BMC Microbiology
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Aims and scope
BMC Microbiology is an open access, peer-reviewed journal that considers articles on all microorganisms - bacteria, archaea, algae and fungi, viruses, unicellular parasites and helminths. It considers studies on all aspects of the biology and biochemistry of microorganisms including but not limited to cell biology, genomics, signalling, the interaction of the microbes with the environment and host, mechanistic and functional insights into infection and disease, and biotechnological application in science and industry.
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More information about our unique article type can be found on the BMC Genomic Data and BMC Research Notes journal websites.
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BMC Microbiology participated in a pilot project in which all accepted papers are evaluated for eligibility to receive an Open data badge.
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Annual Journal Metrics
Citation Impact 2023 Journal Impact Factor: 4.0 5-year Journal Impact Factor: 4.6 Source Normalized Impact per Paper (SNIP): 1.081 SCImago Journal Rank (SJR): 0.999 Speed 2023 Submission to first editorial decision (median days): 15 Submission to acceptance (median days): 135 Usage 2023 Downloads: 2,970,572 Altmetric mentions: 1,619
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ISSN: 1471-2180
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Research in Microbiology
Subject Area and Category
- Molecular Biology
- Microbiology
- Medicine (miscellaneous)
Elsevier Masson s.r.l.
Publication type
09232508, 17697123
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How to publish in this journal
The set of journals have been ranked according to their SJR and divided into four equal groups, four quartiles. Q1 (green) comprises the quarter of the journals with the highest values, Q2 (yellow) the second highest values, Q3 (orange) the third highest values and Q4 (red) the lowest values.
Category | Year | Quartile |
---|---|---|
Medicine (miscellaneous) | 1999 | Q1 |
Medicine (miscellaneous) | 2000 | Q1 |
Medicine (miscellaneous) | 2001 | Q1 |
Medicine (miscellaneous) | 2002 | Q1 |
Medicine (miscellaneous) | 2003 | Q1 |
Medicine (miscellaneous) | 2004 | Q1 |
Medicine (miscellaneous) | 2005 | Q1 |
Medicine (miscellaneous) | 2006 | Q1 |
Medicine (miscellaneous) | 2007 | Q1 |
Medicine (miscellaneous) | 2008 | Q1 |
Medicine (miscellaneous) | 2009 | Q1 |
Medicine (miscellaneous) | 2010 | Q1 |
Medicine (miscellaneous) | 2011 | Q1 |
Medicine (miscellaneous) | 2012 | Q1 |
Medicine (miscellaneous) | 2013 | Q1 |
Medicine (miscellaneous) | 2014 | Q1 |
Medicine (miscellaneous) | 2015 | Q1 |
Medicine (miscellaneous) | 2016 | Q1 |
Medicine (miscellaneous) | 2017 | Q2 |
Medicine (miscellaneous) | 2018 | Q1 |
Medicine (miscellaneous) | 2019 | Q1 |
Medicine (miscellaneous) | 2020 | Q1 |
Medicine (miscellaneous) | 2021 | Q2 |
Medicine (miscellaneous) | 2022 | Q2 |
Medicine (miscellaneous) | 2023 | Q2 |
Microbiology | 1999 | Q2 |
Microbiology | 2000 | Q2 |
Microbiology | 2001 | Q2 |
Microbiology | 2002 | Q2 |
Microbiology | 2003 | Q2 |
Microbiology | 2004 | Q2 |
Microbiology | 2005 | Q2 |
Microbiology | 2006 | Q1 |
Microbiology | 2007 | Q2 |
Microbiology | 2008 | Q2 |
Microbiology | 2009 | Q2 |
Microbiology | 2010 | Q2 |
Microbiology | 2011 | Q1 |
Microbiology | 2012 | Q1 |
Microbiology | 2013 | Q2 |
Microbiology | 2014 | Q1 |
Microbiology | 2015 | Q2 |
Microbiology | 2016 | Q2 |
Microbiology | 2017 | Q3 |
Microbiology | 2018 | Q2 |
Microbiology | 2019 | Q2 |
Microbiology | 2020 | Q1 |
Microbiology | 2021 | Q2 |
Microbiology | 2022 | Q3 |
Microbiology | 2023 | Q3 |
Molecular Biology | 1999 | Q3 |
Molecular Biology | 2000 | Q3 |
Molecular Biology | 2001 | Q3 |
Molecular Biology | 2002 | Q2 |
Molecular Biology | 2003 | Q2 |
Molecular Biology | 2004 | Q2 |
Molecular Biology | 2005 | Q2 |
Molecular Biology | 2006 | Q2 |
Molecular Biology | 2007 | Q3 |
Molecular Biology | 2008 | Q3 |
Molecular Biology | 2009 | Q2 |
Molecular Biology | 2010 | Q2 |
Molecular Biology | 2011 | Q2 |
Molecular Biology | 2012 | Q2 |
Molecular Biology | 2013 | Q2 |
Molecular Biology | 2014 | Q2 |
Molecular Biology | 2015 | Q3 |
Molecular Biology | 2016 | Q3 |
Molecular Biology | 2017 | Q3 |
Molecular Biology | 2018 | Q2 |
Molecular Biology | 2019 | Q2 |
Molecular Biology | 2020 | Q2 |
Molecular Biology | 2021 | Q3 |
Molecular Biology | 2022 | Q3 |
Molecular Biology | 2023 | Q3 |
The SJR is a size-independent prestige indicator that ranks journals by their 'average prestige per article'. It is based on the idea that 'all citations are not created equal'. SJR is a measure of scientific influence of journals that accounts for both the number of citations received by a journal and the importance or prestige of the journals where such citations come from It measures the scientific influence of the average article in a journal, it expresses how central to the global scientific discussion an average article of the journal is.
Year | SJR |
---|---|
1999 | 0.679 |
2000 | 0.727 |
2001 | 0.841 |
2002 | 1.103 |
2003 | 1.116 |
2004 | 1.319 |
2005 | 1.183 |
2006 | 1.418 |
2007 | 1.146 |
2008 | 1.018 |
2009 | 1.169 |
2010 | 1.333 |
2011 | 1.428 |
2012 | 1.373 |
2013 | 1.256 |
2014 | 1.508 |
2015 | 1.089 |
2016 | 1.010 |
2017 | 0.820 |
2018 | 1.045 |
2019 | 1.074 |
2020 | 1.329 |
2021 | 0.860 |
2022 | 0.677 |
2023 | 0.583 |
Evolution of the number of published documents. All types of documents are considered, including citable and non citable documents.
Year | Documents |
---|---|
1999 | 74 |
2000 | 100 |
2001 | 93 |
2002 | 96 |
2003 | 94 |
2004 | 112 |
2005 | 129 |
2006 | 124 |
2007 | 102 |
2008 | 102 |
2009 | 109 |
2010 | 113 |
2011 | 120 |
2012 | 79 |
2013 | 115 |
2014 | 119 |
2015 | 89 |
2016 | 83 |
2017 | 87 |
2018 | 77 |
2019 | 50 |
2020 | 44 |
2021 | 49 |
2022 | 40 |
2023 | 94 |
This indicator counts the number of citations received by documents from a journal and divides them by the total number of documents published in that journal. The chart shows the evolution of the average number of times documents published in a journal in the past two, three and four years have been cited in the current year. The two years line is equivalent to journal impact factor ™ (Thomson Reuters) metric.
Cites per document | Year | Value |
---|---|---|
Cites / Doc. (4 years) | 1999 | 1.249 |
Cites / Doc. (4 years) | 2000 | 1.524 |
Cites / Doc. (4 years) | 2001 | 1.532 |
Cites / Doc. (4 years) | 2002 | 2.090 |
Cites / Doc. (4 years) | 2003 | 2.267 |
Cites / Doc. (4 years) | 2004 | 2.606 |
Cites / Doc. (4 years) | 2005 | 2.853 |
Cites / Doc. (4 years) | 2006 | 2.826 |
Cites / Doc. (4 years) | 2007 | 2.863 |
Cites / Doc. (4 years) | 2008 | 2.636 |
Cites / Doc. (4 years) | 2009 | 2.794 |
Cites / Doc. (4 years) | 2010 | 2.929 |
Cites / Doc. (4 years) | 2011 | 3.063 |
Cites / Doc. (4 years) | 2012 | 3.392 |
Cites / Doc. (4 years) | 2013 | 3.413 |
Cites / Doc. (4 years) | 2014 | 3.403 |
Cites / Doc. (4 years) | 2015 | 2.718 |
Cites / Doc. (4 years) | 2016 | 2.647 |
Cites / Doc. (4 years) | 2017 | 2.419 |
Cites / Doc. (4 years) | 2018 | 2.836 |
Cites / Doc. (4 years) | 2019 | 3.286 |
Cites / Doc. (4 years) | 2020 | 3.929 |
Cites / Doc. (4 years) | 2021 | 4.616 |
Cites / Doc. (4 years) | 2022 | 3.677 |
Cites / Doc. (4 years) | 2023 | 3.355 |
Cites / Doc. (3 years) | 1999 | 1.249 |
Cites / Doc. (3 years) | 2000 | 1.572 |
Cites / Doc. (3 years) | 2001 | 1.616 |
Cites / Doc. (3 years) | 2002 | 2.232 |
Cites / Doc. (3 years) | 2003 | 2.304 |
Cites / Doc. (3 years) | 2004 | 2.777 |
Cites / Doc. (3 years) | 2005 | 2.550 |
Cites / Doc. (3 years) | 2006 | 3.015 |
Cites / Doc. (3 years) | 2007 | 2.704 |
Cites / Doc. (3 years) | 2008 | 2.465 |
Cites / Doc. (3 years) | 2009 | 2.649 |
Cites / Doc. (3 years) | 2010 | 2.693 |
Cites / Doc. (3 years) | 2011 | 3.105 |
Cites / Doc. (3 years) | 2012 | 3.389 |
Cites / Doc. (3 years) | 2013 | 3.420 |
Cites / Doc. (3 years) | 2014 | 3.318 |
Cites / Doc. (3 years) | 2015 | 2.358 |
Cites / Doc. (3 years) | 2016 | 2.502 |
Cites / Doc. (3 years) | 2017 | 2.275 |
Cites / Doc. (3 years) | 2018 | 3.131 |
Cites / Doc. (3 years) | 2019 | 3.150 |
Cites / Doc. (3 years) | 2020 | 4.411 |
Cites / Doc. (3 years) | 2021 | 4.164 |
Cites / Doc. (3 years) | 2022 | 3.238 |
Cites / Doc. (3 years) | 2023 | 2.677 |
Cites / Doc. (2 years) | 1999 | 1.135 |
Cites / Doc. (2 years) | 2000 | 1.662 |
Cites / Doc. (2 years) | 2001 | 1.586 |
Cites / Doc. (2 years) | 2002 | 2.228 |
Cites / Doc. (2 years) | 2003 | 2.423 |
Cites / Doc. (2 years) | 2004 | 2.447 |
Cites / Doc. (2 years) | 2005 | 2.602 |
Cites / Doc. (2 years) | 2006 | 2.776 |
Cites / Doc. (2 years) | 2007 | 2.419 |
Cites / Doc. (2 years) | 2008 | 2.252 |
Cites / Doc. (2 years) | 2009 | 2.181 |
Cites / Doc. (2 years) | 2010 | 2.578 |
Cites / Doc. (2 years) | 2011 | 2.968 |
Cites / Doc. (2 years) | 2012 | 3.210 |
Cites / Doc. (2 years) | 2013 | 3.171 |
Cites / Doc. (2 years) | 2014 | 2.871 |
Cites / Doc. (2 years) | 2015 | 2.051 |
Cites / Doc. (2 years) | 2016 | 2.418 |
Cites / Doc. (2 years) | 2017 | 2.535 |
Cites / Doc. (2 years) | 2018 | 2.906 |
Cites / Doc. (2 years) | 2019 | 3.530 |
Cites / Doc. (2 years) | 2020 | 3.795 |
Cites / Doc. (2 years) | 2021 | 3.766 |
Cites / Doc. (2 years) | 2022 | 2.462 |
Cites / Doc. (2 years) | 2023 | 2.618 |
Evolution of the total number of citations and journal's self-citations received by a journal's published documents during the three previous years. Journal Self-citation is defined as the number of citation from a journal citing article to articles published by the same journal.
Cites | Year | Value |
---|---|---|
Self Cites | 1999 | 15 |
Self Cites | 2000 | 16 |
Self Cites | 2001 | 16 |
Self Cites | 2002 | 12 |
Self Cites | 2003 | 12 |
Self Cites | 2004 | 14 |
Self Cites | 2005 | 22 |
Self Cites | 2006 | 28 |
Self Cites | 2007 | 16 |
Self Cites | 2008 | 16 |
Self Cites | 2009 | 23 |
Self Cites | 2010 | 18 |
Self Cites | 2011 | 13 |
Self Cites | 2012 | 13 |
Self Cites | 2013 | 15 |
Self Cites | 2014 | 8 |
Self Cites | 2015 | 5 |
Self Cites | 2016 | 22 |
Self Cites | 2017 | 9 |
Self Cites | 2018 | 5 |
Self Cites | 2019 | 6 |
Self Cites | 2020 | 3 |
Self Cites | 2021 | 3 |
Self Cites | 2022 | 3 |
Self Cites | 2023 | 4 |
Total Cites | 1999 | 296 |
Total Cites | 2000 | 360 |
Total Cites | 2001 | 391 |
Total Cites | 2002 | 596 |
Total Cites | 2003 | 666 |
Total Cites | 2004 | 786 |
Total Cites | 2005 | 770 |
Total Cites | 2006 | 1010 |
Total Cites | 2007 | 987 |
Total Cites | 2008 | 875 |
Total Cites | 2009 | 869 |
Total Cites | 2010 | 843 |
Total Cites | 2011 | 1006 |
Total Cites | 2012 | 1159 |
Total Cites | 2013 | 1067 |
Total Cites | 2014 | 1042 |
Total Cites | 2015 | 738 |
Total Cites | 2016 | 808 |
Total Cites | 2017 | 662 |
Total Cites | 2018 | 811 |
Total Cites | 2019 | 778 |
Total Cites | 2020 | 944 |
Total Cites | 2021 | 712 |
Total Cites | 2022 | 463 |
Total Cites | 2023 | 356 |
Evolution of the number of total citation per document and external citation per document (i.e. journal self-citations removed) received by a journal's published documents during the three previous years. External citations are calculated by subtracting the number of self-citations from the total number of citations received by the journal’s documents.
Cites | Year | Value |
---|---|---|
External Cites per document | 1999 | 1.186 |
External Cites per document | 2000 | 1.502 |
External Cites per document | 2001 | 1.550 |
External Cites per document | 2002 | 2.187 |
External Cites per document | 2003 | 2.263 |
External Cites per document | 2004 | 2.728 |
External Cites per document | 2005 | 2.477 |
External Cites per document | 2006 | 2.931 |
External Cites per document | 2007 | 2.660 |
External Cites per document | 2008 | 2.420 |
External Cites per document | 2009 | 2.579 |
External Cites per document | 2010 | 2.636 |
External Cites per document | 2011 | 3.065 |
External Cites per document | 2012 | 3.351 |
External Cites per document | 2013 | 3.372 |
External Cites per document | 2014 | 3.293 |
External Cites per document | 2015 | 2.342 |
External Cites per document | 2016 | 2.433 |
External Cites per document | 2017 | 2.244 |
External Cites per document | 2018 | 3.112 |
External Cites per document | 2019 | 3.126 |
External Cites per document | 2020 | 4.397 |
External Cites per document | 2021 | 4.146 |
External Cites per document | 2022 | 3.217 |
External Cites per document | 2023 | 2.647 |
Cites per document | 1999 | 1.249 |
Cites per document | 2000 | 1.572 |
Cites per document | 2001 | 1.616 |
Cites per document | 2002 | 2.232 |
Cites per document | 2003 | 2.304 |
Cites per document | 2004 | 2.777 |
Cites per document | 2005 | 2.550 |
Cites per document | 2006 | 3.015 |
Cites per document | 2007 | 2.704 |
Cites per document | 2008 | 2.465 |
Cites per document | 2009 | 2.649 |
Cites per document | 2010 | 2.693 |
Cites per document | 2011 | 3.105 |
Cites per document | 2012 | 3.389 |
Cites per document | 2013 | 3.420 |
Cites per document | 2014 | 3.318 |
Cites per document | 2015 | 2.358 |
Cites per document | 2016 | 2.502 |
Cites per document | 2017 | 2.275 |
Cites per document | 2018 | 3.131 |
Cites per document | 2019 | 3.150 |
Cites per document | 2020 | 4.411 |
Cites per document | 2021 | 4.164 |
Cites per document | 2022 | 3.238 |
Cites per document | 2023 | 2.677 |
International Collaboration accounts for the articles that have been produced by researchers from several countries. The chart shows the ratio of a journal's documents signed by researchers from more than one country; that is including more than one country address.
Year | International Collaboration |
---|---|
1999 | 21.62 |
2000 | 19.00 |
2001 | 17.20 |
2002 | 22.92 |
2003 | 26.60 |
2004 | 27.68 |
2005 | 27.13 |
2006 | 21.77 |
2007 | 21.57 |
2008 | 22.55 |
2009 | 22.02 |
2010 | 27.43 |
2011 | 28.33 |
2012 | 26.58 |
2013 | 33.91 |
2014 | 35.29 |
2015 | 26.97 |
2016 | 32.53 |
2017 | 35.63 |
2018 | 28.57 |
2019 | 30.00 |
2020 | 15.91 |
2021 | 22.45 |
2022 | 12.50 |
2023 | 35.11 |
Not every article in a journal is considered primary research and therefore "citable", this chart shows the ratio of a journal's articles including substantial research (research articles, conference papers and reviews) in three year windows vs. those documents other than research articles, reviews and conference papers.
Documents | Year | Value |
---|---|---|
Non-citable documents | 1999 | 1 |
Non-citable documents | 2000 | 1 |
Non-citable documents | 2001 | 3 |
Non-citable documents | 2002 | 5 |
Non-citable documents | 2003 | 6 |
Non-citable documents | 2004 | 3 |
Non-citable documents | 2005 | 2 |
Non-citable documents | 2006 | 1 |
Non-citable documents | 2007 | 1 |
Non-citable documents | 2008 | 5 |
Non-citable documents | 2009 | 24 |
Non-citable documents | 2010 | 28 |
Non-citable documents | 2011 | 25 |
Non-citable documents | 2012 | 8 |
Non-citable documents | 2013 | 10 |
Non-citable documents | 2014 | 15 |
Non-citable documents | 2015 | 19 |
Non-citable documents | 2016 | 17 |
Non-citable documents | 2017 | 13 |
Non-citable documents | 2018 | 8 |
Non-citable documents | 2019 | 6 |
Non-citable documents | 2020 | 5 |
Non-citable documents | 2021 | 5 |
Non-citable documents | 2022 | 4 |
Non-citable documents | 2023 | 2 |
Citable documents | 1999 | 236 |
Citable documents | 2000 | 228 |
Citable documents | 2001 | 239 |
Citable documents | 2002 | 262 |
Citable documents | 2003 | 283 |
Citable documents | 2004 | 280 |
Citable documents | 2005 | 300 |
Citable documents | 2006 | 334 |
Citable documents | 2007 | 364 |
Citable documents | 2008 | 350 |
Citable documents | 2009 | 304 |
Citable documents | 2010 | 285 |
Citable documents | 2011 | 299 |
Citable documents | 2012 | 334 |
Citable documents | 2013 | 302 |
Citable documents | 2014 | 299 |
Citable documents | 2015 | 294 |
Citable documents | 2016 | 306 |
Citable documents | 2017 | 278 |
Citable documents | 2018 | 251 |
Citable documents | 2019 | 241 |
Citable documents | 2020 | 209 |
Citable documents | 2021 | 166 |
Citable documents | 2022 | 139 |
Citable documents | 2023 | 131 |
Ratio of a journal's items, grouped in three years windows, that have been cited at least once vs. those not cited during the following year.
Documents | Year | Value |
---|---|---|
Uncited documents | 1999 | 93 |
Uncited documents | 2000 | 81 |
Uncited documents | 2001 | 80 |
Uncited documents | 2002 | 81 |
Uncited documents | 2003 | 88 |
Uncited documents | 2004 | 72 |
Uncited documents | 2005 | 85 |
Uncited documents | 2006 | 67 |
Uncited documents | 2007 | 93 |
Uncited documents | 2008 | 91 |
Uncited documents | 2009 | 77 |
Uncited documents | 2010 | 67 |
Uncited documents | 2011 | 75 |
Uncited documents | 2012 | 60 |
Uncited documents | 2013 | 64 |
Uncited documents | 2014 | 58 |
Uncited documents | 2015 | 100 |
Uncited documents | 2016 | 96 |
Uncited documents | 2017 | 84 |
Uncited documents | 2018 | 52 |
Uncited documents | 2019 | 45 |
Uncited documents | 2020 | 30 |
Uncited documents | 2021 | 34 |
Uncited documents | 2022 | 30 |
Uncited documents | 2023 | 25 |
Cited documents | 1999 | 144 |
Cited documents | 2000 | 148 |
Cited documents | 2001 | 162 |
Cited documents | 2002 | 186 |
Cited documents | 2003 | 201 |
Cited documents | 2004 | 211 |
Cited documents | 2005 | 217 |
Cited documents | 2006 | 268 |
Cited documents | 2007 | 272 |
Cited documents | 2008 | 264 |
Cited documents | 2009 | 251 |
Cited documents | 2010 | 246 |
Cited documents | 2011 | 249 |
Cited documents | 2012 | 282 |
Cited documents | 2013 | 248 |
Cited documents | 2014 | 256 |
Cited documents | 2015 | 213 |
Cited documents | 2016 | 227 |
Cited documents | 2017 | 207 |
Cited documents | 2018 | 207 |
Cited documents | 2019 | 202 |
Cited documents | 2020 | 184 |
Cited documents | 2021 | 137 |
Cited documents | 2022 | 113 |
Cited documents | 2023 | 108 |
Evolution of the percentage of female authors.
Year | Female Percent |
---|---|
1999 | 42.80 |
2000 | 35.83 |
2001 | 45.48 |
2002 | 42.28 |
2003 | 44.71 |
2004 | 46.30 |
2005 | 47.16 |
2006 | 47.96 |
2007 | 43.01 |
2008 | 38.42 |
2009 | 38.34 |
2010 | 46.94 |
2011 | 44.87 |
2012 | 43.48 |
2013 | 46.61 |
2014 | 42.80 |
2015 | 43.33 |
2016 | 44.81 |
2017 | 42.75 |
2018 | 43.00 |
2019 | 40.24 |
2020 | 50.70 |
2021 | 52.63 |
2022 | 48.83 |
2023 | 50.49 |
Evolution of the number of documents cited by public policy documents according to Overton database.
Documents | Year | Value |
---|---|---|
Overton | 1999 | 0 |
Overton | 2000 | 0 |
Overton | 2001 | 0 |
Overton | 2002 | 0 |
Overton | 2003 | 0 |
Overton | 2004 | 10 |
Overton | 2005 | 12 |
Overton | 2006 | 12 |
Overton | 2007 | 12 |
Overton | 2008 | 6 |
Overton | 2009 | 11 |
Overton | 2010 | 11 |
Overton | 2011 | 12 |
Overton | 2012 | 7 |
Overton | 2013 | 5 |
Overton | 2014 | 6 |
Overton | 2015 | 6 |
Overton | 2016 | 2 |
Overton | 2017 | 6 |
Overton | 2018 | 3 |
Overton | 2019 | 0 |
Overton | 2020 | 0 |
Overton | 2021 | 0 |
Overton | 2022 | 0 |
Overton | 2023 | 0 |
Evoution of the number of documents related to Sustainable Development Goals defined by United Nations. Available from 2018 onwards.
Documents | Year | Value |
---|---|---|
SDG | 2018 | 10 |
SDG | 2019 | 11 |
SDG | 2020 | 8 |
SDG | 2021 | 10 |
SDG | 2022 | 5 |
SDG | 2023 | 20 |
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Microbiology
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Advancements in immunology and microbiology research: a comprehensive exploration of key areas.
1. Introduction
2. unveiling the potential of bacterial proteins as antibody reagents and engineering chimeric proteins, 3. illuminating pathways in vaccine development and clinical studies, 3.1. an hiv experimental vaccine, 3.2. african swine fever virus vaccine update, 3.3. vaccine development faces challenges in inducing strong immune responses, 3.4. new developments in hiv vaccines and challenges, 3.5. tuberculosis vaccines, 3.6. messenger rna (mrna) vaccines, 4. microbiological insights and antimicrobial resistance surveillance, 4.1. extended-spectrum beta-lactamases (esbls): a global public health challenge, 4.2. types of esbl and mechanisms of resistance, 4.3. detection of esbls in medical institutions, 4.4. methicillin-resistant staphylococcus aureus (mrsa) in the caribbean and globally, 4.5. mechanisms of bacterial resistance, 5. evolution of immunological techniques and advancements in blood banking, 6. immunological techniques’ impact on global health and the support of quantitative data, 7. navigating clinical immunology: from bench to bedside management, 7.1. severe combined immunodeficiency disorders, 7.2. transient hypogammaglobulinemia of infancy, 7.3. chronic granulomatous disease (cgd), 7.4. neuropsychiatric systemic lupus erythematosus (npsle), 7.5. viral infections in children with scid, 8. advancements in cancer research: insights and innovations, 9. conclusions, author contributions, institutional review board statement, informed consent statement, data availability statement, acknowledgments, conflicts of interest.
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Click here to enlarge figure
Disease | Diagnosis | Management/Treatment | References |
---|---|---|---|
1. Profound deficiencies in T cells, B cells, or both at birth. 2. Due to infections, affected patients usually do not survive beyond infancy. 3. The genetic heterogeneity of SCID frequently delays diagnosis. 4. An NGS-based multigene panel for diagnosing SCID is available. 5. Other problems found in SCID are protein-losing erythroderma, alopecia, hepatosplenomegaly, lymphadenopathies, and severe diarrhoea. 6. TREC/KREC newborn screening. | 1. Haematopoietic stem cell transplantation. 2. Antimicrobials. 3. Intravenous immunoglobulins. 4. Supportive therapy, such as nutritional support, aims to provide essential nutrients to maintain or improve a patient’s health. 5. Gene therapy. | [ , , ] | |
1. THI typically resolves by age four; preterm infants are especially vulnerable to THI. 2. THI, as defined by the WHO and IUIS, is a primary immunodeficiency with reduced immunoglobulin G and A levels. 3. THI diagnosis: the serum IgG levels are two standard deviations below average. 4. THI complications: recurrent infections, prolonged fever, failure to thrive, dermatitis, rhinitis, asthma, and diarrhoea. 5. The isoagglutinin levels and vaccine response are diagnostic tools for THI assessment. | 1. IVIG and antibiotic prophylaxis effectively treat THI; immunotherapy reduces allergies. 2. THI can cause infections by Staphylococcus aureus and Streptococcus, treated with antibiotics like amoxicillin or amoxicillin with clavulanate, dosed by age and weight. | [ , ] | |
1. Recurrent infections by catalase-positive microorganisms like Candida albicans and Staphylococcus aureus are common in CGD. 2. Inflammatory conditions, including bowel inflammatory disease, are associated with CGD. 3. Molecular diagnosis includes next-generation sequencing (NGS), Sanger sequencing, and Genescan analysis. | 1. Treatments for CGD include antibacterial prophylaxis with trimethoprim–sulfamethoxazole. Patients with sulfamethoxazole allergy have other options, such as cloxacillin and ciprofloxacin. 2. Antifungal prophylaxis with itraconazole. 3. Interferon gamma immunotherapy. 4. Haematopoietic stem cell transplantation (HCT) is the treatment of choice. 5. Gene therapy is used in a few cases. | [ , , , , ] | |
1. NPSLE diagnosis depends on clinical signs, symptoms, lab tests, neuroimaging, and histopathology findings, tailored case by case for accuracy. 2. The presence of systemic and anti-CNS antibodies. 3. The presence of headache, psychotic manifestations, mood disorders, convulsions, and other NPSLE manifestations. 4. Testing for anti-dsDNA antibodies. 5. Complement deposition. | 1. Antiepileptics, antipsychotics, anxiolytics, mood stabilisers, and antidepressants. 2. Glucocorticoids. 3. Cyclophosphamide, azathioprine, and mycophenolate mofetil. 4. Biologics: rituximab, belimumab, and anifrolumab. 5. Aspirin, heparin, and warfarin. 6. Novel oral anticoagulants: rivaroxaban, apixaban, and edoxaban. | [ , , ] |
Microorganisms | SCID | CGD | THI |
---|---|---|---|
S. aureus; Pseudomonas spp.; Mycobacterium bovis. Atypical mycobacteria: Klebsiella pneumoniae; Pseudomonas aeruginosa; Burkholderia; Chryseobacterium. | S. aureus; Nocardia spp.; Burkholderia spp.; Serratia spp.; Chromobacter spp.; Salmonella spp. | Streptococcus pneumoniae; Haemophilus; influenzae type b; Pseudomonas aeruginosa; S. aureus; Clostridium difficile. | |
Cytomegalovirus; Adenovirus; Enterovirus; Herpes simplex virus; Respiratory syncytial virus; Epstein–Barr virus; Rotavirus; Parainfluenza virus. | It is not a primary concern. | Respiratory syncytial virus; Enteroviruses; Rotavirus. | |
Pneumocystis jirovecii; Histoplasma capsulatum; Cryptococcus neoformans; Candida albicans; Aspergillus spp. Acremonium; Pichia. | Aspergillus spp.; Candida spp.; Fusarium dimerum; Penicillium; Paecilomyces variotii; Scedosporium. | Candida spp. | |
Giardia duodenalis; Giardia intestinalis; Cryptosporidium spp.; Schistosoma species; Blastocystis hominis; Fasciola spp.; Trichostrongylus spp. Cryptosporidium spp. | It is not a primary concern. | Giardia lamblia. | |
[ , , ] | [ , , ] | [ , ] |
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Justiz-Vaillant, A.; Gopaul, D.; Soodeen, S.; Unakal, C.; Thompson, R.; Pooransingh, S.; Arozarena-Fundora, R.; Asin-Milan, O.; Akpaka, P.E. Advancements in Immunology and Microbiology Research: A Comprehensive Exploration of Key Areas. Microorganisms 2024 , 12 , 1672. https://doi.org/10.3390/microorganisms12081672
Justiz-Vaillant A, Gopaul D, Soodeen S, Unakal C, Thompson R, Pooransingh S, Arozarena-Fundora R, Asin-Milan O, Akpaka PE. Advancements in Immunology and Microbiology Research: A Comprehensive Exploration of Key Areas. Microorganisms . 2024; 12(8):1672. https://doi.org/10.3390/microorganisms12081672
Justiz-Vaillant, Angel, Darren Gopaul, Sachin Soodeen, Chandrashekhar Unakal, Reinand Thompson, Shalini Pooransingh, Rodolfo Arozarena-Fundora, Odalis Asin-Milan, and Patrick Eberechi Akpaka. 2024. "Advancements in Immunology and Microbiology Research: A Comprehensive Exploration of Key Areas" Microorganisms 12, no. 8: 1672. https://doi.org/10.3390/microorganisms12081672
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Production, purification and characterization of phytase from Pichia kudriavevii FSMP-Y17and its application in layers feed
- Biotechnology and Industrial Microbiology - Research Paper
- Published: 20 August 2024
Cite this article
- Ritu Sharma 1 ,
- Arpana Mittal 1 ,
- Varun Gupta 2 &
- Neeraj K. Aggarwal ORCID: orcid.org/0000-0003-3515-1207 1
Introduction
Phytase, recognized for its ability to enhance the nutritional value of phytate-rich foods, has has gained significant prominence. The production of this enzyme has been significantly boosted while preserving economic efficiency by utilizing natural substrates and optimizing essential factors. This study focuses on optimizing phytase production through solid-state fermentation and evaluating its effectiveness in enhancing nutrient utilization in chicken diets.
The objective is to optimize phytase production via solid-state fermentation, characterize purified phytase properties, and assess its impact on nutrient utilization in chicken diets. Through these objectives, we aim to deepen understanding of phytase's role in poultry nutrition and contribute to more efficient feed formulations for improved agricultural outcomes.
Methodology
We utilized solid-state fermentation with Pichia kudriavzevii FSMP-Y17 yeast on orange peel substrate, optimizing variables like temperature, pH, incubation time, and supplementing with glucose and ammonium sulfate. Following fermentation, we purified the phytase enzyme using standard techniques, characterizing its properties, including molecular weight, optimal temperature and pH, substrate affinity, and kinetic parameters.
The optimized conditions yielded a remarkable phytase yield of 7.0 U/gds. Following purification, the enzyme exhibited a molecular weight of 64 kDa and displayed optimal activity at 55 °C and pH 5.5, with kinetic parameters (Km = 3.39 × 10 –3 M and a V max of 7.092 mM/min) indicating efficient substrate affinity.
The addition of purified phytase to chicken diets resulted in significant improvements in nutrient utilization and overall performance, including increased feed intake, improved feed conversion ratio, enhanced bird growth, better phosphorus retention, and improved egg production and quality. By addressing challenges associated with phytate-rich diets, such as reduced nutrient availability and environmental pollution, phytase utilization promotes animal welfare and sustainability in poultry production.
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Abbreviations
Diethylaminoethyl cellulose
Ethylenediaminetetraacetic acid
Feed conversion ratio
β-mercaptoethanol
Polyacrylamide gel electrophoresis
Sodium dodecyl sulphate
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Immunology and microbiology research has witnessed remarkable growth and innovation globally, playing a pivotal role in advancing our understanding of immune mechanisms, disease pathogenesis, and therapeutic interventions. This manuscript presents a comprehensive exploration of the key areas in immunology research, spanning from the utilisation of bacterial proteins as antibody reagents to the ...
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Journal of Advances in Microbiology Research is a Peer Reviewed International Open Access Journal which will be abstracted in various reputed databases. The Journal provides the platform with the aim of motivating the students and personnel. The journal is indexed in Index Copernicus, Google Scholar, ResearchBib, Geneva Foundation for Medical ...
Yuanyuan Ma, Xiuqin Wu, Shuying Li, Lie Tang, ... Qianli An. Article 103924. View PDF. Previous vol/issue. Next vol/issue. ISSN: 0923-2508. Read the latest articles of Research in Microbiology at ScienceDirect.com, Elsevier's leading platform of peer-reviewed scholarly literature.
Brazilian Journal of Microbiology - Phytase, recognized for its ability to enhance the nutritional value of phytate-rich foods, has has gained significant prominence. ... However, it's crucial to acknowledge the limitations and constraints of this study. Firstly, the research focused primarily on layers, and further investigations are required ...
The research, described August 15 in the journal mBio, suggests that loss of a protein called OpgH in a widely studied bacterium known as Caulobacter crescentus creates a cascade of activity that ...
Current Research in Microbial Sciences is a gold open access (OA) journal, which means articles are permanently and freely available. It is a companion to the highly regarded review journal Current Opinion in Microbiology and is part of the Current Opinion and Research (CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion ...
The FASEB Journal publishes multidisciplinary basic and translational research covering biology and biomedical sciences at every level of organization. ... encompassing research from the physiological to molecular levels. Research in this issue will focus on: 1) pain physiology and pharmacology, 2) the molecular mechanisms of pain, and 3 ...
The past century has seen our understanding of biology transformed from phenomenology to programmability. This transformation is the product of several revolutions: mapping the fundamental rules ...