Meta-analysis would be used for the following purposes: To establish statistical significance with studies that have conflicting results. To develop a more correct estimate of effect magnitude. To provide a more complex analysis of harms, safety data, and benefits. To examine subgroups with individual numbers that are not statistically significant.
How to conduct a meta-analysis in eight steps: a practical guide
The first step in the coding process is the design of the coding sheet. A universal template does not exist because the design of the coding sheet depends on the methods used, the respective software, and the complexity of the research design. For univariate meta-analysis or meta-regression, data are typically coded in wide format.
Meta-Analytic Methodology for Basic Research: A Practical Guide
The goal of this study is to present a brief theoretical foundation, computational resources and workflow outline along with a working example for performing systematic or rapid reviews of basic research followed by meta-analysis. Conventional meta-analytic techniques are extended to accommodate methods and practices found in basic research.
Introduction to systematic review and meta-analysis
A systematic review collects all possible studies related to a given topic and design, and reviews and analyzes their results [ 1 ]. During the systematic review process, the quality of studies is evaluated, and a statistical meta-analysis of the study results is conducted on the basis of their quality. A meta-analysis is a valid, objective ...
PDF How to conduct a meta-analysis in eight steps: a practical guide
2 Eight steps in conducting a meta‑analysis 2.1 Step 1: dening the research question The rst step in conducting a meta-analysis, as with any other empirical study, is the denition of the research question. Most importantly, the research question deter-mines the realm of constructs to be considered or the type of interventions whose
A brief introduction of meta‐analyses in clinical practice and research
Although the studies included in a meta‐analysis have the same research hypothesis, there is still the potential for several areas of heterogeneity. 86 Heterogeneity may exist in various parts of the studies' design and conduct, including participant selection, interventions/exposures or outcomes studied, data collection, data analyses and ...
A step by step guide for conducting a systematic review and meta
In the field of tropical medicine and health, a well-conducted systematic review and meta-analysis (SR/MA) is considered a feasible solution for keeping clinicians abreast of current evidence-based medicine. ... Design, Evaluation, Research type. SR/MAs: Systematic review and meta-analyses. References. Bello A, Wiebe N, Garg A, Tonelli M ...
Meta-analysis and the science of research synthesis
Meta-analysis is the quantitative, scientific synthesis of research results. Since the term and modern approaches to research synthesis were first introduced in the 1970s, meta-analysis has had a ...
Chapter 10: Analysing data and undertaking meta-analyses
Many judgements are required in the process of preparing a meta-analysis. Sensitivity analyses should be used to examine whether overall findings are robust to potentially influential decisions. Cite this chapter as: Deeks JJ, Higgins JPT, Altman DG (editors). Chapter 10: Analysing data and undertaking meta-analyses.
Methodological Guidance Paper: High-Quality Meta-Analysis in a
The term meta-analysis was first used by Gene Glass (1976) in his presidential address at the AERA (American Educational Research Association) annual meeting, though Pearson (1904) used methods to combine results from studies on the relationship between enteric fever and mortality in 1904. The 1980s was a period of rapid development of statistical methods (Cooper & Hedges, 2009) leading to the ...
A Guide to Conducting a Meta-Analysis
Meta-analysis is widely accepted as the preferred method to synthesize research findings in various disciplines. This paper provides an introduction to when and how to conduct a meta-analysis. Several practical questions, such as advantages of meta-analysis over conventional narrative review and the number of studies required for a meta-analysis, are addressed. Common meta-analytic models are ...
Meta-Analysis
Definition. "A meta-analysis is a formal, epidemiological, quantitative study design that uses statistical methods to generalise the findings of the selected independent studies. Meta-analysis and systematic review are the two most authentic strategies in research. When researchers start looking for the best available evidence concerning ...
What is meta-analysis?
What is meta-analysis? Meta-analysis is a research process used to systematically synthesise or merge the findings of single, independent studies, using statistical methods to calculate an overall or 'absolute' effect.2 Meta-analysis does not simply pool data from smaller studies to achieve a larger sample size. Analysts use well recognised, systematic methods to account for differences in ...
A Guide to Conducting a Meta-Analysis
Abstract. Meta-analysis is widely accepted as the preferred method to synthesize research findings in various disciplines. This paper provides an introduction to when and how to conduct a meta-analysis. Several practical questions, such as advantages of meta-analysis over conventional narrative review and the number of studies required for a ...
Study designs: Part 8
Keywords: Research design, review, systematic, meta-analysis In a previous article in this series, we looked at systematic reviews - their methods, uses, and limitations.[ 1 ] Systematic reviews are frequently followed by the use of a mathematical or statistical technique to pool the data from individual studies included in the review, to ...
How to conduct a qualitative meta-analysis: Tailoring methods to
Rather than arguing for the adoption of any single meta-method, this paper advocates for considering how procedures can best be selected and adapted to enhance a meta-study's methodological integrity. Method: Through the paper, recommendations are provided to help researchers identify procedures that can best serve their studies' specific goals.
Study designs: Part 8
Abstract. A systematic review is a form of secondary research that answers a clearly formulated research question using systematic and defined methods to identify, collect, appraise, and summarize all the primary research evidence on that topic. In this article, we look at meta-analysis - the statistical technique of combining the results of ...
Non-pharmacological interventions to prevent PICS in critically ill
Study selection. This study will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses criteria, and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses flow diagram [], shown in Fig. 2, demonstrates the proposed research selection methods.The discovered studies will be imported into the online Rayyan literature management tool (https://rayyan.qcri ...
Lottery Evidence on the Impact of Preschool in the United States: A
This paper reviews research on the design and effectiveness of preschools in the United States. Three randomized controlled trials that enrolled roughly 350 total children in demonstration studies during the 1960s and 1970s shape much of the current discussion of preschool.
Efficacy of psilocybin for treating symptoms of depression: systematic
Objective To determine the efficacy of psilocybin as an antidepressant compared with placebo or non-psychoactive drugs. Design Systematic review and meta-analysis. Data sources Five electronic databases of published literature (Cochrane Central Register of Controlled Trials, Medline, Embase, Science Citation Index and Conference Proceedings Citation Index, and PsycInfo) and four databases of ...
Design of Meta-Analysis Studies
Meta-analysis allows a quantitative summary of overall effects, any association between various study design factors and observed outcome, an assessment of the likelihood of publication bias and recommendations for sample size calculations for future experiments.
Meta-Analysis: A Quantitative Approach to Research Integration
Additional statistical research should include study of the impact of outliers on the meta-analysis and the potential insight that they could provide into a research question . Statistically valid methods to combine data across studies of varying quality and design, including data from case-control studies, will enable metaanalysts to maximize ...
The impact of augmented reality learning experiences based on the
This meta-analysis examined the impact of augmented reality learning experiences on the motivational design model to obtain findings related to student attention, material relevance, increased ...
Meta-analysis: Key features, potentials and misunderstandings
A meta-analysis consists of a systematic approach to combine different studies in one design. Preferably, a protocol is written and published spelling out the research question, eligibility criteria, risk of bias assessment, and statistical approach. Included studies are likely to display some diversity regarding populations, calendar period ...
Serum urate levels and neurodegenerative outcomes: a prospective cohort
A meta-analysis of 21 case-control studies and 3 cohort studies indicated a potential inverse association between serum uric acid levels and Alzheimer's disease (AD) risk . Another systematic review involving 23 studies (5,575 participants) reported low serum uric acid levels as a potential risk factor for both AD and PD [ 32 ].
Cancers
All original research of any experimental design reporting clinical and oncological outcomes of surgical treatment for endometrial cancer was included. Study selection was restricted to English-language peer-reviewed journal articles published 1 January 1995-31 December 2021. A Bayesian network meta-analysis was conducted.
Meta-Analysis 101: What You Want to Know in the Era of Comparative
"Comparative effectiveness" research is the best tool available today for making decisions about which new medication, medical device, or diagnostic test is most supported by the evidence.1 The purpose of a systematic review is to synthesize the results of multiple primary studies using explicit and reproducible methods.2,3 Meta-analysis is a form of systematic review that goes one step ...
Accuracy of Cytologic vs Histologic Specimens for Assessment of
Study Design and Methods. The MEDLINE, Embase, Web of Science, and Cochrane Library databases were searched through June 1, 2021. The primary outcome was pooled sensitivity and specificity of PD-L1 testing performed on cytologic specimens compared with the reference standard of histologic specimens, analyzed at the PD-L1 expression cutoffs (tumor proportion score) ≥ 1% and ≥ 50%.
Meta-analysis in medical research
Meta-Analysis and Systematic Review. Glass first defined meta-analysis in the social science literature as "The statistical analysis of a large collection of analysis results from individual studies for the purpose of integrating the findings" 9.Meta-analysis is a quantitative, formal, epidemiological study design used to systematically assess the results of previous research to derive ...
COMMENTS
Meta-analysis would be used for the following purposes: To establish statistical significance with studies that have conflicting results. To develop a more correct estimate of effect magnitude. To provide a more complex analysis of harms, safety data, and benefits. To examine subgroups with individual numbers that are not statistically significant.
The first step in the coding process is the design of the coding sheet. A universal template does not exist because the design of the coding sheet depends on the methods used, the respective software, and the complexity of the research design. For univariate meta-analysis or meta-regression, data are typically coded in wide format.
The goal of this study is to present a brief theoretical foundation, computational resources and workflow outline along with a working example for performing systematic or rapid reviews of basic research followed by meta-analysis. Conventional meta-analytic techniques are extended to accommodate methods and practices found in basic research.
A systematic review collects all possible studies related to a given topic and design, and reviews and analyzes their results [ 1 ]. During the systematic review process, the quality of studies is evaluated, and a statistical meta-analysis of the study results is conducted on the basis of their quality. A meta-analysis is a valid, objective ...
2 Eight steps in conducting a meta‑analysis 2.1 Step 1: dening the research question The rst step in conducting a meta-analysis, as with any other empirical study, is the denition of the research question. Most importantly, the research question deter-mines the realm of constructs to be considered or the type of interventions whose
Although the studies included in a meta‐analysis have the same research hypothesis, there is still the potential for several areas of heterogeneity. 86 Heterogeneity may exist in various parts of the studies' design and conduct, including participant selection, interventions/exposures or outcomes studied, data collection, data analyses and ...
In the field of tropical medicine and health, a well-conducted systematic review and meta-analysis (SR/MA) is considered a feasible solution for keeping clinicians abreast of current evidence-based medicine. ... Design, Evaluation, Research type. SR/MAs: Systematic review and meta-analyses. References. Bello A, Wiebe N, Garg A, Tonelli M ...
Meta-analysis is the quantitative, scientific synthesis of research results. Since the term and modern approaches to research synthesis were first introduced in the 1970s, meta-analysis has had a ...
Many judgements are required in the process of preparing a meta-analysis. Sensitivity analyses should be used to examine whether overall findings are robust to potentially influential decisions. Cite this chapter as: Deeks JJ, Higgins JPT, Altman DG (editors). Chapter 10: Analysing data and undertaking meta-analyses.
The term meta-analysis was first used by Gene Glass (1976) in his presidential address at the AERA (American Educational Research Association) annual meeting, though Pearson (1904) used methods to combine results from studies on the relationship between enteric fever and mortality in 1904. The 1980s was a period of rapid development of statistical methods (Cooper & Hedges, 2009) leading to the ...
Meta-analysis is widely accepted as the preferred method to synthesize research findings in various disciplines. This paper provides an introduction to when and how to conduct a meta-analysis. Several practical questions, such as advantages of meta-analysis over conventional narrative review and the number of studies required for a meta-analysis, are addressed. Common meta-analytic models are ...
Definition. "A meta-analysis is a formal, epidemiological, quantitative study design that uses statistical methods to generalise the findings of the selected independent studies. Meta-analysis and systematic review are the two most authentic strategies in research. When researchers start looking for the best available evidence concerning ...
What is meta-analysis? Meta-analysis is a research process used to systematically synthesise or merge the findings of single, independent studies, using statistical methods to calculate an overall or 'absolute' effect.2 Meta-analysis does not simply pool data from smaller studies to achieve a larger sample size. Analysts use well recognised, systematic methods to account for differences in ...
Abstract. Meta-analysis is widely accepted as the preferred method to synthesize research findings in various disciplines. This paper provides an introduction to when and how to conduct a meta-analysis. Several practical questions, such as advantages of meta-analysis over conventional narrative review and the number of studies required for a ...
Keywords: Research design, review, systematic, meta-analysis In a previous article in this series, we looked at systematic reviews - their methods, uses, and limitations.[ 1 ] Systematic reviews are frequently followed by the use of a mathematical or statistical technique to pool the data from individual studies included in the review, to ...
Rather than arguing for the adoption of any single meta-method, this paper advocates for considering how procedures can best be selected and adapted to enhance a meta-study's methodological integrity. Method: Through the paper, recommendations are provided to help researchers identify procedures that can best serve their studies' specific goals.
Abstract. A systematic review is a form of secondary research that answers a clearly formulated research question using systematic and defined methods to identify, collect, appraise, and summarize all the primary research evidence on that topic. In this article, we look at meta-analysis - the statistical technique of combining the results of ...
Study selection. This study will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses criteria, and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses flow diagram [], shown in Fig. 2, demonstrates the proposed research selection methods.The discovered studies will be imported into the online Rayyan literature management tool (https://rayyan.qcri ...
This paper reviews research on the design and effectiveness of preschools in the United States. Three randomized controlled trials that enrolled roughly 350 total children in demonstration studies during the 1960s and 1970s shape much of the current discussion of preschool.
Objective To determine the efficacy of psilocybin as an antidepressant compared with placebo or non-psychoactive drugs. Design Systematic review and meta-analysis. Data sources Five electronic databases of published literature (Cochrane Central Register of Controlled Trials, Medline, Embase, Science Citation Index and Conference Proceedings Citation Index, and PsycInfo) and four databases of ...
Meta-analysis allows a quantitative summary of overall effects, any association between various study design factors and observed outcome, an assessment of the likelihood of publication bias and recommendations for sample size calculations for future experiments.
Additional statistical research should include study of the impact of outliers on the meta-analysis and the potential insight that they could provide into a research question . Statistically valid methods to combine data across studies of varying quality and design, including data from case-control studies, will enable metaanalysts to maximize ...
This meta-analysis examined the impact of augmented reality learning experiences on the motivational design model to obtain findings related to student attention, material relevance, increased ...
A meta-analysis consists of a systematic approach to combine different studies in one design. Preferably, a protocol is written and published spelling out the research question, eligibility criteria, risk of bias assessment, and statistical approach. Included studies are likely to display some diversity regarding populations, calendar period ...
A meta-analysis of 21 case-control studies and 3 cohort studies indicated a potential inverse association between serum uric acid levels and Alzheimer's disease (AD) risk . Another systematic review involving 23 studies (5,575 participants) reported low serum uric acid levels as a potential risk factor for both AD and PD [ 32 ].
All original research of any experimental design reporting clinical and oncological outcomes of surgical treatment for endometrial cancer was included. Study selection was restricted to English-language peer-reviewed journal articles published 1 January 1995-31 December 2021. A Bayesian network meta-analysis was conducted.
"Comparative effectiveness" research is the best tool available today for making decisions about which new medication, medical device, or diagnostic test is most supported by the evidence.1 The purpose of a systematic review is to synthesize the results of multiple primary studies using explicit and reproducible methods.2,3 Meta-analysis is a form of systematic review that goes one step ...
Study Design and Methods. The MEDLINE, Embase, Web of Science, and Cochrane Library databases were searched through June 1, 2021. The primary outcome was pooled sensitivity and specificity of PD-L1 testing performed on cytologic specimens compared with the reference standard of histologic specimens, analyzed at the PD-L1 expression cutoffs (tumor proportion score) ≥ 1% and ≥ 50%.
Meta-Analysis and Systematic Review. Glass first defined meta-analysis in the social science literature as "The statistical analysis of a large collection of analysis results from individual studies for the purpose of integrating the findings" 9.Meta-analysis is a quantitative, formal, epidemiological study design used to systematically assess the results of previous research to derive ...