research articles about lipids

Lipids in Health and Disease

Featured review : can essential fatty acids (efas) prevent and ameliorate post-covid-19 long haul manifestations.

Featured Article : Polar lipids modify Alzheimer’s Disease pathology by reducing astrocyte pro-inflammatory signaling through platelet-activating factor receptor (PTAFR) modulation

This interesting research article highlights “a novel underlying mechanism, why consuming PL-rich foods such as fish and dairy may reduce the risk of developing dementia and associated disorders.” Read full article here .

Call for Papers: Lipids and Women’s Health

Featured series: Lipids and Sleep

Featured series: Nanomaterials/Biomaterials Target Lipid Metabolism and Fight Diseases

Featured series: Lipid Abnormalities in ASD and ASD-Associated Genetic Disorders and the Associated mTOR Pathway

Have a submission for Lipids in Health and Disease?

Have a submission you want to make sure is right for Lipids in Health and Disease? Or a great idea for a new submission or thematic series? Tell our Editors-in-Chief, A. M. Abd El-Aty and Christine Meisinger!

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Investigating a novel surrogate indicator of adipose accumulation in relation to erectile dysfunction

Authors: Chen-Yuan Deng, Xin-Peng Ke and Xu-Guang Guo

Comparative study of melasma in patients before and after treatment based on lipomics

Authors: Yuan Zhu, Jinhui Xu, Xiuzu Song and Wenzhong Xiang

Machine learning-based algorithm identifies key mitochondria-related genes in non-alcoholic steatohepatitis

Authors: Longfei Dai, Renao Jiang, Zhicheng Zhan, Liangliang Zhang, Yuyang Qian, Xinjian Xu, Wenqi Yang and Zhen Zhang

Algorithm for detection and screening of familial hypercholesterolemia in Lithuanian population

Authors: Urte Aliosaitiene, Zaneta Petrulioniene, Egidija Rinkuniene, Antanas Mainelis, Egle Brazdziuniene, Urte Smailyte, Vaida Sileikiene and Aleksandras Laucevicius

Gender differences in the association between changes in the atherogenic index of plasma and cardiometabolic diseases: a cohort study

Authors: Xingjie Huang, Song Wen, Yuqing Huang and Zehan Huang

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IGOB131, a novel seed extract of the West African plant Irvingia gabonensis , significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind placebo controlled investigation

Authors: Judith L Ngondi, Blanche C Etoundi, Christine B Nyangono, Carl MF Mbofung and Julius E Oben

Bovine milk in human nutrition – a review

Authors: Anna Haug, Arne T. Høstmark and Odd M. Harstad

The use of a Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study

Authors: Julius E Oben, Judith L Ngondi, Claudia N Momo, Gabriel A Agbor and Caroline S Makamto Sobgui

Omega-3 fatty acids and major depression: A primer for the mental health professional

Authors: Alan C Logan

The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome

Authors: Julius Oben, Dieudonne Kuate, Gabriel Agbor, Claudia Momo and Xavio Talla

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Editor-in-Chief

A. M. Abd El-Aty, PhD, Cairo University, Egypt

Christine Meisinger, MPH, University of Augsburg, Germany

Aims and scope

Lipids in Health and Disease is an open access, peer-reviewed journal that publishes articles on all aspects of lipids: their interaction with proteins, (bio) chemistry, (molecular) pharmacology, (molecular) toxicology, natural products chemistry, role in health and disease, in addition to the synthesis of new lipid compounds, and enzyme systems involved in lipid metabolism. Lipids in Health and Disease is aimed at all scientists, health professionals, and physicians interested in lipids. Lipids are defined herein based on their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes, and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology, and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.  

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Annual Journal Metrics

2022 Citation Impact 4.5 - 2-year Impact Factor 4.9 - 5-year Impact Factor 1.358 - SNIP (Source Normalized Impact per Paper) 1.042 - SJR (SCImago Journal Rank)

2023 Speed 2 days submission to first editorial decision for all manuscripts (Median) 68 days submission to accept (Median)

2023 Usage  1,810,907 downloads 1,488 Altmetric mentions 

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ISSN: 1476-511X

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Lipids articles within Nature Chemistry

Article | 22 May 2023

Activity-based directed evolution of a membrane editor in mammalian cells

Cellular membranes contain numerous lipids, and efforts to understand the biological functions of individual lipids demand approaches for controlled modulation of membrane composition in situ. Now, click chemistry-based directed evolution of a microbial phospholipase within mammalian cells affords an editor for optogenetic, targeted modification of phospholipids in cell membranes.

• , Saket R. Bagde
•  &  Jeremy M. Baskin

Article | 11 August 2022

Filling of a water-free void explains the allosteric regulation of the β 1 -adrenergic receptor by cholesterol

The β 1 -adrenergic receptor (β 1 AR) contains empty cavities in its preactive conformation, which disappear in the active one. Now, using X-ray crystallography of xenon-derivatized β 1 AR crystals, a cavity has been shown to be in contact with the cholesterol-binding pocket. Monitoring the binding of a cholesterol analogue in solution has explained the function of cholesterol as a negative allosteric modulator of β 1 AR.

• Layara Akemi Abiko
• , Raphael Dias Teixeira
•  &  Stephan Grzesiek

Perspective | 25 July 2022

Challenges and opportunities in achieving the full potential of droplet interface bilayers

Droplet interface bilayers (DIBs) are a type of artificial bilayer that can act as cell membrane mimics. This Perspective surveys how DIBs can be used to mimic key cellular features (such as bilayer asymmetry) and processes (such as drug movement), and discusses challenges that need to be overcome to enable DIBs to reach their full potential as biomimetic model membranes.

• Elanna B. Stephenson
• , Jaime L. Korner
•  &  Katherine S. Elvira

Article | 12 October 2020

Enzyme-free synthesis of natural phospholipids in water

It is unclear how phospholipid membranes formed on the early Earth, as modern cells synthesize the phospholipid constituents of their membranes enzymatically. Now, a combination of ion pairing and self-assembly has enabled transacylation of lysophospholipids with acyl donors in water, affording a variety of membrane-forming natural diacylphospholipids in high yields.

•  &  Neal K. Devaraj

Article | 01 April 2019

Dual chemical probes enable quantitative system-wide analysis of protein prenylation and prenylation dynamics

Two chemical probes, YnF and YnGG, that enable the identification of prenylated peptides and global analysis of protein prenylation using quantitative chemical proteomics have now been developed. Prenylation dynamics in response to pharmacological inhibition of prenyl-transferase enzymes were also studied. As a final demonstration, defective Rab prenylation in a model of the retinal degenerative disease choroideremia was also quantified.

• Elisabeth M. Storck
• , Julia Morales-Sanfrutos
•  &  Edward W. Tate

Article | 27 August 2018

A fluorescent membrane tension probe

Lipid membranes—which separate cells and organelles from their environment—experience tension during various cell processes; however, measuring membrane tension is notoriously difficult. Now, a new fluorescent, mechanosensitive membrane probe called FliptR has been developed. FliptR enables simple, direct membrane tension measurements in cellular and artificial membranes.

• , Emmanuel Derivery
•  &  Aurélien Roux

News & Views | 23 June 2017

Bringing lipid bilayers into shape

Lipid bilayers form the thin and floppy membranes that define the boundary of compartments such as cells. Now, a method to control the shape and size of bilayers using DNA nanoscaffolds has been developed. Such designer materials advance synthetic biology and could find use in membrane research.

• Stefan Howorka

Article | 13 June 2016

Cell-sized asymmetric lipid vesicles facilitate the investigation of asymmetric membranes

Cell-sized asymmetric giant lipid vesicles containing a very small amount of organic solvent have now been formed via inhomogeneous break-up of a lipid microtube that was generated by applying a jet flow to an asymmetric planar lipid bilayer. The asymmetric giant vesicles were used to investigate the dynamic responses of lipid molecules and the effect of asymmetry on biochemical reactions.

• Koki Kamiya
• , Ryuji Kawano
•  &  Shoji Takeuchi

Article | 21 March 2016

Self-assembly of size-controlled liposomes on DNA nanotemplates

Precise control of vesicle size is highly desirable both for basic biochemical research and biomedical applications. Now, monodispersed sub-100-nm vesicles with predefined sizes have been produced using a method based on membrane self-assembly within a DNA-nanostructure guide.

• , Jing Wang
•  &  Chenxiang Lin

Research Highlights | 20 May 2015

Profiling lipidated proteins

• Russell Johnson

Article | 20 April 2015

Functionalization of cobalt porphyrin–phospholipid bilayers with his-tagged ligands and antigens

Lipid bilayers containing porphyin-phospholipid that is chelated with cobalt have been shown to capture his-tagged proteins and peptides. This method offers a simple route for functionalizing pre-formed lipid bilayers without disrupting their integrity. Using this approach homing peptides were attached to cargo-loaded liposomes to enable tumour targeting, and an HIV-derived protein fragment elicited antibodies following binding to immunogenic liposomes.

• , Jumin Geng
•  &  Jonathan F. Lovell

News & Views | 20 February 2015

Bound in flight

In their natural environment, membrane proteins are surrounded by lipids, but the effect that the lipids have on the proteins is not easy to assess. Now, controlling the extent of delipidation has enabled the study of these interactions.

• Sophie R. Harvey
•  &  Vicki H. Wysocki

Article | 02 February 2015

A subset of annular lipids is linked to the flippase activity of an ABC transporter

Defining the lipid composition that exists around a membrane protein complex in natural bilayers is a challenging task. Now, key lipids that are important for the structure and function of an ABC transporter have been revealed by systematically removing layers of lipids, and using mass spectrometry to monitor those that remained closely associated with the membrane protein.

• Chérine Bechara
• , Anne Nöll
•  &  Carol V. Robinson

Article | 20 April 2014

A mitochondrial pathway for biosynthesis of lipid mediators

The biosynthesis of lipid mediators has not previously been identified in mitochondria. Here, polyunsaturated cardiolipins are shown to be oxidized in the mitochondria by cytochrome c . Subsequent hydrolysis of these oxygenated species generates a variety of oxygenated fatty acids as well as non-oxygenated and oxygenated lyso-cardiolipins. These reactions represent a new biosynthetic pathway for the production of lipid mediators.

• Yulia Y. Tyurina
• , Samuel M. Poloyac
•  &  Valerian E. Kagan

Article | 09 October 2011

In situ quantitative imaging of cellular lipids using molecular sensors

Cellular membrane lipids play key roles in cell regulation. Here, an environmentally sensitive fluorophore is attached to a protein that binds to a key signalling lipid to produce a membrane lipid sensor. This strategy allows sensitive, quantitative, spatiotemporal imaging of the lipid concentration in mammalian cells.

• Youngdae Yoon
• , Park J. Lee
•  &  Wonhwa Cho

Browse broader subjects

• Biochemistry
• Chemical biology

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• Fatty acids
• Fatty alcohols
• Glycolipids
• Lipid peroxides
• Lipopeptides
• Lipopolysaccharides
• Lipoproteins
• Membrane lipids
• Phospholipids
• Polyhydroxyalkanoates
• Sphingolipids

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EDITORIAL article

This article is part of the research topic.

Innovations in Biologically Active Nutrients Extraction and Delivery

Editorial: Innovations in Biologically Active Nutrients Extraction and Delivery Provisionally Accepted

• 1 National Research Centre (Egypt), Egypt
• 2 Institute of Food Science Research, Spanish National Research Council (CSIC), Spain

The final, formatted version of the article will be published soon.

Bioactive compounds have been discussed for a while, but it has recently become one of the most popular topics in research and food communities. Among bioactive compounds, proteins, peptides, lipids, carbohydrates, and antioxidant molecules in food have drawn increasing attention due to their beneficial impacts on human health (1). These substances are known to control the progression of chronic diseases through their antioxidant, anticancer, antimicrobial, and anti-inflammatory properties. The development of food products with natural extracts, including polyunsaturated fatty acids, bioactive peptides, or phenolic compounds, can be considered an innovative strategy not only to boost their nutritional quality but also to attract consumers and influence food marketing. Extraction is essential in obtaining bioactive compounds from food sources, including by-products. Thus, the development of environmentally friendly and sustainable extraction techniques is a significant topic in food science and others (1,2). In this context, the extraction using non-thermal techniques (e.g. ultrasound-assisted extraction, UAE) and thermal techniques (e.g. microwave-assisted extraction, MAE), as well as the incorporation of those compounds to foods are challenging due to the complex composition of the different food matrices. This Research Topic culminated in a total of 16 submissions dealing with novel extraction strategies for bioactive compounds and their applications in the food industry. 5 articles covering the aspects mentioned above were published on this Research Topic after a rigorous single-blind peer-review process. In one of the articles of this Liu et al.

Keywords: Green extraction technologies, by-products, Food applications, bioactive, Health benefits

Received: 30 Apr 2024; Accepted: 13 May 2024.

Copyright: © 2024 Zaky, Gómez Cortés and Hernandez-Ledesma. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Ahmed A. Zaky, National Research Centre (Egypt), Cairo, Egypt

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After a $20M Series A funding, Germany’s Insempra plans eco-friendly lipid production

Lipids are fatty, waxy or oily compounds that typically come in the form of fats and oils. As a result, they are heavily used in the production of beauty products, as well as in fashion and food industries. Right now, most lipids come from environmentally problematic petrochemicals. But new processes mean it’s possible to make lipids from organic materials.

That’s the idea of German startup Insempra , which plans to turn oil yeast in lipids on an industrial scale using yeast fermentation factories. It’s now raised a $20 million Series A financing round led by EQT Ventures. Also participating was BlueYard Capital, Possible Ventures, Taavet Sten and Acequia Capital. Notably, new investors include the venture arm of FMCG (fast-moving consumer goods) giant Henkel, Henkel dx Ventures, Bayern Kapital and Alante Capital.

The Series A follows an initial $15 million seed round that was conducted in 2021.

Lipids are used for cosmetic and food applications, but Insempra is also developing technology that offers a bio-based alternative to everyday materials such as polymers and textiles. It plans to work on generating ingredients used in antioxidants, preservatives, flavors and fragrances as well.

Founder Jens Klein was formerly CEO of AMSilk GmbH, an industrial supplier of vegan silk polymers.

Over a call he told me: “Lipids typically are either extracted from nature — you harvest the plant — or you can produce them petrochemically. We use so-called oil yeast. And these oil yeasts are put under certain conditions in our steel vessels under certain metabolic situations. Then they produce lipids oils, which we can extract later on, and which we can sell into the cosmetics and into the food industry.”

He said Insempra’s main competitors are specialty ingredients companies, largely petrochemical companies: “I don’t know any other company with an approach like ours.”

Insempra will also produce fibers for use in the fashion industry. “There is a spinoff we’ve done together with Imperial College,” he said. “It’s located in London. It’s called Salina, and we do the Salina fibers there. These are protein fibers, which are spun as normal.”

In a statement, Ted Persson, partner at EQT Ventures, added: “New technology platforms such as Insempra’s have the potential to dramatically change the manufacturing processes of multiple multibillion-dollar industries, developing customized ingredients to fit market needs.”

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