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Top 10 Drug Delivery System PowerPoint Presentation Templates in 2024
Introducing our comprehensive Drug Delivery System PowerPoint presentation, designed to provide an in-depth exploration of innovative methodologies in pharmaceutical delivery. This fully editable and customizable PowerPoint template offers a seamless way to present complex concepts, making it ideal for healthcare professionals, researchers, and educators alike. The slides are meticulously crafted to cover various aspects of drug delivery systems, including targeted delivery mechanisms, nanotechnology applications, and the latest advancements in biopharmaceuticals. Use cases for this presentation are diverse; it can be utilized in academic settings to educate students on the intricacies of pharmacology, in industry conferences to showcase cutting-edge research, or in corporate meetings to discuss product development strategies. The flexibility of our PowerPoint allows users to tailor the content to their specific audience, whether it's a technical discussion with scientists or a more general overview for stakeholders. With visually engaging graphics and well-structured layouts, this presentation not only enhances understanding but also encourages collaboration and innovation in the field of drug delivery. Elevate your presentations and effectively communicate your ideas with our Drug Delivery System PowerPoint template.
Polymersomes Nanotechnology Drug Delivery Systems PPT Presentation ST AI
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- Biocompatible Polymersomes
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Drug delivery systems ppt powerpoint presentation outline cpb
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Bioadhesive Drug Delivery System PPT Outline ACP
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Innovations In Drug Delivery Systems ZK Snarks PPT Graphics ACP
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Overview Of Drug Delivery Systems ZK Snarks PPT Information ACP
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Targeted Drug Delivery System In Nanorobotics Ppt Example
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Applications In Drug Delivery Systems Polyamidoamine Dendrimer Nanotechnology Applications
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Xenobots In Drug Delivery Systems Ppt Powerpoint ST AI SS
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Novel Drug Delivery System
Publish Ferdinand Juniper Cunningham Modified over 6 years ago
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Presentation on theme: "Novel Drug Delivery System"— Presentation transcript:
HOW DO DRUGS GET INTO THE BODY?. WHY BE CONCERNED ABOUT HOW DRUGS GET INTO BODY? Bioavailability - % of dose that gets into body Bioequivalence - similarity.
Osmotic Pressure-Controlled Gastrointestinal Delivery System
1 Controlled Release Introduction and Background.
NUR HIDAYAH OMAR SITI HAJAR ABU BAKAR ALIA ZULAIKHA MOHD HANIF NUR HIDAYAH OMAR SITI HAJAR ABU BAKAR ALIA ZULAIKHA MOHD HANIF.
MODIFIED RELEASE DOSAGE FORM
Pharmaceutics 2 & 3 صيدلانيات 2&3 Unit / second semester Transdermal drug delivery system.
PHARMACOLOGY CH. 5 Pharmacokinetics. Pharmacokinetics explained… How the body handles the drugs that are administered to it, how the drugs are changed.
Pharmacokinetics Chapter 4.
PHARMACEUTICAL INDUSTRY Drug Discovery - natural sources, synthesis/modification Preclinical Studies biological properties - pharmacology, pharmacokinetics.
Mosby items and derived items © 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Chapter 2 Drug Action and Handling.
Pharmacology Department
Methods of Drug Delivery
PHARMACEUTICS- IV (PHT 414 ) Dr. Shahid Jamil SALMAN BIN ABDUL AZIZ UNIVERSITY COLLEGE OF PHARMACY L /9/2015 Factors Affecting Drug Absorption (Dosage.
1. Drug delivery is the method or process of administering pharmaceutical compound to achieve a therapeutic effect in humans or animals. Most common.
Tutorial 1 January 18, 2013.
PHARMACOKINETICS CH. 4 Part 2. GETTING IN ABSORPTION Definition – the movement of a drug from the site of administration into the fluids of the body.
DELIVERY OF PROTEINS USING BIODEGRADABLE POLYMERS Mahesh V. Chaubal Guilford Pharmaceuticals Inc. Baltimore, MD 21224
1 Controlled drug release Dr Mohammad Issa. 2 Frequency of dosing and therapeutic index Therapeutic index (TI) is described as the ratio of the maximum.
CHEE 4401 Definitions drug - any substance that affects the structure or functioning of an organism pharmaceutics - the area of study concerned with the.
Dr. Muslim Suardi, MSi., Apt. Faculty of Pharmacy University of Andalas.
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Principles of Drug Delivery
Aug 17, 2014
680 likes | 1.56k Views
Principles of Drug Delivery. Drug Delivery. Definition The appropriate administration of drugs through various routes in the body for the purpose of improving health It is highly interdisciplinary It is not a young field It has recently evolved to take into consideration
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- buccal sublingual
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Presentation Transcript
Drug Delivery • Definition • The appropriate administration of drugs through various routes in the body for the purpose of improving health • It is highly interdisciplinary • It is not a young field • It has recently evolved to take into consideration • Drug physico-chemical properties • Body effects and interactions • Improvement of drug effect • Patient comfort and well being Controlled Drug Delivery
Drug Delivery Conventional Controlled Enteral Sustained Extended Parenteral Site-specific Other Pulsatile
Advantages Patient: Convenience, not invasive, higher compliance Manufacture: well established processes, available infrastructure Disadvantages Unconscious patients cannot take dose Low solubility Low permeability Degradation by GI enzymes or flora First pass metabolism Food interactions Irregular absorption Oral Administration
Oral Administration • Traditional oral delivery systems • Tablets • Capsules • Soft gelatin capsules • Suspensions • Elixirs
Advantages By-pass First pass metabolism Rapid absorption Low enzymatic activity Disadvantages Discomfort during dissolution Probability of swallowing- lost of effect Small doses Traditional delivery system/devices Tablets Chewing gum Buccal/Sublingual
Example from Industry: Generex Biotechnology • Oral-Lyn: liquid formulation of human insulin administered to buccal mucosa by aerosolization • Drug carried in lipid micelles
Advantages By-pass first pass metabolism Useful for children Disadvantages Absorption depends on disease state Degradation by bacterial flora Uncomfortable Traditional delivery system/devices Suppository Enema Rectal
Example from Industry: Valeant Pharmaceuticals • Diastat AcuDial: diazepam rectal gel
Advantages Drug 100% bioavailable Rapid response Total control of blood concentration Maximize incorporation of degradable drugs By-pass FPM Disadvantages Invasive Trained personnel Possible toxicity due to incorrect dosing sterility Traditional delivery system/devices Injection-bolus IV bag - infusion Intravenous (IV)
Advantages Patient self-administration Slow, complete absorption By-pass FPM Disadvantages Invasive Irritation, inflammation Maximum dose volume - 2mL Subcutaneous
Advantages Patient can administer the drug himself Larger volume than subcutaneous By-pass first pass metabolism Disadvantages Invasive – patient disconfort Irritation, inflamation May require some training Intramuscular
Advantages By-pass FPM Gases are rapidly absorbed Disadvantages Solids and liquids can be absorbed if size is below 0.5um Inhalers
aerosol particle lung cell capillary cell solubilized drug molecules Glass stabilizer insulin molecules Example from Industry: Nektar Therapeutics • Pulmonary delivery of Insulin • Amorphous aerosol particles with ~1μm diameters
Advantages Local effect Ease of administration Disadvantages Low absorption for some drugs May cause allergic reactions Requirements Low dosage <10 mg/mL MW< 1,000 Transdermal
Factors Influencing the Selection of the Delivery Route • Drug physico-chemical properties • Drug molecular size (molecular weight) • Half-life • Chemical stability • Loss of biological activity in aqueous solution • Proteins • Denaturation, degradation
Example from Industry: 3M Company • Microstructured Transdermal System: MTS • Microneedle system • Drug-in-adhesive technology platform (a) 3M microneedle system and (b) histological section of microneedles in guinea pig skin
Factors Influencing the Selection of the Delivery Route • Solubility in aqueous solution (hydrophobicity/hydrophilicity) • pH • pKa - ionization • Temperature • Concentration • Crystalinity • Particle size • State of hydration
Factors Influencing the Selection of the Delivery Route • Drug biological interactions • Sensitive to FPM • Low membrane permeabiltiy • Efflux pumps (MRP, MDR) – cancer drugs • Hydrophilicity • High-density charge • Enzymatic degradation • Bacterial degradation • Half-life • Side effects • Irritation
Factors Influencing the Selection of the Delivery Route • Desired pharmacological effect • Local • topical, vaginal • Systemic • oral, buccal, IV, SC, IM, rectal, nasal • Immediate response • IV, SC, IM, nasal • Dose size • Drug molecular size
Manufacture of Classical Oral Delivery Systems • Formulation – combination of active ingredients with the appropriate excipients • Excipients – inactive ingredients employed for the purpose of dilution, protection, stability, controlled release, taste, fillers, coloring, disintegration, etc
Manufacture Process for Tablets and Capsules Blending Wet Granulation Dry Milling Compression Coating Labeling Packing
Pharmacokinetics and Pharmacodynamics Pharmacokinetics Pharmacodynamics • Design • of dosage regimen • Where? • How much? • How often? • How long? Effects Plasma refers to the clear supernatant fluid that results from blood after the cellular components have been removed Plasma Concentration
Toxicity Plasma concentration (mg/mL) Therapeutic window No therapeutic effect Time (min) Plasma Concentration
Unsuccessful therapy Plasma concentration (mg/mL) Successful therapy Time (min)
Magnitude of Drug Response • Depends upon concentration achieved at the site of action • Dosage • Extent of absorption • Distribution to the site • Rate/extent of elimination
From the Site of Delivery to Elimination…steps in drug delivery, absorption, distribution and elimination • Drug Delivery • Selection of drug delivery route • Knowledge of physicochemical properties • Design of dosing regimen • Absorption • Knowledge of PK and PD • First pass effect • MDR or MRP
From the Site of Delivery to Elimination…steps in drug delivery, absorption, distribution and elimination • Distribution • Drugs must reach the site of action • Tissue • Plasma • Elimination • Metabolism • Liver, kidneys, cells • Excretion • Kidneys • Feces Depends upon drug binding capabilities
Gastrointestinal Tract Oral Administration Circulatory System Intravenous Injection Excretion Intramuscular Injection Metabolic Sites Tissues Subcutaneous Injection
Absorption of drugs could vary within different administration routes • 500 mg dose given • intramuscularly • orally **to the same subject on separate occasions • Biological barriers greatly affect the extent of drug absorption
Absorption of drugs could vary within the same administration route
Important Concepts • Volume of distribution • apparent volume into which a drug distributes in the body at equilibrium • direct measure of the extent of distribution • V = amount of drug in the body/Plasma drug concentration
Mathematical Modeling of Drug Disposition • Single compartment • Single compartment with absorption • Two compartments • Two compartments with absorption • Physiological Models
C/C0 absorption C, Vd elimination k, C t Single Compartment Model • Assumptions: • Body one compartment characterized by a volume of distribution (Vd) • Drug is confined to the plasma (small V)
M/D0 M/D0 t t One-Compartment Model with Absorption • Low absorption occurs • Absorption is the rate-limiting step • Slow absorption may represent drug entry through GI tract or leakage into circulation after SC injection • Drugs require multiple doses to maintain drug concentration within therapeutic window
C/C0 C/C0 Compartment 1 Compartment 1 Compartment 2 Compartment 2 t t • Concentration after ingestion Concentration with slow absorption Two-Compartment Model k1, C1 C1, V1 • Drug rapidly injected • Drug distributed instantaneously throughout one compartment and slowly throughout second compartment • Describes drug concentration in plasma injected IV k12 k21 k2, C2 C2, V2
Physiological Models
Determination of the Efficacy of the Delivery Route • Bioavailability (F) • Fraction of the drug that reached the systemic circulation • According to the FDA, Food, Drug, and Cosmetic Act • “The rate and extent to which an active ingredient or active moiety is absorbed from a drug product and becomes available at the site of action. For drugs that are not intended to be absorbed in the bloodstream, bioavailability may be assessed by measurements intended to reflect the rate and extent to which the active ingredient or active moiety becomes available at the site of action.”
Factors Influencing Bioavailabilty • Delivery route • The site of measurement • Type of animal employed • Physiological state of the animal/human • Disease • Anesthesia
Implications of PK and PD in Drug Delivery • The PK and PD of a drug may be affected when administered via different routes • Examples • Proteins – oral vs. intramuscular • Morphine – oral vs. intramuscular • The PK and PD of a drug delineates its therapeutic window • Degree of absorption • Degree of elimination and/or metabolism • Example • Tetracycline (infection) – given 6 to 8 hours • Digoxin (cardiac failure)– given daily
Where to Find PD and PK Information • United States Pharmacopeia • www.usp.org • It is also paper published • Provides standards, chemical properties, and protocols to perform pharmacological experiments • Federal Drug Administration – if it has already being approved • www.fda.org
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Perils of CNS drug delivery
Perils of CNS drug delivery. Howard E. Gendelman, MD Larson Professor of Medicine and Infectious Diseases Chairman, Department of Pharmacology and Experimental Neuroscience Director, Center of Neurovirology and Neurodegenerative Disorders. Points of discussion.
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Drug Formulation / Drug Delivery. Raj Suryanarayanan ( Sury ) Department of Pharmaceutics College of Pharmacy [email protected]. Faculty Research Areas. Biological Pharmaceutics (Pharmacokinetics, Pharmacodynamics, Metabolism) Elmquist, Fairbanks, Sawchuk , Zimmerman
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PHYSICOCHEMICAL PRINCIPLES OF DRUG ACTION
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Transdermal drug delivery
Transdermal drug delivery. Definition : Transdermal drug delivery system can deliver the drugs through the skin portal to systemic circulation at a predetermined rate and maintain clinically the effective concentrations over a prolonged period of time. Advantages of TDDS.
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Basic Principles of Drug Metabolism. 2. NAPLEX. Pg. 51. Phase I (functionalization) Oxidation (most important), reduction, and hydrolysis Function: introduce a polar group to make molecules more hydrophilic Method: catalyzed by hepatic CYP450 system enzymes.
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PARENTERAL DRUG DELIVERY
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Drug Delivery Market
[Research Report] The drug delivery market size is expected to grow from US$ 20,99,856.7 million in 2022 to US$ 32,54,594.2 million by 2028; it is estimated to record a CAGR of 7.7% from 2023 to 2028.
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COMMENTS
Presenting our Targeted Drug Delivery System Ppt Powerpoint Presentation Outline Show Cpb PowerPoint template design. This PowerPoint slide showcases four stages. It is useful to share insightful information on Targeted Drug Delivery System This PPT slide can be easily accessed in standard screen 4.3 and widescreen 16.9 aspect ratios.
Drug Delivery Drug delivery is the method or process of administering pharmaceutical compound to achieve a therapeutic effect in humans or animals. Most common methods of delivery include the preferred non-invasive peroral (through the mouth), topical (skin), transmucosal (nasal, buccal, sublingual, vaginal, ocular and rectal) and inhalation routes.
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Dr. Machluf Marcelle The Faculty of Biotechnology and Food Engineering. Prof. Pollack Shimon The Department of Immunology Bruce Rappaport Medical School. Proteo-liposomes as a new drug delivery system to HIV reservoir cells and free virion entrapment. Bronshtein Tomer ★ ★ ★ ★ ★
Smart Drug Delivery Systems. The presentation captures the IP activity along with the key players in the smart drug delivery system industry. The presentation also captures the distribution of patents across the world. The IP information, competitor activity and the technology classification are also included.
Novel Drug Delivery System "Novel Drug delivery System (NDDS) refers to the approaches, formulations, technologies, and systems for transporting a pharmaceutical compound in the body as needed to safely achieve its desired therapeutic effects.It may involve scientific site-targeting within the body, or it might involve facilitating systemic pharmacokinetics; in any case, it is typically ...
NOVEL DRUG DELIVERY SYSTEMS. Aniket Saigal Class XII, TSRS Aravali, Gurugram. NOVEL DRUG DELIVERY SYSTEMS. From time immemorial it has been the endeavour of the physicians to provide patients with the best possible forms of medicines so that recovery from disease is faster, and complete.
Check out this medical PowerPoint presentation titled "Fundamentals of Drug Delivery Systems".<break><break>This medical PowerPoint presentation is about drug delivery systems, technologies that are used to administer therapeutic agents such as drugs, genes, and proteins to the human body. The aim of drug delivery systems is to increase the efficacy and safety of the drug therapy while ...
Drug delivery systems Dr: AdilAbdelrahman Mahmoud. Objectives of the course • At the conclusion of this chapter the student should be able to: • 1. Distinguish between conventional dosage forms and advanced drug delivery systems. • 2. Appreciate the need for drug delivery systems and recognize their benefits in enhancing drug bioavailability and reducing adverse effects.
Anatomy and physiology of the eye makes it a highly protected organ. Designing an effective therapy for ocular diseases, especially for the posterior segment, has been considered as aformidable task. Limitations of conventional route of administration have challenged scientists to find alternative mode of administration like periocular routes. Targeted drug delivery hasgenerated a great deal ...
Transdermal drug delivery. Definition : Transdermal drug delivery system can deliver the drugs through the skin portal to systemic circulation at a predetermined rate and maintain clinically the effective concentrations over a prolonged period of time. Advantages of TDDS. 5.13k views • 29 slides