The Diabetes Hypothesis Follows A Historical View Of Sugar
Hypothesis of diabetes mellitus (DM; left side) and hypertensive
Hypothesis on the potential mechanisms linking a high glycemic load
Type 2 diabetes remission: latest evidence for health care
Hypothesis of micro and macrovascular complications in diabetes. ROS
Type 2 Diabetes
VIDEO
Concept of Hypothesis
Diabetes Research Shows Promise
What Is A Hypothesis?
Hypersensitivities and Autoimmune Disorders
Leveraging Data Science for Diabetes Prediction
First World Hygiene Causing Rise In Diabetes?
COMMENTS
Testing the Accelerator Hypothesis
Type 2 diabetes is believed to result from the loss of β-cell function in association with insulin resistance (2). The Accelerator Hypothesis regards type 1 diabetes in the same way (3). Awareness of overlap between type 1 and type 2 diabetes is not new. There has long been interest in insulin resistance in type 1 diabetes, although related ...
The accelerator hypothesis: a unifying explanation for type-1 ...
The accelerator hypothesis argues that type-1 and type-2 diabetes are the same disorder of insulin resistance set against different genetic backgrounds. It identifies three processes which variably accelerate beta cell loss: constitution, insulin resistance and the immune response to it. None of the accelerators leads to diabetes in the absence ...
The accelerator hypothesis: a review of the evidence for insulin
Diabetes develops only when the β-cells are unable to produce sufficient insulin for the body's needs. The deficiency might be supply-led, as in the monogenic disorders HNF-1α and Kir-6, where ...
New Aspects of Diabetes Research and Therapeutic Development
I. Introduction. Diabetes mellitus, a metabolic disease defined by elevated fasting blood glucose levels due to insufficient insulin production, has reached epidemic proportions worldwide (World Health Organization, 2020).Type 1 and type 2 diabetes (T1D and T2D, respectively) make up the majority of diabetes cases with T1D characterized by autoimmune destruction of the insulin-producing ...
Pathogenesis and remission of type 2 diabetes: what has the twin cycle
Type 2 diabetes has been regarded a complex multifactorial disease that lead to serious health complications including high cardiovascular risks. The twin cycle hypothesis postulated that both hepatic insulin resistance and dysfunction rather than death of beta (β) cell determine diabetes onset. Several studies were carried out to test this ...
The accelerator hypothesis: a review of the evidence for insulin
The accelerator hypothesis is a singular, unifying concept that argues that type I and type II diabetes are the same disorder of insulin resistance, set against different genetic backgrounds. The hypothesis does not deny the role of autoimmuniy, only its primacy in the process.
Molecular links between Obesity and Diabetes: "Diabesity"
Severe obesity represents a major risk factor for the development of type 2 diabetes mellitus (T2DM). Due to the strong association of obesity and diabetes, the term "diabesity" was coined, suggesting a causal pathophysiological link between both phenomena. The majority of individuals with T2DM are obese, highlighting the pivotal role of increased adiposity as a risk factor for diabetes.
Double or hybrid diabetes: A systematic review on disease ...
Diabetes mellitus is a worldwide epidemic affecting the health of millions of people. ... The convergence of type 1 and type 2 diabetes in childhood: the accelerator hypothesis. Pediatr. Diabetes ...
Testing the Accelerator Hypothesis
The "accelerator hypothesis" postulates that obesity-associated insulin resistance accelerates the disease process of type 1 diabetes. The marker is an earlier age at onset of type 1 diabetes associated with increased BMI (1). In contemporary societies, increasing childhood obesity may account for the increasing incidence and younger age at ...
A New Hypothesis for Type 1 Diabetes Risk: The At-Risk Allele at
Objectives: Type 1 diabetes is characterized by the autoimmune destruction of insulin-secreting beta cells. Genetic variants upstream at the insulin (INS) locus contribute to ∼10% of type 1 diabetes heritable risk. Previous studies showed an association between rs3842753 C/C genotype and type 1 diabetes susceptibility, but the molecular mechanisms remain unclear.
Hypothesis: Induction of Autoimmunity in Type 1 Diabetes—A Lipid Focus
Our hypothesis encourages testing of potential early therapeutic interventions to prevent progression of β-cell destruction. Background and Natural History Type 1 diabetes (T1D) is an autoimmune disease specifically targeted to the pancreatic β-cells within the islets of Langerhans ( 1 ).
Top ten research priorities for type 2 diabetes: results from the
About 20% of the UK population are living with, or are at risk of, type 2 diabetes, with estimated annual National Health Service treatment costs of £8·8 billion.1 This rising tide identifies an urgent need to reduce uncertainties around the causes, prevention, and treatment of type 2 diabetes. A patient-centred approach is a cornerstone of high-quality diabetes care and is mirrored in ...
PDF CHAPTER 1 INTRODUCTION Statement of the problem
Diabetes is a chronic health problem with devastating, yet preventable consequences. It is characterized by high blood glucose levels resulting from defects in insulin production, insulin action, or both.1,2 Globally, rates of type 2 diabetes were 15.1 million in 2000,3 the number of people with diabetes
An automatic hypothesis generation for plausible linkage between
We ranked 2,740,314 paths in total between 35 Xanthium compounds and three diabetes-related phrases: type 1 diabetes, type 2 diabetes, and diabetes mellitus. ... By conducting a hypothesis ...
Hypertension and Diabetes Mellitus
Type 2 diabetes mellitus and hypertension overlap in the population. In many subjects, development of diabetes mellitus is characterized by a relatively rapid increase in plasma glucose values. ... A P value ≤0.05 was considered statistically significant for the test of the hypothesis that diabetes mellitus predicts hypertension or vice versa ...
Type 2 Diabetes
The twin cycle hypothesis of the etiology of type 2 diabetes. During long-term intake of more calories than are expended each day, any excess carbohydrate must undergo de novo lipogenesis, which particularly promotes fat accumulation in the liver. Because insulin stimulates de novo lipogenesis, individuals with a degree of insulin resistance ...
Methods needed to measure predictive accuracy: A study of diabetic
1.2 Fast Food Consumption and Obesity. An inverse relationship exists between BMI and the age of diabetes onset, showing severe weight gain associated with a higher risk of diabetes, regardless of age [19, 20].The high rates of fast food consumption in the United States are a major contributing factor to diabetes and are associated with many risk factors of diabetes such as high BMI, obesity ...
Type 2 Diabetes and Fasting: What to Know
Research supports this hypothesis. Some work on people with diabetes has found that intermittent fasting may increase insulin sensitivity and also reduce insulin levels in the blood. This is a big ...
8.3: Sampling distribution and hypothesis testing
Introduction. Understanding the relationship between sampling distributions, probability distributions, and hypothesis testing is the crucial concept in the NHST — Null Hypothesis Significance Testing — approach to inferential statistics. is crucial, and many introductory text books are excellent here. I will add some here to their discussion, perhaps with a different approach, but the ...
Is the thrifty genotype hypothesis supported by evidence based on
Aims/hypothesis. According to the thrifty genotype hypothesis, the high prevalence of type 2 diabetes and obesity is a consequence of genetic variants that have undergone positive selection during historical periods of erratic food supply.
Using a Quantitative Measure of Diabetes Risk in Clinical Practice to
This article discusses the clinical application of a validated prognostic test (PreDx, Tethys Bioscience, Inc., Emeryville, Calif.) that provides clinicians with an estimate of the 5-year likelihood of progression to type 2 diabetes for patients who have been identified through screening as having prediabetes. 9-12 Patient cases are presented to demonstrate how the PreDx test can be used ...
Symptoms and causes
See your health care provider if you're concerned about diabetes or if you notice any type 2 diabetes signs or symptoms. Ask your health care provider about blood sugar screening if you have any risk factors for diabetes. Causes. The exact cause of prediabetes is unknown. But family history and genetics appear to play an important role.
Epidemiology of diabetes
The disease burden related to diabetes is high and rising in every country, fuelled by the global rise in the prevalence of obesity and unhealthy lifestyles. The latest estimates show a global prevalence of 382 million people with diabetes in 2013, expected to rise to 592 million by 2035. ... This 'thrifty genotype' hypothesis is supported ...
Hypothesis 2. Depression increases the risk for coronary heart disease
By 2020, depression will be the second leading cause of disability. 14 Diabetes is associated with a twofold increase in depression as compared with the general population, with comorbid depression being seen in nearly 30% of patients with type 1 or type 2 diabetes. 15 Depression in diabetes is a chronic disease, is associated with increased ...
IMAGES
VIDEO
COMMENTS
Type 2 diabetes is believed to result from the loss of β-cell function in association with insulin resistance (2). The Accelerator Hypothesis regards type 1 diabetes in the same way (3). Awareness of overlap between type 1 and type 2 diabetes is not new. There has long been interest in insulin resistance in type 1 diabetes, although related ...
The accelerator hypothesis argues that type-1 and type-2 diabetes are the same disorder of insulin resistance set against different genetic backgrounds. It identifies three processes which variably accelerate beta cell loss: constitution, insulin resistance and the immune response to it. None of the accelerators leads to diabetes in the absence ...
Diabetes develops only when the β-cells are unable to produce sufficient insulin for the body's needs. The deficiency might be supply-led, as in the monogenic disorders HNF-1α and Kir-6, where ...
I. Introduction. Diabetes mellitus, a metabolic disease defined by elevated fasting blood glucose levels due to insufficient insulin production, has reached epidemic proportions worldwide (World Health Organization, 2020).Type 1 and type 2 diabetes (T1D and T2D, respectively) make up the majority of diabetes cases with T1D characterized by autoimmune destruction of the insulin-producing ...
Type 2 diabetes has been regarded a complex multifactorial disease that lead to serious health complications including high cardiovascular risks. The twin cycle hypothesis postulated that both hepatic insulin resistance and dysfunction rather than death of beta (β) cell determine diabetes onset. Several studies were carried out to test this ...
The accelerator hypothesis is a singular, unifying concept that argues that type I and type II diabetes are the same disorder of insulin resistance, set against different genetic backgrounds. The hypothesis does not deny the role of autoimmuniy, only its primacy in the process.
Severe obesity represents a major risk factor for the development of type 2 diabetes mellitus (T2DM). Due to the strong association of obesity and diabetes, the term "diabesity" was coined, suggesting a causal pathophysiological link between both phenomena. The majority of individuals with T2DM are obese, highlighting the pivotal role of increased adiposity as a risk factor for diabetes.
Diabetes mellitus is a worldwide epidemic affecting the health of millions of people. ... The convergence of type 1 and type 2 diabetes in childhood: the accelerator hypothesis. Pediatr. Diabetes ...
The "accelerator hypothesis" postulates that obesity-associated insulin resistance accelerates the disease process of type 1 diabetes. The marker is an earlier age at onset of type 1 diabetes associated with increased BMI (1). In contemporary societies, increasing childhood obesity may account for the increasing incidence and younger age at ...
Objectives: Type 1 diabetes is characterized by the autoimmune destruction of insulin-secreting beta cells. Genetic variants upstream at the insulin (INS) locus contribute to ∼10% of type 1 diabetes heritable risk. Previous studies showed an association between rs3842753 C/C genotype and type 1 diabetes susceptibility, but the molecular mechanisms remain unclear.
Our hypothesis encourages testing of potential early therapeutic interventions to prevent progression of β-cell destruction. Background and Natural History Type 1 diabetes (T1D) is an autoimmune disease specifically targeted to the pancreatic β-cells within the islets of Langerhans ( 1 ).
About 20% of the UK population are living with, or are at risk of, type 2 diabetes, with estimated annual National Health Service treatment costs of £8·8 billion.1 This rising tide identifies an urgent need to reduce uncertainties around the causes, prevention, and treatment of type 2 diabetes. A patient-centred approach is a cornerstone of high-quality diabetes care and is mirrored in ...
Diabetes is a chronic health problem with devastating, yet preventable consequences. It is characterized by high blood glucose levels resulting from defects in insulin production, insulin action, or both.1,2 Globally, rates of type 2 diabetes were 15.1 million in 2000,3 the number of people with diabetes
We ranked 2,740,314 paths in total between 35 Xanthium compounds and three diabetes-related phrases: type 1 diabetes, type 2 diabetes, and diabetes mellitus. ... By conducting a hypothesis ...
Type 2 diabetes mellitus and hypertension overlap in the population. In many subjects, development of diabetes mellitus is characterized by a relatively rapid increase in plasma glucose values. ... A P value ≤0.05 was considered statistically significant for the test of the hypothesis that diabetes mellitus predicts hypertension or vice versa ...
The twin cycle hypothesis of the etiology of type 2 diabetes. During long-term intake of more calories than are expended each day, any excess carbohydrate must undergo de novo lipogenesis, which particularly promotes fat accumulation in the liver. Because insulin stimulates de novo lipogenesis, individuals with a degree of insulin resistance ...
1.2 Fast Food Consumption and Obesity. An inverse relationship exists between BMI and the age of diabetes onset, showing severe weight gain associated with a higher risk of diabetes, regardless of age [19, 20].The high rates of fast food consumption in the United States are a major contributing factor to diabetes and are associated with many risk factors of diabetes such as high BMI, obesity ...
Research supports this hypothesis. Some work on people with diabetes has found that intermittent fasting may increase insulin sensitivity and also reduce insulin levels in the blood. This is a big ...
Introduction. Understanding the relationship between sampling distributions, probability distributions, and hypothesis testing is the crucial concept in the NHST — Null Hypothesis Significance Testing — approach to inferential statistics. is crucial, and many introductory text books are excellent here. I will add some here to their discussion, perhaps with a different approach, but the ...
Aims/hypothesis. According to the thrifty genotype hypothesis, the high prevalence of type 2 diabetes and obesity is a consequence of genetic variants that have undergone positive selection during historical periods of erratic food supply.
This article discusses the clinical application of a validated prognostic test (PreDx, Tethys Bioscience, Inc., Emeryville, Calif.) that provides clinicians with an estimate of the 5-year likelihood of progression to type 2 diabetes for patients who have been identified through screening as having prediabetes. 9-12 Patient cases are presented to demonstrate how the PreDx test can be used ...
See your health care provider if you're concerned about diabetes or if you notice any type 2 diabetes signs or symptoms. Ask your health care provider about blood sugar screening if you have any risk factors for diabetes. Causes. The exact cause of prediabetes is unknown. But family history and genetics appear to play an important role.
The disease burden related to diabetes is high and rising in every country, fuelled by the global rise in the prevalence of obesity and unhealthy lifestyles. The latest estimates show a global prevalence of 382 million people with diabetes in 2013, expected to rise to 592 million by 2035. ... This 'thrifty genotype' hypothesis is supported ...
By 2020, depression will be the second leading cause of disability. 14 Diabetes is associated with a twofold increase in depression as compared with the general population, with comorbid depression being seen in nearly 30% of patients with type 1 or type 2 diabetes. 15 Depression in diabetes is a chronic disease, is associated with increased ...