly optimized query in Embase.com can be relatively quickly translated into eight major databases. Basic search strategies will be created to use in many, mostly smaller, databases, because such niche databases often do not have extensive thesauri or advanced syntax options. Also, there is not much need to use extensive syntax because the number of hits and, therefore, the amount of noise in these databases is generally low. In MEDLINE (Ovid), PsycINFO (Ovid), and CINAHL (EBSCOhost), the thesaurus terms must be adapted manually, as each database has its own custom thesaurus. These macros and instructions for their installation, use, and adaptation are available at bit.ly/databasemacros.

15. Test and reiterate

Ideally, exhaustive search strategies should retrieve all references that are covered in a specific database. For SR search strategies, checking searches for their recall is advised. This can be done after included references have been determined by the authors of the systematic review. If additional papers have been identified through other non-database methods (i.e., checking references in included studies), results that were not identified by the database searches should be examined. If these results were available in the databases but not located by the search strategy, the search strategy should be adapted to try to retrieve these results, as they may contain terms that were omitted in the original search strategies. This may enable the identification of additional relevant results.

A methodology for creating exhaustive search strategies has been created that describes all steps of the search process, starting with a question and resulting in thorough search strategies in multiple databases. Many of the steps described are not new, but together, they form a strong method creating high-quality, robust searches in a relatively short time frame.

Our methodology is intended to create thoroughness for literature searches. The optimization method, as described in step 11, will identify missed synonyms or thesaurus terms, unlike any other method that largely depends on predetermined keywords and synonyms. Using this method results in a much quicker search process, compared to traditional methods, especially because of the easier translation between databases and interfaces (step 13). The method is not a guarantee for speed, since speed depends on many factors, including experience. However, by following the steps and using the tools as described above, searchers can gain confidence first and increase speed through practice.

What is new?

This method encourages searchers to start their search development process using empty syntax first and later adding the thesaurus terms and free-text synonyms. We feel this helps the searcher to focus on the search terms, instead of on the structure of the search query. The optimization method in which new terms are found in the already retrieved articles is used in some other institutes as well but has to our knowledge not been described in the literature. The macros to translate search strategies between interfaces are unique in this method.

What is different compared to common practice?

Traditionally, librarians and information specialists have focused on creating complex, multi-line (also called line-by-line) search strategies, consisting of multiple record sets, and this method is frequently advised in the literature and handbooks [ 2 , 19 – 21 ]. Our method, instead, uses single-line searches, which is critical to its success. Single-line search strategies can be easily adapted by adding or dropping a term without having to recode numbers of record sets, which would be necessary in multi-line searches. They can easily be saved in a text document and repeated by copying and pasting for search updates. Single-line search strategies also allow easy translation to other syntaxes using find-and-replace technology to update field codes and other syntax elements or using macros (step 13).

When constructing a search strategy, the searcher might experience that certain parentheses in the syntax are unnecessary, such as parentheses around all search terms in the title/abstract portion, if there is only one such term, there are double parentheses in the proximity statement, or one of the word groups exists for only one word. One might be tempted to omit those parentheses for ease of reading and management. However, during the optimization process, the searcher is likely to find extra synonyms that might consist of one word. To add those terms to the first query (with reduced parentheses) requires adding extra parentheses (meticulously placing and counting them), whereas, in the latter search, it only requires proper placement of those terms.

Many search methods highly depend on the PICO framework. Research states that often PICO or PICOS is not suitable for every question [ 22 , 23 ]. There are other acronyms than PICO—such as sample, phenomenon of interest, design, evaluation, research type (SPIDER) [ 24 ]—but each is just a variant. In our method, the most important and specific elements of a question are being analyzed for building the best search strategy.

Though it is generally recommended that searchers search both MEDLINE and Embase, most use MEDLINE as the starting point. It is considered the gold standard for biomedical searching, partially due to historical reasons, since it was the first of its kind, and more so now that it is freely available via the PubMed interface. Our method can be used with any database as a starting point, but we use Embase instead of MEDLINE or another database for a number of reasons. First, Embase provides both unique content and the complete content of MEDLINE. Therefore, searching Embase will be, by definition, more complete than searching MEDLINE only. Second, the number of terms in Emtree (the Embase thesaurus) is three times as high as that of MeSH (the MEDLINE thesaurus). It is easier to find MeSH terms after all relevant Emtree terms have been identified than to start with MeSH and translate to Emtree.

At Erasmus MC, the researchers sit next to the information specialist during most of the search strategy design process. This way, the researchers can deliver immediate feedback on the relevance of proposed search terms and retrieved references. The search team then combines knowledge about databases with knowledge about the research topic, which is an important condition to create the highest quality searches.

Limitations of the method

One disadvantage of single-line searches compared to multi-line search strategies is that errors are harder to recognize. However, with the methods for optimization as described (step 11), errors are recognized easily because missed synonyms and spelling errors will be identified during the process. Also problematic is that more parentheses are needed, making it more difficult for the searcher and others to assess the logic of the search strategy. However, as parentheses and field codes are typed before the search terms are added (step 10), errors in parentheses can be prevented.

Our methodology works best if used in an interface that allows proximity searching. It is recommended that searchers with access to an interface with proximity searching capabilities select one of those as the initial database to develop and optimize the search strategy. Because the PubMed interface does not allow proximity searches, phrases or Boolean “AND” combinations are required. Phrase searching complicates the process and is more specific, with the higher risk of missing relevant articles, and using Boolean “AND” combinations increases sensitivity but at an often high loss of specificity. Due to some searchers’ lack of access to expensive databases or interfaces, the freely available PubMed interface may be necessary to use, though it should never be the sole database used for an SR [ 2 , 16 , 25 ]. A limitation of our method is that it works best with subscription-based and licensed resources.

Another limitation is the customization of the macros to a specific institution’s resources. The macros for the translation between different database interfaces only work between the interfaces as described. To mitigate this, we recommend using the find-and-replace functionality of text editors like Microsoft Word to ease the translation of syntaxes between other databases. Depending on one’s institutional resources, custom macros can be developed using similar methods.

Results of the method

Whether this method results in exhaustive searches where no important article is missed is difficult to determine, because the number of relevant articles is unknown for any topic. A comparison of several parameters of 73 published reviews that were based on a search developed with this method to 258 reviews that acknowledged information specialists from other Dutch academic hospitals shows that the performance of the searches following our method is comparable to those performed in other institutes but that the time needed to develop the search strategies was much shorter than the time reported for the other reviews [ 9 ].

CONCLUSIONS

With the described method, searchers can gain confidence in their search strategies by finding many relevant words and creating exhaustive search strategies quickly. The approach can be used when performing SR searches or for other purposes such as answering clinical questions, with different expectations of the search’s precision and recall. This method, with practice, provides a stepwise approach that facilitates the search strategy development process from question clarification to final iteration and beyond.

SUPPLEMENTAL FILE

Acknowledgments.

We highly appreciate the work that was done by our former colleague Louis Volkers, who in his twenty years as an information specialist in Erasmus MC laid the basis for our method. We thank Professor Oscar Franco for reviewing earlier drafts of this article.

• Privacy Policy

Home » Research Paper – Structure, Examples and Writing Guide

Research Paper – Structure, Examples and Writing Guide

Table of Contents

Research Paper

Definition:

Research Paper is a written document that presents the author’s original research, analysis, and interpretation of a specific topic or issue.

It is typically based on Empirical Evidence, and may involve qualitative or quantitative research methods, or a combination of both. The purpose of a research paper is to contribute new knowledge or insights to a particular field of study, and to demonstrate the author’s understanding of the existing literature and theories related to the topic.

Structure of Research Paper

The structure of a research paper typically follows a standard format, consisting of several sections that convey specific information about the research study. The following is a detailed explanation of the structure of a research paper:

The title page contains the title of the paper, the name(s) of the author(s), and the affiliation(s) of the author(s). It also includes the date of submission and possibly, the name of the journal or conference where the paper is to be published.

The abstract is a brief summary of the research paper, typically ranging from 100 to 250 words. It should include the research question, the methods used, the key findings, and the implications of the results. The abstract should be written in a concise and clear manner to allow readers to quickly grasp the essence of the research.

Introduction

The introduction section of a research paper provides background information about the research problem, the research question, and the research objectives. It also outlines the significance of the research, the research gap that it aims to fill, and the approach taken to address the research question. Finally, the introduction section ends with a clear statement of the research hypothesis or research question.

Literature Review

The literature review section of a research paper provides an overview of the existing literature on the topic of study. It includes a critical analysis and synthesis of the literature, highlighting the key concepts, themes, and debates. The literature review should also demonstrate the research gap and how the current study seeks to address it.

The methods section of a research paper describes the research design, the sample selection, the data collection and analysis procedures, and the statistical methods used to analyze the data. This section should provide sufficient detail for other researchers to replicate the study.

The results section presents the findings of the research, using tables, graphs, and figures to illustrate the data. The findings should be presented in a clear and concise manner, with reference to the research question and hypothesis.

The discussion section of a research paper interprets the findings and discusses their implications for the research question, the literature review, and the field of study. It should also address the limitations of the study and suggest future research directions.

The conclusion section summarizes the main findings of the study, restates the research question and hypothesis, and provides a final reflection on the significance of the research.

The references section provides a list of all the sources cited in the paper, following a specific citation style such as APA, MLA or Chicago.

How to Write Research Paper

You can write Research Paper by the following guide:

• Choose a Topic: The first step is to select a topic that interests you and is relevant to your field of study. Brainstorm ideas and narrow down to a research question that is specific and researchable.
• Conduct a Literature Review: The literature review helps you identify the gap in the existing research and provides a basis for your research question. It also helps you to develop a theoretical framework and research hypothesis.
• Develop a Thesis Statement : The thesis statement is the main argument of your research paper. It should be clear, concise and specific to your research question.
• Plan your Research: Develop a research plan that outlines the methods, data sources, and data analysis procedures. This will help you to collect and analyze data effectively.
• Collect and Analyze Data: Collect data using various methods such as surveys, interviews, observations, or experiments. Analyze data using statistical tools or other qualitative methods.
• Organize your Paper : Organize your paper into sections such as Introduction, Literature Review, Methods, Results, Discussion, and Conclusion. Ensure that each section is coherent and follows a logical flow.
• Write your Paper : Start by writing the introduction, followed by the literature review, methods, results, discussion, and conclusion. Ensure that your writing is clear, concise, and follows the required formatting and citation styles.
• Edit and Proofread your Paper: Review your paper for grammar and spelling errors, and ensure that it is well-structured and easy to read. Ask someone else to review your paper to get feedback and suggestions for improvement.
• Cite your Sources: Ensure that you properly cite all sources used in your research paper. This is essential for giving credit to the original authors and avoiding plagiarism.

Research Paper Example

Note : The below example research paper is for illustrative purposes only and is not an actual research paper. Actual research papers may have different structures, contents, and formats depending on the field of study, research question, data collection and analysis methods, and other factors. Students should always consult with their professors or supervisors for specific guidelines and expectations for their research papers.

Research Paper Example sample for Students:

Title: The Impact of Social Media on Mental Health among Young Adults

Abstract: This study aims to investigate the impact of social media use on the mental health of young adults. A literature review was conducted to examine the existing research on the topic. A survey was then administered to 200 university students to collect data on their social media use, mental health status, and perceived impact of social media on their mental health. The results showed that social media use is positively associated with depression, anxiety, and stress. The study also found that social comparison, cyberbullying, and FOMO (Fear of Missing Out) are significant predictors of mental health problems among young adults.

Introduction: Social media has become an integral part of modern life, particularly among young adults. While social media has many benefits, including increased communication and social connectivity, it has also been associated with negative outcomes, such as addiction, cyberbullying, and mental health problems. This study aims to investigate the impact of social media use on the mental health of young adults.

Literature Review: The literature review highlights the existing research on the impact of social media use on mental health. The review shows that social media use is associated with depression, anxiety, stress, and other mental health problems. The review also identifies the factors that contribute to the negative impact of social media, including social comparison, cyberbullying, and FOMO.

Methods : A survey was administered to 200 university students to collect data on their social media use, mental health status, and perceived impact of social media on their mental health. The survey included questions on social media use, mental health status (measured using the DASS-21), and perceived impact of social media on their mental health. Data were analyzed using descriptive statistics and regression analysis.

Results : The results showed that social media use is positively associated with depression, anxiety, and stress. The study also found that social comparison, cyberbullying, and FOMO are significant predictors of mental health problems among young adults.

Discussion : The study’s findings suggest that social media use has a negative impact on the mental health of young adults. The study highlights the need for interventions that address the factors contributing to the negative impact of social media, such as social comparison, cyberbullying, and FOMO.

Conclusion : In conclusion, social media use has a significant impact on the mental health of young adults. The study’s findings underscore the need for interventions that promote healthy social media use and address the negative outcomes associated with social media use. Future research can explore the effectiveness of interventions aimed at reducing the negative impact of social media on mental health. Additionally, longitudinal studies can investigate the long-term effects of social media use on mental health.

Limitations : The study has some limitations, including the use of self-report measures and a cross-sectional design. The use of self-report measures may result in biased responses, and a cross-sectional design limits the ability to establish causality.

Implications: The study’s findings have implications for mental health professionals, educators, and policymakers. Mental health professionals can use the findings to develop interventions that address the negative impact of social media use on mental health. Educators can incorporate social media literacy into their curriculum to promote healthy social media use among young adults. Policymakers can use the findings to develop policies that protect young adults from the negative outcomes associated with social media use.

References :

• Twenge, J. M., & Campbell, W. K. (2019). Associations between screen time and lower psychological well-being among children and adolescents: Evidence from a population-based study. Preventive medicine reports, 15, 100918.
• Primack, B. A., Shensa, A., Escobar-Viera, C. G., Barrett, E. L., Sidani, J. E., Colditz, J. B., … & James, A. E. (2017). Use of multiple social media platforms and symptoms of depression and anxiety: A nationally-representative study among US young adults. Computers in Human Behavior, 69, 1-9.
• Van der Meer, T. G., & Verhoeven, J. W. (2017). Social media and its impact on academic performance of students. Journal of Information Technology Education: Research, 16, 383-398.

Appendix : The survey used in this study is provided below.

Social Media and Mental Health Survey

• How often do you use social media per day?
• Less than 30 minutes
• 30 minutes to 1 hour
• 1 to 2 hours
• 2 to 4 hours
• More than 4 hours
• Which social media platforms do you use?
• Others (Please specify)
• How often do you experience the following on social media?
• Social comparison (comparing yourself to others)
• Cyberbullying
• Fear of Missing Out (FOMO)
• Have you ever experienced any of the following mental health problems in the past month?
• Do you think social media use has a positive or negative impact on your mental health?
• Very positive
• Somewhat positive
• Somewhat negative
• Very negative
• In your opinion, which factors contribute to the negative impact of social media on mental health?
• Social comparison
• In your opinion, what interventions could be effective in reducing the negative impact of social media on mental health?
• Education on healthy social media use
• Counseling for mental health problems caused by social media
• Social media detox programs
• Regulation of social media use

Thank you for your participation!

Applications of Research Paper

Research papers have several applications in various fields, including:

• Advancing knowledge: Research papers contribute to the advancement of knowledge by generating new insights, theories, and findings that can inform future research and practice. They help to answer important questions, clarify existing knowledge, and identify areas that require further investigation.
• Informing policy: Research papers can inform policy decisions by providing evidence-based recommendations for policymakers. They can help to identify gaps in current policies, evaluate the effectiveness of interventions, and inform the development of new policies and regulations.
• Improving practice: Research papers can improve practice by providing evidence-based guidance for professionals in various fields, including medicine, education, business, and psychology. They can inform the development of best practices, guidelines, and standards of care that can improve outcomes for individuals and organizations.
• Educating students : Research papers are often used as teaching tools in universities and colleges to educate students about research methods, data analysis, and academic writing. They help students to develop critical thinking skills, research skills, and communication skills that are essential for success in many careers.
• Fostering collaboration: Research papers can foster collaboration among researchers, practitioners, and policymakers by providing a platform for sharing knowledge and ideas. They can facilitate interdisciplinary collaborations and partnerships that can lead to innovative solutions to complex problems.

When to Write Research Paper

Research papers are typically written when a person has completed a research project or when they have conducted a study and have obtained data or findings that they want to share with the academic or professional community. Research papers are usually written in academic settings, such as universities, but they can also be written in professional settings, such as research organizations, government agencies, or private companies.

Here are some common situations where a person might need to write a research paper:

• For academic purposes: Students in universities and colleges are often required to write research papers as part of their coursework, particularly in the social sciences, natural sciences, and humanities. Writing research papers helps students to develop research skills, critical thinking skills, and academic writing skills.
• For publication: Researchers often write research papers to publish their findings in academic journals or to present their work at academic conferences. Publishing research papers is an important way to disseminate research findings to the academic community and to establish oneself as an expert in a particular field.
• To inform policy or practice : Researchers may write research papers to inform policy decisions or to improve practice in various fields. Research findings can be used to inform the development of policies, guidelines, and best practices that can improve outcomes for individuals and organizations.
• To share new insights or ideas: Researchers may write research papers to share new insights or ideas with the academic or professional community. They may present new theories, propose new research methods, or challenge existing paradigms in their field.

Purpose of Research Paper

The purpose of a research paper is to present the results of a study or investigation in a clear, concise, and structured manner. Research papers are written to communicate new knowledge, ideas, or findings to a specific audience, such as researchers, scholars, practitioners, or policymakers. The primary purposes of a research paper are:

• To contribute to the body of knowledge : Research papers aim to add new knowledge or insights to a particular field or discipline. They do this by reporting the results of empirical studies, reviewing and synthesizing existing literature, proposing new theories, or providing new perspectives on a topic.
• To inform or persuade: Research papers are written to inform or persuade the reader about a particular issue, topic, or phenomenon. They present evidence and arguments to support their claims and seek to persuade the reader of the validity of their findings or recommendations.
• To advance the field: Research papers seek to advance the field or discipline by identifying gaps in knowledge, proposing new research questions or approaches, or challenging existing assumptions or paradigms. They aim to contribute to ongoing debates and discussions within a field and to stimulate further research and inquiry.
• To demonstrate research skills: Research papers demonstrate the author’s research skills, including their ability to design and conduct a study, collect and analyze data, and interpret and communicate findings. They also demonstrate the author’s ability to critically evaluate existing literature, synthesize information from multiple sources, and write in a clear and structured manner.

Characteristics of Research Paper

Research papers have several characteristics that distinguish them from other forms of academic or professional writing. Here are some common characteristics of research papers:

• Evidence-based: Research papers are based on empirical evidence, which is collected through rigorous research methods such as experiments, surveys, observations, or interviews. They rely on objective data and facts to support their claims and conclusions.
• Structured and organized: Research papers have a clear and logical structure, with sections such as introduction, literature review, methods, results, discussion, and conclusion. They are organized in a way that helps the reader to follow the argument and understand the findings.
• Formal and objective: Research papers are written in a formal and objective tone, with an emphasis on clarity, precision, and accuracy. They avoid subjective language or personal opinions and instead rely on objective data and analysis to support their arguments.
• Citations and references: Research papers include citations and references to acknowledge the sources of information and ideas used in the paper. They use a specific citation style, such as APA, MLA, or Chicago, to ensure consistency and accuracy.
• Peer-reviewed: Research papers are often peer-reviewed, which means they are evaluated by other experts in the field before they are published. Peer-review ensures that the research is of high quality, meets ethical standards, and contributes to the advancement of knowledge in the field.
• Objective and unbiased: Research papers strive to be objective and unbiased in their presentation of the findings. They avoid personal biases or preconceptions and instead rely on the data and analysis to draw conclusions.

Advantages of Research Paper

Research papers have many advantages, both for the individual researcher and for the broader academic and professional community. Here are some advantages of research papers:

• Contribution to knowledge: Research papers contribute to the body of knowledge in a particular field or discipline. They add new information, insights, and perspectives to existing literature and help advance the understanding of a particular phenomenon or issue.
• Opportunity for intellectual growth: Research papers provide an opportunity for intellectual growth for the researcher. They require critical thinking, problem-solving, and creativity, which can help develop the researcher’s skills and knowledge.
• Career advancement: Research papers can help advance the researcher’s career by demonstrating their expertise and contributions to the field. They can also lead to new research opportunities, collaborations, and funding.
• Academic recognition: Research papers can lead to academic recognition in the form of awards, grants, or invitations to speak at conferences or events. They can also contribute to the researcher’s reputation and standing in the field.
• Impact on policy and practice: Research papers can have a significant impact on policy and practice. They can inform policy decisions, guide practice, and lead to changes in laws, regulations, or procedures.
• Advancement of society: Research papers can contribute to the advancement of society by addressing important issues, identifying solutions to problems, and promoting social justice and equality.

Limitations of Research Paper

Research papers also have some limitations that should be considered when interpreting their findings or implications. Here are some common limitations of research papers:

• Limited generalizability: Research findings may not be generalizable to other populations, settings, or contexts. Studies often use specific samples or conditions that may not reflect the broader population or real-world situations.
• Potential for bias : Research papers may be biased due to factors such as sample selection, measurement errors, or researcher biases. It is important to evaluate the quality of the research design and methods used to ensure that the findings are valid and reliable.
• Ethical concerns: Research papers may raise ethical concerns, such as the use of vulnerable populations or invasive procedures. Researchers must adhere to ethical guidelines and obtain informed consent from participants to ensure that the research is conducted in a responsible and respectful manner.
• Limitations of methodology: Research papers may be limited by the methodology used to collect and analyze data. For example, certain research methods may not capture the complexity or nuance of a particular phenomenon, or may not be appropriate for certain research questions.
• Publication bias: Research papers may be subject to publication bias, where positive or significant findings are more likely to be published than negative or non-significant findings. This can skew the overall findings of a particular area of research.
• Time and resource constraints: Research papers may be limited by time and resource constraints, which can affect the quality and scope of the research. Researchers may not have access to certain data or resources, or may be unable to conduct long-term studies due to practical limitations.

About the author

Muhammad Hassan

Researcher, Academic Writer, Web developer

You may also like

How to Cite Research Paper – All Formats and...

Data Collection – Methods Types and Examples

Delimitations in Research – Types, Examples and...

Research Paper Format – Types, Examples and...

Research Process – Steps, Examples and Tips

Research Design – Types, Methods and Examples

Find top journals in a research field: a step-by-step guide

Joanna Wilkinson

This blog about how to find top journals is part of our Research Smarter series. Download our cheat sheet, which brings together top tips for finding relevant journals, papers, and authors in your field, sign up for our webinar on the same topic or read the related blog posts for each, here .

Finding relevant journals can be a challenging task for researchers both new and experienced. The myriad tools and technologies can be difficult to navigate. This is frustrating when many databases vary in the reliability, relevancy and organization of their data. Beyond that, the rise of open access, preprint repositories and transparent peer review (to name a few) have had a transformative impact on academic journals in recent years. It has reshaped the way journals are shared, used and valued by scholars across all disciplines.

Web of Science™ delivers unique journal insight at any given time. The comprehensive and complete citation network provides all the data you need to understand a journal’s value and impact. Web of Science Core Collection™ titles are all carefully selected for quality. Furthermore, the tools and features we outline in this guide help you quickly and accurately assess them for your own research.

Journal Citation Reports™: Discover quality research journals

Journal Citation Reports  (JCR) is the most powerful product for journal intelligence. It provides researchers with a definitive list and guide to discover and select the most appropriate journals to read and publish findings. JCR delivers a rich array of publisher-independent data, metrics and analysis throughout tens of thousands of journal profile pages. The research community powers these pages via meaningful citation connections.

Researchers and organizations use this comprehensive and trusted subscription-based product to confidently find and assess journals. Head over to JCR now or watch the video below to learn more.

“Journal Citation Reports is the most powerful product for journal intelligence.”

Master Journal List: Quickly assess top journals

Master Journal List (MJL) is a free and trusted resource that supports researchers to find and compare reputable journals, books and conference proceedings indexed in Web of Science. MJL is not as comprehensive as Journal Citation Reports. However, its profile pages help researchers assess the quality of individual journals at a glance. Each journal page lists its publication details and Web of Science coverage and journal metrics. It also as lists open access and peer review characteristics. A range of filters are available to sort and group results, and you can also take advantage of EndNote’s free Manuscript Matcher tool to find the best match for your manuscript. Watch the video below to learn more.

“Master Journal List profile pages help researchers assess the quality of individual journals at a glance.”

Web of Science: Explore influential and emerging journals

The Analyze Results feature in Web of Science identifies the journals publishing the greatest number of papers on any given topic. It helps you dig deep into your specific subject area and identify any trends. Furthermore, it reveals all the influential and emerging journals that can be further analyzed using the products above. The Analyze Results feature can also find trends among the top institutions, funding agencies and authors publishing research. Learn more about Analyze Results here,  in the video below, or visit  the Web of Science search page to try this out today.

Stay connected

Interested in discovering more tips to really understand your research field? You can d ownload our cheat sheet , which brings together top tips for finding relevant journals, papers and authors in your field, or sign up for our webinar on the same topic. You can also read the related blog posts in our Research Smarter series, here .

Related posts

Journal citation reports 2024 preview: unified rankings for more inclusive journal assessment.

Introducing the Clarivate Academic AI Platform

Reimagining research impact: Introducing Web of Science Research Intelligence

61 intriguing psychology research topics to explore

Last updated

11 January 2024

Reviewed by

Brittany Ferri, PhD, OTR/L

Psychology is an incredibly diverse, critical, and ever-changing area of study in the medical and health industries. Because of this, it’s a common area of study for students and healthcare professionals.

We’re walking you through picking the perfect topic for your upcoming paper or study. Keep reading for plenty of example topics to pique your interest and curiosity.

• How to choose a psychology research topic

Exploring a psychology-based topic for your research project? You need to pick a specific area of interest to collect compelling data. 

Use these tips to help you narrow down which psychology topics to research:

Focus on a particular area of psychology

The most effective psychological research focuses on a smaller, niche concept or disorder within the scope of a study. 

Psychology is a broad and fascinating area of science, including everything from diagnosed mental health disorders to sports performance mindset assessments. 

This gives you plenty of different avenues to explore. Having a hard time choosing? Check out our list of 61 ideas further down in this article to get started.

Read the latest clinical studies

Once you’ve picked a more niche topic to explore, you need to do your due diligence and explore other research projects on the same topic. 

This practice will help you learn more about your chosen topic, ask more specific questions, and avoid covering existing projects. 

For the best results, we recommend creating a research folder of associated published papers to reference throughout your project. This makes it much easier to cite direct references and find inspiration down the line.

Find a topic you enjoy and ask questions

Once you’ve spent time researching and collecting references for your study, you finally get to explore. 

Whether this research project is for work, school, or just for fun, having a passion for your research will make the project much more enjoyable. (Trust us, there will be times when that is the only thing that keeps you going.) 

Now you’ve decided on the topic, ask more nuanced questions you might want to explore. 

If you can, pick the direction that interests you the most to make the research process much more enjoyable.

• 61 psychology topics to research in 2024

Need some extra help starting your psychology research project on the right foot? Explore our list of 61 cutting-edge, in-demand psychology research topics to use as a starting point for your research journey.

• Psychology research topics for university students

As a university student, it can be hard to pick a research topic that fits the scope of your classes and is still compelling and unique. 

Here are a few exciting topics we recommend exploring for your next assigned research project:

Mental health in post-secondary students

Seeking post-secondary education is a stressful and overwhelming experience for most students, making this topic a great choice to explore for your in-class research paper. 

Examples of post-secondary mental health research topics include:

Student mental health status during exam season

Mental health disorder prevalence based on study major

The impact of chronic school stress on overall quality of life

The impacts of cyberbullying

Cyberbullying can occur at all ages, starting as early as elementary school and carrying through into professional workplaces. 

Examples of cyberbullying-based research topics you can study include:

The impact of cyberbullying on self-esteem

Common reasons people engage in cyberbullying 

Cyberbullying themes and commonly used terms

Cyberbullying habits in children vs. adults

The long-term effects of cyberbullying

• Clinical psychology research topics

If you’re looking to take a more clinical approach to your next project, here are a few topics that involve direct patient assessment for you to consider:

Chronic pain and mental health

Living with chronic pain dramatically impacts every aspect of a person’s life, including their mental and emotional health. 

Here are a few examples of in-demand pain-related psychology research topics:

The connection between diabetic neuropathy and depression

Neurological pain and its connection to mental health disorders

Efficacy of meditation and mindfulness for pain management

The long-term effects of insomnia

Insomnia is where you have difficulty falling or staying asleep. It’s a common health concern that impacts millions of people worldwide. 

This is an excellent topic because insomnia can have a variety of causes, offering many research possibilities. 

Here are a few compelling psychology research topics about insomnia you could investigate:

The prevalence of insomnia based on age, gender, and ethnicity

Insomnia and its impact on workplace productivity

The connection between insomnia and mental health disorders

Efficacy and use of melatonin supplements for insomnia

The risks and benefits of prescription insomnia medications

Lifestyle options for managing insomnia symptoms

The efficacy of mental health treatment options

Management and treatment of mental health conditions is an ever-changing area of study. If you can witness or participate in mental health therapies, this can make a great research project. 

Examples of mental health treatment-related psychology research topics include:

The efficacy of cognitive behavioral therapy (CBT) for patients with severe anxiety

The benefits and drawbacks of group vs. individual therapy sessions

Music therapy for mental health disorders

Electroconvulsive therapy (ECT) for patients with depression 

• Controversial psychology research paper topics

If you are looking to explore a more cutting-edge or modern psychology topic, you can delve into a variety of controversial and topical options:

The impact of social media and digital platforms

Ever since access to internet forums and video games became more commonplace, there’s been growing concern about the impact these digital platforms have on mental health. 

Examples of social media and video game-related psychology research topics include:

The effect of edited images on self-confidence

How social media platforms impact social behavior

Video games and their impact on teenage anger and violence

Digital communication and the rapid spread of misinformation

The development of digital friendships

Psychotropic medications for mental health

In recent years, the interest in using psychoactive medications to treat and manage health conditions has increased despite their inherently controversial nature. 

Examples of psychotropic medication-related research topics include:

The risks and benefits of using psilocybin mushrooms for managing anxiety

The impact of marijuana on early-onset psychosis

Childhood marijuana use and related prevalence of mental health conditions

Ketamine and its use for complex PTSD (C-PTSD) symptom management

The effect of long-term psychedelic use and mental health conditions

• Mental health disorder research topics

As one of the most popular subsections of psychology, studying mental health disorders and how they impact quality of life is an essential and impactful area of research. 

While studies in these areas are common, there’s always room for additional exploration, including the following hot-button topics:

Anxiety and depression disorders

Anxiety and depression are well-known and heavily researched mental health disorders. 

Despite this, we still don’t know many things about these conditions, making them great candidates for psychology research projects:

Social anxiety and its connection to chronic loneliness

C-PTSD symptoms and causes

The development of phobias

Obsessive-compulsive disorder (OCD) behaviors and symptoms

Depression triggers and causes

Self-care tools and resources for depression

The prevalence of anxiety and depression in particular age groups or geographic areas

Bipolar disorder

Bipolar disorder is a complex and multi-faceted area of psychology research. 

Use your research skills to learn more about this condition and its impact by choosing any of the following topics:

Early signs of bipolar disorder

The incidence of bipolar disorder in young adults

The efficacy of existing bipolar treatment options

Bipolar medication side effects

Cognitive behavioral therapy for people with bipolar 

Schizoaffective disorder

Schizoaffective disorder is often stigmatized, and less common mental health disorders are a hotbed for new and exciting research. 

Here are a few examples of interesting research topics related to this mental health disorder:

The prevalence of schizoaffective disorder by certain age groups or geographic locations

Risk factors for developing schizoaffective disorder

The prevalence and content of auditory and visual hallucinations

Alternative therapies for schizoaffective disorder

• Societal and systematic psychology research topics

Modern society’s impact is deeply enmeshed in our mental and emotional health on a personal and community level. 

Here are a few examples of societal and systemic psychology research topics to explore in more detail:

Access to mental health services

While mental health awareness has risen over the past few decades, access to quality mental health treatment and resources is still not equitable. 

This can significantly impact the severity of a person’s mental health symptoms, which can result in worse health outcomes if left untreated. 

Explore this crucial issue and provide information about the need for improved mental health resource access by studying any of the following topics:

Rural vs. urban access to mental health resources

Access to crisis lines by location

Wait times for emergency mental health services

Inequities in mental health access based on income and location

Insurance coverage for mental health services

Systemic racism and mental health

Societal systems and the prevalence of systemic racism heavily impact every aspect of a person’s overall health.

Researching these topics draws attention to existing problems and contributes valuable insights into ways to improve access to care moving forward.

Examples of systemic racism-related psychology research topics include: 

Access to mental health resources based on race

The prevalence of BIPOC mental health therapists in a chosen area

The impact of systemic racism on mental health and self-worth

Racism training for mental health workers

The prevalence of mental health disorders in discriminated groups

LGBTQIA+ mental health concerns

Research about LGBTQIA+ people and their mental health needs is a unique area of study to explore for your next research project. It’s a commonly overlooked and underserved community.

Examples of LGBTQIA+ psychology research topics to consider include:

Mental health supports for queer teens and children

The impact of queer safe spaces on mental health

The prevalence of mental health disorders in the LGBTQIA+ community

The benefits of queer mentorship and found family

Substance misuse in LQBTQIA+ youth and adults

• Collect data and identify trends with Dovetail

Psychology research is an exciting and competitive study area, making it the perfect choice for projects or papers.

Take the headache out of analyzing your data and instantly access the insights you need to complete your next psychology research project by teaming up with Dovetail today.

Should you be using a customer insights hub?

Do you want to discover previous research faster?

Do you share your research findings with others?

Do you analyze research data?

Start for free today, add your research, and get to key insights faster

Editor’s picks

Last updated: 11 January 2024

Last updated: 15 January 2024

Last updated: 17 January 2024

Last updated: 25 November 2023

Last updated: 12 May 2023

Last updated: 30 April 2024

Last updated: 13 May 2024

Latest articles

Related topics, .css-je19u9{-webkit-align-items:flex-end;-webkit-box-align:flex-end;-ms-flex-align:flex-end;align-items:flex-end;display:-webkit-box;display:-webkit-flex;display:-ms-flexbox;display:flex;-webkit-flex-direction:row;-ms-flex-direction:row;flex-direction:row;-webkit-box-flex-wrap:wrap;-webkit-flex-wrap:wrap;-ms-flex-wrap:wrap;flex-wrap:wrap;-webkit-box-pack:center;-ms-flex-pack:center;-webkit-justify-content:center;justify-content:center;row-gap:0;text-align:center;max-width:671px;}@media (max-width: 1079px){.css-je19u9{max-width:400px;}.css-je19u9>span{white-space:pre;}}@media (max-width: 799px){.css-je19u9{max-width:400px;}.css-je19u9>span{white-space:pre;}} decide what to .css-1kiodld{max-height:56px;display:-webkit-box;display:-webkit-flex;display:-ms-flexbox;display:flex;-webkit-align-items:center;-webkit-box-align:center;-ms-flex-align:center;align-items:center;}@media (max-width: 1079px){.css-1kiodld{display:none;}} build next, decide what to build next.

Users report unexpectedly high data usage, especially during streaming sessions.

Users find it hard to navigate from the home page to relevant playlists in the app.

It would be great to have a sleep timer feature, especially for bedtime listening.

I need better filters to find the songs or artists I’m looking for.

Log in or sign up

Get started for free

• Free Tools for Students
• Harvard Referencing Generator

Free Harvard Referencing Generator

Generate accurate Harvard reference lists quickly and for FREE, with MyBib!

🤔 What is a Harvard Referencing Generator?

A Harvard Referencing Generator is a tool that automatically generates formatted academic references in the Harvard style.

It takes in relevant details about a source -- usually critical information like author names, article titles, publish dates, and URLs -- and adds the correct punctuation and formatting required by the Harvard referencing style.

The generated references can be copied into a reference list or bibliography, and then collectively appended to the end of an academic assignment. This is the standard way to give credit to sources used in the main body of an assignment.

👩‍🎓 Who uses a Harvard Referencing Generator?

Harvard is the main referencing style at colleges and universities in the United Kingdom and Australia. It is also very popular in other English-speaking countries such as South Africa, Hong Kong, and New Zealand. University-level students in these countries are most likely to use a Harvard generator to aid them with their undergraduate assignments (and often post-graduate too).

🙌 Why should I use a Harvard Referencing Generator?

A Harvard Referencing Generator solves two problems:

• It provides a way to organise and keep track of the sources referenced in the content of an academic paper.
• It ensures that references are formatted correctly -- inline with the Harvard referencing style -- and it does so considerably faster than writing them out manually.

A well-formatted and broad bibliography can account for up to 20% of the total grade for an undergraduate-level project, and using a generator tool can contribute significantly towards earning them.

⚙️ How do I use MyBib's Harvard Referencing Generator?

Here's how to use our reference generator:

• If citing a book, website, journal, or video: enter the URL or title into the search bar at the top of the page and press the search button.
• Choose the most relevant results from the list of search results.
• Our generator will automatically locate the source details and format them in the correct Harvard format. You can make further changes if required.
• Then either copy the formatted reference directly into your reference list by clicking the 'copy' button, or save it to your MyBib account for later.

MyBib supports the following for Harvard style:

🍏 What other versions of Harvard referencing exist?

There isn't "one true way" to do Harvard referencing, and many universities have their own slightly different guidelines for the style. Our generator can adapt to handle the following list of different Harvard styles:

• Cite Them Right
• Manchester Metropolitan University (MMU)
• University of the West of England (UWE)

Daniel is a qualified librarian, former teacher, and citation expert. He has been contributing to MyBib since 2018.

Epigenetic Biomarkers of Socioeconomic Status are Associated with Age-Related Chronic Diseases and Mortality in Older Adults

• Find this author on Google Scholar
• Find this author on PubMed
• Search for this author on this site
• ORCID record for Lauren L. Schmitz
• For correspondence: [email protected] [email protected]
• ORCID record for Jennifer A. Smith
• Info/History
• Supplementary material
• Preview PDF

Later-life health is patterned by socioeconomic influences across the lifecourse. However, the pathways underlying the biological embedding of socioeconomic status (SES) and its consequences on downstream morbidity and mortality are not fully understood. Epigenetic markers like DNA methylation (DNAm) may be promising surrogates of underlying biological processes that can enhance our understanding of how SES shapes population health. Studies have shown that SES is associated with epigenetic aging measures, but few have examined relationships between early and later-life SES and DNAm sites across the epigenome. In this study, we trained and tested DNAm-based surrogates, or “biomarkers,” of childhood and adult SES in two large, multi-racial/ethnic samples of older adults—the Health and Retirement Study (HRS) (N=3,527) and the Multi-Ethnic Study of Atherosclerosis (MESA) (N=1,182). Both biomarkers were associated with downstream morbidity and mortality, and these associations persisted after controlling for measured SES, and in some cases, epigenetic aging clocks. Both childhood and adult SES biomarker CpG sites were enriched for genomic features that regulate gene expression (e.g., DNAse hypersensitivity sites and enhancers) and were implicated in prior epigenome-wide studies of inflammation, aging, and chronic disease. Distinct patterns also emerged between childhood CpGs and immune system dysregulation and adult CpGs and metabolic functioning, health behaviors, and cancer. Results suggest DNAm-based surrogate biomarkers of SES may be useful proxies for unmeasured social exposures that can augment our understanding of the biological mechanisms between social disadvantage and downstream health.

Significance Statement Information on DNA methylation (DNAm)—an epigenetic modification that plays a central role in regulating gene expression—is increasingly available in large epidemiological studies. Since DNAm is relatively stable but responsive to environmental influences, genome-wide signatures are promising surrogates or biomarkers of exposure that may both shed light on biological mechanisms between adverse environments and downstream health and/or act as proxies for unmeasured exposures. To better understand the biological embedding of social disadvantage, this study trained and tested DNAm-based surrogates of childhood and adult socioeconomic status (SES) in two US-based cohorts of older adults. Findings reveal distinct DNAm signatures of SES that connect social adversity across the lifecourse with dysregulated immune system responses, inflammatory pathways, poorer metabolic functioning, chronic diseases, and cancer.

Competing Interest Statement

The authors have declared no competing interest.

Funding Statement

This analysis was supported by the National Institute on Aging (NIA, R00 AG056599 (Schmitz)), the National Heart, Lung, and Blood Institute (NHLBI, R01 HL141292 (Smith)), and the National Human Genome Research Institute (NHGRI, T32 HG000040 (Opsasnick)). The NIA supports the Health and Retirement Study (U01AG009740) and its genotyping (RC2 AG0336495, RC4 AG039029). Research in MESA is supported by contracts 75N92020D00001, HHSN268201500003I, N01-HC-95159, 75N92020D00005, N01-HC-95160, 75N92020D00002, N01-HC-95161, 75N92020D00003, N01-HC-95162, 75N92020D00006, N01-HC-95163, 75N92020D00004, N01-HC-95164, 75N92020D00007, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168 and N01-HC-95169 from the NHLBI and by grants UL1-TR-000040, UL1-TR-001079, and UL1-TR-001420 from the National Center for Advancing Translational Sciences (NCATS). The provision of genotyping data was supported in part by the National Center for Advancing Translational Sciences, CTSI grant UL1TR001881, and the National Institute of Diabetes and Digestive and Kidney Disease Diabetes Research Center (DRC) grant DK063491 to the Southern California Diabetes Endocrinology Research Center. Funding for SHARe genotyping was provided by NHLBI Contract N02-HL-64278. A full list of participating MESA investigators and institutions can be found at http://www.mesa-nhlbi.org [mesa-nhlbi.org]. Funding for MESA SHARe genotyping was provided by NHLBI Contract N02-HL-64278. Genotyping was performed at Affymetrix (Santa Clara, California, USA) and the Broad Institute of Harvard and MIT (Boston, Massachusetts, USA) using the Affymetrix Genome-Wide Human SNP Array 6.0. The MESA Epigenomics & Transcriptomics Studies were funded by NIH grants R01HL101250, R01HL119962, R01DK101921, R01HL135009, and 1RF1AG054474. This paper has been reviewed and approved by the MESA Publications and Presentations Committee. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIA, NHLBI, NHGRI, or NCATS.

Author Declarations

I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.

The details of the IRB/oversight body that provided approval or exemption for the research described are given below:

IRBs of University of Wisconsin-Madison and University of Michigan gave ethical approval for this work.

I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals.

I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).

I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable.

Competing Interest Statement: The authors declare no conflicts of interest.

Data Availability

This study used restricted individual level information from the HRS, and our contractual agreement does not permit public dissemination of the data. Details on how to access restricted data for the HRS can be found at https://hrs.isr.umich.edu/data-products/restricted-data. Data used in this analysis from MESA can be obtained through the MESA Data Coordinating Center (https://www.mesanhlbi.org/) and through the database of Genotypes and Phenotypes (dbGaP; phs000209). Analysis code is posted on github: https://github.com/laurenschmitz/epigenetic-SES-biomarker.

View the discussion thread.

Supplementary Material

Thank you for your interest in spreading the word about medRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Citation Manager Formats

• EndNote (tagged)
• EndNote 8 (xml)
• RefWorks Tagged
• Ref Manager
• Tweet Widget
• Facebook Like
• Google Plus One

Subject Area

• Public and Global Health
• Addiction Medicine (324)
• Allergy and Immunology (632)
• Anesthesia (168)
• Cardiovascular Medicine (2398)
• Dentistry and Oral Medicine (289)
• Dermatology (207)
• Emergency Medicine (381)
• Endocrinology (including Diabetes Mellitus and Metabolic Disease) (850)
• Epidemiology (11795)
• Forensic Medicine (10)
• Gastroenterology (705)
• Genetic and Genomic Medicine (3766)
• Geriatric Medicine (350)
• Health Economics (637)
• Health Informatics (2408)
• Health Policy (939)
• Health Systems and Quality Improvement (905)
• Hematology (342)
• HIV/AIDS (786)
• Infectious Diseases (except HIV/AIDS) (13346)
• Intensive Care and Critical Care Medicine (769)
• Medical Education (368)
• Medical Ethics (105)
• Nephrology (401)
• Neurology (3523)
• Nursing (199)
• Nutrition (528)
• Obstetrics and Gynecology (679)
• Occupational and Environmental Health (667)
• Oncology (1832)
• Ophthalmology (538)
• Orthopedics (221)
• Otolaryngology (287)
• Pain Medicine (234)
• Palliative Medicine (66)
• Pathology (447)
• Pediatrics (1037)
• Pharmacology and Therapeutics (426)
• Primary Care Research (424)
• Psychiatry and Clinical Psychology (3187)
• Public and Global Health (6178)
• Radiology and Imaging (1290)
• Rehabilitation Medicine and Physical Therapy (751)
• Respiratory Medicine (832)
• Rheumatology (380)
• Sexual and Reproductive Health (373)
• Sports Medicine (324)
• Surgery (403)
• Toxicology (50)
• Transplantation (172)
• Urology (147)

NTRS - NASA Technical Reports Server

Available downloads, related records.