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SciSpace Resources

How To Write a Research Question

Deeptanshu D

Academic writing and research require a distinct focus and direction. A well-designed research question gives purpose and clarity to your research. In addition, it helps your readers understand the issue you are trying to address and explore.

Every time you want to know more about a subject, you will pose a question. The same idea is used in research as well. You must pose a question in order to effectively address a research problem. That's why the research question is an integral part of the research process. Additionally, it offers the author writing and reading guidelines, be it qualitative research or quantitative research.

In your research paper , you must single out just one issue or problem. The specific issue or claim you wish to address should be included in your thesis statement in order to clarify your main argument.

A good research question must have the following characteristics.

in research question

  • Should include only one problem in the research question
  • Should be able to find the answer using primary data and secondary data sources
  • Should be possible to resolve within the given time and other constraints
  • Detailed and in-depth results should be achievable
  • Should be relevant and realistic.
  • It should relate to your chosen area of research

While a larger project, like a thesis, might have several research questions to address, each one should be directed at your main area of study. Of course, you can use different research designs and research methods (qualitative research or quantitative research) to address various research questions. However, they must all be pertinent to the study's objectives.

What is a Research Question?

what-is-a-research-question

A research question is an inquiry that the research attempts to answer. It is the heart of the systematic investigation. Research questions are the most important step in any research project. In essence, it initiates the research project and establishes the pace for the specific research A research question is:

  • Clear : It provides enough detail that the audience understands its purpose without any additional explanation.
  • Focused : It is so specific that it can be addressed within the time constraints of the writing task.
  • Succinct: It is written in the shortest possible words.
  • Complex : It is not possible to answer it with a "yes" or "no", but requires analysis and synthesis of ideas before somebody can create a solution.
  • Argumental : Its potential answers are open for debate rather than accepted facts.

A good research question usually focuses on the research and determines the research design, methodology, and hypothesis. It guides all phases of inquiry, data collection, analysis, and reporting. You should gather valuable information by asking the right questions.

Why are Research Questions so important?

Regardless of whether it is a qualitative research or quantitative research project, research questions provide writers and their audience with a way to navigate the writing and research process. Writers can avoid "all-about" papers by asking straightforward and specific research questions that help them focus on their research and support a specific thesis.

Types of Research Questions

types-of-research-question

There are two types of research: Qualitative research and Quantitative research . There must be research questions for every type of research. Your research question will be based on the type of research you want to conduct and the type of data collection.

The first step in designing research involves identifying a gap and creating a focused research question.

Below is a list of common research questions that can be used in a dissertation. Keep in mind that these are merely illustrations of typical research questions used in dissertation projects. The real research questions themselves might be more difficult.

Example Research Questions

examples-of-research-question

The following are a few examples of research questions and research problems to help you understand how research questions can be created for a particular research problem.

Steps to Write Research Questions

steps-to-write-a-research-question

You can focus on the issue or research gaps you're attempting to solve by using the research questions as a direction.

If you're unsure how to go about writing a good research question, these are the steps to follow in the process:

  • Select an interesting topic Always choose a topic that interests you. Because if your curiosity isn’t aroused by a subject, you’ll have a hard time conducting research around it. Alos, it’s better that you pick something that’s neither too narrow or too broad.
  • Do preliminary research on the topic Search for relevant literature to gauge what problems have already been tackled by scholars. You can do that conveniently through repositories like Scispace , where you’ll find millions of papers in one place. Once you do find the papers you’re looking for, try our reading assistant, SciSpace Copilot to get simple explanations for the paper . You’ll be able to quickly understand the abstract, find the key takeaways, and the main arguments presented in the paper. This will give you a more contextual understanding of your subject and you’ll have an easier time identifying knowledge gaps in your discipline.

     Also: ChatPDF vs. SciSpace Copilot: Unveiling the best tool for your research

  • Consider your audience It is essential to understand your audience to develop focused research questions for essays or dissertations. When narrowing down your topic, you can identify aspects that might interest your audience.
  • Ask questions Asking questions will give you a deeper understanding of the topic. Evaluate your question through the What, Why, When, How, and other open-ended questions assessment.
  • Assess your question Once you have created a research question, assess its effectiveness to determine if it is useful for the purpose. Refine and revise the dissertation research question multiple times.

Additionally, use this list of questions as a guide when formulating your research question.

Are you able to answer a specific research question? After identifying a gap in research, it would be helpful to formulate the research question. And this will allow the research to solve a part of the problem. Is your research question clear and centered on the main topic? It is important that your research question should be specific and related to your central goal. Are you tackling a difficult research question? It is not possible to answer the research question with a simple yes or no. The problem requires in-depth analysis. It is often started with "How" and "Why."

Start your research Once you have completed your dissertation research questions, it is time to review the literature on similar topics to discover different perspectives.

Strong  Research Question Samples

Uncertain: How should social networking sites work on the hatred that flows through their platform?

Certain: What should social media sites like Twitter or Facebook do to address the harm they are causing?

This unclear question does not specify the social networking sites that are being used or what harm they might be causing. In addition, this question assumes that the "harm" has been proven and/or accepted. This version is more specific and identifies the sites (Twitter, Facebook), the type and extent of harm (privacy concerns), and who might be suffering from that harm (users). Effective research questions should not be ambiguous or interpreted.

Unfocused: What are the effects of global warming on the environment?

Focused: What are the most important effects of glacial melting in Antarctica on penguins' lives?

This broad research question cannot be addressed in a book, let alone a college-level paper. Focused research targets a specific effect of global heating (glacial  melting), an area (Antarctica), or a specific animal (penguins). The writer must also decide which effect will have the greatest impact on the animals affected. If in doubt, narrow down your research question to the most specific possible.

Too Simple: What are the U.S. doctors doing to treat diabetes?

Appropriately complex: Which factors, if any, are most likely to predict a person's risk of developing diabetes?

This simple version can be found online. It is easy to answer with a few facts. The second, more complicated version of this question is divided into two parts. It is thought-provoking and requires extensive investigation as well as evaluation by the author. So, ensure that a quick Google search should not answer your research question.

How to write a strong Research Question?

how-to-write-a-strong-research-question

The foundation of all research is the research question. You should therefore spend as much time as necessary to refine your research question based on various data.

You can conduct your research more efficiently and analyze your results better if you have great research questions for your dissertation, research paper , or essay .

The following criteria can help you evaluate the strength and importance of your research question and can be used to determine the strength of your research question:

  • Researchable
  • It should only cover one issue.
  • A subjective judgment should not be included in the question.
  • It can be answered with data analysis and research.
  • Specific and Practical
  • It should not contain a plan of action, policy, or solution.
  • It should be clearly defined
  • Within research limits
  • Complex and Arguable
  • It shouldn't be difficult to answer.
  • To find the truth, you need in-depth knowledge
  • Allows for discussion and deliberation
  • Original and Relevant
  • It should be in your area of study
  • Its results should be measurable
  • It should be original

Conclusion - How to write Research Questions?

Research questions provide a clear guideline for research. One research question may be part of a larger project, such as a dissertation. However, each question should only focus on one topic.

Research questions must be answerable, practical, specific, and applicable to your field. The research type that you use to base your research questions on will determine the research topic. You can start by selecting an interesting topic and doing preliminary research. Then, you can begin asking questions, evaluating your questions, and start your research.

Now it's easier than ever to streamline your research workflow with SciSpace ResearchGPT . Its integrated, comprehensive end-to-end platform for research allows scholars to easily discover, read, write and publish their research and fosters collaboration.

in research question

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How to Write a Research Question: Types and Examples 

research quetsion

The first step in any research project is framing the research question. It can be considered the core of any systematic investigation as the research outcomes are tied to asking the right questions. Thus, this primary interrogation point sets the pace for your research as it helps collect relevant and insightful information that ultimately influences your work.   

Typically, the research question guides the stages of inquiry, analysis, and reporting. Depending on the use of quantifiable or quantitative data, research questions are broadly categorized into quantitative or qualitative research questions. Both types of research questions can be used independently or together, considering the overall focus and objectives of your research.  

What is a research question?

A research question is a clear, focused, concise, and arguable question on which your research and writing are centered. 1 It states various aspects of the study, including the population and variables to be studied and the problem the study addresses. These questions also set the boundaries of the study, ensuring cohesion. 

Designing the research question is a dynamic process where the researcher can change or refine the research question as they review related literature and develop a framework for the study. Depending on the scale of your research, the study can include single or multiple research questions. 

A good research question has the following features: 

  • It is relevant to the chosen field of study. 
  • The question posed is arguable and open for debate, requiring synthesizing and analysis of ideas. 
  • It is focused and concisely framed. 
  • A feasible solution is possible within the given practical constraint and timeframe. 

A poorly formulated research question poses several risks. 1   

  • Researchers can adopt an erroneous design. 
  • It can create confusion and hinder the thought process, including developing a clear protocol.  
  • It can jeopardize publication efforts.  
  • It causes difficulty in determining the relevance of the study findings.  
  • It causes difficulty in whether the study fulfils the inclusion criteria for systematic review and meta-analysis. This creates challenges in determining whether additional studies or data collection is needed to answer the question.  
  • Readers may fail to understand the objective of the study. This reduces the likelihood of the study being cited by others. 

Now that you know “What is a research question?”, let’s look at the different types of research questions. 

Types of research questions

Depending on the type of research to be done, research questions can be classified broadly into quantitative, qualitative, or mixed-methods studies. Knowing the type of research helps determine the best type of research question that reflects the direction and epistemological underpinnings of your research. 

The structure and wording of quantitative 2 and qualitative research 3 questions differ significantly. The quantitative study looks at causal relationships, whereas the qualitative study aims at exploring a phenomenon. 

  • Quantitative research questions:  
  • Seeks to investigate social, familial, or educational experiences or processes in a particular context and/or location.  
  • Answers ‘how,’ ‘what,’ or ‘why’ questions. 
  • Investigates connections, relations, or comparisons between independent and dependent variables. 

Quantitative research questions can be further categorized into descriptive, comparative, and relationship, as explained in the Table below. 

  • Qualitative research questions  

Qualitative research questions are adaptable, non-directional, and more flexible. It concerns broad areas of research or more specific areas of study to discover, explain, or explore a phenomenon. These are further classified as follows: 

  • Mixed-methods studies  

Mixed-methods studies use both quantitative and qualitative research questions to answer your research question. Mixed methods provide a complete picture than standalone quantitative or qualitative research, as it integrates the benefits of both methods. Mixed methods research is often used in multidisciplinary settings and complex situational or societal research, especially in the behavioral, health, and social science fields. 

What makes a good research question

A good research question should be clear and focused to guide your research. It should synthesize multiple sources to present your unique argument, and should ideally be something that you are interested in. But avoid questions that can be answered in a few factual statements. The following are the main attributes of a good research question. 

  • Specific: The research question should not be a fishing expedition performed in the hopes that some new information will be found that will benefit the researcher. The central research question should work with your research problem to keep your work focused. If using multiple questions, they should all tie back to the central aim. 
  • Measurable: The research question must be answerable using quantitative and/or qualitative data or from scholarly sources to develop your research question. If such data is impossible to access, it is better to rethink your question. 
  • Attainable: Ensure you have enough time and resources to do all research required to answer your question. If it seems you will not be able to gain access to the data you need, consider narrowing down your question to be more specific. 
  • You have the expertise 
  • You have the equipment and resources 
  • Realistic: Developing your research question should be based on initial reading about your topic. It should focus on addressing a problem or gap in the existing knowledge in your field or discipline. 
  • Based on some sort of rational physics 
  • Can be done in a reasonable time frame 
  • Timely: The research question should contribute to an existing and current debate in your field or in society at large. It should produce knowledge that future researchers or practitioners can later build on. 
  • Novel 
  • Based on current technologies. 
  • Important to answer current problems or concerns. 
  • Lead to new directions. 
  • Important: Your question should have some aspect of originality. Incremental research is as important as exploring disruptive technologies. For example, you can focus on a specific location or explore a new angle. 
  • Meaningful whether the answer is “Yes” or “No.” Closed-ended, yes/no questions are too simple to work as good research questions. Such questions do not provide enough scope for robust investigation and discussion. A good research question requires original data, synthesis of multiple sources, and original interpretation and argumentation before providing an answer. 

Steps for developing a good research question

The importance of research questions cannot be understated. When drafting a research question, use the following frameworks to guide the components of your question to ease the process. 4  

  • Determine the requirements: Before constructing a good research question, set your research requirements. What is the purpose? Is it descriptive, comparative, or explorative research? Determining the research aim will help you choose the most appropriate topic and word your question appropriately. 
  • Select a broad research topic: Identify a broader subject area of interest that requires investigation. Techniques such as brainstorming or concept mapping can help identify relevant connections and themes within a broad research topic. For example, how to learn and help students learn. 
  • Perform preliminary investigation: Preliminary research is needed to obtain up-to-date and relevant knowledge on your topic. It also helps identify issues currently being discussed from which information gaps can be identified. 
  • Narrow your focus: Narrow the scope and focus of your research to a specific niche. This involves focusing on gaps in existing knowledge or recent literature or extending or complementing the findings of existing literature. Another approach involves constructing strong research questions that challenge your views or knowledge of the area of study (Example: Is learning consistent with the existing learning theory and research). 
  • Identify the research problem: Once the research question has been framed, one should evaluate it. This is to realize the importance of the research questions and if there is a need for more revising (Example: How do your beliefs on learning theory and research impact your instructional practices). 

How to write a research question

Those struggling to understand how to write a research question, these simple steps can help you simplify the process of writing a research question. 

Sample Research Questions

The following are some bad and good research question examples 

  • Example 1 
  • Example 2 

References:  

  • Thabane, L., Thomas, T., Ye, C., & Paul, J. (2009). Posing the research question: not so simple.  Canadian Journal of Anesthesia/Journal canadien d’anesthésie ,  56 (1), 71-79. 
  • Rutberg, S., & Bouikidis, C. D. (2018). Focusing on the fundamentals: A simplistic differentiation between qualitative and quantitative research.  Nephrology Nursing Journal ,  45 (2), 209-213. 
  • Kyngäs, H. (2020). Qualitative research and content analysis.  The application of content analysis in nursing science research , 3-11. 
  • Mattick, K., Johnston, J., & de la Croix, A. (2018). How to… write a good research question.  The clinical teacher ,  15 (2), 104-108. 
  • Fandino, W. (2019). Formulating a good research question: Pearls and pitfalls.  Indian Journal of Anaesthesia ,  63 (8), 611. 
  • Richardson, W. S., Wilson, M. C., Nishikawa, J., & Hayward, R. S. (1995). The well-built clinical question: a key to evidence-based decisions.  ACP journal club ,  123 (3), A12-A13 

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Language and grammar rules for academic writing, you may also like, measuring academic success: definition & strategies for excellence, phd qualifying exam: tips for success , quillbot review: features, pricing, and free alternatives, what is an academic paper types and elements , 9 steps to publish a research paper, what are the different types of research papers, how to make translating academic papers less challenging, 6 tips for post-doc researchers to take their..., presenting research data effectively through tables and figures, ethics in science: importance, principles & guidelines .

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Home » Research Questions – Types, Examples and Writing Guide

Research Questions – Types, Examples and Writing Guide

Table of Contents

Research Questions

Research Questions

Definition:

Research questions are the specific questions that guide a research study or inquiry. These questions help to define the scope of the research and provide a clear focus for the study. Research questions are usually developed at the beginning of a research project and are designed to address a particular research problem or objective.

Types of Research Questions

Types of Research Questions are as follows:

Descriptive Research Questions

These aim to describe a particular phenomenon, group, or situation. For example:

  • What are the characteristics of the target population?
  • What is the prevalence of a particular disease in a specific region?

Exploratory Research Questions

These aim to explore a new area of research or generate new ideas or hypotheses. For example:

  • What are the potential causes of a particular phenomenon?
  • What are the possible outcomes of a specific intervention?

Explanatory Research Questions

These aim to understand the relationship between two or more variables or to explain why a particular phenomenon occurs. For example:

  • What is the effect of a specific drug on the symptoms of a particular disease?
  • What are the factors that contribute to employee turnover in a particular industry?

Predictive Research Questions

These aim to predict a future outcome or trend based on existing data or trends. For example :

  • What will be the future demand for a particular product or service?
  • What will be the future prevalence of a particular disease?

Evaluative Research Questions

These aim to evaluate the effectiveness of a particular intervention or program. For example:

  • What is the impact of a specific educational program on student learning outcomes?
  • What is the effectiveness of a particular policy or program in achieving its intended goals?

How to Choose Research Questions

Choosing research questions is an essential part of the research process and involves careful consideration of the research problem, objectives, and design. Here are some steps to consider when choosing research questions:

  • Identify the research problem: Start by identifying the problem or issue that you want to study. This could be a gap in the literature, a social or economic issue, or a practical problem that needs to be addressed.
  • Conduct a literature review: Conducting a literature review can help you identify existing research in your area of interest and can help you formulate research questions that address gaps or limitations in the existing literature.
  • Define the research objectives : Clearly define the objectives of your research. What do you want to achieve with your study? What specific questions do you want to answer?
  • Consider the research design : Consider the research design that you plan to use. This will help you determine the appropriate types of research questions to ask. For example, if you plan to use a qualitative approach, you may want to focus on exploratory or descriptive research questions.
  • Ensure that the research questions are clear and answerable: Your research questions should be clear and specific, and should be answerable with the data that you plan to collect. Avoid asking questions that are too broad or vague.
  • Get feedback : Get feedback from your supervisor, colleagues, or peers to ensure that your research questions are relevant, feasible, and meaningful.

How to Write Research Questions

Guide for Writing Research Questions:

  • Start with a clear statement of the research problem: Begin by stating the problem or issue that your research aims to address. This will help you to formulate focused research questions.
  • Use clear language : Write your research questions in clear and concise language that is easy to understand. Avoid using jargon or technical terms that may be unfamiliar to your readers.
  • Be specific: Your research questions should be specific and focused. Avoid broad questions that are difficult to answer. For example, instead of asking “What is the impact of climate change on the environment?” ask “What are the effects of rising sea levels on coastal ecosystems?”
  • Use appropriate question types: Choose the appropriate question types based on the research design and objectives. For example, if you are conducting a qualitative study, you may want to use open-ended questions that allow participants to provide detailed responses.
  • Consider the feasibility of your questions : Ensure that your research questions are feasible and can be answered with the resources available. Consider the data sources and methods of data collection when writing your questions.
  • Seek feedback: Get feedback from your supervisor, colleagues, or peers to ensure that your research questions are relevant, appropriate, and meaningful.

Examples of Research Questions

Some Examples of Research Questions with Research Titles:

Research Title: The Impact of Social Media on Mental Health

  • Research Question : What is the relationship between social media use and mental health, and how does this impact individuals’ well-being?

Research Title: Factors Influencing Academic Success in High School

  • Research Question: What are the primary factors that influence academic success in high school, and how do they contribute to student achievement?

Research Title: The Effects of Exercise on Physical and Mental Health

  • Research Question: What is the relationship between exercise and physical and mental health, and how can exercise be used as a tool to improve overall well-being?

Research Title: Understanding the Factors that Influence Consumer Purchasing Decisions

  • Research Question : What are the key factors that influence consumer purchasing decisions, and how do these factors vary across different demographics and products?

Research Title: The Impact of Technology on Communication

  • Research Question : How has technology impacted communication patterns, and what are the effects of these changes on interpersonal relationships and society as a whole?

Research Title: Investigating the Relationship between Parenting Styles and Child Development

  • Research Question: What is the relationship between different parenting styles and child development outcomes, and how do these outcomes vary across different ages and developmental stages?

Research Title: The Effectiveness of Cognitive-Behavioral Therapy in Treating Anxiety Disorders

  • Research Question: How effective is cognitive-behavioral therapy in treating anxiety disorders, and what factors contribute to its success or failure in different patients?

Research Title: The Impact of Climate Change on Biodiversity

  • Research Question : How is climate change affecting global biodiversity, and what can be done to mitigate the negative effects on natural ecosystems?

Research Title: Exploring the Relationship between Cultural Diversity and Workplace Productivity

  • Research Question : How does cultural diversity impact workplace productivity, and what strategies can be employed to maximize the benefits of a diverse workforce?

Research Title: The Role of Artificial Intelligence in Healthcare

  • Research Question: How can artificial intelligence be leveraged to improve healthcare outcomes, and what are the potential risks and ethical concerns associated with its use?

Applications of Research Questions

Here are some of the key applications of research questions:

  • Defining the scope of the study : Research questions help researchers to narrow down the scope of their study and identify the specific issues they want to investigate.
  • Developing hypotheses: Research questions often lead to the development of hypotheses, which are testable predictions about the relationship between variables. Hypotheses provide a clear and focused direction for the study.
  • Designing the study : Research questions guide the design of the study, including the selection of participants, the collection of data, and the analysis of results.
  • Collecting data : Research questions inform the selection of appropriate methods for collecting data, such as surveys, interviews, or experiments.
  • Analyzing data : Research questions guide the analysis of data, including the selection of appropriate statistical tests and the interpretation of results.
  • Communicating results : Research questions help researchers to communicate the results of their study in a clear and concise manner. The research questions provide a framework for discussing the findings and drawing conclusions.

Characteristics of Research Questions

Characteristics of Research Questions are as follows:

  • Clear and Specific : A good research question should be clear and specific. It should clearly state what the research is trying to investigate and what kind of data is required.
  • Relevant : The research question should be relevant to the study and should address a current issue or problem in the field of research.
  • Testable : The research question should be testable through empirical evidence. It should be possible to collect data to answer the research question.
  • Concise : The research question should be concise and focused. It should not be too broad or too narrow.
  • Feasible : The research question should be feasible to answer within the constraints of the research design, time frame, and available resources.
  • Original : The research question should be original and should contribute to the existing knowledge in the field of research.
  • Significant : The research question should have significance and importance to the field of research. It should have the potential to provide new insights and knowledge to the field.
  • Ethical : The research question should be ethical and should not cause harm to any individuals or groups involved in the study.

Purpose of Research Questions

Research questions are the foundation of any research study as they guide the research process and provide a clear direction to the researcher. The purpose of research questions is to identify the scope and boundaries of the study, and to establish the goals and objectives of the research.

The main purpose of research questions is to help the researcher to focus on the specific area or problem that needs to be investigated. They enable the researcher to develop a research design, select the appropriate methods and tools for data collection and analysis, and to organize the results in a meaningful way.

Research questions also help to establish the relevance and significance of the study. They define the research problem, and determine the research methodology that will be used to address the problem. Research questions also help to determine the type of data that will be collected, and how it will be analyzed and interpreted.

Finally, research questions provide a framework for evaluating the results of the research. They help to establish the validity and reliability of the data, and provide a basis for drawing conclusions and making recommendations based on the findings of the study.

Advantages of Research Questions

There are several advantages of research questions in the research process, including:

  • Focus : Research questions help to focus the research by providing a clear direction for the study. They define the specific area of investigation and provide a framework for the research design.
  • Clarity : Research questions help to clarify the purpose and objectives of the study, which can make it easier for the researcher to communicate the research aims to others.
  • Relevance : Research questions help to ensure that the study is relevant and meaningful. By asking relevant and important questions, the researcher can ensure that the study will contribute to the existing body of knowledge and address important issues.
  • Consistency : Research questions help to ensure consistency in the research process by providing a framework for the development of the research design, data collection, and analysis.
  • Measurability : Research questions help to ensure that the study is measurable by defining the specific variables and outcomes that will be measured.
  • Replication : Research questions help to ensure that the study can be replicated by providing a clear and detailed description of the research aims, methods, and outcomes. This makes it easier for other researchers to replicate the study and verify the results.

Limitations of Research Questions

Limitations of Research Questions are as follows:

  • Subjectivity : Research questions are often subjective and can be influenced by personal biases and perspectives of the researcher. This can lead to a limited understanding of the research problem and may affect the validity and reliability of the study.
  • Inadequate scope : Research questions that are too narrow in scope may limit the breadth of the study, while questions that are too broad may make it difficult to focus on specific research objectives.
  • Unanswerable questions : Some research questions may not be answerable due to the lack of available data or limitations in research methods. In such cases, the research question may need to be rephrased or modified to make it more answerable.
  • Lack of clarity : Research questions that are poorly worded or ambiguous can lead to confusion and misinterpretation. This can result in incomplete or inaccurate data, which may compromise the validity of the study.
  • Difficulty in measuring variables : Some research questions may involve variables that are difficult to measure or quantify, making it challenging to draw meaningful conclusions from the data.
  • Lack of generalizability: Research questions that are too specific or limited in scope may not be generalizable to other contexts or populations. This can limit the applicability of the study’s findings and restrict its broader implications.

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in research question

Developing a Research Question

by acburton | Mar 22, 2024 | Resources for Students , Writing Resources

Selecting your research question and creating a clear goal and structure for your writing can be challenging – whether you are doing it for the first time or if you’ve done it many times before. It can be especially difficult when your research question starts to look and feel a little different somewhere between your first and final draft. Don’t panic! It’s normal for your research question to change a little (or even quite a bit) as you move through and engage with the writing process. Anticipating this can remind you to stay on track while you work and that it’ll be okay even if the literature takes you in a different direction.

What Makes an Effective Research Question?

The most effective research question will usually be a critical thinking question and should use “how” or “why” to ensure it can move beyond a yes/no or one-word type of answer. Consider how your research question can aim to reveal something new, fill in a gap, even if small, and contribute to the field in a meaningful way; How might the proposed project move knowledge forward about a particular place or process? This should be specific and achievable!

The CEWC’s Grad Writing Consultant Tariq says, “I definitely concentrated on those aspects of what I saw in the field where I believed there was an opportunity to move the discipline forward.”

General Tips

Do your research.

Utilize the librarians at your university and take the time to research your topic first. Try looking at very general sources to get an idea of what could be interesting to you before you move to more academic articles that support your rough idea of the topic. It is important that research is grounded in what you see or experience regarding the topic you have chosen and what is already known in the literature. Spend time researching articles, books, etc. that supports your thesis. Once you have a number of sources that you know support what you want to write about, formulate a research question that serves as the interrogative form of your thesis statement.

Grad Writing Consultant Deni advises, “Delineate your intervention in the literature (i.e., be strategic about the literature you discuss and clear about your contributions to it).”

Start Broadly…. then Narrow Your Topic Down to Something Manageable

When brainstorming your research question, let your mind veer toward connections or associations that you might have already considered or that seem to make sense and consider if new research terms, language or concepts come to mind that may be interesting or exciting for you as a researcher. Sometimes testing out a research question while doing some preliminary researching is also useful to see if the language you are using or the direction you are heading toward is fruitful when trying to search strategically in academic databases. Be prepared to focus on a specific area of a broad topic.

Writing Consultant Jessie recommends outlining: “I think some rough outlining with a research question in mind can be helpful for me. I’ll have a research question and maybe a working thesis that I feel may be my claim to the research question based on some preliminary materials, brainstorming, etc.” — Jessie, CEWC Writing Consultant

Try an Exercise

In the earliest phase of brainstorming, try an exercise suggested by CEWC Writing Specialist, Percival! While it is normally used in classroom or workshop settings, this exercise can easily be modified for someone working alone. The flow of the activity, if done within a group setting, is 1) someone starts with an idea, 2) three other people share their idea, and 3) the starting person picks two of these new ideas they like best and combines their original idea with those. The activity then begins again with the idea that was not chosen. The solo version of this exercise substitutes a ‘word bank,’ created using words, topics, or ideas similar to your broad, overarching theme. Pick two words or phrases from your word bank, combine it with your original idea or topic, and ‘start again’ with two different words. This serves as a replacement for different people’s suggestions. Ideas for your ‘word bank’ can range from vague prompts about mapping or webbing (e.g., where your topic falls within the discipline and others like it), to more specific concepts that come from tracing the history of an idea (its past, present, future) or mapping the idea’s related ideas, influences, etc. Care for a physics analogy? There is a particle (your topic) that you can describe, a wave that the particle traces, and a field that the particle is mapped on.

Get Feedback and Affirm Your Confidence!

Creating a few different versions of your research question (they may be the same topic/issue/theme or differ slightly) can be useful during this process. Sharing these with trusted friends, colleagues, mentors, (or tutors!) and having conversations about your questions and ideas with other people can help you decide which version you may feel most confident or interested in. Ask colleagues and mentors to share their research questions with you to get a lot of examples. Once you have done the work of developing an effective research question, do not forget to affirm your confidence! Based on your working thesis, think about how you might organize your chapters or paragraphs and what resources you have for supporting this structure and organization. This can help boost your confidence that the research question you have created is effective and fruitful.

Be Open to Change

Remember, your research question may change from your first to final draft. For questions along the way, make an appointment with the Writing Center. We are here to help you develop an effective and engaging research question and build the foundation for a solid research paper!

Example 1: In my field developing a research question involves navigating the relationship between 1) what one sees/experiences at their field site and 2) what is already known in the literature. During my preliminary research, I found that the financial value of land was often a matter of precisely these cultural factors. So, my research question ended up being: How do the social and material qualities of land entangle with processes of financialization in the city of Lahore. Regarding point #1, this question was absolutely informed by what I saw in the field. But regarding point #2, the question was also heavily shaped by the literature. – Tariq

Example 2: A research question should not be a yes/no question like “Is pollution bad?”; but an open-ended question where the answer has to be supported with reasons and explanation. The question also has to be narrowed down to a specific topic—using the same example as before—”Is pollution bad?” can be revised to “How does pollution affect people?” I would encourage students to be more specific then; e.g., what area of pollution do you want to talk about: water, air, plastic, climate change… what type of people or demographic can we focus on? …how does this affect marginalized communities, minorities, or specific areas in California? After researching and deciding on a focus, your question might sound something like: How does government policy affect water pollution and how does it affect the marginalized communities in the state of California? -Janella

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How to Develop a Good Research Question? — Types & Examples

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Cecilia is living through a tough situation in her research life. Figuring out where to begin, how to start her research study, and how to pose the right question for her research quest, is driving her insane. Well, questions, if not asked correctly, have a tendency to spiral us!

Image Source: https://phdcomics.com/

Questions lead everyone to answers. Research is a quest to find answers. Not the vague questions that Cecilia means to answer, but definitely more focused questions that define your research. Therefore, asking appropriate question becomes an important matter of discussion.

A well begun research process requires a strong research question. It directs the research investigation and provides a clear goal to focus on. Understanding the characteristics of comprising a good research question will generate new ideas and help you discover new methods in research.

In this article, we are aiming to help researchers understand what is a research question and how to write one with examples.

Table of Contents

What Is a Research Question?

A good research question defines your study and helps you seek an answer to your research. Moreover, a clear research question guides the research paper or thesis to define exactly what you want to find out, giving your work its objective. Learning to write a research question is the beginning to any thesis, dissertation , or research paper. Furthermore, the question addresses issues or problems which is answered through analysis and interpretation of data.

Why Is a Research Question Important?

A strong research question guides the design of a study. Moreover, it helps determine the type of research and identify specific objectives. Research questions state the specific issue you are addressing and focus on outcomes of the research for individuals to learn. Therefore, it helps break up the study into easy steps to complete the objectives and answer the initial question.

Types of Research Questions

Research questions can be categorized into different types, depending on the type of research you want to undergo. Furthermore, knowing the type of research will help a researcher determine the best type of research question to use.

1. Qualitative Research Question

Qualitative questions concern broad areas or more specific areas of research. However, unlike quantitative questions, qualitative research questions are adaptable, non-directional and more flexible. Qualitative research question focus on discovering, explaining, elucidating, and exploring.

i. Exploratory Questions

This form of question looks to understand something without influencing the results. The objective of exploratory questions is to learn more about a topic without attributing bias or preconceived notions to it.

Research Question Example: Asking how a chemical is used or perceptions around a certain topic.

ii. Predictive Questions

Predictive research questions are defined as survey questions that automatically predict the best possible response options based on text of the question. Moreover, these questions seek to understand the intent or future outcome surrounding a topic.

Research Question Example: Asking why a consumer behaves in a certain way or chooses a certain option over other.

iii. Interpretive Questions

This type of research question allows the study of people in the natural setting. The questions help understand how a group makes sense of shared experiences with regards to various phenomena. These studies gather feedback on a group’s behavior without affecting the outcome.

Research Question Example: How do you feel about AI assisting publishing process in your research?

2. Quantitative Research Question

Quantitative questions prove or disprove a researcher’s hypothesis through descriptions, comparisons, and relationships. These questions are beneficial when choosing a research topic or when posing follow-up questions that garner more information.

i. Descriptive Questions

It is the most basic type of quantitative research question and it seeks to explain when, where, why, or how something occurred. Moreover, they use data and statistics to describe an event or phenomenon.

Research Question Example: How many generations of genes influence a future generation?

ii. Comparative Questions

Sometimes it’s beneficial to compare one occurrence with another. Therefore, comparative questions are helpful when studying groups with dependent variables.

Example: Do men and women have comparable metabolisms?

iii. Relationship-Based Questions

This type of research question answers influence of one variable on another. Therefore, experimental studies use this type of research questions are majorly.

Example: How is drought condition affect a region’s probability for wildfires.  

How to Write a Good Research Question?

good research question

1. Select a Topic

The first step towards writing a good research question is to choose a broad topic of research. You could choose a research topic that interests you, because the complete research will progress further from the research question. Therefore, make sure to choose a topic that you are passionate about, to make your research study more enjoyable.

2. Conduct Preliminary Research

After finalizing the topic, read and know about what research studies are conducted in the field so far. Furthermore, this will help you find articles that talk about the topics that are yet to be explored. You could explore the topics that the earlier research has not studied.

3. Consider Your Audience

The most important aspect of writing a good research question is to find out if there is audience interested to know the answer to the question you are proposing. Moreover, determining your audience will assist you in refining your research question, and focus on aspects that relate to defined groups.

4. Generate Potential Questions

The best way to generate potential questions is to ask open ended questions. Questioning broader topics will allow you to narrow down to specific questions. Identifying the gaps in literature could also give you topics to write the research question. Moreover, you could also challenge the existing assumptions or use personal experiences to redefine issues in research.

5. Review Your Questions

Once you have listed few of your questions, evaluate them to find out if they are effective research questions. Moreover while reviewing, go through the finer details of the question and its probable outcome, and find out if the question meets the research question criteria.

6. Construct Your Research Question

There are two frameworks to construct your research question. The first one being PICOT framework , which stands for:

  • Population or problem
  • Intervention or indicator being studied
  • Comparison group
  • Outcome of interest
  • Time frame of the study.

The second framework is PEO , which stands for:

  • Population being studied
  • Exposure to preexisting conditions
  • Outcome of interest.

Research Question Examples

  • How might the discovery of a genetic basis for alcoholism impact triage processes in medical facilities?
  • How do ecological systems respond to chronic anthropological disturbance?
  • What are demographic consequences of ecological interactions?
  • What roles do fungi play in wildfire recovery?
  • How do feedbacks reinforce patterns of genetic divergence on the landscape?
  • What educational strategies help encourage safe driving in young adults?
  • What makes a grocery store easy for shoppers to navigate?
  • What genetic factors predict if someone will develop hypothyroidism?
  • Does contemporary evolution along the gradients of global change alter ecosystems function?

How did you write your first research question ? What were the steps you followed to create a strong research question? Do write to us or comment below.

Frequently Asked Questions

Research questions guide the focus and direction of a research study. Here are common types of research questions: 1. Qualitative research question: Qualitative questions concern broad areas or more specific areas of research. However, unlike quantitative questions, qualitative research questions are adaptable, non-directional and more flexible. Different types of qualitative research questions are: i. Exploratory questions ii. Predictive questions iii. Interpretive questions 2. Quantitative Research Question: Quantitative questions prove or disprove a researcher’s hypothesis through descriptions, comparisons, and relationships. These questions are beneficial when choosing a research topic or when posing follow-up questions that garner more information. Different types of quantitative research questions are: i. Descriptive questions ii. Comparative questions iii. Relationship-based questions

Qualitative research questions aim to explore the richness and depth of participants' experiences and perspectives. They should guide your research and allow for in-depth exploration of the phenomenon under investigation. After identifying the research topic and the purpose of your research: • Begin with Broad Inquiry: Start with a general research question that captures the main focus of your study. This question should be open-ended and allow for exploration. • Break Down the Main Question: Identify specific aspects or dimensions related to the main research question that you want to investigate. • Formulate Sub-questions: Create sub-questions that delve deeper into each specific aspect or dimension identified in the previous step. • Ensure Open-endedness: Make sure your research questions are open-ended and allow for varied responses and perspectives. Avoid questions that can be answered with a simple "yes" or "no." Encourage participants to share their experiences, opinions, and perceptions in their own words. • Refine and Review: Review your research questions to ensure they align with your research purpose, topic, and objectives. Seek feedback from your research advisor or peers to refine and improve your research questions.

Developing research questions requires careful consideration of the research topic, objectives, and the type of study you intend to conduct. Here are the steps to help you develop effective research questions: 1. Select a Topic 2. Conduct Preliminary Research 3. Consider Your Audience 4. Generate Potential Questions 5. Review Your Questions 6. Construct Your Research Question Based on PICOT or PEO Framework

There are two frameworks to construct your research question. The first one being PICOT framework, which stands for: • Population or problem • Intervention or indicator being studied • Comparison group • Outcome of interest • Time frame of the study The second framework is PEO, which stands for: • Population being studied • Exposure to preexisting conditions • Outcome of interest

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Developing a Research Question

  • Introduction
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  • Scholarly & Peer-Reviewed
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  • Quantitative vs. Qualitative
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What is a research question?

A research question is an essential tool to help guide your research paper, project, or thesis. It poses a specific question that you are seeking to answer in your paper. Research questions can be broad or narrow, and can change throughout the research process.

A good research question should be:

  • Focused on a single issue
  • Specific enough to answer thoroughly in your paper
  • Feasible to answer within the length of your paper
  • Researchable using the resources available to you
  • Relevant to your field of study and/or to society at large

The length of your paper and the research you're able to locate will help to shape your research question. A longer paper, like a thesis or dissertation, may require multiple research questions.

The answer to your research question develops into your thesis statement .

Writing Your Research Question

Chose a Topic

You should choose a research topic that is interesting to you. This will make the research and writing process much more bearable.

A good way to begin brainstorming research questions is to list all the questions you would like to see answered, or topics you would like to learn more about. You may have been provided a list of potential topics by your professor, if none are interesting to you ask if you can develop your own.

It is better to start broad and narrow down your focus as you go.

Do Preliminary Research

graphic depicting an upside down triangle showing the process of narrowing a research subject

Reference materials like encyclopedias can also be good for this purpose.

Narrow Your Topic

Now that you have a basic idea of what research exists on your topic, you can begin to narrow your focus.

Make sure that your question is specific enough that it can be answered thoroughly in the length of your paper.

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Research Question Examples 🧑🏻‍🏫

25+ Practical Examples & Ideas To Help You Get Started 

By: Derek Jansen (MBA) | October 2023

A well-crafted research question (or set of questions) sets the stage for a robust study and meaningful insights.  But, if you’re new to research, it’s not always clear what exactly constitutes a good research question. In this post, we’ll provide you with clear examples of quality research questions across various disciplines, so that you can approach your research project with confidence!

Research Question Examples

  • Psychology research questions
  • Business research questions
  • Education research questions
  • Healthcare research questions
  • Computer science research questions

Examples: Psychology

Let’s start by looking at some examples of research questions that you might encounter within the discipline of psychology.

How does sleep quality affect academic performance in university students?

This question is specific to a population (university students) and looks at a direct relationship between sleep and academic performance, both of which are quantifiable and measurable variables.

What factors contribute to the onset of anxiety disorders in adolescents?

The question narrows down the age group and focuses on identifying multiple contributing factors. There are various ways in which it could be approached from a methodological standpoint, including both qualitatively and quantitatively.

Do mindfulness techniques improve emotional well-being?

This is a focused research question aiming to evaluate the effectiveness of a specific intervention.

How does early childhood trauma impact adult relationships?

This research question targets a clear cause-and-effect relationship over a long timescale, making it focused but comprehensive.

Is there a correlation between screen time and depression in teenagers?

This research question focuses on an in-demand current issue and a specific demographic, allowing for a focused investigation. The key variables are clearly stated within the question and can be measured and analysed (i.e., high feasibility).

Free Webinar: How To Find A Dissertation Research Topic

Examples: Business/Management

Next, let’s look at some examples of well-articulated research questions within the business and management realm.

How do leadership styles impact employee retention?

This is an example of a strong research question because it directly looks at the effect of one variable (leadership styles) on another (employee retention), allowing from a strongly aligned methodological approach.

What role does corporate social responsibility play in consumer choice?

Current and precise, this research question can reveal how social concerns are influencing buying behaviour by way of a qualitative exploration.

Does remote work increase or decrease productivity in tech companies?

Focused on a particular industry and a hot topic, this research question could yield timely, actionable insights that would have high practical value in the real world.

How do economic downturns affect small businesses in the homebuilding industry?

Vital for policy-making, this highly specific research question aims to uncover the challenges faced by small businesses within a certain industry.

Which employee benefits have the greatest impact on job satisfaction?

By being straightforward and specific, answering this research question could provide tangible insights to employers.

Examples: Education

Next, let’s look at some potential research questions within the education, training and development domain.

How does class size affect students’ academic performance in primary schools?

This example research question targets two clearly defined variables, which can be measured and analysed relatively easily.

Do online courses result in better retention of material than traditional courses?

Timely, specific and focused, answering this research question can help inform educational policy and personal choices about learning formats.

What impact do US public school lunches have on student health?

Targeting a specific, well-defined context, the research could lead to direct changes in public health policies.

To what degree does parental involvement improve academic outcomes in secondary education in the Midwest?

This research question focuses on a specific context (secondary education in the Midwest) and has clearly defined constructs.

What are the negative effects of standardised tests on student learning within Oklahoma primary schools?

This research question has a clear focus (negative outcomes) and is narrowed into a very specific context.

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Examples: Healthcare

Shifting to a different field, let’s look at some examples of research questions within the healthcare space.

What are the most effective treatments for chronic back pain amongst UK senior males?

Specific and solution-oriented, this research question focuses on clear variables and a well-defined context (senior males within the UK).

How do different healthcare policies affect patient satisfaction in public hospitals in South Africa?

This question is has clearly defined variables and is narrowly focused in terms of context.

Which factors contribute to obesity rates in urban areas within California?

This question is focused yet broad, aiming to reveal several contributing factors for targeted interventions.

Does telemedicine provide the same perceived quality of care as in-person visits for diabetes patients?

Ideal for a qualitative study, this research question explores a single construct (perceived quality of care) within a well-defined sample (diabetes patients).

Which lifestyle factors have the greatest affect on the risk of heart disease?

This research question aims to uncover modifiable factors, offering preventive health recommendations.

Research topic evaluator

Examples: Computer Science

Last but certainly not least, let’s look at a few examples of research questions within the computer science world.

What are the perceived risks of cloud-based storage systems?

Highly relevant in our digital age, this research question would align well with a qualitative interview approach to better understand what users feel the key risks of cloud storage are.

Which factors affect the energy efficiency of data centres in Ohio?

With a clear focus, this research question lays a firm foundation for a quantitative study.

How do TikTok algorithms impact user behaviour amongst new graduates?

While this research question is more open-ended, it could form the basis for a qualitative investigation.

What are the perceived risk and benefits of open-source software software within the web design industry?

Practical and straightforward, the results could guide both developers and end-users in their choices.

Remember, these are just examples…

In this post, we’ve tried to provide a wide range of research question examples to help you get a feel for what research questions look like in practice. That said, it’s important to remember that these are just examples and don’t necessarily equate to good research topics . If you’re still trying to find a topic, check out our topic megalist for inspiration.

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Designing a Research Question

  • First Online: 29 November 2023

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  • Ahmed Ibrahim 3 &
  • Camille L. Bryant 3  

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This chapter discusses (1) the important role of research questions for descriptive, predictive, and causal studies across the three research paradigms (i.e., quantitative, qualitative, and mixed methods); (2) characteristics of quality research questions, and (3) three frameworks to support the development of research questions and their dissemination within scholarly work. For the latter, a description of the P opulation/ P articipants, I ntervention/ I ndependent variable, C omparison, and O utcomes (PICO) framework for quantitative research as well as variations depending on the type of research is provided. Second, we discuss the P articipants, central Ph enomenon, T ime, and S pace (PPhTS) framework for qualitative research. The combination of these frameworks is discussed for mixed-methods research. Further, templates and examples are provided to support the novice health scholar in developing research questions for applied and theoretical studies. Finally, we discuss the Create a Research Space (CARS) model for introducing research questions as part of a research study, to demonstrate how scholars can apply their knowledge when disseminating research.

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Ibrahim, A., Bryant, C.L. (2023). Designing a Research Question. In: Fitzgerald, A.S., Bosch, G. (eds) Education Scholarship in Healthcare. Springer, Cham. https://doi.org/10.1007/978-3-031-38534-6_4

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How to Write a Good Research Question (w/ Examples)

in research question

What is a Research Question?

A research question is the main question that your study sought or is seeking to answer. A clear research question guides your research paper or thesis and states exactly what you want to find out, giving your work a focus and objective. Learning  how to write a hypothesis or research question is the start to composing any thesis, dissertation, or research paper. It is also one of the most important sections of a research proposal . 

A good research question not only clarifies the writing in your study; it provides your readers with a clear focus and facilitates their understanding of your research topic, as well as outlining your study’s objectives. Before drafting the paper and receiving research paper editing (and usually before performing your study), you should write a concise statement of what this study intends to accomplish or reveal.

Research Question Writing Tips

Listed below are the important characteristics of a good research question:

A good research question should:

  • Be clear and provide specific information so readers can easily understand the purpose.
  • Be focused in its scope and narrow enough to be addressed in the space allowed by your paper
  • Be relevant and concise and express your main ideas in as few words as possible, like a hypothesis.
  • Be precise and complex enough that it does not simply answer a closed “yes or no” question, but requires an analysis of arguments and literature prior to its being considered acceptable. 
  • Be arguable or testable so that answers to the research question are open to scrutiny and specific questions and counterarguments.

Some of these characteristics might be difficult to understand in the form of a list. Let’s go into more detail about what a research question must do and look at some examples of research questions.

The research question should be specific and focused 

Research questions that are too broad are not suitable to be addressed in a single study. One reason for this can be if there are many factors or variables to consider. In addition, a sample data set that is too large or an experimental timeline that is too long may suggest that the research question is not focused enough.

A specific research question means that the collective data and observations come together to either confirm or deny the chosen hypothesis in a clear manner. If a research question is too vague, then the data might end up creating an alternate research problem or hypothesis that you haven’t addressed in your Introduction section .

The research question should be based on the literature 

An effective research question should be answerable and verifiable based on prior research because an effective scientific study must be placed in the context of a wider academic consensus. This means that conspiracy or fringe theories are not good research paper topics.

Instead, a good research question must extend, examine, and verify the context of your research field. It should fit naturally within the literature and be searchable by other research authors.

References to the literature can be in different citation styles and must be properly formatted according to the guidelines set forth by the publishing journal, university, or academic institution. This includes in-text citations as well as the Reference section . 

The research question should be realistic in time, scope, and budget

There are two main constraints to the research process: timeframe and budget.

A proper research question will include study or experimental procedures that can be executed within a feasible time frame, typically by a graduate doctoral or master’s student or lab technician. Research that requires future technology, expensive resources, or follow-up procedures is problematic.

A researcher’s budget is also a major constraint to performing timely research. Research at many large universities or institutions is publicly funded and is thus accountable to funding restrictions. 

The research question should be in-depth

Research papers, dissertations and theses , and academic journal articles are usually dozens if not hundreds of pages in length.

A good research question or thesis statement must be sufficiently complex to warrant such a length, as it must stand up to the scrutiny of peer review and be reproducible by other scientists and researchers.

Research Question Types

Qualitative and quantitative research are the two major types of research, and it is essential to develop research questions for each type of study. 

Quantitative Research Questions

Quantitative research questions are specific. A typical research question involves the population to be studied, dependent and independent variables, and the research design.

In addition, quantitative research questions connect the research question and the research design. In addition, it is not possible to answer these questions definitively with a “yes” or “no” response. For example, scientific fields such as biology, physics, and chemistry often deal with “states,” in which different quantities, amounts, or velocities drastically alter the relevance of the research.

As a consequence, quantitative research questions do not contain qualitative, categorical, or ordinal qualifiers such as “is,” “are,” “does,” or “does not.”

Categories of quantitative research questions

Qualitative research questions.

In quantitative research, research questions have the potential to relate to broad research areas as well as more specific areas of study. Qualitative research questions are less directional, more flexible, and adaptable compared with their quantitative counterparts. Thus, studies based on these questions tend to focus on “discovering,” “explaining,” “elucidating,” and “exploring.”

Categories of qualitative research questions

Quantitative and qualitative research question examples.

stacks of books in black and white; research question examples

Good and Bad Research Question Examples

Below are some good (and not-so-good) examples of research questions that researchers can use to guide them in crafting their own research questions.

Research Question Example 1

The first research question is too vague in both its independent and dependent variables. There is no specific information on what “exposure” means. Does this refer to comments, likes, engagement, or just how much time is spent on the social media platform?

Second, there is no useful information on what exactly “affected” means. Does the subject’s behavior change in some measurable way? Or does this term refer to another factor such as the user’s emotions?

Research Question Example 2

In this research question, the first example is too simple and not sufficiently complex, making it difficult to assess whether the study answered the question. The author could really only answer this question with a simple “yes” or “no.” Further, the presence of data would not help answer this question more deeply, which is a sure sign of a poorly constructed research topic.

The second research question is specific, complex, and empirically verifiable. One can measure program effectiveness based on metrics such as attendance or grades. Further, “bullying” is made into an empirical, quantitative measurement in the form of recorded disciplinary actions.

Steps for Writing a Research Question

Good research questions are relevant, focused, and meaningful. It can be difficult to come up with a good research question, but there are a few steps you can follow to make it a bit easier.

1. Start with an interesting and relevant topic

Choose a research topic that is interesting but also relevant and aligned with your own country’s culture or your university’s capabilities. Popular academic topics include healthcare and medical-related research. However, if you are attending an engineering school or humanities program, you should obviously choose a research question that pertains to your specific study and major.

Below is an embedded graph of the most popular research fields of study based on publication output according to region. As you can see, healthcare and the basic sciences receive the most funding and earn the highest number of publications. 

in research question

2. Do preliminary research  

You can begin doing preliminary research once you have chosen a research topic. Two objectives should be accomplished during this first phase of research. First, you should undertake a preliminary review of related literature to discover issues that scholars and peers are currently discussing. With this method, you show that you are informed about the latest developments in the field.

Secondly, identify knowledge gaps or limitations in your topic by conducting a preliminary literature review . It is possible to later use these gaps to focus your research question after a certain amount of fine-tuning.

3. Narrow your research to determine specific research questions

You can focus on a more specific area of study once you have a good handle on the topic you want to explore. Focusing on recent literature or knowledge gaps is one good option. 

By identifying study limitations in the literature and overlooked areas of study, an author can carve out a good research question. The same is true for choosing research questions that extend or complement existing literature.

4. Evaluate your research question

Make sure you evaluate the research question by asking the following questions:

Is my research question clear?

The resulting data and observations that your study produces should be clear. For quantitative studies, data must be empirical and measurable. For qualitative, the observations should be clearly delineable across categories.

Is my research question focused and specific?

A strong research question should be specific enough that your methodology or testing procedure produces an objective result, not one left to subjective interpretation. Open-ended research questions or those relating to general topics can create ambiguous connections between the results and the aims of the study. 

Is my research question sufficiently complex?

The result of your research should be consequential and substantial (and fall sufficiently within the context of your field) to warrant an academic study. Simply reinforcing or supporting a scientific consensus is superfluous and will likely not be well received by most journal editors.  

reverse triangle chart, how to write a research question

Editing Your Research Question

Your research question should be fully formulated well before you begin drafting your research paper. However, you can receive English paper editing and proofreading services at any point in the drafting process. Language editors with expertise in your academic field can assist you with the content and language in your Introduction section or other manuscript sections. And if you need further assistance or information regarding paper compositions, in the meantime, check out our academic resources , which provide dozens of articles and videos on a variety of academic writing and publication topics.

  • Research Questions: Definitions, Types + [Examples]

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Research questions lie at the core of systematic investigation and this is because recording accurate research outcomes is tied to asking the right questions. Asking the right questions when conducting research can help you collect relevant and insightful information that ultimately influences your work, positively. 

The right research questions are typically easy to understand, straight to the point, and engaging. In this article, we will share tips on how to create the right research questions and also show you how to create and administer an online questionnaire with Formplus . 

What is a Research Question? 

A research question is a specific inquiry which the research seeks to provide a response to. It resides at the core of systematic investigation and it helps you to clearly define a path for the research process. 

A research question is usually the first step in any research project. Basically, it is the primary interrogation point of your research and it sets the pace for your work.  

Typically, a research question focuses on the research, determines the methodology and hypothesis, and guides all stages of inquiry, analysis, and reporting. With the right research questions, you will be able to gather useful information for your investigation. 

Types of Research Questions 

Research questions are broadly categorized into 2; that is, qualitative research questions and quantitative research questions. Qualitative and quantitative research questions can be used independently and co-dependently in line with the overall focus and objectives of your research. 

If your research aims at collecting quantifiable data , you will need to make use of quantitative research questions. On the other hand, qualitative questions help you to gather qualitative data bothering on the perceptions and observations of your research subjects. 

Qualitative Research Questions  

A qualitative research question is a type of systematic inquiry that aims at collecting qualitative data from research subjects. The aim of qualitative research questions is to gather non-statistical information pertaining to the experiences, observations, and perceptions of the research subjects in line with the objectives of the investigation. 

Types of Qualitative Research Questions  

  • Ethnographic Research Questions

As the name clearly suggests, ethnographic research questions are inquiries presented in ethnographic research. Ethnographic research is a qualitative research approach that involves observing variables in their natural environments or habitats in order to arrive at objective research outcomes. 

These research questions help the researcher to gather insights into the habits, dispositions, perceptions, and behaviors of research subjects as they interact in specific environments. 

Ethnographic research questions can be used in education, business, medicine, and other fields of study, and they are very useful in contexts aimed at collecting in-depth and specific information that are peculiar to research variables. For instance, asking educational ethnographic research questions can help you understand how pedagogy affects classroom relations and behaviors. 

This type of research question can be administered physically through one-on-one interviews, naturalism (live and work), and participant observation methods. Alternatively, the researcher can ask ethnographic research questions via online surveys and questionnaires created with Formplus.  

Examples of Ethnographic Research Questions

  • Why do you use this product?
  • Have you noticed any side effects since you started using this drug?
  • Does this product meet your needs?

ethnographic-research-questions

  • Case Studies

A case study is a qualitative research approach that involves carrying out a detailed investigation into a research subject(s) or variable(s). In the course of a case study, the researcher gathers a range of data from multiple sources of information via different data collection methods, and over a period of time. 

The aim of a case study is to analyze specific issues within definite contexts and arrive at detailed research subject analyses by asking the right questions. This research method can be explanatory, descriptive , or exploratory depending on the focus of your systematic investigation or research. 

An explanatory case study is one that seeks to gather information on the causes of real-life occurrences. This type of case study uses “how” and “why” questions in order to gather valid information about the causative factors of an event. 

Descriptive case studies are typically used in business researches, and they aim at analyzing the impact of changing market dynamics on businesses. On the other hand, exploratory case studies aim at providing answers to “who” and “what” questions using data collection tools like interviews and questionnaires. 

Some questions you can include in your case studies are: 

  • Why did you choose our services?
  • How has this policy affected your business output?
  • What benefits have you recorded since you started using our product?

case-study-example

An interview is a qualitative research method that involves asking respondents a series of questions in order to gather information about a research subject. Interview questions can be close-ended or open-ended , and they prompt participants to provide valid information that is useful to the research. 

An interview may also be structured, semi-structured , or unstructured , and this further influences the types of questions they include. Structured interviews are made up of more close-ended questions because they aim at gathering quantitative data while unstructured interviews consist, primarily, of open-ended questions that allow the researcher to collect qualitative information from respondents. 

You can conduct interview research by scheduling a physical meeting with respondents, through a telephone conversation, and via digital media and video conferencing platforms like Skype and Zoom. Alternatively, you can use Formplus surveys and questionnaires for your interview. 

Examples of interview questions include: 

  • What challenges did you face while using our product?
  • What specific needs did our product meet?
  • What would you like us to improve our service delivery?

interview-questions

Quantitative Research Questions

Quantitative research questions are questions that are used to gather quantifiable data from research subjects. These types of research questions are usually more specific and direct because they aim at collecting information that can be measured; that is, statistical information. 

Types of Quantitative Research Questions

  • Descriptive Research Questions

Descriptive research questions are inquiries that researchers use to gather quantifiable data about the attributes and characteristics of research subjects. These types of questions primarily seek responses that reveal existing patterns in the nature of the research subjects. 

It is important to note that descriptive research questions are not concerned with the causative factors of the discovered attributes and characteristics. Rather, they focus on the “what”; that is, describing the subject of the research without paying attention to the reasons for its occurrence. 

Descriptive research questions are typically closed-ended because they aim at gathering definite and specific responses from research participants. Also, they can be used in customer experience surveys and market research to collect information about target markets and consumer behaviors. 

Descriptive Research Question Examples

  • How often do you make use of our fitness application?
  • How much would you be willing to pay for this product?

descriptive-research-question

  • Comparative Research Questions

A comparative research question is a type of quantitative research question that is used to gather information about the differences between two or more research subjects across different variables. These types of questions help the researcher to identify distinct features that mark one research subject from the other while highlighting existing similarities. 

Asking comparative research questions in market research surveys can provide insights on how your product or service matches its competitors. In addition, it can help you to identify the strengths and weaknesses of your product for a better competitive advantage.  

The 5 steps involved in the framing of comparative research questions are: 

  • Choose your starting phrase
  • Identify and name the dependent variable
  • Identify the groups you are interested in
  • Identify the appropriate adjoining text
  • Write out the comparative research question

Comparative Research Question Samples 

  • What are the differences between a landline telephone and a smartphone?
  • What are the differences between work-from-home and on-site operations?

comparative-research-question

  • Relationship-based Research Questions  

Just like the name suggests, a relationship-based research question is one that inquires into the nature of the association between two research subjects within the same demographic. These types of research questions help you to gather information pertaining to the nature of the association between two research variables. 

Relationship-based research questions are also known as correlational research questions because they seek to clearly identify the link between 2 variables. 

Read: Correlational Research Designs: Types, Examples & Methods

Examples of relationship-based research questions include: 

  • What is the relationship between purchasing power and the business site?
  • What is the relationship between the work environment and workforce turnover?

relationship-based-research-question

Examples of a Good Research Question

Since research questions lie at the core of any systematic investigations, it is important to know how to frame a good research question. The right research questions will help you to gather the most objective responses that are useful to your systematic investigation. 

A good research question is one that requires impartial responses and can be answered via existing sources of information. Also, a good research question seeks answers that actively contribute to a body of knowledge; hence, it is a question that is yet to be answered in your specific research context.

  • Open-Ended Questions

 An open-ended question is a type of research question that does not restrict respondents to a set of premeditated answer options. In other words, it is a question that allows the respondent to freely express his or her perceptions and feelings towards the research subject. 

Examples of Open-ended Questions

  • How do you deal with stress in the workplace?
  • What is a typical day at work like for you?
  • Close-ended Questions

A close-ended question is a type of survey question that restricts respondents to a set of predetermined answers such as multiple-choice questions . Close-ended questions typically require yes or no answers and are commonly used in quantitative research to gather numerical data from research participants. 

Examples of Close-ended Questions

  • Did you enjoy this event?
  • How likely are you to recommend our services?
  • Very Likely
  • Somewhat Likely
  • Likert Scale Questions

A Likert scale question is a type of close-ended question that is structured as a 3-point, 5-point, or 7-point psychometric scale . This type of question is used to measure the survey respondent’s disposition towards multiple variables and it can be unipolar or bipolar in nature. 

Example of Likert Scale Questions

  • How satisfied are you with our service delivery?
  • Very dissatisfied
  • Not satisfied
  • Very satisfied
  • Rating Scale Questions

A rating scale question is a type of close-ended question that seeks to associate a specific qualitative measure (rating) with the different variables in research. It is commonly used in customer experience surveys, market research surveys, employee reviews, and product evaluations. 

Example of Rating Questions

  • How would you rate our service delivery?

  Examples of a Bad Research Question

Knowing what bad research questions are would help you avoid them in the course of your systematic investigation. These types of questions are usually unfocused and often result in research biases that can negatively impact the outcomes of your systematic investigation. 

  • Loaded Questions

A loaded question is a question that subtly presupposes one or more unverified assumptions about the research subject or participant. This type of question typically boxes the respondent in a corner because it suggests implicit and explicit biases that prevent objective responses. 

Example of Loaded Questions

  • Have you stopped smoking?
  • Where did you hide the money?
  • Negative Questions

A negative question is a type of question that is structured with an implicit or explicit negator. Negative questions can be misleading because they upturn the typical yes/no response order by requiring a negative answer for affirmation and an affirmative answer for negation. 

Examples of Negative Questions

  • Would you mind dropping by my office later today?
  • Didn’t you visit last week?
  • Leading Questions  

A l eading question is a type of survey question that nudges the respondent towards an already-determined answer. It is highly suggestive in nature and typically consists of biases and unverified assumptions that point toward its premeditated responses. 

Examples of Leading Questions

  • If you enjoyed this service, would you be willing to try out our other packages?
  • Our product met your needs, didn’t it?
Read More: Leading Questions: Definition, Types, and Examples

How to Use Formplus as Online Research Questionnaire Tool  

With Formplus, you can create and administer your online research questionnaire easily. In the form builder, you can add different form fields to your questionnaire and edit these fields to reflect specific research questions for your systematic investigation. 

Here is a step-by-step guide on how to create an online research questionnaire with Formplus: 

  • Sign in to your Formplus accoun t, then click on the “create new form” button in your dashboard to access the Form builder.

in research question

  • In the form builder, add preferred form fields to your online research questionnaire by dragging and dropping them into the form. Add a title to your form in the title block. You can edit form fields by clicking on the “pencil” icon on the right corner of each form field.

online-research-questionnaire

  • Save the form to access the customization section of the builder. Here, you can tweak the appearance of your online research questionnaire by adding background images, changing the form font, and adding your organization’s logo.

formplus-research-question

  • Finally, copy your form link and share it with respondents. You can also use any of the multiple sharing options available.

in research question

Conclusion  

The success of your research starts with framing the right questions to help you collect the most valid and objective responses. Be sure to avoid bad research questions like loaded and negative questions that can be misleading and adversely affect your research data and outcomes. 

Your research questions should clearly reflect the aims and objectives of your systematic investigation while laying emphasis on specific contexts. To help you seamlessly gather responses for your research questions, you can create an online research questionnaire on Formplus.  

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Research Questions – How to-Guide | Definition & Examples

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Definition: Research Question

The research question states the aim of a paper in form of a question. The purpose of writing the paper is to provide an answer to the research questions No article/paper can cover all aspects of a broad topic.

You must select a more specific aspect that has the potential to yield significant results as part of the topic and then find a connection to your Thesis Statement .

Inhaltsverzeichnis

  • 1 What is a Research Question?
  • 4 Dos and Don’ts
  • 5 Finding the right words
  • 6 Sample research questions
  • 7 Research question vs. title
  • 8 The research question: Where it belongs
  • 9 In summary
  • 10 References

What is a Research Question?

The research question lies at the heart of every piece of academic writing . The research question determines the sources to be quoted, how to structure the argument, and what a paper aims at.

The research question narrows down the topic and makes sure that the paper has a common thread. Moreover, the research question gives the reader a clear idea of what to expect from the paper.

You cannot start writing without having a research question in mind. It is easiest to think of a research question as a Wh-question . Finding an answer to the research question you formulate is your personal contribution. You must state your research question right at the beginning, as part of the introduction.

Also useful: What is plagiarism?

How do you write a research question?

  • Choose an interesting research topic . Something you’re interested in.
  • Conduct some exploratory research.
  • Begin formulating questions around areas of your topic that you think need more research.
  • Conduct further research and narrow in on a few of your preliminary research questions.
  • Pick your final research question and refine it.

What makes a good research question?

It’s important that your research question is focused on one single research topic , or a few interdependent topics. If your research question is too vague, then you will find it difficult to stay on topic whilst writing. It’s a good idea to focus on an unresolved problem- a problem that you never found a solution/many solutions for in your research. Your goal will be to resolve this problem in your paper.

How is the research question different from the hypothesis?

The hypothesis states your educated prediction regarding what you will find during your research. A hypothesis is used mostly in experimental or correlational research. It is your preliminary answer to your research question.

On the other hand, your research question states the aim of your paper and it is connected to your thesis statement . Throughout your paper, the hypothesis will be supported or contradicted with the collection and analysis of data.

What are the types of research questions?

There are many different types of research questions. However, the most common types are:

  • Descriptive questions
  • Relationship-based questions (explanation)
  • criticism/improvement-based questions

Already refined your research question? Then you’re ready to begin writing your research proposal . It’s a long process, but stick with it and your paper will be done before you know it!

How do I write a research question for a thesis?

The process for writing a research question for a bachelor’s thesis or a master’s thesis stays the same. You begin with your inital research before narrowing in further  on a few specific topics. The only difference is that your thesis will be significantly larger than a mid-semester paper so you will need more time to conduct some very intensive research before you begin writing.

The aim of a research question

“The research question is also the question why you should delight the world with another pile of printed paper” (cf. Winter 2004: 28).

A bachelor’s or master’s thesis is not something you write just for the sake of writing something. The aim is to create new scientific knowledge or to test and newly interpret existing theories. To achieve this aim, a thorough literature research is necessary to find an under-researched topic having new aspects you can focus on – a gap in scientific literature, so to speak.

To be even more precise: you can pose a very specific research question that nobody has asked before.

Esselborn-Krumbiegel says it is essential to understand what is required of every academic piece of writing, namely finding an answer to an open question (cf. 2002: 60). First, you have to find a topic and then formulate a research question derived from said topic . The topic as such will only be dealt with in terms of your specific research question (cf. Franck & Stary 2009: 167).

General example for creating a research question

The following diagram depicts how to proceed from a broad topic to a precise research question.

Research-Question-Example-Write-1

Concrete example using the topic of media violence

The following example shows how to derive a detailed research question from the topic “Media Violence”:

Formulate-Research-Question-2

Example: How the topic, problem, research question, and aim of the paper are interrelated

Examples: deriving a research question from a topic.

Research-Question-Examples

Dos and Don’ts

Take your time when formulating your research question – it will definitely pay off! Be careful not to pose a research question that is ambiguous. People might wonder if you actually know what you want to work on and which research question you are setting out to answer (cf. Kornmeier 2013: 71).

The following list details Dos and Don’ts of writing a good research question to make sure you know what to include and what to avoid when formulating your research question (cf. Karmasin & Ribing 2014: 24; Samac, Prenner & Schwetz 2009: 47).

Examples of good and bad research questions

The Center for Innovation in Research and Teaching (CIRT) suggests how to transform a bad research question into a good research questions using the following examples:

(cf. CIRT, n.d., https://cirt.gcu.edu/research/developmentresources/tutorials/question . Last accessed 19 th Feb 2019)

Finding the right words

The easiest way to formulate a research question is to turn your whole bachelor’s thesis into one question . This will help to define the aim of your bachelor’s thesis (cf. Samac, Prenner & Schwetz 2009: 46). You can make choices concerning the literature, the structure and the content, as well as the study design, only if you have a very clear idea of what you want to write about (cf. Kornmeier 2013: 56).

The research question can also be formulated as an interrogative sentence, e.g. “The question this paper sets out to answer is…” or “This paper deals with the following question:…” (cf. Kruse 2010: 80). A question mark signals to the reader that there is an unresolved problem and your work offers a solution.

A good research question is precise and narrow . Andermann, Drees & Grätz say it is a cardinal error if an author thinks that everything that s/he has read about a topic must go into the paper. In a figurative sense, starting with Adam and Eve and the original sin, as well as trying to reinvent the wheel, are major mistakes for prospective scientists (cf. 2006: 33).

Sample research questions

In addition to developing the main research question, you have to be clear about the connection of your sub-research questions. Moreover, you have to figure out what type of research question you want to deal with. Otherwise, you run the risk of including everything you find out about a term or a statement during your literature research even if the latter play only a minor role in your research question (cf. Bänsch & Alewell 2013: 3-4).

Research question vs. title

(cf. Kruse 2007: 128)

The research question: Where it belongs

The research question determines the contents and the methods used in your bachelor’s and master’s thesis. Therefore, the research question must be introduced at the very beginning of your work. Moreover, the sole purpose of your paper is to answer the research question, so it is essential that the reader understands your research question. So you need to know: How to write an introduction

In your introduction, you should briefly introduce the topic and its relevance. Right after this, you have to pose your research question and highlight how it is part of a larger topic (cf. Oertner, St. John, & Thelen 2014: 31). You can split the research question into sub research questions, which should reflect in the structure of your paper. This means you are answering a bigger research question successively (cf. Karmasin & Ribing 2014: 24; Esselborn-Krumbiegel 2002: 64).

After all, longer papers like a master’s thesis do not consist of one big chapter only. Rather, several chapters building on each other are needed to adequately answer the research question (state of research, methods, empirical data collection, data analysis, etc.). Don’t forget to answer the research question in your thesis statement .

  • The research question is central to every bachelor’s and master’s thesis. It determines the content, the structure, and the aim of an academic paper  — i.e., finding an answer to the research question.
  • The research question is closely related to the topic and the title of the paper. You will never be able to deal with all aspects of a topic. The research question is the narrowed down version that shows which particular aspect you want to focus on in your thesis/paper.
  • The research question is best phrased as a Wh-question and must address a problem/an aspect that is new (no other paper has dealt with this issue/looked at this issue from the same angle).
  • It is not your task to reinvent the wheel. The research question narrows down the topic and, thus, excludes aspects that are not essential to the research question.
  • Answering your research question is your personal contribution to science and represents newly generated knowledge.
  • The research question is part of the introduction , right after a brief introduction of the topic.
  • There are different types of research questions: descriptive, explanatory, creative, critical/evaluative, and utopic.
  • It is important to ensure that a research question is never vague or biased. It pays off to take enough time to formulate a research question properly. Moreover, a research question must be researchable and relevant for the field of study.

Andermann, Ulrich, Martin Drees & Frank Götz. 2006. Wie verfasst man wissenschaftliche Arbeiten? 3 rd Ed. Mannheim: Dudenverlag.

Bänsch, Axel & Dorothea Alewell. 2013. Wissenschaftliches Arbeiten . 11 th Ed. Munich: Oldenbourg Verlag.

CIRT. “Writing a Good Research Question”, in: CIRT.  https://cirt.gcu.edu/research/developmentresources/tutorials/question . Last accessed 26 th  Mar 2019.

Esselborn-Krumbiegel, Helga. 2002. Von der Idee zum Text – Eine Anleitung zum wissenschaftlichen Schreiben . Paderborn: Ferdinand Schöningh.

Flinn, Chad. “What makes a good research question”, in: Chad Flinn.  https://malat-webspace.royalroads.ca/rru0054/what-makes-a-good-research-question/ . Last accessed 26 th  Mar 2019.

Franck, Norbert & Joachim Stary. 2009. Die Technik des wissenschaftlichen Arbeitens . 15 th Ed. Paderborn: Ferdinand Schöningh.

Karmasin, Matthias & Rainer Ribing. 2014. Die Gestaltung wissenschaftlicher Arbeiten. 8 th Ed. Vienna: Facultas.

Kruse, Otto. 2007. Keine Angst vor dem leeren Blatt – Ohne Schreibblockaden durchs Studium . 12 th Ed. Frankfurt: Campus.

Kruse, Otto. 2010. Lesen und Schreiben – Der richtige Umgang mit Texten im Studium. Konstanz: UVK Verlagsgesellschaft.

Kornmeier, Martin. 2013. Wissenschaftlich schreiben leicht gemacht – für Bachelor, Master und Dissertation . 6 th Ed. Bern: Haupt.

Lamar Memorial Library. “Creating a Research Question”, in: Lamar Memorial Library. https://library.maryvillecollege.edu/c.php?g=616334&p=4320157 . Last accessed 26 th  Mar 2019.

Lewis A. Jackson Library. “Forming a Research Question”, in: Lewis A. Jackson Library.  http://indwes.libguides.com/c.php?g=71141&p=458447 . Last accessed 26 th  Mar 2019.

Oertner, Monika, Illona St. John & Gabriele Thelen. 2014. Wissenschaftlich Schreiben – Ein Praxisbuch für Schreibtrainer und Studierende . Paderborn: Wilhelm Fink.

Rossig, Wolfram E. & Joachim Prätsch. 2005. Wissenschaftliche Arbeiten . 5 th Ed. Weyhe: PRINT-TEC.

Samac, Klaus, Monika Prenner & Herbert Schwetz. 2009. Die Bachelorarbeit an Universität und Fachhochschule . Vienna: Facultas.

Winter, Wolfgang. 2005. Wissenschaftliche Arbeiten schreiben . 2 nd Ed. Frankfurt: Redline Wirtschaft.

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In Tight Presidential Race, Voters Are Broadly Critical of Both Biden and Trump

About half of voters say that, if given the chance, they would replace both candidates on the ballot, table of contents.

  • The state of the 2024 presidential race
  • Other findings: Biden’s job approval ticks up, Trump’s election-related criminal charges
  • Educational differences in candidate support
  • What are 2020 voters’ preferences today?
  • How Biden’s supporters view his personal traits
  • How Trump’s supporters view his personal traits
  • Views of Biden’s presidency and retrospective evaluations of Trump’s time in office
  • Attention to the candidates
  • Does it matter who wins?
  • What if voters could change the presidential ballot?
  • How important is it for the losing candidate to publicly acknowledge the winner?
  • 4. Joe Biden’s approval ratings
  • Acknowledgments
  • The American Trends Panel survey methodology
  • Validated voters

Donald Trump speaks at a rally in Green Bay, Wisconsin, on April 2, 2024. President Joe Biden speaks at a campaign event in Atlanta on March 9, 2024. (Scott Olson and Megan Varner, both via Getty Images)

Pew Research Center conducted this study to understand voters’ views on the 2024 presidential election, as well how the public views President Joe Biden. For this analysis, we surveyed 8,709 adults – including 7,166 registered voters – from April 8 to April 14, 2024. Everyone who took part in this survey is a member of the Center’s American Trends Panel (ATP), an online survey panel that is recruited through national, random sampling of residential addresses. This way nearly all U.S. adults have a chance of selection. The survey is weighted to be representative of the U.S. adult population by gender, race, ethnicity, partisan affiliation, education and other categories. Read more about the ATP’s methodology .

Here are the questions used for this report , along with responses, and the survey methodology .

As the 2024 presidential race heats up, American voters face a similar set of choices as they did four years ago – and many are not happy about it.

With the election still more than six months away, a new Pew Research Center survey finds that the presidential race is virtually tied : 49% of registered voters favor Donald Trump or lean toward voting for him, while 48% support or lean toward Joe Biden.

Chart shows About two-thirds of voters have little or no confidence that Biden is physically fit to be president; nearly as many lack confidence in Trump to act ethically

A defining characteristic of the contest is that voters overall have little confidence in either candidate across a range of key traits, including fitness for office, personal ethics and respect for democratic values.

Where Trump has the advantage: More than a third of voters say they are extremely or very confident that Trump has the physical fitness (36%) and mental fitness (38%) needed to do the job of president.

Far fewer say the same of Biden (15% are at least very confident in his physical fitness; 21% are extremely or very confident in his mental fitness). Majorities say they are not too or not at all confident in Biden’s physical and mental fitness.

Where Biden has the advantage: More voters are extremely or very confident in Biden (34%) than in Trump (26%) to act ethically in office. And while 38% say they are at least very confident in Biden to respect the country’s democratic values, fewer (34%) express that level of confidence in Trump. The survey was conducted before the start of Trump’s “hush money” trial in New York City .

( Read more about voters’ views of Biden and Trump in Chapter 2. )

Chart showing In 2020 rematch, nearly identical shares of voters favor Trump and Biden

The new Center survey of 8,709 adults – including 7,166 registered voters – conducted April 8-14, 2024, finds large divides in voters’ candidate preference by age, education, and race and ethnicity. As was the case in 2020, younger voters and those with a four-year college degree are more likely to favor Biden than Trump.

Older voters and those with no college degree favor Trump by large margins.

Among racial and ethnic groups:

  • White voters favor Trump (56%) over Biden (42%) by a wide margin.
  • Roughly three-quarters of Black voters (77%) support Biden, while 18% back Trump.
  • Hispanic voters are more evenly divided – 52% favor Biden, while 44% back Trump.
  • Asian voters favor Biden (59%) over Trump (36%).

( Read more about voters’ candidate preferences in Chapter 1. )

Most voters who turned out in 2020 favor the same candidate in 2024. Among validated 2020 voters, overwhelming majorities of those who cast ballots for Biden (91%) and Trump (94%) support the same candidate this year. Registered voters who did not vote in 2020 are about evenly divided: 48% back Trump, while 46% support Biden.

A majority of voters say “it really matters who wins” the 2024 race. Today, 69% of voters say it really matters which candidate wins the presidential contest this November. This is somewhat smaller than the share who said this in April 2020 about that year’s election (74%). Nearly identical shares of Biden’s and Trump’s supporters say the outcome of the presidential race really matters.

About half of voters would replace both Biden and Trump on the 2024 ballot

Reflecting their dissatisfaction with the Biden-Trump matchup, nearly half of registered voters (49%) say that, if they had the ability to decide the major party candidates for the 2024 election, they would replace both Biden and Trump on the ballot .

Chart shows About half of voters would like to see both Biden and Trump replaced on the 2024 ballot

Biden’s supporters are especially likely to say they would replace both candidates if they had the chance. Roughly six-in-ten (62%) express this view, compared with 35% of Trump supporters.

There also are stark age differences in these views: 66% of voters under 30 say they would replace both candidates if they had the chance, compared with 54% of those ages 30 to 49 and fewer than half (43%) of those 50 and older.

( Read more about voters’ feelings toward the upcoming election in Chapter 3. )

Evaluations of the Biden and Trump presidencies

Chart shows About 4 in 10 voters say Trump was a good or great president; around 3 in 10 say this about Biden today

  • 42% of voters overall say Trump was a good or great president, while 11% say he was average. This is a modest improvement since March 2021, two months after he left office.
  • 28% of voters say Biden is a good or great president, while 21% say he is average. These views are mostly on par with June 2020 assessments of the kind of president Biden would be – but today, a smaller share of voters say he is average.

( Read more about ratings of Biden’s and Trump’s presidencies in Chapter 1. )

  • Biden’s approval among the general public: Today, Biden’s approval rating sits at 35% – roughly on par with his rating in January (33%). His job rating has climbed slightly among Democrats over that period, however. Today, 65% of Democrats approve of him – up 4 percentage points since January. ( Read more about Biden’s approval rating in Chapter 4. )
  • Conceding the presidential election: A majority of voters say it is important that the losing candidate in November publicly acknowledge the winner as the legitimate president. But Trump’s supporters are far less likely than Biden’s to say it is very important (44% vs. 77%).  ( Read more about voters’ views on election concession in Chapter 3. )

Trump’s criminal charges related to the 2020 election

As Trump faces charges that he sought to overturn the outcome of the 2020 election, 45% of Americans say they think Trump’s actions broke the law. This compares with 38% who say his actions did not break the law – including 15% who say his actions were wrong but not illegal, and 23% who say he did nothing wrong. Nearly two-in-ten are not sure.

Chart shows Public divided over criminal allegations that Trump tried to overturn the 2020 election

Democrats mostly say Trump broke the law; Republicans are more divided. An overwhelming majority of Democrats and Democratic-leaning independents (78%) say Trump’s actions in seeking to change the outcome of the 2020 election broke the law. 

Among Republicans and Republican leaners:

  • 49% say Trump did nothing wrong.
  • 21% say he did something wrong but did not break the law.
  • 9% say Trump broke the law.
  • 20% are not sure.

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3 Questions: A shared vocabulary for how infectious diseases spread

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MIT Associate Professor Lydia Bourouiba describes how her fluid dynamics research influenced new guidance from the World Health Organization, which will shape how health agencies respond to infectious diseases.

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On April 18, the World Health Organization (WHO) released new guidance on airborne disease transmission that seeks to create a consensus around the terminology used to describe the transmission of infectious pathogens through the air.

Lydia Bourouiba, the director of the MIT Fluid Dynamics of Disease Transmission Laboratory and the Fluids and Health Network, an associate professor in the MIT departments of Civil and Environmental Engineering and Mechanical Engineering, and a core member of the Institute for Medical Engineering and Science, served on the WHO expert team that developed the guidance. For more than a decade, Bourouiba’s laboratory has been researching fundamental physical processes underlying how infectious diseases spread from person to person.

The new WHO guidance puts forth new definitions of key terminology pertaining to respiratory infectious disease transmission. This reflects a new, shared understanding of how respiratory infectious pathogens move from one person to the next: through the exhalations of turbulent “puff clouds” that carry infectious contaminants in a continuum of droplet sizes and can lead to exposure at a range of distances.

Bourouiba’s lab has pioneered this physical picture and worked closely with a range of stakeholders over the years to ensure that public health guidance incorporates the latest science, improving preparedness for emerging respiratory pathogens. Bourouiba spoke with MIT News about the new WHO guidance.

Q: How did you become involved in creating these new guidelines?

A: I have been researching exhalation emissions for more than a decade. After the first SARS outbreak in 2003, I realized that the mechanisms by which respiratory pathogens are transmitted from one host to the next were essentially considered too random and too brief to be amenable to systematic investigation. Hence, the physical act of pathogen transmission was relegated to a black box. However, I also realized the fundamental importance of understanding these events mechanistically, to ultimately be able to mitigate such transmission events in a rational and principled manner. For this, we needed to understand the fluid physics and biophysics of respiratory emissions.

In the Fluid Dynamics of Disease Transmission Laboratory at MIT, we have been investigating these respiratory emissions. Our work showed that prior guidelines — specifically, the dichotomy of “large” versus “small” drops and isolated droplet emissions (essentially from spray bottles) — were not at all what we actually see and quantify when investigating respiratory emissions. We focused on establishing the full physics of such processes, from emission physiology to the fluid dynamics and biophysics of the exhalation flows and the interaction of the exhaled turbulent multiphase flow with the conditions of the ambient environment (air currents, temperature, and humidity).

Since 2015, I have also been working with the MIT Policy Lab at the Center for International Studies to disseminate our findings to public health officials and various agencies. We organized multiple conferences where we brought in scientists, clinicians, virologists, epidemiologists, microbiologists, and representatives from the U.S. Centers for Disease Control and Prevention and other groups, both before and during the pandemic.

In 2022, I was asked to serve on the World Health Organization’s technical consultation expert team, which was tasked with reaching a consensus on a new framework on respiratory infectious disease transmission. That process lasted about two years and culminated so far in the publication of the new guidelines. The process was obviously accelerated by the Covid-19 pandemic and the issues it brought to the fore regarding the inadequate old definitions. The goal of convening the consultation group was to bring together leading experts from around the globe and from very diverse fields — ranging from fluid physics to clinical medicine and epidemiology — to think through how best to redefine terms related to respiratory infectious disease transmission in light of the latest science. These new guidelines are very much a first step in a series of important consultations and efforts.

Q: How did your research change the WHO’s description of how diseases are transmitted through the air?

A: Our research established that these isolated droplets are not just exhaled as isolated droplets moving semiballistically [that will settle out of the air relatively near to the person who released them]. Instead, they are part of a multiphase turbulent puff gas cloud that contains a continuum of droplet sizes, where the cloud provides a comparatively warm and moist — and hence protective — environment for these droplets and the pathogens they contain, with respect to ambient air. One of our first papers establishing this concept was published in 2014. And we have showed since that models that do not include the proper physics of these turbulent puff clouds can dramatically underestimate the ranges of propagation and also completely shift estimates of risk and pathogen persistence in an indoor space.

These turbulent puff clouds are inhomogeneous, with potential for highly concentrated pathogen-bearing droplet load regions that can persist for a comparatively long time while moving very quickly across an indoor space in some of the most violent exhalations. Their dynamics enable potential effective inhalation exposure at a range of distances, long and short. This continuum and physical picture of concentrated packets of droplets and their impact on persistence of pathogen infectivity and exposure are in complete contrast with the notion of homogeneous mixing indoors, and the prior false dichotomy of “large” droplets that fall ballistically and “small” droplets that essentially evaporate immediately to form aerosols assumed to be deactivated. The prior picture led to the belief that only very few infectious diseases are airborne or requiring air management. This dichotomy, with other misconceptions, rooted in science from the 1930s, has surprisingly persisted in guidelines for decades.

The new guideline is a major milestone, not only because these guidelines do not change very often — every 10 or 15 years at best — but also because in addition to the WHO, five national or transnational health agencies have already endorsed the findings, including the U.S. Centers for Disease Control and Prevention, which also acknowledged the importance of the shift. 

Q: What are the biggest implications of these changes?

A: An agreed-upon common terminology is critical in infectious disease research and mitigation. The new guidelines set the foundation for such a common understanding and process. One might think it is just semantics or a small, incremental change in our understanding. However, risk calculations actually vary tremendously based on the framework one uses. We used mathematical models and physical experiments and found that the physical picture change has dramatic implications on risk estimations.

Another major implication was discussed in one of our publications from the very early stages of the pandemic, which stressed the urgent need for health care workers to have N95 masks because of these cloud dynamics and the associated importance of paying attention to indoor air management. Here again, risk calculations without the puff cloud dynamics would suggest that a typical hospital room or emergency department would dilute sufficiently the pathogen load so as to not pose a high risk. But with the puff cloud and dynamic of the droplets of a continuum of sizes within it, and coupled with it, it becomes clear that health care workers could still be exposed via inhalation to significant viral loads. Thus, they should have been provided N95 masks, in most conditions, when entering the space hosting a Covid-19 patient, even if they were not in their immediate vicinity. That article was the first to call attention to the importance of masking of health care workers due to the actual exhalation puff cloud and continuum of droplet sizes, shaping airborne transmission.

It took public health agencies more than six months to start considering shifting their masking guidelines during Covid-19. But this WHO document is broader than Covid-19. It redefines the basic definitions surrounding all respiratory infectious diseases — those that we know and those yet to come. That means there will be a different risk assessment and thereby different decision trees and policies, trickling down to different choices of protective equipment and mitigation protocols, and different parts of health agencies or facilities that might be activated or deployed.

The new guidelines are also a major acknowledgement that infectious disease transmission is truly an interdisciplinary area where scientists, clinicians, and public health officials of different backgrounds need to communicate with each other efficiently and clearly and share their insights, be it fundamental physics or clinical infectious diseases.  So, it is not just the content of these guidelines, but also the way this update unfolded. Hopefully it changes the mindset for responding to such public health threats.

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  • WHO Report: “Global technical consultation report on proposed terminology for pathogens that transmit through the air”
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Research questions, hypotheses and objectives

Patricia farrugia.

* Michael G. DeGroote School of Medicine, the

Bradley A. Petrisor

† Division of Orthopaedic Surgery and the

Forough Farrokhyar

‡ Departments of Surgery and

§ Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ont

Mohit Bhandari

There is an increasing familiarity with the principles of evidence-based medicine in the surgical community. As surgeons become more aware of the hierarchy of evidence, grades of recommendations and the principles of critical appraisal, they develop an increasing familiarity with research design. Surgeons and clinicians are looking more and more to the literature and clinical trials to guide their practice; as such, it is becoming a responsibility of the clinical research community to attempt to answer questions that are not only well thought out but also clinically relevant. The development of the research question, including a supportive hypothesis and objectives, is a necessary key step in producing clinically relevant results to be used in evidence-based practice. A well-defined and specific research question is more likely to help guide us in making decisions about study design and population and subsequently what data will be collected and analyzed. 1

Objectives of this article

In this article, we discuss important considerations in the development of a research question and hypothesis and in defining objectives for research. By the end of this article, the reader will be able to appreciate the significance of constructing a good research question and developing hypotheses and research objectives for the successful design of a research study. The following article is divided into 3 sections: research question, research hypothesis and research objectives.

Research question

Interest in a particular topic usually begins the research process, but it is the familiarity with the subject that helps define an appropriate research question for a study. 1 Questions then arise out of a perceived knowledge deficit within a subject area or field of study. 2 Indeed, Haynes suggests that it is important to know “where the boundary between current knowledge and ignorance lies.” 1 The challenge in developing an appropriate research question is in determining which clinical uncertainties could or should be studied and also rationalizing the need for their investigation.

Increasing one’s knowledge about the subject of interest can be accomplished in many ways. Appropriate methods include systematically searching the literature, in-depth interviews and focus groups with patients (and proxies) and interviews with experts in the field. In addition, awareness of current trends and technological advances can assist with the development of research questions. 2 It is imperative to understand what has been studied about a topic to date in order to further the knowledge that has been previously gathered on a topic. Indeed, some granting institutions (e.g., Canadian Institute for Health Research) encourage applicants to conduct a systematic review of the available evidence if a recent review does not already exist and preferably a pilot or feasibility study before applying for a grant for a full trial.

In-depth knowledge about a subject may generate a number of questions. It then becomes necessary to ask whether these questions can be answered through one study or if more than one study needed. 1 Additional research questions can be developed, but several basic principles should be taken into consideration. 1 All questions, primary and secondary, should be developed at the beginning and planning stages of a study. Any additional questions should never compromise the primary question because it is the primary research question that forms the basis of the hypothesis and study objectives. It must be kept in mind that within the scope of one study, the presence of a number of research questions will affect and potentially increase the complexity of both the study design and subsequent statistical analyses, not to mention the actual feasibility of answering every question. 1 A sensible strategy is to establish a single primary research question around which to focus the study plan. 3 In a study, the primary research question should be clearly stated at the end of the introduction of the grant proposal, and it usually specifies the population to be studied, the intervention to be implemented and other circumstantial factors. 4

Hulley and colleagues 2 have suggested the use of the FINER criteria in the development of a good research question ( Box 1 ). The FINER criteria highlight useful points that may increase the chances of developing a successful research project. A good research question should specify the population of interest, be of interest to the scientific community and potentially to the public, have clinical relevance and further current knowledge in the field (and of course be compliant with the standards of ethical boards and national research standards).

FINER criteria for a good research question

Adapted with permission from Wolters Kluwer Health. 2

Whereas the FINER criteria outline the important aspects of the question in general, a useful format to use in the development of a specific research question is the PICO format — consider the population (P) of interest, the intervention (I) being studied, the comparison (C) group (or to what is the intervention being compared) and the outcome of interest (O). 3 , 5 , 6 Often timing (T) is added to PICO ( Box 2 ) — that is, “Over what time frame will the study take place?” 1 The PICOT approach helps generate a question that aids in constructing the framework of the study and subsequently in protocol development by alluding to the inclusion and exclusion criteria and identifying the groups of patients to be included. Knowing the specific population of interest, intervention (and comparator) and outcome of interest may also help the researcher identify an appropriate outcome measurement tool. 7 The more defined the population of interest, and thus the more stringent the inclusion and exclusion criteria, the greater the effect on the interpretation and subsequent applicability and generalizability of the research findings. 1 , 2 A restricted study population (and exclusion criteria) may limit bias and increase the internal validity of the study; however, this approach will limit external validity of the study and, thus, the generalizability of the findings to the practical clinical setting. Conversely, a broadly defined study population and inclusion criteria may be representative of practical clinical practice but may increase bias and reduce the internal validity of the study.

PICOT criteria 1

A poorly devised research question may affect the choice of study design, potentially lead to futile situations and, thus, hamper the chance of determining anything of clinical significance, which will then affect the potential for publication. Without devoting appropriate resources to developing the research question, the quality of the study and subsequent results may be compromised. During the initial stages of any research study, it is therefore imperative to formulate a research question that is both clinically relevant and answerable.

Research hypothesis

The primary research question should be driven by the hypothesis rather than the data. 1 , 2 That is, the research question and hypothesis should be developed before the start of the study. This sounds intuitive; however, if we take, for example, a database of information, it is potentially possible to perform multiple statistical comparisons of groups within the database to find a statistically significant association. This could then lead one to work backward from the data and develop the “question.” This is counterintuitive to the process because the question is asked specifically to then find the answer, thus collecting data along the way (i.e., in a prospective manner). Multiple statistical testing of associations from data previously collected could potentially lead to spuriously positive findings of association through chance alone. 2 Therefore, a good hypothesis must be based on a good research question at the start of a trial and, indeed, drive data collection for the study.

The research or clinical hypothesis is developed from the research question and then the main elements of the study — sampling strategy, intervention (if applicable), comparison and outcome variables — are summarized in a form that establishes the basis for testing, statistical and ultimately clinical significance. 3 For example, in a research study comparing computer-assisted acetabular component insertion versus freehand acetabular component placement in patients in need of total hip arthroplasty, the experimental group would be computer-assisted insertion and the control/conventional group would be free-hand placement. The investigative team would first state a research hypothesis. This could be expressed as a single outcome (e.g., computer-assisted acetabular component placement leads to improved functional outcome) or potentially as a complex/composite outcome; that is, more than one outcome (e.g., computer-assisted acetabular component placement leads to both improved radiographic cup placement and improved functional outcome).

However, when formally testing statistical significance, the hypothesis should be stated as a “null” hypothesis. 2 The purpose of hypothesis testing is to make an inference about the population of interest on the basis of a random sample taken from that population. The null hypothesis for the preceding research hypothesis then would be that there is no difference in mean functional outcome between the computer-assisted insertion and free-hand placement techniques. After forming the null hypothesis, the researchers would form an alternate hypothesis stating the nature of the difference, if it should appear. The alternate hypothesis would be that there is a difference in mean functional outcome between these techniques. At the end of the study, the null hypothesis is then tested statistically. If the findings of the study are not statistically significant (i.e., there is no difference in functional outcome between the groups in a statistical sense), we cannot reject the null hypothesis, whereas if the findings were significant, we can reject the null hypothesis and accept the alternate hypothesis (i.e., there is a difference in mean functional outcome between the study groups), errors in testing notwithstanding. In other words, hypothesis testing confirms or refutes the statement that the observed findings did not occur by chance alone but rather occurred because there was a true difference in outcomes between these surgical procedures. The concept of statistical hypothesis testing is complex, and the details are beyond the scope of this article.

Another important concept inherent in hypothesis testing is whether the hypotheses will be 1-sided or 2-sided. A 2-sided hypothesis states that there is a difference between the experimental group and the control group, but it does not specify in advance the expected direction of the difference. For example, we asked whether there is there an improvement in outcomes with computer-assisted surgery or whether the outcomes worse with computer-assisted surgery. We presented a 2-sided test in the above example because we did not specify the direction of the difference. A 1-sided hypothesis states a specific direction (e.g., there is an improvement in outcomes with computer-assisted surgery). A 2-sided hypothesis should be used unless there is a good justification for using a 1-sided hypothesis. As Bland and Atlman 8 stated, “One-sided hypothesis testing should never be used as a device to make a conventionally nonsignificant difference significant.”

The research hypothesis should be stated at the beginning of the study to guide the objectives for research. Whereas the investigators may state the hypothesis as being 1-sided (there is an improvement with treatment), the study and investigators must adhere to the concept of clinical equipoise. According to this principle, a clinical (or surgical) trial is ethical only if the expert community is uncertain about the relative therapeutic merits of the experimental and control groups being evaluated. 9 It means there must exist an honest and professional disagreement among expert clinicians about the preferred treatment. 9

Designing a research hypothesis is supported by a good research question and will influence the type of research design for the study. Acting on the principles of appropriate hypothesis development, the study can then confidently proceed to the development of the research objective.

Research objective

The primary objective should be coupled with the hypothesis of the study. Study objectives define the specific aims of the study and should be clearly stated in the introduction of the research protocol. 7 From our previous example and using the investigative hypothesis that there is a difference in functional outcomes between computer-assisted acetabular component placement and free-hand placement, the primary objective can be stated as follows: this study will compare the functional outcomes of computer-assisted acetabular component insertion versus free-hand placement in patients undergoing total hip arthroplasty. Note that the study objective is an active statement about how the study is going to answer the specific research question. Objectives can (and often do) state exactly which outcome measures are going to be used within their statements. They are important because they not only help guide the development of the protocol and design of study but also play a role in sample size calculations and determining the power of the study. 7 These concepts will be discussed in other articles in this series.

From the surgeon’s point of view, it is important for the study objectives to be focused on outcomes that are important to patients and clinically relevant. For example, the most methodologically sound randomized controlled trial comparing 2 techniques of distal radial fixation would have little or no clinical impact if the primary objective was to determine the effect of treatment A as compared to treatment B on intraoperative fluoroscopy time. However, if the objective was to determine the effect of treatment A as compared to treatment B on patient functional outcome at 1 year, this would have a much more significant impact on clinical decision-making. Second, more meaningful surgeon–patient discussions could ensue, incorporating patient values and preferences with the results from this study. 6 , 7 It is the precise objective and what the investigator is trying to measure that is of clinical relevance in the practical setting.

The following is an example from the literature about the relation between the research question, hypothesis and study objectives:

Study: Warden SJ, Metcalf BR, Kiss ZS, et al. Low-intensity pulsed ultrasound for chronic patellar tendinopathy: a randomized, double-blind, placebo-controlled trial. Rheumatology 2008;47:467–71.

Research question: How does low-intensity pulsed ultrasound (LIPUS) compare with a placebo device in managing the symptoms of skeletally mature patients with patellar tendinopathy?

Research hypothesis: Pain levels are reduced in patients who receive daily active-LIPUS (treatment) for 12 weeks compared with individuals who receive inactive-LIPUS (placebo).

Objective: To investigate the clinical efficacy of LIPUS in the management of patellar tendinopathy symptoms.

The development of the research question is the most important aspect of a research project. A research project can fail if the objectives and hypothesis are poorly focused and underdeveloped. Useful tips for surgical researchers are provided in Box 3 . Designing and developing an appropriate and relevant research question, hypothesis and objectives can be a difficult task. The critical appraisal of the research question used in a study is vital to the application of the findings to clinical practice. Focusing resources, time and dedication to these 3 very important tasks will help to guide a successful research project, influence interpretation of the results and affect future publication efforts.

Tips for developing research questions, hypotheses and objectives for research studies

  • Perform a systematic literature review (if one has not been done) to increase knowledge and familiarity with the topic and to assist with research development.
  • Learn about current trends and technological advances on the topic.
  • Seek careful input from experts, mentors, colleagues and collaborators to refine your research question as this will aid in developing the research question and guide the research study.
  • Use the FINER criteria in the development of the research question.
  • Ensure that the research question follows PICOT format.
  • Develop a research hypothesis from the research question.
  • Develop clear and well-defined primary and secondary (if needed) objectives.
  • Ensure that the research question and objectives are answerable, feasible and clinically relevant.

FINER = feasible, interesting, novel, ethical, relevant; PICOT = population (patients), intervention (for intervention studies only), comparison group, outcome of interest, time.

Competing interests: No funding was received in preparation of this paper. Dr. Bhandari was funded, in part, by a Canada Research Chair, McMaster University.

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April 24, 2024

Thomson Reuters unveils Checkpoint Edge with CoCounsel, featuring its generative AI assistant for tax research

First Thomson Reuters generative AI product for tax professionals uses AWS to deliver better, faster answers to complex tax research questions, rooted in the company’s trusted proprietary content

TORONTO, April 24, 2024 – Thomson Reuters (NYSE/TSX: TRI), a global content and technology company, is expanding access to the power of generative AI (GenAI) with the launch of Checkpoint Edge with CoCounsel to help redefine how professionals perform tax research. The enhanced solution is built on Amazon Web Services (AWS) and delivers a GenAI assistant to tax professionals, enabling them to quickly get answers to complex research questions, saving them time and increasing their efficiency. In addition, with the AI-Assisted Research skill on Checkpoint Edge, the solution empowers tax professionals with trusted answers, accessed through Thomson Reuters GenAI assistant, named CoCounsel.

Tax research has historically been a labor-intensive process, often requiring extensive manual effort and expertise, combined with the pressure of ensuring accuracy to enable professionals to take and defend tax positions with confidence. The introduction of Checkpoint Edge with CoCounsel gives tax professionals the ability to leverage the transformative capabilities of AI-Assisted Research. Through dialogue with a GenAI assistant, tax professionals can simply ask a question in everyday language. The solution will provide a relevant answer with links to trusted Checkpoint Edge editorial content and source materials in moments.

“Research is essential for tax professionals and getting it right can take hours; it is hard and time-consuming,” said Nancy Hawkins, vice president of Product Management, Research, Thomson Reuters. “Yet accountants are not lawyers trained in interpreting legislation, and the workforce is shrinking. That is why a GenAI-powered solution has the power to transform the profession. GenAI enables accountants to get it right, fast.”

When it comes to how GenAI can help reduce the burden, 77% of tax professionals think GenAI can be applied to professional work, with increased efficiency and productivity being rated the top reason it should be applied to tax work according to the 2024 Generative AI in Professional Services report by Thomson Reuters.

Trusted technology the tax industry can rely on

Tax firms (83%) and corporate tax professionals (71%) rate technology companies as the primary influencers on the future of GenAI. With influence comes responsibility, and Thomson Reuters works within a rigorous set of AI and data principles to ensure trustworthiness in its design, development, and deployment of AI in its solutions.

To expand access to GenAI by unlocking its potential in tax research for its customers, Thomson Reuters built Checkpoint Edge with CoCounsel securely using Amazon Bedrock. Amazon Bedrock is a fully managed service that offers a choice of high-performing foundation models from leading AI companies via a single API, along with a broad set of capabilities for building GenAI applications that meet the high Thomson Reuters standards for security, privacy, and responsible AI.

The use of Amazon Bedrock enabled the Thomson Reuters engineering team to accelerate AI model deployment time from days to hours. The solution is rooted in Thomson Reuters-verified databases to deliver reliable, accurate results, while keeping customer data private and secure.

Matt Wood, vice president of Artificial Intelligence Products, AWS said: “Generative AI has the potential to revolutionize industries, significantly enhancing operational and cost efficiency. By choosing Amazon Bedrock to build and scale generative AI applications like Checkpoint Edge with CoCounsel, Thomson Reuters can access leading foundation models and customize them using their proprietary data, with the confidence that this data is secure and private by default. We look forward to continuing our work with Thomson Reuters to support generative AI-powered tools that increase productivity and boost innovation.”

Key features of Checkpoint Edge with CoCounsel

Checkpoint Edge with CoCounsel empowers tax professionals with trusted answers in a simple chat interface.

  • Trusted answers: The solution enhances customers’ efficiency by delivering synthesized, easily digestible answers along with links to Checkpoint Edge editorial content and source materials, helping professionals spot key risks and resolve questions using powerful summaries from thousands of documents in a matter of seconds.

Since AI-Assisted Research is grounded in Thomson Reuters curated, vetted, and up-to-date Checkpoint Edge content, customers can be assured that they are getting trusted guidance and expert analysis.

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Available for purchase now as part of an early adopter program, Checkpoint Edge with CoCounsel is expected to debut initially in the United States, starting from summer 2024.

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A view through misty snow of an elk at the top of a ridge and a wolf climbing up that same ridge from below.

Yellowstone’s Wolves: A Debate Over Their Role in the Park’s Ecosystem

New research questions the long-held theory that reintroduction of such a predator caused a trophic cascade, spawning renewal of vegetation and spurring biodiversity.

Yellowstone’s ecological transformation through the reintroduction of wolves has become a case study for how to correct out-of-balance ecosystems. But new research challenges that notion. Credit... Elizabeth Boehm/Danita Delimont, via Alamy

Supported by

By Jim Robbins

  • April 23, 2024

In 1995, 14 wolves were delivered by truck and sled to the heart of Yellowstone National Park in Wyoming, where the animal had long been absent. Others followed.

Since then, a story has grown up, based on early research, that as the wolves increased in number, they hunted the park’s elk herds, significantly reducing them by about half from 17,000.

The wolves’ return and predatory dominance was believed to have had a widespread effect known as a trophic cascade, by decreasing grazing and restoring and expanding forests, grasses and other wildlife. It supposedly even changed the course of rivers as streamside vegetation returned.

Yellowstone’s dramatic transformation through the reintroduction of wolves has become a global parable for how to correct out-of-balance ecosystems.

In recent years, however, new research has walked that story back. Yes, stands of aspen and willows are thriving again — in some places. But decades of damage from elk herds’ grazing and trampling so thoroughly changed the landscape that large areas remain scarred and may not recover for a long time, if ever.

Wolf packs, in other words, are not magic bullets for restoring ecosystems.

“I would say it’s exaggerated, greatly exaggerated,” said Thomas Hobbs, a professor of natural resource ecology at Colorado State University and the lead author of a long-term study that adds new fuel to the debate over whether Yellowstone experienced a trophic cascade.

“You could argue a trophic trickle maybe,” said Daniel Stahler, the park’s lead wolf biologist who has studied the phenomenon. “Not a trophic cascade.”

Not only is the park’s recovery far less robust than first thought, but the story as it has been told is more complex, Dr. Hobbs said.

But the legend of the wolves’ influence on the park persists.

A group of people in winter gear carrying a large silver metal box with air holes over the snow.

“How in the world does this lovely story — and it is a beautiful story — come to be seen as fact?” Dr. Hobbs wondered. A chapter of a book tried to answer that, concluding that a video called “ How Wolves Change Rivers ,” which has received tens of millions of views, contributed mightily to the tale.

The ecological record is complicated by the fact that, as elk declined, the number of bison increased substantially, continuing some of the same patterns, like heavy grazing in some places. Moreover, Yellowstone is growing warmer and drier with climate change.

Large numbers of elk in the north of the park had caused significant ecological changes — vegetation disappeared, trampled streams led to extensive erosion, and invasive plant species took hold. Riparian vegetation, or the grasses, the trees and the shrubs along riverbanks and streams, provides a critical habitat for birds, insects and other species to flourish and to maintain biodiversity in the park.

Once elk numbers dwindled, willows and aspens returned along rivers and streams and flourished. The beaver, an engineer of ecosystems, reappeared, using the dense new growth of willows for both food and construction materials. Colonies built new dams, creating ponds that enhanced stream habitats for birds, fish, grizzlies and other bears as well as promoting the growth of more willows and spring vegetation.

But wolves were only one piece of a larger picture, argue Dr. Hobbs and other skeptics of a full-blown trophic cascade at Yellowstone. Grizzly bears and humans played a role, too. For eight years after wolves re-entered the park, hunters killed more elk than the wolves did.

“The other members of the predator guild increased, and human harvest outside of the park has been clearly shown to be responsible for the decline in elk numbers the first 10 years after the wolves were introduced,” Dr. Hobbs said.

The changes attributed to the presence of stalking wolves, some research showed, weren’t only the result of fewer elk, but of a change in elk behavior called “the ecology of fear.” Scientists suggested that the big ungulates could no longer safely hang out along river or stream banks and eat everything in sight. They became extremely cautious, hiding in places where they could be vigilant. That allowed a return of vegetation in those places.

Dr. Hobbs and others contend that subsequent research has not borne that theory out.

Another overlooked factor is that around the same time wolves were returning, 129 beavers were reintroduced by the U.S. Forest Service onto streams north of the park. So it wasn’t just wolf predation on elk and the subsequent return of wolves that enabled an increase in beavers, experts say.

Some researchers say the so-called trophic cascade and rebirth of streamside ecosystems would have been far more robust if it weren’t for the park’s growing bison herd. The bison population is at an all-time high — the most recent count last summer found nearly 5,000 animals. Much larger than elk, bison are less likely to be vulnerable to wolves, which numbered 124 this winter.

The park’s bison, some researchers say, are overgrazing and otherwise seriously damaging the ecosystems — allowing the spread of invasive species and trampling and destroying native plants.

The heavily grazed landscape is why, critics say, some 4,000 bison, also a record, left Yellowstone for Montana in the winter of 2023-24, when an unusually heavy snow buried forage. Because some bison harbor a disease, called brucellosis, that state officials say could infect cattle, they are not welcome outside the park’s borders. (There are no documented cases of transmission between bison and cattle.)

Montana officials say killing animals that may carry disease as they leave the park is the only way to stem the flow. During a hunt that began in the winter of 2023, Native Americans from tribes around the region took part. All told, hunters killed about 1,085 bison; 88 more were shipped to slaughter and 282 were transferred to tribes. This year, just a few animals have left the park.

The Park Service is expected to release a bison management plan in the coming months. It is considering three options: to allow for 3,500 to 5,000 animals, 3,500 to 6,000, or a more natural population that could reach 7,000.

Richard Keigley, who was a research ecologist for the federal Geological Survey in the 1990s, has become an outspoken critic of the park’s bison management.

“They have created this juggernaut where we’ve got thousands of bison and the public believes this is the way things always were,” he said. “The bison that are there now have destroyed and degraded their primary ranges. People have to realize there’s something wrong in Yellowstone.”

Dr. Keigley said the bison population in the park fluctuated in the early years of the park, with about 229 animals in 1967. It has grown steadily since and peaked last year at 5,900.

“There is a hyperabundant bison population in our first national park,” said Robert Beschta, a professor emeritus of forest ecosystems at Oregon State University who has studied Yellowstone riparian areas for 20 years. He pointed to deteriorating conditions along the Lamar River from bison overgrazing.

“They are hammering it,” Mr. Beschta said. “The Lamar ranks right up there with the worst cattle allotments I’ve seen in the American West. Willows can’t grow. Cottonwoods can’t grow.”

A warmer and drier climate, he said, is making matters worse.

Such opinions, however, are not settled science. Some park experts believe that the presence of thousands of bison enhances park habitats because of something called the Green Wave Hypothesis.

Chris Geremia, a park biologist, is an author of a paper that makes the case that a large numbers of bison can stimulate plant growth by grazing grasses to the length of a suburban lawn. “By creating these grazing lawns bison and other herbivores — grasshoppers, elk — these lawns are sustaining more nutritious food for these animals,” he said.

Dr. Geremia contends that a tiny portion — perhaps one-tenth of one percent — of the park may be devoid of some plants. “The other 99.9 percent of those habitats exists in all different levels of willow, aspen and cottonwood,” he said.

The Greater Yellowstone Coalition, a conservation organization, favors a bison population of 4,000 to 6,000 animals. Shana Drimal, who heads the group’s bison conservation program, said that park officials needed to monitor closely changing conditions like climate, drought and bison movement to ensure the ecosystems wouldn’t become further degraded.

Several scientists propose allowing the bison to migrate to the buffer zones beyond the park’s borders, where they are naturally inclined to travel. But it remains controversial because of the threat of disease.

“The only solution is to provide suitable winter range outside the park where they should be tolerated,” said Robert Crabtree, a chief scientist for the Yellowstone Ecological Research Center, a nonprofit. “When they migrate outside the park now it’s to habitat they evolved to prefer — and instead we kill them and ship them away.”

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Poll: Election interest hits new low in tight Biden-Trump race

The share of voters who say they have high interest in the 2024 election has hit a nearly 20-year low at this point in a presidential race, according to the latest national NBC News poll , with majorities holding negative views of both President Joe Biden and former President Donald Trump.

The poll also shows Biden trimming Trump’s previous lead to just 2 points in a head-to-head contest, an improvement within the margin of error compared to the previous survey, as Biden bests Trump on the issues of abortion and uniting the country, while Trump is ahead on competency and dealing with inflation.

And it finds inflation and immigration topping the list of most important issues facing the country, as just one-third of voters give Biden credit for an improving economy.

But what also stands out in the survey is how the low voter interest and the independent candidacy of Robert F. Kennedy Jr. could scramble what has been a stable presidential contest with more than six months until Election Day. While Trump holds a 2-point edge over Biden head to head, Biden leads Trump by 2 points in a five-way ballot test including Kennedy and other third-party candidates.

“I don’t think Biden has done much as a president. And if Trump gets elected, I just feel like it’s going to be the same thing as it was before Biden got elected,” said poll respondent Devin Fletcher, 37, of Wayne, Michigan, a Democrat who said he’s still voting for Biden.

“I just don’t feel like I have a candidate that I’m excited to vote for,” Fletcher added.

Another poll respondent from New Jersey, who declined to provide her name and voted for Biden in 2020, said she wouldn’t be voting in November.

“Our candidates are horrible. I have no interest in voting for Biden. He did nothing. And I absolutely will not vote for Trump,” she said.

Democratic pollster Jeff Horwitt of Hart Research Associates, who conducted the survey with Republican pollster Bill McInturff of Public Opinion Strategies, said, “Americans don’t agree on much these days, but nothing unites the country more than voters’ desire to tune this election out.”

The poll was conducted April 12-16, during yet another turbulent time in American politics, including the  beginning of Trump’s criminal trial  in New York and new attacks and heightened tensions  in the Middle East.

According to the poll, 64% of registered voters say they have high levels of interest in November’s election — registering either a “9” or a 10” on a 10-point scale of interest.

That’s lower than what the NBC News poll showed at this time in the 2008 (74%), 2012 (67%), 2016 (69%) and 2020 (77%) presidential contests.

The question dates to the 2008 election cycle. The lowest level of high election interest in the poll during a presidential cycle was in March 2012 — at 59%. But it quickly ticked up in the next survey.

This election cycle, high interest has been both low and relatively flat for months, according to the poll.

McInturff, the Republican pollster, says the high level of interest in the poll has “always been a signal for the level of turnout” for a presidential contest.

“It makes it very hard for us to predict turnout this far in advance of November, but every signal is turnout will be a lower percentage of eligible voters than in 2020,” he said.

By party, the current poll shows 70% of self-identified Republicans saying they have high interest in the coming election, compared with 65% of Democrats who say so.

Independents are at 48%, while only 36% of voters ages 18 to 34 rate themselves as highly interested in the election.

“They just aren’t low interest,” McInturff said of young voters. “They are off-the-charts low.”

NBC News poll: Frequently asked questions

Professional pollsters at a Democratic polling firm (Hart Research Associates) and a Republican firm (Public Opinion Strategies) have worked together to conduct and operate this poll since 1989. (Coldwater Corporation served as the Republican firm from 1989-2004.)

The polling firms employ a call center, where live interviewers speak by cell phone and telephone with a cross section of (usually) 1,000 respondents. The respondents are randomly selected from national lists of households and cell numbers. Respondents are asked for by name, starting with the youngest male adult or female adult in the household.

One of the common questions that critics ask of polls is, "I wasn't interviewed, so why should this poll matter?” By interviewing 1,000 respondents and applying minimal weights based on race, ethnicity, age, gender, education and the 2020 presidential vote, the poll achieves a representative sample of the nation at large – with a margin of error at a 95% confidence level.

NBC News editors and reporters — along with the pollsters at Hart Research and Public Opinion Strategies — all work to formulate the questions to try to capture the news and current events NBC is trying to gauge. Both Hart Research and Public Opinion Strategies work to ensure the language and placement of the questions are as neutral as possible.

Biden trims Trump’s lead

The poll also finds Trump narrowly ahead of Biden by 2 points among registered voters in a head-to-head matchup, 46% to 44% — down from Trump’s 5-point advantage in January, 47% to 42%.

The movement, which is within the poll’s margin of error of plus or minus 3.1 percentage points, is consistent with what other national polls have found in the Trump-Biden race.

Trump’s biggest advantages are among men (53% to 37%), white voters (54% to 37%) and white voters without college degrees (65% to 25%).

Biden’s top advantages are among Black voters (71% to 13%), women (50% to 39%) and Latinos (49% to 39%).

The poll shows the two candidates are essentially tied among independents (Biden 36%, Trump 34%) and voters ages 18-34 (Biden 44%, Trump 43%). One of the big polling mysteries this cycle is whether young voters have defected from Biden (as the NBC News poll has found over multiple surveys) or whether Democrats have maintained their advantage among that demographic.

When the ballot is expanded to five named candidates, Biden takes a 2-point lead over Trump: Biden 39%, Trump 37%, Kennedy 13%, Jill Stein 3% and Cornel West 2%.

Again, the result between Biden and Trump is within the poll’s margin of error.

Notably, the poll finds a greater share of Trump voters from the head-to-head matchup supporting Kennedy in the expanded ballot compared with Biden voters, different from the results of some other surveys.

(Read more here about how Kennedy's candidacy affe cts the 2024 race, according to the poll.)

The president’s approval rating ticks up to 42%

In addition, the poll found 42% of registered voters approving of Biden’s overall job performance — up 5 points since January’s NBC News poll, which found Biden at the lowest point of his presidency.

Fifty-six percent of voters say they disapprove of the job he has done, which is down 4 points from January.

Biden’s gains over the past few months have come from key parts of his 2020   base, especially among Democrats and Black voters. But he continues to hold low ratings among Latinos (40% approval), young voters (37%) and independents (36%).

“The data across this poll show that Joe Biden has begun to gain some ground in rebuilding his coalition from 2020,” said Horwitt, the Democratic pollster. “The question is whether he can build upon this momentum and make inroads with the groups of voters that still are holding back support.”

But McInturff, the GOP pollster, points out that the only recent presidents   who lost re-election had approval ratings higher than Biden’s at this point in the election cycle: George H.W. Bush (43%) and Trump (46%).

“President Biden has a precarious hold on the presidency and is in a difficult position as it relates to his re-election,” McInturff said.

On the issues, 39% of voters say they approve of Biden’s handling of the economy (up from 36% in January), 28% approve of his handling of border security and immigration, and just 27% approve of his handling of the Israel-Hamas war (down from 29% in January).

Voters gave Biden his highest issue rating on   addressing student loan debt, with 44% approving of his handling of the issue, compared with 51% who say they disapprove.

Biden leads on abortion and unity; Trump leads on inflation and competency

The NBC News poll asked voters to determine which candidate they thought is better on several different issues and attributes.

Biden holds a 15-point advantage over Trump on dealing with the issue of abortion, and he is ahead by 9 points on having the ability to bring the country together — though that is down from his 24-point advantage on that issue in the September 2020 NBC News poll.

Trump, meanwhile, leads in having the ability to handle a crisis (by 4 points), in having a strong record of accomplishments (by 7 points), in being competent and effective (by 11 points), in having the necessary mental and physical health to be president (by 19 points) and in dealing with inflation and the cost of living (by 22 points).

Inflation, immigration are the top 2024 issues

Inflation and the cost of living top the list of issues in the poll, with 23% of voters saying they’re the most important issue facing the country.

The other top voters is   immigration and the situation at the border (22%) — followed by   threats to democracy (16%), jobs and the economy (11%), abortion (6%) and health care (6%).

In addition, 63% of voters say their families’ incomes are falling behind the cost of living — essentially unchanged from what the poll found in 2022 and 2023.

And 53% of voters say the country’s economy hasn’t improved, compared with 33% who say that it has improved and that Biden deserves some credit for it and another 8% who agree the economy has improved but don’t give him credit for it.

“If I look back to when I had all three of my children in the house — we only have one child left in the house now, and we’re spending more now than what we did when we had a family of five,” said poll respondent Art Fales, 45, of Florida, who says he’s most likely voting for Trump.

But on a separate question — is there an issue so important that you’ll vote for or against a candidate solely on that basis? — the top responses are protecting democracy and constitutional rights (28%), immigration and border security (20%) and abortion (19%).

Indeed, 30% of Democrats, 29% of young voters and 27% of women say they are single-issue voters on abortion.

“I have a right to what I do with my body,” said poll respondent Amanda Willis, 28, of Louisiana, who said she’s voting for Biden. “And I don’t believe that other people should have the ability to determine that.”

Other poll findings

  • With Trump’s first criminal trial underway, 50% of voters say he is being held to the same standard as anyone else when it comes to his multiple legal challenges. That compares with 43% who believe he’s being unfairly targeted in the trials. 
  • 52% of voters have unfavorable views of Biden, while 53% share the same views of Trump.
  • And Democrats and Republicans are essentially tied in congressional preference, with 47% of voters preferring Republicans to control Congress and 46% wanting Democrats in charge. Republicans held a 4-point lead on this question in January.

The NBC News poll of 1,000 registered voters nationwide — 891 contacted via cellphone — was conducted April 12-16, and it has an overall margin of error of plus or minus 3.1 percentage points.

in research question

Mark Murray is a senior political editor at NBC News.

in research question

Sarah Dean is a 2024 NBC News campaign embed.

ScienceDaily

Synthetic droplets cause a stir in the primordial soup

A synthetic droplet may give researchers clues on how simplest forms of life on the planet could navigate their surroundings.

Our bodies are made up of trillions of different cells, each fulfilling their own unique function to keep us alive.

How do cells move around inside these extremely complicated systems? How do they know where to go? And how did they get so complicated to begin with? Simple yet profound questions like these are at the heart of curiosity-driven basic research, which focuses on the fundamental principles of natural phenomena. An important example is the process by which cells or organisms move in response to chemical signals in their environment, also known as chemotaxis.

A constellation of researchers from three different research units at the Okinawa Institute of Science and Technology (OIST) came together to answer basic questions about chemotaxis by creating synthetic droplets to mimic the phenomena in the lab, allowing them to precisely isolate, control and study the phenomena. Their results, which helps answering questions about the principles of movement in simple biological systems, have now been published in the Journal of The American Chemical Society . "We have shown that it is possible to make protein droplets migrate through simple chemical interactions," says Alessandro Bevilacqua, PhD student in the Protein Engineering and Evolution Unit and co-first author on the paper. Professor Paola Laurino, head of the unit and leading author, adds that they "have created a simple system that mimic a very complex phenomenon, and which can be modulated through enzymatic activity."

Tensions on the surface

While the process of creating droplets might not sound like the most complicated task, mimicking biological processes as close to reality as possible while keeping accurate control over all the variables certainly is. The synthetic, membrane-less droplets contain a very high concentration of the bovine protein BSA to mimic the crowded conditions inside cells, as well as urease, an enzyme that catalyzes the breakdown of urea into ammonia.

Ammonia is basic, meaning it has a high pH-value. As the enzyme gradually catalyzes the production of ammonia, it diffuses into the solution, creating a 'halo' of higher pH around the droplet, which in turn enables droplets to detect other droplets and migrate towards each other.

The researchers found that the key to understanding the chemotaxis of the droplets is the pH-gradient, as it facilitates the Marangoni effect, which describes how molecules flow from areas of high surface tension to low. Surface tension is the measure of energy required to keep molecules at the surface together, like glue. When pH increases, this glue weakens, causing molecules to spread out and lowering surface tension, which in turn makes it easier for molecules to move. You can see this by adding soap, which has a high pH, to one end of a bathtub of still water: the water will flow towards the end with soap because of the Marangoni effect.

When two synthetic droplets are close enough, their halos interact, raising the pH in the environment between them, which makes them move together. Because the surface tension is still strong on the opposite ends of the droplets, they keep their shape until the surfaces touch, and the cohesive forces within the droplets overcome the surface tension, causing them to merge. As larger droplets both produce more ammonia and have a larger surface area (which decreases surface tension), they attract droplets smaller than themselves.

Collaborating on ancient soup and future biotech

Thanks to the development of these droplets, the researchers have made headway in answering basic questions about biological movement -- and in doing so, they have gained insight into the directed movement of the earliest forms of life in the primordial soup billions of years ago, as well as a lead on creating new biologically inspired materials.

Our knowledge of life as it looked billions of years ago is fuzzy at best. A prominent hypothesis is that life originated in the oceans, as organic molecules gradually assembled and became more sophisticated in a 'primordial soup' -- and this could have been facilitated by chemotaxis through the Marangoni effect. "It would have been beneficial for droplets to have this mechanism of migration in the hypothetical origin of life scenario," as Professor Laurino puts it. This migration could have triggered the formation of primitive metabolic pathways whereby enzymes catalyze a variety of substances that ultimately produce a chemical gradient that drives the droplets together, leading to larger and more sophisticated communities.

The research also points ahead in time, providing leads on new technology. "One example is the creation of responsive materials inspired by biology," suggests Alessandro Bevilacqua. "We have shown how simple droplets can migrate thanks to a chemical gradient. A future application of this could be technologies that sense or react to chemical gradients, for example in micro-robotics or drug delivery."

The work to produce and analyze the synthetic droplets is the result of a combination of deeply integrated interdisciplinarity and the human factors undergirding scientific work. The project began during the coronavirus pandemic, when a member of the Protein Engineering and Evolution Unit was in quarantine with a member of the Complex Fluids and Flows Unit. The two began talking, and though the two units are from two disparate fields -- biochemistry and mechanics, respectively -- the project evolved in tandem. Eventually, members from the Micro/Bio/Nanofluidics Unit joined the project with sophisticated measurements of the droplets' surface tension.

The unique non-disciplinary research environment at OIST catalyzed the collaboration. As Professor Laurino puts it, "this project could never have existed if we were separated by departments. It hasn't been an easy collaboration, because we communicate our field in very different ways -- but being physically close made it significantly easier." Alessandro Bevilacqua joins in: "The coffee factor has been very important. Being able to sit down with other unit members made the process much faster and more productive." Their cooperation doesn't stop here -- rather, this paper is the beginning of a fruitful partnership between the three units. "We see a lot of synergy in our work, and we work effectively and efficiently together. I don't see a reason why we should stop," as Professor Laurino states it. It's thanks to the combined efforts of the three units that we now know more about the minute movements of life at the smallest, earliest, and possibly future scale.

  • Biotechnology and Bioengineering
  • Biotechnology
  • Biochemistry Research
  • Extreme Survival
  • Microbiology
  • Molecular Biology
  • Human biology
  • Somatic cell
  • Natural killer cell
  • Origin of life

Story Source:

Materials provided by Okinawa Institute of Science and Technology (OIST) Graduate University . Original written by Adrian Skov. Note: Content may be edited for style and length.

Journal Reference :

  • Mirco Dindo, Alessandro Bevilacqua, Giovanni Soligo, Vincenzo Calabrese, Alessandro Monti, Amy Q. Shen, Marco Edoardo Rosti, Paola Laurino. Chemotactic Interactions Drive Migration of Membraneless Active Droplets . Journal of the American Chemical Society , 2024; DOI: 10.1021/jacs.4c02823

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