thyroid cancer research articles

Find the latest news and updates on thyroid cancer research, including clinical trials, genomic tests, and drug approvals. Learn about the causes, diagnosis, and treatment of thyroid cancer from NCI experts.

Five-year relative survival is approximately 98.5%. This review summarizes current evidence regarding pathophysiology, diagnosis, and management of early-stage and advanced thyroid cancer. Observations Papillary thyroid cancer accounts for approximately 84% of all thyroid cancers. Papillary, follicular (≈4%), and oncocytic (≈2%) forms arise ...

The past 5-10 years have brought in a new era in the care of patients with thyroid cancer, with the introduction of transformative diagnostic and management options. Several international ultrasound-based thyroid nodule risk stratification systems have been developed with the goal of reducing unnecessary biopsies. Less invasive alternatives to surgery for low-risk thyroid cancer, such as ...

Thyroid cancer is the most common endocrine malignancy with almost one million people living with thyroid cancer in the United States. Although early-stage well-differentiated thyroid cancers account for the majority of thyroid cancers on diagnosis and have excellent survival rates, the incidence of advanced-stage disease has increased over the past few years and confers poorer prognosis ...

Micrograph of medullary thyroid carcinoma. NCI-funded researchers are working to advance our understanding of how to treat thyroid cancer. The four main types of thyroid cancer are papillary , follicular , medullary , and anaplastic thyroid cancer. Most thyroid cancers are found at an early stage and can be treated successfully.

From 1975 through 2009, the incidence of thyroid cancer tripled in the United States, ... Cancer Genome Atlas Research Network. Integrated genomic characterization of papillary thyroid carcinoma.

We extracted age-standardised incidence and mortality rates per 100 000 person-years of thyroid cancer as defined by the International Classification of Diseases for Oncology 10th Revision (code C73), for 185 countries or territories by sex and 18 age groups (ie, 0-4, 5-9, …, 80-84, and ≥85 years) from the GLOBOCAN database.

Genomic data from patients with thyroid cancer, combined with information on mutation-specific mechanisms from experimental models, is transforming the thyroid cancer research field. This Review ...

This Comment article provides a behind-the-scenes perspective and update of our 2016 Review, which discussed possible factors contributing to thyroid cancer incidence trends worldwide. We also ...

Herein, the authors summarize the progress made to date in molecular medicine for the different histotypes of thyroid cancer, and highlight the questions for future research focused on treatment ...

The incidence of thyroid cancer has increased significantly in the United States and worldwide, driven predominantly by the increased annual incidence of DTC. ... Promising areas of research include the examination of the efficacy of novel therapies, including RET inhibitors such as LOXO-282 and BLU-667, as well as BOS172738 , ...

Thyroid cancer is a malignancy of the thyroid parenchymal cells. The thyroid parenchyma consists of two major cell types, the thyroid follicular cells that give rise to differentiated thyroid cancer(DTC) and the parafollicular or C-cells that give rise to medullary thyroid carcinoma (MTC). DTC comprises papillary thyroid cancer(PTC), follicular thyroid cancer(FTC), and Hurthle cell cancer ...

Guidelines from multiple societies across the world reflect these changes, which focus on taking a more individualized approach to clinical management. In this review, we discuss the current more personalized approach to patients with follicular cell-derived thyroid cancer and point toward areas of future research still needed in the field.

The International Journal of Cancer is a cancer journal from the Union for International Cancer Control covering experimental and clinical cancer research. Abstract Over the past several decades, the approach to the diagnosis and management of patients with follicular cell-derived thyroid cancer has evolved based on improved classification of ...

Primary leiomyosarcoma of the thyroid with concurrent papillary thyroid cancer: a rare case report and a review of literature. Leiomyosarcoma (LMS) is a soft tissue malignant tumor that has a predilection to the abdominopelvic and limb smooth muscles. LMS of the thyroid is exceptionally rare. Papillary thyroid cancer (PTC) is the most...

Thyroid carcinoma or thyroid cancer (TC) is a malignant tumor of the thyroid gland. It is the most common malignancy of the endocrine (hormonal) system, but is very rare, accounting for about 1% of all malignant tumors, however, it has been increasing in frequency in recent years. The latest Global Cancer Observatory survey from 2020 reports ...

The incidence of thyroid cancer has risen dramatically in the United States over the past four decades, with similar patterns observed internationally. Thyroid cancer currently ranks as the 13th most common cancer diagnosis overall and the 6th most common among women. Because the greatest increases in incidence have been observed for small and localized tumors having the highest rate of ...

Seminar. The past 5-10 years have brought in a new era in the care of patients with thyroid cancer, with the introduction of transformative diagnostic and management options. Several international ultrasound-based thyroid nodule risk stratification systems have been developed with the goal of reducing unnecessary biopsies.

This Comment article provides a behind-the-scenes perspective and update of our 2016 Review, which discussed possible factors contributing to thyroid cancer incidence trends worldwide.

Anaplastic thyroid cancer (ATC) is undoubtedly the thyroid cancer histotype with the poorest prognosis. The conventional treatment includes surgery, radiotherapy, and conventional chemotherapy. Surgery should be as complete as possible, securing the airway and ensuring access for nutritional support; the current standard of care of radiotherapy is the intensity-modulated radiation therapy ...

Cancer is an international interdisciplinary journal publishing articles on the latest clinical cancer research findings, spanning the breadth of oncology disciplines. Abstract Background Infiltrative follicular variant of papillary thyroid carcinoma (IFVPTC) exhibits nuclear characteristics typical of papillary thyroid carcinoma (PTC) but ...

Research Article. Open Access. ... Here, we aimed to screen the potential survival-related DNA repair-related genes in thyroid cancer (TC). TCGA datasets were utilized to analyze the differentially expressed DNA repair-related genes between TC and nontumor tissues. The K-M approach and univariate analysis were employed to screen survival ...

PATIENTS: Differentiated thyroid cancer, which includes papillary and follicular cancers, represents approximately 90% of all cases of thyroid cancer. In their article in this issue of American Health & Drug Benefits, Nguyen and colleagues report the lifetime risk for thyroid cancer as 1.1% and the 5-year survival rate having risen to 97.8% ...

Kinase inhibitors: A class of targeted drugs known as kinase inhibitors may help treat thyroid cancer cells with mutations in certain genes, such as BRAF and RET/PTC. Many of these drugs also affect tumor blood vessel growth. In many papillary thyroid cancers, the cells have changes in the BRAF gene, which helps them grow.

Read the latest Research articles in Thyroid cancer from Nature Reviews Endocrinology ... A landmark article by The Cancer Genome Atlas Research network describes the genetic landscape of ...

For disease-specific survival, the survival tree indicated 3 prognostic groups on the basis of age, lung metastases, and tumor size. The best prognostic group (5-year disease-specific survival ...

Due to disease complexity, cancer research is a multidisciplinary field that spans basic, translational, and clinical research. Advancements depend on an increased understanding of the tumor cell environment and cancer biological, etiologic, clinical, and genetic heterogeneity. Insights into the causes and mechanisms of cancer development and ...

The prevalence of thyroid nodules increases with age, is higher in female individuals and varies by country as well as by the detection method (palpation, ultrasonography or autopsy) 10,11.A 2022 ...