research proposal in science education

Research in Science Education

Research in Science Education is an international journal publishing and promoting scholarly science education research of interest to a wide group of people. The journal examines early childhood, primary, secondary, tertiary, workplace, and informal learning as they relate to science education.

In publishing scholarly articles, RISE is looking for articulation of the principles and practices used by scholars to make valid claims about the world and their critique of such claims. Publishing such work is important as it makes these principles and practices known to the scholarly community so that they can be considered, debated, judged, and accepted, rejected or reframed. Importantly, these principles and practices must be constantly advancing in ways that allow our knowledge to advance within the field. In looking for works to publish, RISE will seek articles that advance our knowledge in science education research rather than reproducing what we already know.

Research can take many forms, quantitative, qualitative and mixed methods to name a few. RISE is interested in producing valid and trustworthy research that takes on a variety of forms and embraces new capabilities at hand, particularly around new technologies. Innovative practices and how these relate to science education will be at the forefront of our thinking in RISE.

Scholarly works of interest need to encompass the wide diversity of readership. RISE is the journal associated with the Australasian Science Education Research Association (ASERA), one of the oldest such association in the world. With ASERA’s history from a colonial western tradition, combined with its location within the highly productive and exciting Asian region, the membership of ASERA and the readership of RISE spans the globe and cultural perspectives. Hence, the scholarly works of interest published within RISE need to reflect this diversity. Additionally, they must also include a diversity of form. So, RISE will continue to review articles, editorials, book reviews, and other material deemed appropriate by the Editors.

This is a transformative journal , you may have access to funding.

• Wendy Nielsen,
• Kok-Sing Tang

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Epistemic goals and practices in biology curriculum—the philippines and japan.

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Adolescents’ Intentions to Study Science: the Role of Classroom-based Social Support, Task Values, and Self-efficacy

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Quantitative Measurement of Pre-Service Teachers’ Competency of Questioning in Scaffolding Students’ Science Learning

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Participatory Research with Museum Practitioners: A reflection on the process

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Meet the editors: wendy nielsen & kok-sing tang.

Topical Collections in RISE

Research in Science Education (RISE) is pleased to announce the introduction of topical collections to complement the ongoing publication of papers through regular and special issues. A topical collection curates papers on a given topic, theme or problem. The articles in a topical collection are published continuously over several issues, making them different from special issues that are time-bounded and assigned to one issue. Articles selected for a topical collection will appear in that collection. At the same time, they will still be published in a regular issue.

Topical collections represent a chance for editors to gather related papers on a topic of contemporary interest to the RISE readership and the wider science education research community. As such, we are interested to develop collections that both consolidate a series of thematically-related papers previously published in RISE and encourage future developments in the field. This approach allows us to connect the rich  historical conversation in RISE with contemporary issues that matter to the science education community.

With this objective, RISE has launched two inaugural topical collections on “Artificial Intelligence in Science Education” and “STEM and teaching engineering design”. Interested authors are encouraged to explore these collections and contribute new articles that build upon the ongoing work within the collection. To read more of these collections, please click here .

Authors wishing to submit their manuscripts to a topical collection can indicate their intention via the Editorial Manager submission system. All submissions to a topical collection will undergo the same peer review process and standards. The Editors-in-Chief have the final discretions to choose and include articles in any collection.

Furthermore, RISE welcomes proposals for new topical collections that meet the following criteria:

1.      Relevance to RISE: The topic should have a solid foundation within RISE, as evidenced by a substantial number of previously published articles in RISE. These articles will be curated to form the initial core of the collection.

2.      Timeliness: The topic should focus on current and urgent issues in science education, demonstrating a strong potential to draw future contributions to the collection

Researchers interested in editing a topical collection are encouraged to contact the Editors-in-Chief.

Call for Papers: Science Education: Fit for the Future

Guest Editors: 

Peta White and Russell Tytler

Please email abstracts to [email protected] before you submit the full manuscripts online .  To read more, please click here

Abstracts should be 300 – 400 words making clear the nature of the contribution to new knowledge

Call for Papers: Special Issue: Enterpreneurial STEM Education

Guest Editors

James P. Davis (Queensland University of Technology)

Lyn English (Queensland University of Technology)

Feng-Kuang Chiang (Shanghai Jiaotong University)

To read more, please click  here

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Science & Quantitative Reasoning Education

Yale undergraduate research, how to write a proposal.

The abstract should summarize your proposal. Include one sentence to introduce the problem you are investigating, why this problem is significant, the hypothesis to be tested, a brief summary of experiments that you wish to conduct and a single concluding sentence. (250 word limit)

Introduction

The introduction discusses the background and significance of the problem you are investigating. Lead the reader from the general to the specific. For example, if you want to write about the role that Brca1 mutations play in breast cancer pathogenesis, talk first about the significance of breast cancer as a disease in the US/world population, then about familial breast cancer as a small subset of breast cancers in general, then about discovery of Brca1 mutations in familial breast cancer, then Brca1’s normal functions in DNA repair, then about how Brca1 mutations result in damaged DNA and onset of familial breast cancer, etc. Definitely include figures with properly labeled text boxes (designated as Figure 1, Figure 2, etc) here to better illustrate your points and help your reader wade through unfamiliar science. (3 pages max)

Formulate a hypothesis that will be tested in your grant proposal. Remember, you are doing hypothesis-driven research so there should be a hypothesis to be tested! The hypothesis should be focused, concise and flow logically from the introduction. For example, your hypothesis could be “I hypothesize that overexpressing wild type Brca1 in Brca1 null tumor cells will prevent metastatic spread in a mouse xenograph model.” Based on your hypothesis, your Specific Aims section should be geared to support it. The hypothesis is stated in one sentence in the proposal. 

Specific Aims (listed as Specific Aim 1, Specific Aim 2)

This is where you will want to work with your mentor to craft the experimental portion of your proposal. Propose two original specific aims to test your hypothesis. Don’t propose more than two aims-you will NOT have enough time to do more. In the example presented, Specific Aim 1 might be “To determine the oncogenic potential of Brca1 null cell lines expressing wild type Brca1 cDNA”. Specific aim 2 might be “To determine the metastatic potential of Brca1 null cells that express WT Brca1”. You do not have to go into extensive technical details, just enough for the reader to understand what you propose to do. The best aims yield mechanistic insights-that is, experiments proposed address some mechanisms of biology. A less desirable aim proposes correlative experiments that does not address mechanistically how BRCA1 mutations generate cancer. It is also very important that the two aims are related but NOT interdependent. What this means is that if Aim 1 doesn’t work, Aim 2 is not automatically dead. For example, say you propose in Aim 1 to generate a BRCA1 knockout mouse model, and in Aim 2 you will take tissues from this mouse to do experiments. If knocking out BRCA1 results in early embryonic death, you will never get a mouse that yields tissues for Aim 2. You can include some of your mentor’s data here as “Preliminary data”. Remember to carefully cite all your sources. (4 pages max; 2 pages per Aim)

Potential pitfalls and alternative strategies

This is a very important part of any proposal. This is where you want to discuss the experiments you propose in Aims 1 and 2. Remember, no experiment is perfect. Are there any reasons why experiments you proposed might not work? Why? What will you do to resolve this? What are other possible strategies you might use if your experiments don’t work? If a reviewer spots these deficiencies and you don’t propose methods to correct them, your proposal will not get funded. You will want to work with your mentor to write this section. (1/2 page per Aim)

Cite all references, including unpublished data from your mentor. Last, First, (year), Title, Journal, volume, pages.

*8 page proposal limit (not including References), 1.5 spacing, 12pt Times New Roman font

• View an example of a research proposal submitted for the Yale College First-Year Summer Research Fellowship (PDF).  
• View an example of a research proposal submitted for the Yale College Dean’s Research Fellowship and the Rosenfeld Science Scholars Program (PDF) .

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The goal of a research proposal is twofold: to present and justify the need to study a research problem and to present the practical ways in which the proposed study should be conducted. The design elements and procedures for conducting research are governed by standards of the predominant discipline in which the problem resides, therefore, the guidelines for research proposals are more exacting and less formal than a general project proposal. Research proposals contain extensive literature reviews. They must provide persuasive evidence that a need exists for the proposed study. In addition to providing a rationale, a proposal describes detailed methodology for conducting the research consistent with requirements of the professional or academic field and a statement on anticipated outcomes and benefits derived from the study's completion.

Krathwohl, David R. How to Prepare a Dissertation Proposal: Suggestions for Students in Education and the Social and Behavioral Sciences . Syracuse, NY: Syracuse University Press, 2005.

How to Approach Writing a Research Proposal

Your professor may assign the task of writing a research proposal for the following reasons:

• Develop your skills in thinking about and designing a comprehensive research study;
• Learn how to conduct a comprehensive review of the literature to determine that the research problem has not been adequately addressed or has been answered ineffectively and, in so doing, become better at locating pertinent scholarship related to your topic;
• Improve your general research and writing skills;
• Practice identifying the logical steps that must be taken to accomplish one's research goals;
• Critically review, examine, and consider the use of different methods for gathering and analyzing data related to the research problem; and,
• Nurture a sense of inquisitiveness within yourself and to help see yourself as an active participant in the process of conducting scholarly research.

A proposal should contain all the key elements involved in designing a completed research study, with sufficient information that allows readers to assess the validity and usefulness of your proposed study. The only elements missing from a research proposal are the findings of the study and your analysis of those findings. Finally, an effective proposal is judged on the quality of your writing and, therefore, it is important that your proposal is coherent, clear, and compelling.

Regardless of the research problem you are investigating and the methodology you choose, all research proposals must address the following questions:

• What do you plan to accomplish? Be clear and succinct in defining the research problem and what it is you are proposing to investigate.
• Why do you want to do the research? In addition to detailing your research design, you also must conduct a thorough review of the literature and provide convincing evidence that it is a topic worthy of in-depth study. A successful research proposal must answer the "So What?" question.
• How are you going to conduct the research? Be sure that what you propose is doable. If you're having difficulty formulating a research problem to propose investigating, go here for strategies in developing a problem to study.

Common Mistakes to Avoid

• Failure to be concise . A research proposal must be focused and not be "all over the map" or diverge into unrelated tangents without a clear sense of purpose.
• Failure to cite landmark works in your literature review . Proposals should be grounded in foundational research that lays a foundation for understanding the development and scope of the the topic and its relevance.
• Failure to delimit the contextual scope of your research [e.g., time, place, people, etc.]. As with any research paper, your proposed study must inform the reader how and in what ways the study will frame the problem.
• Failure to develop a coherent and persuasive argument for the proposed research . This is critical. In many workplace settings, the research proposal is a formal document intended to argue for why a study should be funded.
• Sloppy or imprecise writing, or poor grammar . Although a research proposal does not represent a completed research study, there is still an expectation that it is well-written and follows the style and rules of good academic writing.
• Too much detail on minor issues, but not enough detail on major issues . Your proposal should focus on only a few key research questions in order to support the argument that the research needs to be conducted. Minor issues, even if valid, can be mentioned but they should not dominate the overall narrative.

Procter, Margaret. The Academic Proposal.  The Lab Report. University College Writing Centre. University of Toronto; Sanford, Keith. Information for Students: Writing a Research Proposal. Baylor University; Wong, Paul T. P. How to Write a Research Proposal. International Network on Personal Meaning. Trinity Western University; Writing Academic Proposals: Conferences, Articles, and Books. The Writing Lab and The OWL. Purdue University; Writing a Research Proposal. University Library. University of Illinois at Urbana-Champaign.

Structure and Writing Style

Beginning the Proposal Process

As with writing most college-level academic papers, research proposals are generally organized the same way throughout most social science disciplines. The text of proposals generally vary in length between ten and thirty-five pages, followed by the list of references. However, before you begin, read the assignment carefully and, if anything seems unclear, ask your professor whether there are any specific requirements for organizing and writing the proposal.

A good place to begin is to ask yourself a series of questions:

• What do I want to study?
• Why is the topic important?
• How is it significant within the subject areas covered in my class?
• What problems will it help solve?
• How does it build upon [and hopefully go beyond] research already conducted on the topic?
• What exactly should I plan to do, and can I get it done in the time available?

In general, a compelling research proposal should document your knowledge of the topic and demonstrate your enthusiasm for conducting the study. Approach it with the intention of leaving your readers feeling like, "Wow, that's an exciting idea and I can’t wait to see how it turns out!"

Most proposals should include the following sections:

I.  Introduction

In the real world of higher education, a research proposal is most often written by scholars seeking grant funding for a research project or it's the first step in getting approval to write a doctoral dissertation. Even if this is just a course assignment, treat your introduction as the initial pitch of an idea based on a thorough examination of the significance of a research problem. After reading the introduction, your readers should not only have an understanding of what you want to do, but they should also be able to gain a sense of your passion for the topic and to be excited about the study's possible outcomes. Note that most proposals do not include an abstract [summary] before the introduction.

Think about your introduction as a narrative written in two to four paragraphs that succinctly answers the following four questions :

• What is the central research problem?
• What is the topic of study related to that research problem?
• What methods should be used to analyze the research problem?
• Answer the "So What?" question by explaining why this is important research, what is its significance, and why should someone reading the proposal care about the outcomes of the proposed study?

II.  Background and Significance

This is where you explain the scope and context of your proposal and describe in detail why it's important. It can be melded into your introduction or you can create a separate section to help with the organization and narrative flow of your proposal. Approach writing this section with the thought that you can’t assume your readers will know as much about the research problem as you do. Note that this section is not an essay going over everything you have learned about the topic; instead, you must choose what is most relevant in explaining the aims of your research.

To that end, while there are no prescribed rules for establishing the significance of your proposed study, you should attempt to address some or all of the following:

• State the research problem and give a more detailed explanation about the purpose of the study than what you stated in the introduction. This is particularly important if the problem is complex or multifaceted .
• Present the rationale of your proposed study and clearly indicate why it is worth doing; be sure to answer the "So What? question [i.e., why should anyone care?].
• Describe the major issues or problems examined by your research. This can be in the form of questions to be addressed. Be sure to note how your proposed study builds on previous assumptions about the research problem.
• Explain the methods you plan to use for conducting your research. Clearly identify the key sources you intend to use and explain how they will contribute to your analysis of the topic.
• Describe the boundaries of your proposed research in order to provide a clear focus. Where appropriate, state not only what you plan to study, but what aspects of the research problem will be excluded from the study.
• If necessary, provide definitions of key concepts, theories, or terms.

III.  Literature Review

Connected to the background and significance of your study is a section of your proposal devoted to a more deliberate review and synthesis of prior studies related to the research problem under investigation . The purpose here is to place your project within the larger whole of what is currently being explored, while at the same time, demonstrating to your readers that your work is original and innovative. Think about what questions other researchers have asked, what methodological approaches they have used, and what is your understanding of their findings and, when stated, their recommendations. Also pay attention to any suggestions for further research.

Since a literature review is information dense, it is crucial that this section is intelligently structured to enable a reader to grasp the key arguments underpinning your proposed study in relation to the arguments put forth by other researchers. A good strategy is to break the literature into "conceptual categories" [themes] rather than systematically or chronologically describing groups of materials one at a time. Note that conceptual categories generally reveal themselves after you have read most of the pertinent literature on your topic so adding new categories is an on-going process of discovery as you review more studies. How do you know you've covered the key conceptual categories underlying the research literature? Generally, you can have confidence that all of the significant conceptual categories have been identified if you start to see repetition in the conclusions or recommendations that are being made.

NOTE: Do not shy away from challenging the conclusions made in prior research as a basis for supporting the need for your proposal. Assess what you believe is missing and state how previous research has failed to adequately examine the issue that your study addresses. Highlighting the problematic conclusions strengthens your proposal. For more information on writing literature reviews, GO HERE .

To help frame your proposal's review of prior research, consider the "five C’s" of writing a literature review:

• Cite , so as to keep the primary focus on the literature pertinent to your research problem.
• Compare the various arguments, theories, methodologies, and findings expressed in the literature: what do the authors agree on? Who applies similar approaches to analyzing the research problem?
• Contrast the various arguments, themes, methodologies, approaches, and controversies expressed in the literature: describe what are the major areas of disagreement, controversy, or debate among scholars?
• Critique the literature: Which arguments are more persuasive, and why? Which approaches, findings, and methodologies seem most reliable, valid, or appropriate, and why? Pay attention to the verbs you use to describe what an author says/does [e.g., asserts, demonstrates, argues, etc.].
• Connect the literature to your own area of research and investigation: how does your own work draw upon, depart from, synthesize, or add a new perspective to what has been said in the literature?

IV.  Research Design and Methods

This section must be well-written and logically organized because you are not actually doing the research, yet, your reader must have confidence that you have a plan worth pursuing . The reader will never have a study outcome from which to evaluate whether your methodological choices were the correct ones. Thus, the objective here is to convince the reader that your overall research design and proposed methods of analysis will correctly address the problem and that the methods will provide the means to effectively interpret the potential results. Your design and methods should be unmistakably tied to the specific aims of your study.

Describe the overall research design by building upon and drawing examples from your review of the literature. Consider not only methods that other researchers have used, but methods of data gathering that have not been used but perhaps could be. Be specific about the methodological approaches you plan to undertake to obtain information, the techniques you would use to analyze the data, and the tests of external validity to which you commit yourself [i.e., the trustworthiness by which you can generalize from your study to other people, places, events, and/or periods of time].

When describing the methods you will use, be sure to cover the following:

• Specify the research process you will undertake and the way you will interpret the results obtained in relation to the research problem. Don't just describe what you intend to achieve from applying the methods you choose, but state how you will spend your time while applying these methods [e.g., coding text from interviews to find statements about the need to change school curriculum; running a regression to determine if there is a relationship between campaign advertising on social media sites and election outcomes in Europe ].
• Keep in mind that the methodology is not just a list of tasks; it is a deliberate argument as to why techniques for gathering information add up to the best way to investigate the research problem. This is an important point because the mere listing of tasks to be performed does not demonstrate that, collectively, they effectively address the research problem. Be sure you clearly explain this.
• Anticipate and acknowledge any potential barriers and pitfalls in carrying out your research design and explain how you plan to address them. No method applied to research in the social and behavioral sciences is perfect, so you need to describe where you believe challenges may exist in obtaining data or accessing information. It's always better to acknowledge this than to have it brought up by your professor!

V.  Preliminary Suppositions and Implications

Just because you don't have to actually conduct the study and analyze the results, doesn't mean you can skip talking about the analytical process and potential implications . The purpose of this section is to argue how and in what ways you believe your research will refine, revise, or extend existing knowledge in the subject area under investigation. Depending on the aims and objectives of your study, describe how the anticipated results will impact future scholarly research, theory, practice, forms of interventions, or policy making. Note that such discussions may have either substantive [a potential new policy], theoretical [a potential new understanding], or methodological [a potential new way of analyzing] significance.   When thinking about the potential implications of your study, ask the following questions:

• What might the results mean in regards to challenging the theoretical framework and underlying assumptions that support the study?
• What suggestions for subsequent research could arise from the potential outcomes of the study?
• What will the results mean to practitioners in the natural settings of their workplace, organization, or community?
• Will the results influence programs, methods, and/or forms of intervention?
• How might the results contribute to the solution of social, economic, or other types of problems?
• Will the results influence policy decisions?
• In what way do individuals or groups benefit should your study be pursued?
• What will be improved or changed as a result of the proposed research?
• How will the results of the study be implemented and what innovations or transformative insights could emerge from the process of implementation?

NOTE:   This section should not delve into idle speculation, opinion, or be formulated on the basis of unclear evidence . The purpose is to reflect upon gaps or understudied areas of the current literature and describe how your proposed research contributes to a new understanding of the research problem should the study be implemented as designed.

ANOTHER NOTE : This section is also where you describe any potential limitations to your proposed study. While it is impossible to highlight all potential limitations because the study has yet to be conducted, you still must tell the reader where and in what form impediments may arise and how you plan to address them.

VI.  Conclusion

The conclusion reiterates the importance or significance of your proposal and provides a brief summary of the entire study . This section should be only one or two paragraphs long, emphasizing why the research problem is worth investigating, why your research study is unique, and how it should advance existing knowledge.

Someone reading this section should come away with an understanding of:

• Why the study should be done;
• The specific purpose of the study and the research questions it attempts to answer;
• The decision for why the research design and methods used where chosen over other options;
• The potential implications emerging from your proposed study of the research problem; and
• A sense of how your study fits within the broader scholarship about the research problem.

VII.  Citations

As with any scholarly research paper, you must cite the sources you used . In a standard research proposal, this section can take two forms, so consult with your professor about which one is preferred.

• References -- a list of only the sources you actually used in creating your proposal.
• Bibliography -- a list of everything you used in creating your proposal, along with additional citations to any key sources relevant to understanding the research problem.

In either case, this section should testify to the fact that you did enough preparatory work to ensure the project will complement and not just duplicate the efforts of other researchers. It demonstrates to the reader that you have a thorough understanding of prior research on the topic.

Most proposal formats have you start a new page and use the heading "References" or "Bibliography" centered at the top of the page. Cited works should always use a standard format that follows the writing style advised by the discipline of your course [e.g., education=APA; history=Chicago] or that is preferred by your professor. This section normally does not count towards the total page length of your research proposal.

Develop a Research Proposal: Writing the Proposal. Office of Library Information Services. Baltimore County Public Schools; Heath, M. Teresa Pereira and Caroline Tynan. “Crafting a Research Proposal.” The Marketing Review 10 (Summer 2010): 147-168; Jones, Mark. “Writing a Research Proposal.” In MasterClass in Geography Education: Transforming Teaching and Learning . Graham Butt, editor. (New York: Bloomsbury Academic, 2015), pp. 113-127; Juni, Muhamad Hanafiah. “Writing a Research Proposal.” International Journal of Public Health and Clinical Sciences 1 (September/October 2014): 229-240; Krathwohl, David R. How to Prepare a Dissertation Proposal: Suggestions for Students in Education and the Social and Behavioral Sciences . Syracuse, NY: Syracuse University Press, 2005; Procter, Margaret. The Academic Proposal. The Lab Report. University College Writing Centre. University of Toronto; Punch, Keith and Wayne McGowan. "Developing and Writing a Research Proposal." In From Postgraduate to Social Scientist: A Guide to Key Skills . Nigel Gilbert, ed. (Thousand Oaks, CA: Sage, 2006), 59-81; Wong, Paul T. P. How to Write a Research Proposal. International Network on Personal Meaning. Trinity Western University; Writing Academic Proposals: Conferences , Articles, and Books. The Writing Lab and The OWL. Purdue University; Writing a Research Proposal. University Library. University of Illinois at Urbana-Champaign.

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Research proposal - template, PhD programme in Educational Sciences for Teacher Education

Template for research proposals in connection with applications for a PhD position or admission to the PhD programme in Educational Sciences for Teacher Education at the Faculty of Education and international Studies.

All research proposals must be based on this template. Research proposals must be between 8- 10 pages including a reference list.

Title of the project

1. main objective and summary of the project.

(Present the main objective of your project and a brief summary, explaining how you intend to attain this goal. The purpose is to give the reader sufficient information to decide whether the project is of interest. You need to be clear and precise in formulating the project objectives. )

2. Background to the project

(Provide a brief account of the existing knowledge in the field the project is part of and show how the project will contribute to new knowledge. Explain how your project is relevant to the research at the Faculty of Education and International Studies – for individual researchers, research groups or projects.)

3. Theoretical framework

(Outline the theoretical foundation of the project and the reasons you have chosen this particular foundation.)

4. Research question(s) and expected findings (hypothesis)

(Describe the question(s) you want to answer through your project, and briefly outline what answer(s) you expect to find or what outcomes you might expect on the basis of previous research and theoretical background. Your research questions or hypotheses should focus and delimit the topic.)

(Give an account of the methodological foundation for your project and any research-ethical problems linked to the project. Describe the underlying data, source material and sampling approaches that will be used and how these will be collected and analyzed)

6. Proposed dissemination

(Outline your proposed outputs: your plans for communicating / publishing your doctoral project – articles, monographs, lectures, etc.)

7. Progress plan

(Outline briefly how you intend to organize your doctoral work over six semesters, including any planned or anticipated periods of study outside OsloMet and/or field work. We do not expect you to know about individual courses, seminars, etc. that will be included in the training component, but you should include course work in your overall timeframe.)

Total: no more than 8-10 pages in Times New Roman, 12 point type, with one and a half line spacing (including reference list. The reference list must be sorted alphabetically by author.). It is up to you to decide how they are distributed among the different sections of the research proposal.

Some general guidelines

A PhD proposal is generally developed when applying for a funded PhD position. This same proposal is used for applying for admission to the PhD program in Educational Sciences for Teacher Education at the Faculty of Education and international Studies. You need to keep in mind, both with regard to proposals for funding and admission to the PhD program, that you will need to convince the reader that the proposed research and the research objective(s) are important and in some way original or move beyond the current research. How will your proposed study make a contribution to the research field? You also need to be aware of the time limit in doing a PhD and that you cannot be overly ambitious, in total you have three years to complete the work and the reader needs to see that you will be able to complete the study within this time limit.

Make sure to use enough space in the proposal to discuss your research design, research methods, sampling and so forth. Here you need to reference the relevant and up to date literature regarding research methods and research design. Be specific in terms of what you are planning to do and how you will obtain the data you seek. What are the sampling procedures you will use and how will you recruit your participants. Also, think about any ethical issues as well as how you might analyze the data. Be as specific as possible in this section.

You will also need a realistic time plan, which should include the research process, fieldwork/data collection, analysis writing up, and dissemination plan as well as course work, all within the space of three years.

Oslo 13.08.2019,

Professor Halla B. Holmarsdottir, Vice-Dean of Research at the Faculty of Education and International Studies, OsloMet - Oslo Metropolitan University

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Research Topics & Ideas: Education

170+ Research Ideas To Fast-Track Your Project

If you’re just starting out exploring education-related topics for your dissertation, thesis or research project, you’ve come to the right place. In this post, we’ll help kickstart your research topic ideation process by providing a hearty list of research topics and ideas , including examples from actual dissertations and theses..

PS – This is just the start…

We know it’s exciting to run through a list of research topics, but please keep in mind that this list is just a starting point . To develop a suitable education-related research topic, you’ll need to identify a clear and convincing research gap , and a viable plan of action to fill that gap.

If this sounds foreign to you, check out our free research topic webinar that explores how to find and refine a high-quality research topic, from scratch. Alternatively, if you’d like hands-on help, consider our 1-on-1 coaching service .

Overview: Education Research Topics

• How to find a research topic (video)
• List of 50+ education-related research topics/ideas
• List of 120+ level-specific research topics 
• Examples of actual dissertation topics in education
• Tips to fast-track your topic ideation (video)
• Free Webinar : Topic Ideation 101
• Where to get extra help

Education-Related Research Topics & Ideas

Below you’ll find a list of education-related research topics and idea kickstarters. These are fairly broad and flexible to various contexts, so keep in mind that you will need to refine them a little. Nevertheless, they should inspire some ideas for your project.

• The impact of school funding on student achievement
• The effects of social and emotional learning on student well-being
• The effects of parental involvement on student behaviour
• The impact of teacher training on student learning
• The impact of classroom design on student learning
• The impact of poverty on education
• The use of student data to inform instruction
• The role of parental involvement in education
• The effects of mindfulness practices in the classroom
• The use of technology in the classroom
• The role of critical thinking in education
• The use of formative and summative assessments in the classroom
• The use of differentiated instruction in the classroom
• The use of gamification in education
• The effects of teacher burnout on student learning
• The impact of school leadership on student achievement
• The effects of teacher diversity on student outcomes
• The role of teacher collaboration in improving student outcomes
• The implementation of blended and online learning
• The effects of teacher accountability on student achievement
• The effects of standardized testing on student learning
• The effects of classroom management on student behaviour
• The effects of school culture on student achievement
• The use of student-centred learning in the classroom
• The impact of teacher-student relationships on student outcomes
• The achievement gap in minority and low-income students
• The use of culturally responsive teaching in the classroom
• The impact of teacher professional development on student learning
• The use of project-based learning in the classroom
• The effects of teacher expectations on student achievement
• The use of adaptive learning technology in the classroom
• The impact of teacher turnover on student learning
• The effects of teacher recruitment and retention on student learning
• The impact of early childhood education on later academic success
• The impact of parental involvement on student engagement
• The use of positive reinforcement in education
• The impact of school climate on student engagement
• The role of STEM education in preparing students for the workforce
• The effects of school choice on student achievement
• The use of technology in the form of online tutoring

Level-Specific Research Topics

Looking for research topics for a specific level of education? We’ve got you covered. Below you can find research topic ideas for primary, secondary and tertiary-level education contexts. Click the relevant level to view the respective list.

Research Topics: Pick An Education Level

Primary education.

• Investigating the effects of peer tutoring on academic achievement in primary school
• Exploring the benefits of mindfulness practices in primary school classrooms
• Examining the effects of different teaching strategies on primary school students’ problem-solving skills
• The use of storytelling as a teaching strategy in primary school literacy instruction
• The role of cultural diversity in promoting tolerance and understanding in primary schools
• The impact of character education programs on moral development in primary school students
• Investigating the use of technology in enhancing primary school mathematics education
• The impact of inclusive curriculum on promoting equity and diversity in primary schools
• The impact of outdoor education programs on environmental awareness in primary school students
• The influence of school climate on student motivation and engagement in primary schools
• Investigating the effects of early literacy interventions on reading comprehension in primary school students
• The impact of parental involvement in school decision-making processes on student achievement in primary schools
• Exploring the benefits of inclusive education for students with special needs in primary schools
• Investigating the effects of teacher-student feedback on academic motivation in primary schools
• The role of technology in developing digital literacy skills in primary school students
• Effective strategies for fostering a growth mindset in primary school students
• Investigating the role of parental support in reducing academic stress in primary school children
• The role of arts education in fostering creativity and self-expression in primary school students
• Examining the effects of early childhood education programs on primary school readiness
• Examining the effects of homework on primary school students’ academic performance
• The role of formative assessment in improving learning outcomes in primary school classrooms
• The impact of teacher-student relationships on academic outcomes in primary school
• Investigating the effects of classroom environment on student behavior and learning outcomes in primary schools
• Investigating the role of creativity and imagination in primary school curriculum
• The impact of nutrition and healthy eating programs on academic performance in primary schools
• The impact of social-emotional learning programs on primary school students’ well-being and academic performance
• The role of parental involvement in academic achievement of primary school children
• Examining the effects of classroom management strategies on student behavior in primary school
• The role of school leadership in creating a positive school climate Exploring the benefits of bilingual education in primary schools
• The effectiveness of project-based learning in developing critical thinking skills in primary school students
• The role of inquiry-based learning in fostering curiosity and critical thinking in primary school students
• The effects of class size on student engagement and achievement in primary schools
• Investigating the effects of recess and physical activity breaks on attention and learning in primary school
• Exploring the benefits of outdoor play in developing gross motor skills in primary school children
• The effects of educational field trips on knowledge retention in primary school students
• Examining the effects of inclusive classroom practices on students’ attitudes towards diversity in primary schools
• The impact of parental involvement in homework on primary school students’ academic achievement
• Investigating the effectiveness of different assessment methods in primary school classrooms
• The influence of physical activity and exercise on cognitive development in primary school children
• Exploring the benefits of cooperative learning in promoting social skills in primary school students

Secondary Education

• Investigating the effects of school discipline policies on student behavior and academic success in secondary education
• The role of social media in enhancing communication and collaboration among secondary school students
• The impact of school leadership on teacher effectiveness and student outcomes in secondary schools
• Investigating the effects of technology integration on teaching and learning in secondary education
• Exploring the benefits of interdisciplinary instruction in promoting critical thinking skills in secondary schools
• The impact of arts education on creativity and self-expression in secondary school students
• The effectiveness of flipped classrooms in promoting student learning in secondary education
• The role of career guidance programs in preparing secondary school students for future employment
• Investigating the effects of student-centered learning approaches on student autonomy and academic success in secondary schools
• The impact of socio-economic factors on educational attainment in secondary education
• Investigating the impact of project-based learning on student engagement and academic achievement in secondary schools
• Investigating the effects of multicultural education on cultural understanding and tolerance in secondary schools
• The influence of standardized testing on teaching practices and student learning in secondary education
• Investigating the effects of classroom management strategies on student behavior and academic engagement in secondary education
• The influence of teacher professional development on instructional practices and student outcomes in secondary schools
• The role of extracurricular activities in promoting holistic development and well-roundedness in secondary school students
• Investigating the effects of blended learning models on student engagement and achievement in secondary education
• The role of physical education in promoting physical health and well-being among secondary school students
• Investigating the effects of gender on academic achievement and career aspirations in secondary education
• Exploring the benefits of multicultural literature in promoting cultural awareness and empathy among secondary school students
• The impact of school counseling services on student mental health and well-being in secondary schools
• Exploring the benefits of vocational education and training in preparing secondary school students for the workforce
• The role of digital literacy in preparing secondary school students for the digital age
• The influence of parental involvement on academic success and well-being of secondary school students
• The impact of social-emotional learning programs on secondary school students’ well-being and academic success
• The role of character education in fostering ethical and responsible behavior in secondary school students
• Examining the effects of digital citizenship education on responsible and ethical technology use among secondary school students
• The impact of parental involvement in school decision-making processes on student outcomes in secondary schools
• The role of educational technology in promoting personalized learning experiences in secondary schools
• The impact of inclusive education on the social and academic outcomes of students with disabilities in secondary schools
• The influence of parental support on academic motivation and achievement in secondary education
• The role of school climate in promoting positive behavior and well-being among secondary school students
• Examining the effects of peer mentoring programs on academic achievement and social-emotional development in secondary schools
• Examining the effects of teacher-student relationships on student motivation and achievement in secondary schools
• Exploring the benefits of service-learning programs in promoting civic engagement among secondary school students
• The impact of educational policies on educational equity and access in secondary education
• Examining the effects of homework on academic achievement and student well-being in secondary education
• Investigating the effects of different assessment methods on student performance in secondary schools
• Examining the effects of single-sex education on academic performance and gender stereotypes in secondary schools
• The role of mentoring programs in supporting the transition from secondary to post-secondary education

Tertiary Education

• The role of student support services in promoting academic success and well-being in higher education
• The impact of internationalization initiatives on students’ intercultural competence and global perspectives in tertiary education
• Investigating the effects of active learning classrooms and learning spaces on student engagement and learning outcomes in tertiary education
• Exploring the benefits of service-learning experiences in fostering civic engagement and social responsibility in higher education
• The influence of learning communities and collaborative learning environments on student academic and social integration in higher education
• Exploring the benefits of undergraduate research experiences in fostering critical thinking and scientific inquiry skills
• Investigating the effects of academic advising and mentoring on student retention and degree completion in higher education
• The role of student engagement and involvement in co-curricular activities on holistic student development in higher education
• The impact of multicultural education on fostering cultural competence and diversity appreciation in higher education
• The role of internships and work-integrated learning experiences in enhancing students’ employability and career outcomes
• Examining the effects of assessment and feedback practices on student learning and academic achievement in tertiary education
• The influence of faculty professional development on instructional practices and student outcomes in tertiary education
• The influence of faculty-student relationships on student success and well-being in tertiary education
• The impact of college transition programs on students’ academic and social adjustment to higher education
• The impact of online learning platforms on student learning outcomes in higher education
• The impact of financial aid and scholarships on access and persistence in higher education
• The influence of student leadership and involvement in extracurricular activities on personal development and campus engagement
• Exploring the benefits of competency-based education in developing job-specific skills in tertiary students
• Examining the effects of flipped classroom models on student learning and retention in higher education
• Exploring the benefits of online collaboration and virtual team projects in developing teamwork skills in tertiary students
• Investigating the effects of diversity and inclusion initiatives on campus climate and student experiences in tertiary education
• The influence of study abroad programs on intercultural competence and global perspectives of college students
• Investigating the effects of peer mentoring and tutoring programs on student retention and academic performance in tertiary education
• Investigating the effectiveness of active learning strategies in promoting student engagement and achievement in tertiary education
• Investigating the effects of blended learning models and hybrid courses on student learning and satisfaction in higher education
• The role of digital literacy and information literacy skills in supporting student success in the digital age
• Investigating the effects of experiential learning opportunities on career readiness and employability of college students
• The impact of e-portfolios on student reflection, self-assessment, and showcasing of learning in higher education
• The role of technology in enhancing collaborative learning experiences in tertiary classrooms
• The impact of research opportunities on undergraduate student engagement and pursuit of advanced degrees
• Examining the effects of competency-based assessment on measuring student learning and achievement in tertiary education
• Examining the effects of interdisciplinary programs and courses on critical thinking and problem-solving skills in college students
• The role of inclusive education and accessibility in promoting equitable learning experiences for diverse student populations
• The role of career counseling and guidance in supporting students’ career decision-making in tertiary education
• The influence of faculty diversity and representation on student success and inclusive learning environments in higher education

Education-Related Dissertations & Theses

While the ideas we’ve presented above are a decent starting point for finding a research topic in education, they are fairly generic and non-specific. So, it helps to look at actual dissertations and theses in the education space to see how this all comes together in practice.

Below, we’ve included a selection of education-related research projects to help refine your thinking. These are actual dissertations and theses, written as part of Master’s and PhD-level programs, so they can provide some useful insight as to what a research topic looks like in practice.

• From Rural to Urban: Education Conditions of Migrant Children in China (Wang, 2019)
• Energy Renovation While Learning English: A Guidebook for Elementary ESL Teachers (Yang, 2019)
• A Reanalyses of Intercorrelational Matrices of Visual and Verbal Learners’ Abilities, Cognitive Styles, and Learning Preferences (Fox, 2020)
• A study of the elementary math program utilized by a mid-Missouri school district (Barabas, 2020)
• Instructor formative assessment practices in virtual learning environments : a posthumanist sociomaterial perspective (Burcks, 2019)
• Higher education students services: a qualitative study of two mid-size universities’ direct exchange programs (Kinde, 2020)
• Exploring editorial leadership : a qualitative study of scholastic journalism advisers teaching leadership in Missouri secondary schools (Lewis, 2020)
• Selling the virtual university: a multimodal discourse analysis of marketing for online learning (Ludwig, 2020)
• Advocacy and accountability in school counselling: assessing the use of data as related to professional self-efficacy (Matthews, 2020)
• The use of an application screening assessment as a predictor of teaching retention at a midwestern, K-12, public school district (Scarbrough, 2020)
• Core values driving sustained elite performance cultures (Beiner, 2020)
• Educative features of upper elementary Eureka math curriculum (Dwiggins, 2020)
• How female principals nurture adult learning opportunities in successful high schools with challenging student demographics (Woodward, 2020)
• The disproportionality of Black Males in Special Education: A Case Study Analysis of Educator Perceptions in a Southeastern Urban High School (McCrae, 2021)

As you can see, these research topics are a lot more focused than the generic topic ideas we presented earlier. So, in order for you to develop a high-quality research topic, you’ll need to get specific and laser-focused on a specific context with specific variables of interest.  In the video below, we explore some other important things you’ll need to consider when crafting your research topic.

Get 1-On-1 Help

If you’re still unsure about how to find a quality research topic within education, check out our Research Topic Kickstarter service, which is the perfect starting point for developing a unique, well-justified research topic.

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63 Comments

This is an helpful tool 🙏

Special education

Really appreciated by this . It is the best platform for research related items

Research title related to school of students

I think this platform is actually good enough.

Research title related to students

My field is research measurement and evaluation. Need dissertation topics in the field

Assalam o Alaikum I’m a student Bs educational Resarch and evaluation I’m confused to choose My thesis title please help me in choose the thesis title

Good idea I’m going to teach my colleagues

You can find our list of nursing-related research topic ideas here: https://gradcoach.com/research-topics-nursing/

Write on action research topic, using guidance and counseling to address unwanted teenage pregnancy in school

Thanks a lot

I learned a lot from this site, thank you so much!

Thank you for the information.. I would like to request a topic based on school major in social studies

parental involvement and students academic performance

Science education topics?

plz tell me if you got some good topics, im here for finding research topic for masters degree

How about School management and supervision pls.?

Hi i am an Deputy Principal in a primary school. My wish is to srudy foe Master’s degree in Education.Please advice me on which topic can be relevant for me. Thanks.

Every topic proposed above on primary education is a starting point for me. I appreciate immensely the team that has sat down to make a detail of these selected topics just for beginners like us. Be blessed.

Kindly help me with the research questions on the topic” Effects of workplace conflict on the employees’ job performance”. The effects can be applicable in every institution,enterprise or organisation.

Greetings, I am a student majoring in Sociology and minoring in Public Administration. I’m considering any recommended research topic in the field of Sociology.

I’m a student pursuing Mphil in Basic education and I’m considering any recommended research proposal topic in my field of study

Kindly help me with a research topic in educational psychology. Ph.D level. Thank you.

Project-based learning is a teaching/learning type,if well applied in a classroom setting will yield serious positive impact. What can a teacher do to implement this in a disadvantaged zone like “North West Region of Cameroon ( hinterland) where war has brought about prolonged and untold sufferings on the indegins?

I wish to get help on topics of research on educational administration

I wish to get help on topics of research on educational administration PhD level

I am also looking for such type of title

I am a student of undergraduate, doing research on how to use guidance and counseling to address unwanted teenage pregnancy in school

the topics are very good regarding research & education .

Can i request your suggestion topic for my Thesis about Teachers as an OFW. thanx you

Would like to request for suggestions on a topic in Economics of education,PhD level

Would like to request for suggestions on a topic in Economics of education

Hi 👋 I request that you help me with a written research proposal about education the format

Am offering degree in education senior high School Accounting. I want a topic for my project work

l would like to request suggestions on a topic in managing teaching and learning, PhD level (educational leadership and management)

request suggestions on a topic in managing teaching and learning, PhD level (educational leadership and management)

I would to inquire on research topics on Educational psychology, Masters degree

I am PhD student, I am searching my Research topic, It should be innovative,my area of interest is online education,use of technology in education

request suggestion on topic in masters in medical education .

Look at British Library as they keep a copy of all PhDs in the UK Core.ac.uk to access Open University and 6 other university e-archives, pdf downloads mostly available, all free.

May I also ask for a topic based on mathematics education for college teaching, please?

Please I am a masters student of the department of Teacher Education, Faculty of Education Please I am in need of proposed project topics to help with my final year thesis

Am a PhD student in Educational Foundations would like a sociological topic. Thank

please i need a proposed thesis project regardging computer science

Greetings and Regards I am a doctoral student in the field of philosophy of education. I am looking for a new topic for my thesis. Because of my work in the elementary school, I am looking for a topic that is from the field of elementary education and is related to the philosophy of education.

Masters student in the field of curriculum, any ideas of a research topic on low achiever students

In the field of curriculum any ideas of a research topic on deconalization in contextualization of digital teaching and learning through in higher education

Amazing guidelines

I am a graduate with two masters. 1) Master of arts in religious studies and 2) Master in education in foundations of education. I intend to do a Ph.D. on my second master’s, however, I need to bring both masters together through my Ph.D. research. can I do something like, ” The contribution of Philosophy of education for a quality religion education in Kenya”? kindly, assist and be free to suggest a similar topic that will bring together the two masters. thanks in advance

Hi, I am an Early childhood trainer as well as a researcher, I need more support on this topic: The impact of early childhood education on later academic success.

I’m a student in upper level secondary school and I need your support in this research topics: “Impact of incorporating project -based learning in teaching English language skills in secondary schools”.

Although research activities and topics should stem from reflection on one’s practice, I found this site valuable as it effectively addressed many issues we have been experiencing as practitioners.

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Research proposals

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In your proposal, please tell us if you have an interest in the work of a specific academic at York St John. You can get in touch with this academic to discuss your proposal. You can also speak to one of our Research Leads. There is a list of our Research Leads on the Apply page.

When you write your proposal you need to:

• Highlight how it is original or significant
• Explain how it will develop or challenge current knowledge of your subject
• Identify the importance of your research
• Show why you are the right person to do this research
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3 ways we’re engaging educators in learning sciences research.

May 1, 2024 | By KellyAnn Tsai

• To conduct impactful learning sciences research, we should bridge the gap between researchers and educators.
• Practitioner engagement helps our researchers create evidence-based educational materials that include the perspectives of those who are most impacted: teachers and students.
• Our researchers engage with practitioners in several ways, such as conducting surveys, co-designing materials, and co-writing, to design innovations that are meaningful and sustainable in the communities we serve.

When it comes to researching how we learn, educators must be in the loop. At Digital Promise, our Learning Sciences Research (LSR) team connects with networks of educators and educational leaders to bring research-based knowledge into practice.

By bridging the gap between researchers and practitioners, our researchers:

• Gain feedback on research questions and materials from teachers and students
• Develop evidence-based classroom materials that center the practitioner experience
• Conduct rigorous, mixed-method research to ensure that innovations designed are meaningful, feasible, and sustainable in the communities we serve

Included here are three examples of how our LSR researchers collaborate with practitioners to expand opportunities for every learner.

Shaping Research Questions

The OpenSciEd Research Community project connects innovators, researchers, practitioners, and policymakers to support the widespread adoption of OpenSciEd , a set of freely available curriculum materials addressing the Next Generation Science Standards (NGSS). Practitioner engagement is key to help shape the project’s research questions.

Practitioners provide invaluable insights into what works—and what doesn’t—when implementing the OpenSciEd curriculum. Our researchers began by conducting surveys and focus groups with practitioners to discuss their challenges implementing the OpenSciEd curriculum, such as the need for more lesson-planning time. These efforts help researchers identify areas of investigation to support the broader rollout of OpenSciEd curriculum in schools.

“The voices and perspectives of practitioners are necessary for conducting high quality research in schools,” said Kevin McElhaney, director of science and engineering education research, who leads the project. “Our conversations with teachers and leaders point to important research questions, provide unique insights about students and how to meet their needs, and inform solutions to make curriculum implementation coherent and sustainable.”

Based on these conversations, the OpenSciEd Research Community team has a forthcoming report synthesizing what they have learned from practitioners. They will also release a guide to help education systems leaders, teachers, and researchers clarify challenges and identify opportunities to expand the implementation of OpenSciEd.

Co-Designing Lesson Plans

World history is a vast topic, and for many teachers of the subject, it can be challenging to foster meaningful discussions among their students. Researchers involved in Deeper Discussions in World History , a joint project between Digital Promise’s LSR team, the Center for Inclusive Innovation , the OER Project , and the University of Pennsylvania Graduate School of Education , are designing materials to help teachers deepen world history discussions in their classrooms.

To create these resources, researchers have spent the last year collaborating with a cohort of teachers to co-design culturally responsive world history materials . This co-design process is iterative: researchers and practitioners co-design lesson plans, practitioners test them in the classroom, and researchers modify materials based on feedback. Researchers and teachers also gather annually for in-person design workshops to further foster collaboration.

Reflecting on the co-design process, teacher Daryn Cohen said: “In terms of being treated like a professional, it has really helped build community. Everyone feels very valued, and that’s really important in making it a community of everyone, and not just teachers over here and researchers over there.”

Using feedback from the co-design process, researchers will develop two resources: Deeper Discussions, a suite of world history curricula, and a professional development toolkit to help high school world history teachers facilitate powerful discussions in their classes and promote historical thinking for students.

Developing Meaningful Materials

Our researchers are also engaging teachers of science, technology, engineering, and math (STEM). Learning sciences research often leads to discoveries that impact how teachers teach, but it can be difficult for teachers to understand these research findings, let alone implement them in their classrooms.

To address this issue, researchers in the Mapping, Clarifying, and Communicating Key Ideas about Collaborative Learning to STEM Audiences (MC 2 ) project are bringing together researchers and practitioners (teachers and coaches) to co-develop materials that will translate research on collaborative learning for one of its most important audiences: educators.

Judi Fusco, who leads the MC 2 project, is passionate about closing the gap between researchers and STEM educators. “Both researchers and practitioners have invaluable insights on learning with few occasions to share with each other,” she said. “The MC 2 project bridges that gap by creating opportunities for meaningful collaboration to occur.”

Educators have been significantly involved in the MC 2 project. Initially, a panel of researchers and practitioners worked together to determine topics from collaborative learning research relevant to classroom practice. Now, practitioner and researcher experts are creating “primers” that will translate key research findings on collaborative learning, which can then be used to develop research-based materials for use in the classroom.

By working, discussing, and writing together, researchers and practitioners can better understand each other’s perspectives and how each thinks about collaborative learning. Following co-development, the project team will conduct an additional review to ensure primers include perspectives from both groups and that the additional research-based materials will be truly usable by the educator community.

Engage with Our Research

Educators have an essential role in shaping learning sciences research. Their partnership ensures that our researchers conduct works that meaningfully impacts students and teachers.

Want to learn more about Digital Promise’s learning sciences research work?

• Meet the Learning Sciences Research team
• Explore our current research projects
• Read our reports in the Digital Promise Resource Repository
• Sign up for our Learning Sciences Connections newsletter

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In this image, the clear wafer at the center of the confocal microscope is a diamond plate with atomic-sized flaws. Green, orange and red lasers excite these flaws to manipulate and measure them, which allows for measuring small magnetic fields at nanometer length scales. [Research supported by U.S. National Science Foundation grant DMR 1752047.] Learn more in the Princeton University news story That flawed diamond could be a quantum physicist's best friend . (Date of image: 2022; date originally posted to NSF Multimedia Gallery: May 10, 2024)

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High school student helps transform 'crazy idea' into innovative research tool

Like many good ideas in science, it started with a walk in the woods.

During a stroll through the Berlin Botanic Garden in 2019, HHMI Janelia Research Campus Group Leader Jan Funke and some of his scientific colleagues started chatting about a familiar topic: how to get more information out of insect connectomes.

These wiring diagrams give researchers unprecedented information about brain cells and how they connect to each other, but they don't tell scientists how the signal from one neuron affects the other neurons in its network.

The group wondered if they might be able to use information from previous experiments identifying the neurotransmitters released from some neurons to predict the neurotransmitters released from others in the connectome. Neurons use neurotransmitters to communicate with each other, with different chemicals responsible for different signals.

The human eye can't tell the difference between the synapses on neurons where different neurotransmitters are released, but perhaps a computer model could. Funke and his colleagues were skeptical, but they thought it might be worth giving it a try.

"This is basically where we left it: we have the data, I guess we could try," Funke says. "We were not particularly optimistic."

Back at Janelia, Funke decided to give the project to Michelle Du, a high school student who was starting a summer internship in his lab. The project would allow Du to learn how to train a neural network to recognize images -- a useful skill for a budding computer scientist even if the project did not yield results.

A few days into her internship, Du showed up in Funke's office having trained the model on published data and evaluated its performance on test data. Though Funke had little hope it would work, the model was more than 90 percent accurate in predicting some neurotransmitters.

"I couldn't believe it," Funke says. "The numbers were way too good."

After checking the data and the model, Funke, Du, and their colleagues were convinced that the numbers weren't a mistake: The model could predict neurotransmitters. But the team was still cautious, and they didn't have a good grasp on how the network was making the predictions.

"I should have been very happy, but instead I was worried because we didn't understand what was going on," Funke says.

After ruling out possible confounders that could be skewing their results, the team developed a way to understand what the network was seeing that allowed it to make predictions.

First, they used their network to predict a neurotransmitter from a known image, which it did successfully. Then, they asked a separate network to take that known image and change it slightly to create an image corresponding to the release of a different neurotransmitter -- essentially identifying the minimum traits that need to be changed for the model to predict one neurotransmitter over 4another. Lastly, the team developed a separate method to identify these distinct traits.

From this information, the team understood the different features their original network used to make predictions. This gave them confidence to release their method to the wider neuroscience community in 2020.

"What most of the neuroscience community has seen from this work is the predictions," Funke says. "They were happy to use it, but for us it was very important to make sure it was actually working."

Five years later, Du is now an undergraduate at Duke University, and the method she helped develop has been used to predict neurotransmitters in connectomes of the fruit fly hemibrain, ventral nerve cord, and optic lobe created by Janelia researchers and collaborators, as well as the adult fly brain connectome created by FlyWire.

The information helps scientists understand how neurons in a circuit affect each other so they can then form hypotheses about the function of brain circuits that can be tested in the lab.

"It really all started with a bit of a crazy idea, something that no one was really too optimistic about. And what do you do with a crazy idea? You give it to a high school student as a learning experience," Funke says. "We were very fortunate that Michelle was extremely talented."

• Neuroscience
• Educational Psychology
• K-12 Education
• Behavioral Science
• Telecommunications
• Drosophila melanogaster
• Double blind
• Neurotransmitter
• Earth science
• Brachiosaurus
• Positron emission tomography

Story Source:

Materials provided by Howard Hughes Medical Institute . Note: Content may be edited for style and length.

Journal Reference :

• Nils Eckstein, Alexander Shakeel Bates, Andrew Champion, Michelle Du, Yijie Yin, Philipp Schlegel, Alicia Kun-Yang Lu, Thomson Rymer, Samantha Finley-May, Tyler Paterson, Ruchi Parekh, Sven Dorkenwald, Arie Matsliah, Szi-Chieh Yu, Claire McKellar, Amy Sterling, Katharina Eichler, Marta Costa, Sebastian Seung, Mala Murthy, Volker Hartenstein, Gregory S.X.E. Jefferis, Jan Funke. Neurotransmitter classification from electron microscopy images at synaptic sites in Drosophila melanogaster . Cell , 2024; 187 (10): 2574 DOI: 10.1016/j.cell.2024.03.016

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Life Science Research Professional 1

🔍 school of medicine, stanford, california, united states.

Life Science Research Professional 1 – Heitzeneder Lab Onsite Work Agreement

Stanford University is seeking a computational Life Science Research Professional 1 to perform basic analytical functions and activities in defined research projects and independently conduct bioinformatic data analyses focused on adoptive T cell immunotherapy for pediatric solid tumors and brain tumors.

The LSRP1 will be working in the laboratory of Dr. Sabine Heitzeneder, which focuses on the identification of novel target antigens expressed at high levels on childhood cancer and the development of adoptive T cell immunotherapies to treat pediatric cancers. As part of the Department of Pediatrics (Division of Hematology/Oncology) and the Stanford Cancer Institute (SCI) at the Stanford University School of Medicine, the Heitzeneder Lab will contribute to the clinical and translational research pipeline in the Stanford Center for Cancer Cell Therapy. Dr. Heitzeneder has developed T cell-based therapies currently in the clinical translational pipeline with plans for human studies in the near future. Drawing on this success, we continue to seek out further ways to improve care for children with cancer.

The Stanford Cancer Institute (SCI) is one of an elite number of National Cancer Institute-Designated Comprehensive Cancer Centers in the country, and is a prominent, dynamic, growing and complex Institute within the Stanford 

University School of Medicine. The SCI actively works to build synergies and collaborations among faculty with cancer-relevant expertise from four Schools and over 30 departments across Stanford University.

We seek a LSRP1 to help us enact our mission to reduce cancer mortality through comprehensive programs of cancer research, treatment, education and outreach. Given the SCI’s mission, breadth, and depth, it employs over 325 staff members in a fast-paced, team-oriented, and forward-thinking environment with tremendous opportunities for personal and professional growth.

Reporting to the Principal Investigator and working with postdoctoral fellows and scientists, the LSRP1 will be conversant in the goals, mission and priorities of the Institute. We are seeking candidates with excellent organizational and communication skills. Our staff run toward challenges, and you will have a demonstrated history of doing the same with a high degree of professionalism, initiative, and flexibility.

Duties include*:

• Plan approach to data analysis in support of research projects in the lab based on knowledge of scientific theory.
• Independently conduct analysis of bulk and single-cell sequencing data, deconvolute bulk sequencing datasets, and perform differential gene expression analyses; maintain detailed records of pipelines, workflows and outcomes.
• Independently conduct analysis of immunopeptidome data, deconvolute data and integrate with transcriptome and whole exome sequencing data to identify promising peptide-MHC target antigens for immunotherapeutic targeting, maintain detailed records of pipelines, workflows and outcomes.
• Independently conduct analysis of single-cell T cell receptor datasets, maintain detailed records of pipelines, workflows and outcomes.
• Apply the theories and methods of data science, computational biology, and statistics to the life science discipline to interpret results; offer suggestions regarding modifications to procedures and datasets in collaboration with senior researcher.
• Review literature on an ongoing basis to remain current with new procedures and apply learnings to related research.
• Contribute to publication of findings as needed. Participate in the preparation of written documents, including procedures, presentations, and proposals.
• Help with lab data analyses as needed; provide general lab support in statistics and data science methods as needed.
• Assist with orientation and training of new staff or students on lab procedures or techniques.

*-Other duties may be assigned.

DESIRED QUALIFICATIONS:

Desired candidate should have experience in computational biology and data science related to CAR T cell or immunotherapy research. He/she should be trained in single-cell sequencing and bulk sequencing data analysis, survival analysis, deconvolution techniques, and general theory and methods of data science, computational biology, and statistics. Experience with differential gene expression analysis of large datasets derived from normal and tumor tissues is highly desired. A bachelor’s degree in cell/molecular biology or data science is preferred.

EDUCATION & EXPERIENCE (REQUIRED):

Bachelor's degree in related scientific field.

KNOWLEDGE, SKILLS AND ABILITIES (REQUIRED):

• General understanding of scientific principles. Demonstrated performance to use knowledge and skills when needed.
• Demonstrated ability to apply theoretical knowledge of science principals to problem solve work.
• Ability to maintain detailed records of experiments and outcomes.
• General computer skills and ability to quickly learn and master computer programs, databases, and scientific applications.
• Ability to work under deadlines with general guidance.
• Excellent organizational skills and demonstrated ability to accurately complete detailed work.

PHYSICAL REQUIREMENTS*:

• Must have correctible vision to perform duties of the job.
• Position may require repetitive motion.

*- Consistent with its obligations under the law, the University will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of his or her job.

WORKING CONDITIONS:

• Desk for Computational work next to the wetlab is provided.
• May require extended or unusual work hours based on research requirements and business needs.

WORK STANDARDS:

• Interpersonal Skills: Demonstrates the ability to work well with Stanford colleagues and clients and with external organizations.
• Promote Culture of Safety: Demonstrates commitment to personal responsibility and value for safety; communicates safety concerns; uses and promotes safe behaviors bases on training and lessons learned.
• Subject to and expected to comply with all applicable University policies and procedures, including but not limited to the personnel policies and other policies found in the University’s Administrative Guide, http://adminguide.stanford.edu .

The expected pay range for this position is $26.44 to $36.54 per hour.

Stanford University provides pay ranges representing its good faith estimate of what the university reasonably expects to pay for a position. The pay offered to a selected candidate will be determined based on factors such as (but not limited to) the scope and responsibilities of the position, the qualifications of the selected candidate, departmental budget availability, internal equity, geographic location and external market pay for comparable jobs.

At Stanford University, base pay represents only one aspect of the comprehensive rewards package. The Cardinal at Work website ( https://cardinalatwork.stanford.edu/benefits-rewards ) provides detailed information on Stanford’s extensive range of benefits and rewards offered to employees. Specifics about the rewards package for this position may be discussed during the hiring process.

Consistent with its obligations under the law, the University will provide reasonable accommodations to applicants and employees with disabilities. Applicants requiring a reasonable accommodation for any part of the application or hiring process should contact Stanford University Human Resources by submitting a contact form .

Stanford is an equal employment opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.

The job duties listed are typical examples of work performed by positions in this job classification and are not designed to contain or be interpreted as a comprehensive inventory of all duties, tasks, and responsibilities. Specific duties and responsibilities may vary depending on department or program needs without changing the general nature and scope of the job or level of responsibility. Employees may also perform other duties as assigned.

• Schedule: Full-time
• Job Code: 4943
• Employee Status: Regular
• Requisition ID: 103173
• Work Arrangement : On Site

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