research journal article mean

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What is a journal article? (What is an article?)

Definitions.

Journal articles are shorter than books and written about very specific topics. 

A  journal  is a collection of articles (like a magazine) that is published regularly throughout the year. Journals present the most recent research, and journal articles are written by experts, for experts. They may be published in print or online formats, or both. 

Sample images

The front cover of a sample academic journal ( PORTAL: Journal of Multidisciplinary International Studies ). Note that it includes a year, as well as "Vol." (for "Volume") and "No." (for "Number"). Because journals are published regularly, this information identifies different issues (like month and year on a popular magazine).

A sample table of contents from the same academic journal, listing the articles that appear in this issue. (Note: When accessing journals online, articles are usually available as separate PDF documents.)

A sample  article (first page) from the same academic journal:

More information

Finding academic or scholarly journal articles Tips for searching for journal articles in the Library.

What is a scholarly (or peer-reviewed) journal ? For the differences between scholarly journals, magazines, and trade publications -- and when to use them.

Finding and evaluating sources Searching for and evaluating sources on the open web, with tips for evaluating all sources, including journals and journal articles.

What is peer review? What is a peer-reviewed journal? What peer review means and how to tell if a journal is peer-reviewed.

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Social Work Research Guide

What is a research journal.

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Reading an Academic Article

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Anatomy of a Scholarly Article

TIP: When possible, keep your research question(s) in mind when reading scholarly articles. It will help you to focus your reading.

Title : Generally are straightforward and describe what the article is about. Titles often include relevant key words.

Abstract : A summary of the author(s)'s research findings and tells what to expect when you read the full article. It is often a good idea to read the abstract first, in order to determine if you should even bother reading the whole article.

Discussion and Conclusion : Read these after the Abstract (even though they come at the end of the article). These sections can help you see if this article will meet your research needs. If you don’t think that it will, set it aside.

Introduction : Describes the topic or problem researched. The authors will present the thesis of their argument or the goal of their research.

Literature Review : May be included in the introduction or as its own separate section. Here you see where the author(s) enter the conversation on this topic. That is to say, what related research has come before, and how do they hope to advance the discussion with their current research?

Methods : This section explains how the study worked. In this section, you often learn who and how many participated in the study and what they were asked to do. You will need to think critically about the methods and whether or not they make sense given the research question.

Results : Here you will often find numbers and tables. If you aren't an expert at statistics this section may be difficult to grasp. However you should attempt to understand if the results seem reasonable given the methods.

Works Cited (also be called References or Bibliography ): This section comprises the author(s)’s sources. Always be sure to scroll through them. Good research usually cites many different kinds of sources (books, journal articles, etc.). As you read the Works Cited page, be sure to look for sources that look like they will help you to answer your own research question.

Adapted from http://library.hunter.cuny.edu/research-toolkit/how-do-i-read-stuff/anatomy-of-a-scholarly-article

A research journal is a periodical that contains articles written by experts in a particular field of study who report the results of research in that field. The articles are intended to be read by other experts or students of the field, and they are typically much more sophisticated and advanced than the articles found in general magazines. This guide offers some tips to help distinguish scholarly journals from other periodicals.

CHARACTERISTICS OF RESEARCH JOURNALS

PURPOSE : Research journals communicate the results of research in the field of study covered by the journal. Research articles reflect a systematic and thorough study of a single topic, often involving experiments or surveys. Research journals may also publish review articles and book reviews that summarize the current state of knowledge on a topic.

APPEARANCE : Research journals lack the slick advertising, classified ads, coupons, etc., found in popular magazines. Articles are often printed one column to a page, as in books, and there are often graphs, tables, or charts referring to specific points in the articles.

AUTHORITY : Research articles are written by the person(s) who did the research being reported. When more than two authors are listed for a single article, the first author listed is often the primary researcher who coordinated or supervised the work done by the other authors. The most highly‑regarded scholarly journals are typically those sponsored by professional associations, such as the American Psychological Association or the American Chemical Society.

VALIDITY AND RELIABILITY : Articles submitted to research journals are evaluated by an editorial board and other experts before they are accepted for publication. This evaluation, called peer review, is designed to ensure that the articles published are based on solid research that meets the normal standards of the field of study covered by the journal. Professors sometimes use the term "refereed" to describe peer-reviewed journals.

WRITING STYLE : Articles in research journals usually contain an advanced vocabulary, since the authors use the technical language or jargon of their field of study. The authors assume that the reader already possesses a basic understanding of the field of study.

REFERENCES : The authors of research articles always indicate the sources of their information. These references are usually listed at the end of an article, but they may appear in the form of footnotes, endnotes, or a bibliography.

PERIODICALS THAT ARE NOT RESEARCH JOURNALS

POPULAR MAGAZINES : These are periodicals that one typically finds at grocery stores, airport newsstands, or bookstores at a shopping mall. Popular magazines are designed to appeal to a broad audience, and they usually contain relatively brief articles written in a readable, non‑technical language.

Examples include: Car and Driver , Cosmopolitan , Esquire , Essence , Gourmet , Life , People Weekly , Readers' Digest , Rolling Stone , Sports Illustrated , Vanity Fair , and Vogue .

NEWS MAGAZINES : These periodicals, which are usually issued weekly, provide information on topics of current interest, but their articles seldom have the depth or authority of scholarly articles.

Examples include: Newsweek , Time , U.S. News and World Report .

OPINION MAGAZINES : These periodicals contain articles aimed at an educated audience interested in keeping up with current events or ideas, especially those pertaining to topical issues. Very often their articles are written from a particular political, economic, or social point of view.

Examples include: Catholic World , Christianity Today , Commentary , Ms. , The Militant , Mother Jones , The Nation , National Review , The New Republic , The Progressive , and World Marxist Review .

TRADE MAGAZINES : People who need to keep up with developments in a particular industry or occupation read these magazines. Many trade magazines publish one or more special issues each year that focus on industry statistics, directory lists, or new product announcements.

Examples include: Beverage World , Progressive Grocer , Quick Frozen Foods International , Rubber World , Sales and Marketing Management , Skiing Trade News , and Stores .

Literature Reviews

• Literature Review Guide General information on how to organize and write a literature review.
• The Literature Review: A Few Tips On Conducting It Contains two sets of questions to help students review articles, and to review their own literature reviews.
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What is a Scholarly Article: What is a scholarly article

Determineif a source is scholarly, determine if a source is scholarly, what is a scholarly source.

Scholarly sources (also referred to as academic, peer-reviewed, or refereed sources) are written by experts in a particular field and serve to keep others interested in that field up to date on the most recent research, findings, and news. These resources will provide the most substantial information for your research and papers.

What is peer-review?

When a source has been peer-reviewed, it has undergone the review and scrutiny of a review board of colleagues in the author’s field. They evaluate this source as part of the body of research for a particular discipline and make recommendations regarding its publication in a journal, revisions prior to publication, or, in some cases, reject its publication.

Why use scholarly sources?

Scholarly sources’ authority and credibility improve the quality of your own paper or research project.

How can I tell if a source is scholarly?

The following characteristics can help you differentiate scholarly sources from those that are not. Be sure to look at the criteria in each category when making your determination, rather than basing your decision on only one piece of information.

• Are author names provided?
• Are the authors’ credentials provided?
• Are the credentials relevant to the information provided?
• Who is the publisher of the information?
• Is the publisher an academic institution, scholarly, or professional organization?
• Is their purpose for publishing this information evident?
• Who is the intended audience of this source?
• Is the language geared toward those with knowledge of a specific discipline rather than the general public?
• Why is the information being provided?
• Are sources cited?
• Are there charts, graphs, tables, and bibliographies included?
• Are research claims documented?
• Are conclusions based on evidence provided?
• How long is the source?

Currency/Timeliness

• Is the date of publication evident?

Additional Tips for Specific Scholarly Source Types

Each resource type below will also have unique criteria that can be applied to it to determine if it is scholarly.

• Books published by a University Press are likely to be scholarly.
• Professional organizations and the U.S. Government Printing Office can also be indicators that a book is scholarly.
• Book reviews can provide clues as to if a source is scholarly and highlight the intended audience. See our  Find Reviews  guide to locate reviews on titles of interest.
• Are the author’s professional affiliations provided?
• Who is the publisher?
• How frequently is the periodical published?
• How many and what kinds of advertisements are present? For example, is the advertising clearly geared towards readers in a specific discipline or occupation?
• For more information about different periodical types, see our  Selecting Sources  guide.
• What is the domain of the page (for example: .gov, .edu, etc.)?
• Who is publishing or sponsoring the page?
• Is contact information for the author/publisher provided?
• How recently was the page updated?
• Is the information biased? Scholarly materials published online should not have any evidence of bias.

Is My Source Scholarly? (Accessible View)

Step 1: Source

The article is most likely scholarly if:

• You found the article in a library database or Google Scholar
• The journal the article appears in is peer-reviewed

Move to Step 2: Authors

Step 2: Authors

The source is most likely scholarly if:

• The authors’ credentials are provided
• The authors are affiliated with a university or other research institute

Move to Step 3: Content

Step 3: Content

• The source is longer than 10 pages
• Has a works cited or bibliography
• It does not attempt to persuade or bias the reader
• It attempts to persuade or bias the reader, but treats the topic objectively, the information is well-supported, and it includes a works cited or bibliography

If the article meets the criteria in Steps 1-3 it is most likely scholarly.

Common Characteristics of a Scholarly Article

Common characteristics of scholarly (research) articles.

Articles in scholarly journals may also be called research journals, peer reviewed journals, or refereed journals. These types of articles share many common features, including:

• articles always provide the name of the author or multiple authors
• author(s) always have academic credentials (e.g. biologist, chemist, anthropologist, lawyer)
• articles often have a sober, serious look
• articles may contain many graphs and charts; few glossy pages or color pictures
• author(s) write in the language of the discipline (e.g. biology, chemistry, anthropology, law, etc.)
• authors write for other scholars, and emerging scholars
• authors always cite their sources in footnotes, bibliographies, notes, etc.
• often (but not always) associated with universities or professional organizations

Types of Scholarly Articles

Peer Review in 3 Minutes

North Carolina State University (NCSU) Libraries (3:15)

• What do peer reviewers do?  How are they similar to or different from editors?
• Who are the primary customers of scholarly journals?
• Do databases only include peer-reviewed articles?  How do you know?

Is my source scholarly

Is My Source Scholarly?: INFOGRAPHIC

This infographic is part of the Illinois Library's Determine if a source is scholarly.

"Is my source scholarly" by Illinois Library  https://www.library.illinois.edu/ugl/howdoi/scholarly/

Anatomy of a Scholarly Article: Interactive Tutorial

Typical Sections of a Peer-Reviewed Research Article

Typical sections of peer-reviewed research articles.

Research articles in many disciplines are organized into standard sections. Although these sections may vary by discipline, common sections include:

• Introduction
• Materials and Methods

It's not hard to spot these sections; just look for bold headings in the article, as shown in these illustrations:

• Last Updated: Oct 22, 2020 11:31 AM
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Types of journal articles

It is helpful to familiarise yourself with the different types of articles published by journals. Although it may appear there are a large number of types of articles published due to the wide variety of names they are published under, most articles published are one of the following types; Original Research, Review Articles, Short reports or Letters, Case Studies, Methodologies.

Original Research:

This is the most common type of journal manuscript used to publish full reports of data from research. It may be called an  Original Article, Research Article, Research, or just  Article, depending on the journal. The Original Research format is suitable for many different fields and different types of studies. It includes full Introduction, Methods, Results, and Discussion sections.

Short reports or Letters:

These papers communicate brief reports of data from original research that editors believe will be interesting to many researchers, and that will likely stimulate further research in the field. As they are relatively short the format is useful for scientists with results that are time sensitive (for example, those in highly competitive or quickly-changing disciplines). This format often has strict length limits, so some experimental details may not be published until the authors write a full Original Research manuscript. These papers are also sometimes called Brief communications .

Review Articles:

Review Articles provide a comprehensive summary of research on a certain topic, and a perspective on the state of the field and where it is heading. They are often written by leaders in a particular discipline after invitation from the editors of a journal. Reviews are often widely read (for example, by researchers looking for a full introduction to a field) and highly cited. Reviews commonly cite approximately 100 primary research articles.

TIP: If you would like to write a Review but have not been invited by a journal, be sure to check the journal website as some journals to not consider unsolicited Reviews. If the website does not mention whether Reviews are commissioned it is wise to send a pre-submission enquiry letter to the journal editor to propose your Review manuscript before you spend time writing it.  

Case Studies:

These articles report specific instances of interesting phenomena. A goal of Case Studies is to make other researchers aware of the possibility that a specific phenomenon might occur. This type of study is often used in medicine to report the occurrence of previously unknown or emerging pathologies.

Methodologies or Methods

These articles present a new experimental method, test or procedure. The method described may either be completely new, or may offer a better version of an existing method. The article should describe a demonstrable advance on what is currently available.

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How to Read an Academic Journal Article (UNH Manchester Library)

• About Journal Articles
• Anatomy of an Article
• Devise a Strategy

Attribution

This guide, "How to Read an Academic Journal Article" is derivative of How to Read a Journal Article by Frederique Laubepin licensed CC BY.

What is an academic journal article? Academic journals are periodicals in which researchers publish their work. They are typically peer-­reviewed, meaning that the work is reviewed and evaluated by other scholars prior to publication in an effort to ensure that only the best, most rigorously researched articles are published. Journal articles offer a window into the inner workings of a discipline. They demonstrate how researchers in various disciplines formulate hypotheses, design research, analyze the observations they collect, and interpret their results. Journal articles can appear daunting and often make for dense, dry reading, but they generally follow a standardized format.

When it comes to reading journal articles, reading linearly (like you would a novel, starting at the beginning and reading word for word until you reach the end) is often not the most efficient approach. Depending on your goal, you may need to cut through peripheral details, ignore sophisticated statistics with which you may not be familiar, and focus on the central ideas. Once you understand the structure of each article, knowing where to look for important information and understanding the content becomes much easier.

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• Last Updated: Oct 10, 2023 4:55 PM
• URL: https://libraryguides.unh.edu/readarticle

Finding Scholarly Articles: Home

What's a Scholarly Article?

Your professor has specified that you are to use scholarly (or primary research or peer-reviewed or refereed or academic) articles only in your paper. What does that mean?

Scholarly or primary research articles are peer-reviewed , which means that they have gone through the process of being read by reviewers or referees  before being accepted for publication. When a scholar submits an article to a scholarly journal, the manuscript is sent to experts in that field to read and decide if the research is valid and the article should be published. Typically the reviewers indicate to the journal editors whether they think the article should be accepted, sent back for revisions, or rejected.

To decide whether an article is a primary research article, look for the following:

• The author’s (or authors') credentials and academic affiliation(s) should be given;
• There should be an abstract summarizing the research;
• The methods and materials used should be given, often in a separate section;
• There are citations within the text or footnotes referencing sources used;
• Results of the research are given;
• There should be discussion   and  conclusion ;
• With a bibliography or list of references at the end.

Caution: even though a journal may be peer-reviewed, not all the items in it will be. For instance, there might be editorials, book reviews, news reports, etc. Check for the parts of the article to be sure.   

You can limit your search results to primary research, peer-reviewed or refereed articles in many databases. To search for scholarly articles in  HOLLIS , type your keywords in the box at the top, and select  Catalog&Articles  from the choices that appear next.   On the search results screen, look for the  Show Only section on the right and click on  Peer-reviewed articles . (Make sure to  login in with your HarvardKey to get full-text of the articles that Harvard has purchased.)

Many of the databases that Harvard offers have similar features to limit to peer-reviewed or scholarly articles.  For example in Academic Search Premier , click on the box for Scholarly (Peer Reviewed) Journals  on the search screen.

Review articles are another great way to find scholarly primary research articles.   Review articles are not considered "primary research", but they pull together primary research articles on a topic, summarize and analyze them.  In Google Scholar , click on Review Articles  at the left of the search results screen. Ask your professor whether review articles can be cited for an assignment.

A note about Google searching.  A regular Google search turns up a broad variety of results, which can include scholarly articles but Google results also contain commercial and popular sources which may be misleading, outdated, etc.  Use Google Scholar  through the Harvard Library instead.

About Wikipedia .  W ikipedia is not considered scholarly, and should not be cited, but it frequently includes references to scholarly articles. Before using those references for an assignment, double check by finding them in Hollis or a more specific subject  database .

Still not sure about a source? Consult the course syllabus for guidance, contact your professor or teaching fellow, or use the Ask A Librarian service.

• Last Updated: Oct 3, 2023 3:37 PM
• URL: https://guides.library.harvard.edu/FindingScholarlyArticles

Harvard University Digital Accessibility Policy

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Evaluating Resources: Research Articles

Research articles.

A research article is a journal article in which the authors report on the research they did. Research articles are always primary sources. Whether or not a research article is peer reviewed depends on the journal that publishes it.

Published research articles follow a predictable pattern and will contain most, if not all, of the sections listed below. However, the names for these sections may vary.

• Title & Author(s)
• Introduction
• Methodology

To learn about the different parts of a research article, please view this tutorial:

Short video: How to Read Scholarly Articles

Learn some tips on how to efficiently read scholarly articles.

Video: How to Read a Scholarly Article

(4 min 16 sec) Recorded August 2019 Transcript 

More information

The Academic Skills Center and the Writing Center both have helpful resources on critical and academic reading that can further help you understand and evaluate research articles.

• Academic Skills Center Guide: Developing Your Reading Skills
• Academic Skills Center Webinar Archive: Savvy Strategies for Academic Reading
• Writing Center Podcast: WriteCast Episode 5: Five Strategies for Critical Reading

If you'd like to learn how to find research articles in the Library, you can view this Quick Answer.

• Quick Answer: How do I find research articles?
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Article Types: What's the Difference Between Newspapers, Magazines, and Journals?

• Journal Articles
• Definitions
• Choosing What's Best

Journal Article Characteristics

• Magazine Articles
• Trade Magazine/Journal Articles
• Newspaper Articles
• Newsletter Articles

PMLA -- Publications of the Modern Language Association (an example of an academic journal)

Analyzing a Journal Article

Authors : Authors of journal articles are usually affiliated with universities, research institutions, or professional associations. Author degrees are usually specified with the author names, as are the affiliations.

Abstract : The article text is usually preceded with an abstract. The abstract will provide an overview of what the article discusses or reveals and frequently is useful in identifying articles that report the results of scientific studies. Use of Professional Terminology and Language: The language used in journal articles is specific to the subject matter being covered by the journal. For example, an article written for a psychological journal is written in an academic rather than popular style and will make heavy use of psychological terms.

In Text References : Journal articles normally will be profusely documented with sources that have provided information to the article authors and/or that provide further related information. Documentation of sources can be handled by in-text parenthetical references (MLA, APA, Chicago sciences styles), by the use of footnotes (Chicago humanities style), or by the use of endnotes (Turabian style). Individual journals will specify their own requirements for documentation.

Bibliography : Because journal articles use numerous sources as documentation, these sources are often referenced in an alphabetically or numerically arranged bibliography located at the end of the article. Format of the bibliography will vary depending on the documentation style used in the article.

Charts, Graphs, Tables, Statistical Data : Articles that result from research studies will often include statistical data gathered during the course of the studies. These data are often presented in charts and tables.

Length of Article : Journal articles, in general, tend to be fairly lengthy, often consisting of a dozen or more pages. Some journals also publish book reviews. These are typically brief and should not be confused with the full-length research articles that the journal focuses on.

Use of volume and issue numbering : Journals normally make use of volume and issue numbering to help identify individual issues in their series. Normally a volume will encompass an entire year's worth of a journal's issues. For example, a journal that is published four times yearly (quarterly) will have four issues in its yearly volume. Issues may be identified solely with numbers or with both numbers and date designations. For example, a quarterly journal will typically number its issues 1 through 4, but it might also assign season designations to the individual numbers, such as Spring, Summer, Fall, and Winter. A monthly journal will have twelve issues in a yearly volume and might use the month names along with the issue numbers (issue 1, January; issue 2, February; and so on). Some magazines, trade publications, and newspapers might also make use of volume and issue numbering, so this isn't always the best indicator.

Subject Focus : Journals typically gather and publish research that focuses on a very specific field of inquiry, like criminology, or southern history, or statistics.

Overall Appearance : Journals are typically heavy on text and light on illustration. Journal covers tend toward the plain with an emphasis on highlighting key research articles that appear within a particular issue.

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What are Peer-Reviewed Journals?

• A Definition of Peer-Reviewed
• Research Guides and Tutorials
• Library FAQ Page This link opens in a new window

Research Help

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• What are Peer-reviewed Articles and How Do I Find Them? From Capella University Libraries

Introduction

Peer-reviewed journals (also called scholarly or refereed journals) are a key information source for your college papers and projects. They are written by scholars for scholars and are an reliable source for information on a topic or discipline. These journals can be found either in the library's online databases, or in the library's local holdings. This guide will help you identify whether a journal is peer-reviewed and show you tips on finding them.

What is Peer-Review?

Peer-review is a process where an article is verified by a group of scholars before it is published.

When an author submits an article to a peer-reviewed journal, the editor passes out the article to a group of scholars in the related field (the author's peers). They review the article, making sure that its sources are reliable, the information it presents is consistent with the research, etc. Only after they give the article their "okay" is it published.

The peer-review process makes sure that only quality research is published: research that will further the scholarly work in the field.

When you use articles from peer-reviewed journals, someone has already reviewed the article and said that it is reliable, so you don't have to take the steps to evaluate the author or his/her sources. The hard work is already done for you!

Identifying Peer-Review Journals

If you have the physical journal, you can look for the following features to identify if it is peer-reviewed.

Masthead (The first few pages) : includes information on the submission process, the editorial board, and maybe even a phrase stating that the journal is "peer-reviewed."

Publisher: Peer-reviewed journals are typically published by professional organizations or associations (like the American Chemical Society). They also may be affiliated with colleges/universities.

Graphics:  Typically there either won't be any images at all, or the few charts/graphs are only there to supplement the text information. They are usually in black and white.

Authors: The authors are listed at the beginning of the article, usually with information on their affiliated institutions, or contact information like email addresses.

Abstracts: At the beginning of the article the authors provide an extensive abstract detailing their research and any conclusions they were able to draw.

Terminology:  Since the articles are written by scholars for scholars, they use uncommon terminology specific to their field and typically do not define the words used.

Citations: At the end of each article is a list of citations/reference. These are provided for scholars to either double check their work, or to help scholars who are researching in the same general area.

Advertisements: Peer-reviewed journals rarely have advertisements. If they do the ads are for professional organizations or conferences, not for national products.

Identifying Articles from Databases

When you are looking at an article in an online database, identifying that it comes from a peer-reviewed journal can be more difficult. You do not have access to the physical journal to check areas like the masthead or advertisements, but you can use some of the same basic principles.

Points you may want to keep in mind when you are evaluating an article from a database:

• A lot of databases provide you with the option to limit your results to only those from peer-reviewed or refereed journals. Choosing this option means all of your results will be from those types of sources.  
• When possible, choose the PDF version of the article's full text. Since this is exactly as if you photocopied from the journal, you can get a better idea of its layout, graphics, advertisements, etc.  
• Even in an online database you still should be able to check for author information, abstracts, terminology, and citations.
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Making sense of research: A guide for critiquing a paper

Affiliation.

• 1 School of Nursing, Griffith University, Meadowbrook, Queensland.
• PMID: 16114192
• DOI: 10.5172/conu.14.1.38

Learning how to critique research articles is one of the fundamental skills of scholarship in any discipline. The range, quantity and quality of publications available today via print, electronic and Internet databases means it has become essential to equip students and practitioners with the prerequisites to judge the integrity and usefulness of published research. Finding, understanding and critiquing quality articles can be a difficult process. This article sets out some helpful indicators to assist the novice to make sense of research.

Publication types

• Data Interpretation, Statistical
• Research Design
• Review Literature as Topic

An Introduction to Statistics for Librarians (Part Two):

Frequency distributions and measures of central tendency.

• Caitlin Bakker University of Regina https://orcid.org/0000-0003-4154-8382

In Part One of this column, the different types of data were discussed. Understanding the type of data is essential to interpreting them. If the type of data isn’t correctly identified, it’s not possible to answer some fundamental questions accurately. One of these fundamental questions is “what’s the average value?” This is often the building block for more advanced statistical tests. In statistical terms, this question is asking us for the central tendency of the data. The central tendency is a single value that represents the midpoint of the data set. It tells us what is “average” or “normal” in the data set. There are three different ways to measure central tendency: mode, median, and mean. The measure chosen will depend on the type of data and the distribution of that data.

Bakker CJ. An Introduction to Statistics for Librarians (Part One): Types of Data. Hypothesis Res J Health Inf Prof [Internet]. 2022 Aug 24 [cited 2022 Dec 17];34(1). Available from: https://journals.iupui.edu/index.php/hypothesis/article/view/26428

Illowsky B, Dean S. Measures of the Spread of the Data. In: Introductory Statistics [Internet]. Houston, TX: OpenStax; 2013 [cited 2022 Dec 17]. Available from: https://openstax.org/details/books/introductory-statistics

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Hypothesis ISSN: 1093-5665 eISSN: 2688-1268

Using quality improvement approaches to increase emergency department provider engagement in research participant enrollment during COVID-19 and opioid overdose public health emergencies

• Quality Improvement and Patient Safety (QIPS)
• Published: 05 May 2024

Cite this article

• Alisha Hussey   ORCID: orcid.org/0000-0003-2143-8397 1 , 5 ,
• Kaela Pozsgay 2 ,
• Carolyn M. L. Crawford 3 ,
• Yueqiao Elle Wang   ORCID: orcid.org/0009-0000-1022-8752 1 ,
• Anthony Lau   ORCID: orcid.org/0000-0001-7643-9405 2 , 4 ,
• Andrew Kestler   ORCID: orcid.org/0000-0002-9358-0272 1 , 6 &
• Jessica Moe   ORCID: orcid.org/0000-0001-9557-1671 1 , 2  

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We utilized quality improvement (QI) approaches to increase emergency department (ED) provider engagement with research participant enrollment during the opioid crisis and coronavirus disease (COVID-19) pandemic. The context of this work is the Evaluating Microdosing in the Emergency Department (EMED) study, a randomized trial offering buprenorphine/naloxone to ED patients through randomization to standard or microdosing induction. Engaging providers is crucial for participant recruitment to our study. Anticipating challenges sustaining long-term engagement after a 63% decline in provider referrals four months into enrollments, we applied Plan-Do-Study-Act (PDSA) cycles to develop and implement an engagement strategy to increase and sustain provider engagement by 50% from baseline within 9 months.

Our engagement strategy was centered on Coffee Carts rounds: 5-min study-related educational presentations for providers on shift; and a secondary initiative, a Suboxone Champions program, to engage interested providers as study-related peer educators. We used provider referrals to our team as a proxy for study engagement and report the percent change in mean weekly referrals across two PDSA cycles relative to our established referral baseline.

A QI approach afforded real-time review of interventions based on research and provider priorities, increasing engagement via mean weekly provider referrals by 14.5% and 49% across two PDSA cycles relative to baseline, respectively.

Conclusions

Our Coffee Carts and Suboxone Champions program are efficient, low-barrier, educational initiatives to convey study-related information to providers. This work supported our efforts to maximally engage providers, minimize burden, and provide life-saving buprenorphine/naloxone to patients at risk of fatal overdose.

Nous avons utilisé des approches d’amélioration de la qualité (AQ) pour accroître l’engagement des fournisseurs des services d’urgence (SU) avec l’inscription des participants à la recherche pendant la crise des opioïdes et la pandémie de maladie à coronavirus (COVID-19). Le contexte de ce travail est l’étude Evaluating Microdosing in the Emergency Department (EMED), un essai randomisé offrant de la buprénorphine/naloxone aux patients aux urgences par randomisation à l’induction standard ou au microdosage. L’engagement des fournisseurs est crucial pour le recrutement des participants à notre étude. En anticipant les difficultés à maintenir un engagement à long terme après une baisse de 63 % des recommandations de fournisseurs quatre mois après les inscriptions, nous avons appliqué le Plan-Do-Study-Act (PDSA) cycles d’élaboration et de mise en œuvre d’une stratégie d’engagement visant à accroître et à maintenir l’engagement des fournisseurs de 50 % par rapport au niveau de référence dans les neuf mois.

Notre stratégie de mobilisation était axée sur les tournées de Coffee Carts : des présentations éducatives de cinq minutes sur l’étude pour les fournisseurs sur le quart de travail; et une initiative secondaire, un programme Suboxone Champions, pour mobiliser les fournisseurs intéressés en tant que pairs éducateurs liés à l’étude. Nous avons utilisé les recommandations des fournisseurs à notre équipe comme indicateur de la participation à l’étude et nous avons signalé le pourcentage de changement dans les recommandations hebdomadaires moyennes pour deux cycles PDSA par rapport à notre base de référence établie.

Une approche d’AQ a permis d’examiner en temps réel les interventions en fonction des priorités de la recherche et des fournisseurs, ce qui a augmenté l’engagement par l’intermédiaire des recommandations hebdomadaires moyennes des fournisseurs de 14,5 % et de 49 % au cours de deux cycles de PDSA par rapport au niveau de référence, respectivement.

Notre programme Coffee Carts and Suboxone Champions est une initiative éducative efficace et peu contraignante qui permet de transmettre aux fournisseurs des renseignements sur les études. Ce travail a appuyé nos efforts visant à mobiliser au maximum les fournisseurs, à réduire au minimum le fardeau et à fournir de la buprénorphine/naloxone vitale aux patients à risque de surdose mortelle.

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Implementation facilitation to introduce and support emergency department-initiated buprenorphine for opioid use disorder in high need, low resource settings: protocol for multi-site implementation-feasibility study

Implementation facilitation to promote emergency department-initiated buprenorphine for opioid use disorder: protocol for a hybrid type III effectiveness-implementation study (Project ED HEALTH)

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The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Acknowledgements

This work would not be possible without the dedicated support of our Nursing Educators, ED Research Nurses, Clinical Pharmacy and Physician Leads, Suboxone Champions, ED Physicians, Addictions Medicine colleagues, and our EMED study team members. Specifically, we would like to thank Lisa Welch, Dr. Jessica Hann, Dr. Asha Olmstead, and Cindy Liu.

Health Canada/Substance Use and Addictions Program, 2021-HQ-000012, Jessica Moe, Canadian Institutes of Health Research, PJT-178119, Jessica Moe.

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Alisha Hussey, Yueqiao Elle Wang, Andrew Kestler & Jessica Moe

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Faculty of Psychology, University of British Columbia, Kelowna, BC, Canada

Carolyn M. L. Crawford

Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada

Anthony Lau

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Hussey, A., Pozsgay, K., Crawford, C.M.L. et al. Using quality improvement approaches to increase emergency department provider engagement in research participant enrollment during COVID-19 and opioid overdose public health emergencies. Can J Emerg Med (2024). https://doi.org/10.1007/s43678-024-00691-7

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Gain-of -function research is more than just tweaking risky viruses – it’s a routine and essential tool in all biology research

Associate Professor of Microbiology and Immunology at Emory University and Adjunct Professor Microbiology and Molecular Genetics, University of Pittsburgh

Associate Professor of Microbiology and Immunology, Emory University

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Seema Lakdawala receives funding from National Institutes of Health and the Flu Lab.

Anice Lowen receives research funding from the National Institutes of Health and Flu Lab.

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The term “gain of function” is often taken to refer to research with viruses that puts society at risk of an infectious disease outbreak for questionable gain. Some research on emerging viruses can result in variants that gain the ability to infect people but this does not necessarily mean the research is dangerous or that it is not fruitful. Concerns have focused on lab research on the virus that causes bird flu in 2012 and on the virus that causes COVID-19 since 2020. The National Institutes of Health had previously implemented a three-year moratorium on gain-of-function research on certain viruses, and some U.S. legislatures have proposed bills prohibiting gain-of-function research on “potentially pandemic pathogens.”

The possibility that a genetically modified virus could escape the lab needs to be taken seriously. But it does not mean that gain-of-function experiments are inherently risky or the purview of mad scientists. In fact, gain-of-function approaches are a fundamental tool in biology used to study much more than just viruses, contributing to many, if not most, modern discoveries in the field, including penicillin , cancer immunotherapies and drought-resistant crops .

As scientists who study viruses , we believe that misunderstanding the term “gain of function” as something nefarious comes at the cost of progress in human health, ecological sustainability and technological advancement. Clarifying what gain-of-function research really is can help clarify why it is an essential scientific tool.

What is gain of function?

To study how a living thing operates, scientists can change a specific part of it and then observe the effects. These changes sometimes result in the organism’s gaining a function it didn’t have before or losing a function it once had.

For example, if the goal is to enhance the tumor-killing ability of immune cells, researchers can take a sample of a person’s immune cells and modify them to express a protein that specifically targets cancer cells. This mutated immune cell, called a CAR-T cell thereby “gains the function” of being able to bind to cancerous cells and kill them. The advance of similar immunotherapies that help the immune system attack cancer cells is based on the exploratory research of scientists who synthesized such “ Frankenstein” proteins in the 1980s. At that time, there was no way to know how useful these chimeric proteins would be to cancer treatment today, some 40 years later.

Similarly, by adding specific genes into rice, corn or wheat plants that increase their production in diverse climates, scientists have been able to produce plants that are able to grow and thrive in geographical regions they previously could not. This is a critical advance to maintain food supplies in the face of climate change. Well-known examples of food sources that have their origins in gain-of-function research include rice plants that can grow in high flood plains or in drought conditions or that contain vitamin A to reduce malnutrition.

Medical advances from gain-of-function research

Gain-of-function experiments are ingrained in the scientific process. In many instances, the benefits that stem from gain-of-function experiments are not immediately clear. Only decades later does the research bring a new treatment to the clinic or a new technology within reach.

The development of most antibiotics have relied on the manipulation of bacteria or mold in gain-of-function experiments. Alexander Fleming’s initial discovery that the mold Penicillium rubens could produce a compound toxic to bacteria was a profound medical advance. But it wasn’t until scientists experimented with growth conditions and mold strains that therapeutic use of penicillin became feasible. Using a specific growth medium allowed the mold to gain the function of increased penicillin production, which was essential for its mass production and widespread use as a drug.

Research on antibiotic resistance also relies heavily on gain-of-function approaches. Studying how bacteria gain resistance against drugs is essential to developing new treatments microbes are unable to evade quickly.

Gain-of-function research in virology has also been critical to the advancement of science and health. Oncolytic viruses are genetically modified in the laboratory to infect and kill cancerous cells like melanoma. Similarly, the Johnson & Johnson COVID-19 vaccine contains an adenovirus altered to produce the spike protein that helps the COVID-19 virus infect cells. Scientists developed live attenuated flu vaccines by adapting them to grow at low temperatures and thereby lose the ability to grow at human lung temperatures.

By giving viruses new functions, scientists were able to develop new tools to treat and prevent disease.

Nature’s gain-of-function experiments

Gain-of-function approaches are needed to advance understanding of viruses in part because these processes already occur in nature.

Many viruses that infect such nonhuman animals as bats, pigs, birds and mice have the potential to spill over into people . Every time a virus copies its genome, it makes mistakes. Most of these mutations are detrimental – they reduce a virus’s ability to replicate – but some may allow a virus to replicate faster or better in human cells. Variant viruses with these rare, beneficial mutations will spread better than other variants and therefore come to dominate the viral population – that is how natural selection works .

If these viruses can replicate even a little bit within people, they have the potential to adapt and thereby thrive in their new human hosts. That is nature’s gain-of-function experiment, and it is happening constantly .

Gain-of-function experiments in the lab can help scientists anticipate the changes viruses may undergo in nature by understanding what specific features allow them to transmit between people and infect them. In contrast to nature’s experiments, these are conducted in highly controlled lab conditions designed to limit infection risk to laboratory personnel and others, including air flow control, personal protective equipment and waste sterilization.

It is important that researchers carefully observe lab safety to minimize the theoretical risk of infecting the general population. It is equally important that virologists continue to apply the tools of modern science to gauge the risk of natural viral spillovers before they become outbreaks.

A bird flu outbreak is currently raging across multiple continents. While the H5N1 virus is primarily infecting birds, some people have gotten sick too. More spillover events can change the virus in ways that would allow it to transmit more efficiently among people , potentially leading to a pandemic.

Scientists have a better appreciation of the tangible risk of bird flu spillover because of gain-of-function experiments published a decade ago . Those lab studies showed that bird flu viruses could be transmitted through the air between ferrets within a few feet of one another. They also revealed multiple features of the evolutionary path the H5N1 virus would need to take before it becomes transmissible in mammals, informing what signatures researchers need to look out for during surveillance of the current outbreak.

Oversight on gain of function

Perhaps this sounds like a semantic argument, and in many respects it is. Many researchers would likely agree that gain of function as a general tool is an important way to study biology that should not be restricted, while also arguing that it should be curtailed for research on specific dangerous pathogens. The problem with this argument is that pathogen research needs to include gain-of-function approaches in order to be effective – just as in any area of biology.

Oversight of gain-of-function research on potential pandemic pathogens already exists. Multiple layers of safety measures at the institutional and national levels minimize the risks of virus research.

While updates to current oversight are not unreasonable, we believe that blanket bans or additional restrictions on gain-of-function research do not make society safer. They may instead slow research in areas ranging from cancer therapies to agriculture. Clarifying which specific research areas are of concern regarding gain-of-function approaches can help identify how the current oversight framework can be improved.

• Antibiotics
• Avian flu H5N1
• Golden rice
• Immunotherapy
• Cancer immunotherapy
• Penicillin antibiotics
• Laboratory studies
• COVID-19 vaccines
• Gain-of-function
• Gain of function

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A Peek Inside the Brains of ‘Super-Agers’

New research explores why some octogenarians have exceptional memories.

By Dana G. Smith

When it comes to aging, we tend to assume that cognition gets worse as we get older. Our thoughts may slow down or become confused, or we may start to forget things, like the name of our high school English teacher or what we meant to buy at the grocery store.

But that’s not the case for everyone.

For a little over a decade, scientists have been studying a subset of people they call “super-agers.” These individuals are age 80 and up, but they have the memory ability of a person 20 to 30 years younger.

Most research on aging and memory focuses on the other side of the equation — people who develop dementia in their later years. But, “if we’re constantly talking about what’s going wrong in aging, it’s not capturing the full spectrum of what’s happening in the older adult population,” said Emily Rogalski, a professor of neurology at the University of Chicago, who published one of the first studies on super-agers in 2012.

A paper published Monday in the Journal of Neuroscience helps shed light on what’s so special about the brains of super-agers. The biggest takeaway, in combination with a companion study that came out last year on the same group of individuals, is that their brains have less atrophy than their peers’ do.

The research was conducted on 119 octogenarians from Spain: 64 super-agers and 55 older adults with normal memory abilities for their age. The participants completed multiple tests assessing their memory, motor and verbal skills; underwent brain scans and blood draws; and answered questions about their lifestyle and behaviors.

The scientists found that the super-agers had more volume in areas of the brain important for memory, most notably the hippocampus and entorhinal cortex. They also had better preserved connectivity between regions in the front of the brain that are involved in cognition. Both the super-agers and the control group showed minimal signs of Alzheimer’s disease in their brains.

“By having two groups that have low levels of Alzheimer’s markers, but striking cognitive differences and striking differences in their brain, then we’re really speaking to a resistance to age-related decline,” said Dr. Bryan Strange, a professor of clinical neuroscience at the Polytechnic University of Madrid, who led the studies.

These findings are backed up by Dr. Rogalski’s research , initially conducted when she was at Northwestern University, which showed that super-agers’ brains looked more like 50- or 60-year-olds’ brains than their 80-year-old peers. When followed over several years, the super-agers’ brains atrophied at a slower rate than average.

No precise numbers exist on how many super-agers there are among us, but Dr. Rogalski said they’re “relatively rare,” noting that “far less than 10 percent” of the people she sees end up meeting the criteria.

But when you meet a super-ager, you know it, Dr. Strange said. “They are really quite energetic people, you can see. Motivated, on the ball, elderly individuals.”

Experts don’t know how someone becomes a super-ager, though there were a few differences in health and lifestyle behaviors between the two groups in the Spanish study. Most notably, the super-agers had slightly better physical health, both in terms of blood pressure and glucose metabolism, and they performed better on a test of mobility . The super-agers didn’t report doing more exercise at their current age than the typical older adults, but they were more active in middle age. They also reported better mental health .

But overall, Dr. Strange said, there were a lot of similarities between the super-agers and the regular agers. “There are a lot of things that are not particularly striking about them,” he said. And, he added, “we see some surprising omissions, things that you would expect to be associated with super-agers that weren’t really there.” For example, there were no differences between the groups in terms of their diets, the amount of sleep they got, their professional backgrounds or their alcohol and tobacco use.

The behaviors of some of the Chicago super-agers were similarly a surprise. Some exercised regularly, but some never had; some stuck to a Mediterranean diet, others subsisted off TV dinners; and a few of them still smoked cigarettes. However, one consistency among the group was that they tended to have strong social relationships , Dr. Rogalski said.

“In an ideal world, you’d find out that, like, all the super-agers, you know, ate six tomatoes every day and that was the key,” said Tessa Harrison, an assistant project scientist at the University of California, Berkeley, who collaborated with Dr. Rogalski on the first Chicago super-ager study.

Instead, Dr. Harrison continued, super-agers probably have “some sort of lucky predisposition or some resistance mechanism in the brain that’s on the molecular level that we don’t understand yet,” possibly related to their genes.

While there isn’t a recipe for becoming a super-ager, scientists do know that, in general , eating healthily, staying physically active, getting enough sleep and maintaining social connections are important for healthy brain aging.

Dana G. Smith is a Times reporter covering personal health, particularly aging and brain health. More about Dana G. Smith

A Guide to Aging Well

Looking to grow old gracefully we can help..

The “car key conversation,” when it’s time for an aging driver to hit the brakes, can be painful for families to navigate . Experts say there are ways to have it with empathy and care.

Calorie restriction and intermittent fasting both increase longevity in animals, aging experts say. Here’s what that means for you .

Researchers are investigating how our biology changes as we grow older — and whether there are ways to stop it .

You need more than strength to age well — you also need power. Here’s how to measure how much power you have  and here’s how to increase yours .

Ignore the hyperbaric chambers and infrared light: These are the evidence-backed secrets to aging well .

Your body’s need for fuel shifts as you get older. Your eating habits should shift , too.

People who think positively about getting older often live longer, healthier lives. These tips can help you reconsider your perspective .

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Effect of pastoral counselling and social support on the management of psychological well-being of widows in anglican communion of lagos state, nigeria, oginni sunday folorunso, i.p. nwadinigwe, n. osarenren.

Widowhood is a catastrophic event at any stage of life for the surviving partner at any age, with serious repercussions on their  psychological well-being. Thus, this study examined effect of pastoral counselling and social support on the psychological wellbeing of  widows in Anglican Communion of Lagos State, Nigeria. Six research questions and hypotheses were generated and tested; data were  analyzed using descriptive statistics and ANCOVA. The quasi-experimental pretest/posttest control group research design was adopted.  The samples consisted of 92 widows. The first stage was the selection of one Anglican Diocese out of the four in Lagos State using simple  random sampling, through hat and draw method. The second stage involved using proportionate stratified random sampling technique  to select three Archdeaconries from the selected Diocese in Lagos state. The third stage involved selection of widows with psychological  wellbeing problems from each of the Archdeaconries selected using “The Bell Global Psychopathology Scale (BGPS)” and the “Widows'  Psychological Adjustment Scale (WPAS)” with 0.80 and 0.73 reliability coefficient respectively. The last stage involved purposive sampling  technique to select all 92 identified widows with psychological wellbeing problems into experimental groups and control group. The  Pastoral Counselling and Social Support were used as treatments in the experimental groups. The findings revealed that: There is  significant difference in the post-test mean scores on depression of participants exposed to experimental conditions and there is  significant difference in the post-test mean scores on anxiety of participants exposed to experimental conditions. Both pastoral  counselling and social support should be used in managing psychological wellbeing of widows.

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