thesis topics in pediatrics in aiims

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Enabling teaching opportunities continues to be our cherished objective. We prepare future leaders in pediatric medicine by offering broad-based training in MD Pediatrics, critical care, and pediatric subspecialties within a variety of ambulatory, emergency, and inpatient settings. Besides MD and PhD programs, the Department offers DM programs in Neonatology, Pediatric Neurology, Pediatric Pulmonology & Intensive Care, Pediatric Nephrology, Genetics, Pediatric Oncology, and Pediatric Endocrinology.

The faculty has been at the forefront of conceptualizing, planning, and implementing clinical and translational research, directly impacting health care and public health. We are a leading department at the Institute in terms of funding for extramural research, hold multiple patents, and have contributed landmark papers across various specialties of Pediatrics. We are credited with the development of a vaccine (Rotavirus), two new diagnostics (cystic fibrosis, celiac disease), and innovations in therapy (low osmolality ORS, zinc for acute diarrhea).

The Department has excelled in developing innovative educational programs for doctors and nurses, including an online educational program and Apps on mobile phones for newborn care. Division of Neonatology developed a multimodal learning resource material on “Care of preterm neonates” for district health facilities by a collaborative effort involving institutions and neonatologists in the country. The Department has taken the lead in spreading quality improvement methodology at AIIMS and initiating an antibiotic stewardship program.

The Department has made outstanding contributions to national and global child health policy and the following public health programs: IMNCI, HBNC, RBSK, JSSK, RMNCH+A, ARI, Diarrhea, HIV, Nutrition, Newborn health, Tuberculosis, Newborn screening, Birth defect surveillance, Pradhan Mantri National Dialysis Program, and more recently, for COVID.

1. Ghai Essential Pediatrics. Eds. Paul VK, Bagga A; 9th edition. CBS Publishers, New Delhi; 2019

2. PG Textbook of Pediatrics. Eds. Gupta P, Menon PSN, Ramji S, Lodha R; 3rd edition. Jaypee Brothers, Delhi; 2022

3. Principles of Pediatric and Neonatal Emergencies. Gupta P, Bagga A, Ramji S, et al; 4th edition. Jaypee, Delhi; 2020

4. Pediatrics: A concise text. Eds. Srivastava RN, Kabra SK. Elsevier, New Delhi; 2011

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PG (Thesis)

Research Review Board (Thesis) regularly reviews average 150 thesis yearly

Comparative study between 0.5% ropivacaine with fentanyl and 0.5% bupivacaine with fentanyl in usg guided supraclavicular brachial plexus block in upper limb surgeries.

Jha N; Guide: Tidke S

The effect of nebulized ketamine in decreasing the incidence and severity of post operative sore throat after endotracheal intubation in patients receiving general anaesthesia.

Katrale S; Guide: Dhande P

A comparison of hemodynamics and ease of intubation in intubating the trachea using intubating laryngeal mask airway after induction versus awake fiberoptic bronchoscopy in patients with difficult airway.

Rathi S; Guide: Jain S

A randomized controlled study for comparative evaluation of pre-emptive single dose analgesia with pregabalin vs. Lumbar epidural analgesia using bupivacaine in adult patients undergoing laparoscopic surgeries on postoperative pain and haemodynamics.

Community Medicine

Development and validation of a tool to assess home environment conducive to child development for young children”

Joshi S; Guide: Maliye C

Impact of package of intervention promoting responsive feeding practices on nutritional status and eating behaviour of infants and young children. A cluster randomized controlled study.

Kolhe R; Guide: Gupta SS

Association of Father’s participation in responsive caregiving at 3 - 6 months of age with child development outcomes at 16 - 18 months of age: A cohort study

Muneshwar K; Guide: Gupta SS

A study to assess quality of complementary feeding and determinants of inadequate complementary feeding practices among mothers of children aged 6 – 24 months in rural area of central India: A cross sectional study with mixed methods.

Dermatology

A cross-sectional study of mucocutaneous manifestations in patients with End Stage Renal Disease on hemodialysis at a rural tertiary care hospital in central India.

Deshmukh A; Guide: Jain S

Association between AcanthosisNigricans and Metabolic syndromes at rural tertiary care hospital in Central India: A case control study.

ENT Karad P; Guide: Nagpure PS

Evaluation of nasal obstruction in a tertiary health care Centre.”

Kumar S VS; Guide:Garg D

A prospective observational study of Endoscopic Septoplasty and Surgical Outcome in a Rural based Tertiary Health care Hospital.

Acute Undifferentiated Febrile illness in patients presenting to a tertiary care Teaching Hospital in central India : Etiology ,Clinical Spectrum and Outcome

Khan S; Guide: Jain J

Prevalence of dementia in elderly diabetics: A case control study from rural hospital in Central India.

Dhake V; Guide:Taksande B

Study of peripheral nervous system in sickle cell anemia

Thokal D; Guide:Saxena B

Predictors of mortality and length of hospital stay in elderly patients admitted to medicine intensive care unit in a rural tertiary care hospital.

Soni P; Guide: Jain V

Clinico-demographic profile and clinical outcomes of patients requiring ventilation support in a tertiary care intensive care unit of a rural teaching medical college: a prospective cohort

Microbiology

Prevalence of invasive candiadiasis in a rural tertiary care hospital: An Observational study.

Obstetrics & Gynecology

Assessment of Growth Restricted fetus with special reference to Doppler studies and its perinatal outcomes

Ophthalmology

Visual Outcome of Cataract Surgery After Small Incision Cataract Surgery (SICS) or Phacoemulsification In Diabetic And Non-Diabetic Patients.

RathiN; Guide: Singh S

To Study The Effect Of Laser Assisted In –Situ Keratomileusis (LASIK) Surgery On Ratio Of Axial Length To Corneal Radius Curvature In Eyes With Refractive Error

SundarkarT; Guide: Dhabarde A

A Clinical Profile of ProptosisIn A Rural Based Tertiary Care Hospital

Barghare T; Guide: ShuklaA K

A Study of the Prevalence of Concomitant Squint Among Primary School Children and an Evaluation of Their Binocular Functional Outcome Following Surgical Management”

Orthopedics

Functional outcome of patellar fractures treated by open reduction and internal fixation : A prospective study

Rathod H; Guide: Patond KR

Hospital based cross sectional study of osteoporosis in men with proximal femur fractures by peripheral DEXA

Role of Caspase 8 as a prognostic biomarker in breast carcinoma

Hagone S; Guide: Gupta A

FoxP3 expression and overall survival in breast cancer

Vaidya V; Guide: Shivkumar VB

Audit of transfusion practices in a rural tertiary care hospital

Bhutia D; Guide: Anshu

Immunohistochemical expression of cyclin D1 in lesions of the thyroid

Umbilical cord blood gases analysis and composite neonatal outcome –A Cohort study

Kolhe S; Chauhan V

Prospective study of early and immediate outcome of preterm neonates in rural Medical College in Central India.

Pharmacology

To study the effect of wound healing activity of Musa Balbisiana sp. peel after application of low molecular weight heparin and anti-inflammatory activity on Wister Albino Rats.

Pandhare S; Guide:Gosavi DD

Adverse drug reaction of anticraving agents like Baclofen,Naltraxone and acamprosate in relapse prevention of alcohol withdrawal syndrome:observationalprospective study

Gorjelwar P; Guide:Kale R

Transfusion related adverse reaction in patients admitted in medicine department at tertiary care teaching hospital in central india.

A cross- sectional study for assessmentand comparison of the magnitude andpattern of substance abuse in diagnosedcases of bipolar affective disorder andSchizophrenia in a rural medical college

Patil V; Guide: Mishra KK

A study of thrombocytopenia andhypokalemia in alcohol withdrawaldelirium in tertiary health care center inrural India

Association of Biochemical Parameters and Risk factors with Non Alcoholic Fatty liver disease in adults

Chavan N; Guide: Kale SK

“Role of Magnetic Resonance Imaging in Evaluation of Bone Tumours with Histopathological Correlation in Radiograph Suspected Patients in Rural Tertiary Care”.

Radiotherapy

Experimental study to compare hypofractionated radiotherapy v/s conventional concomitant chemoradiotherapy in terms of overall response, toxicity profile and quality of life in head and neck cancers

A Prospective comparative study of perioperative complication of total extraperitonial hernia repair under general anaesthesia and Lichtenstein repair under local anaesthesia in rural tertiary care center.

Shah J; Guide: Gupta DO

Evaluation of Peptic Ulcer Perforation with a new prognostic scoring system.

Kakade R; Guide: Gupta DO

APACHE II Score in assessing surgical outcome in patients of perforation peritonitis

Page S; Guide:Pande R

“Comparative Study of Local and systemic antibiotics in prevention of surgical site infections”

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Thesis Topics for MS Surgery ( selected ) AIIMS

• Diffuse Dermal Angiomatosis of the Breast

Diffuse dermal angiomatosis is rare and usually considered a variant of reactive angioendotheliomatosis. It generally involves the extremities of patients with severe vascular disease and other comorbidities. Two patients with… Continue reading Diffuse Dermal Angiomatosis of the Breast

• Targeted therapy

Targeted therapy is a type of cancer treatment that works differently to chemotherapy. Chemotherapy attacks all rapidly dividing cells in the body, but targeted therapy works by “targeting” those differences that… Continue reading Targeted therapy

• Cancer treatment centres in Nepal

1.   B. P. Koirala Memorial Cancer Hospital (BPKMCH): BPKMCH is the first tertiary level cancer hospital in Nepal, which provides all types of cancer treatment services, such as surgical oncology,… Continue reading Cancer treatment centres in Nepal

Treatment of breast cancer

Treatments are less invasive when breast cancer is detected at an early stage. Challenges for breast cancer treatment in Nepal include patient’s financial status (given the huge out-of-pocket expenditure), accessibility… Continue reading Treatment of breast cancer

Disclaimer Articles, videos, online books, pictures,online videos, Exam Information, MCQs and Related topics in this medicospase is entirely intended  for study and general information purpose . Medicine and its updates… Continue reading Disclaimer

Hearing Loss. Save

Hearing is a gift.hearing is the ability to be able to listen to the external sounds. Hearing loss or hearing impairment is the reduced ability to listen to external sounds.… Continue reading Hearing Loss. Save

Oncotype Dx – Predicts how likely6 cancer comes back or not.

The test gives a score, known as a Recurrence Score, from 0 to 100. 

The higher the score, the more likely breast cancer is to come back and the more likely you are to benefit from having chemotherapy as well as hormone therapy. 

Your specialist will use the score, along with other information about your breast cancer, to help decide whether chemotherapy would benefit you.5… Continue reading Oncotype Dx – Predicts how likely6 cancer comes back or not.

Jaundice – Pathophysiology

Jaundice aundice results from high levels of bilirubin in the blood. Bilirubin is the normal breakdown product from the catabolism of haem, and thus is formed from the destruction of red blood cells. Under normal… Continue reading Jaundice – Pathophysiology

Thesis Topics for MS – Surgery ( selected ) AIIMS

• Accuracy of Sentinel node biopsy in predicting axillary nodal status following neo adjuvant chemotherapy in locally advanced breast cancer. Co -Guide.
• Role of in vitro MR spectroscopy in evaluation of lymph nodes in patients with lymphadenopathy. Co-Guide.
• Effect of bisphosphonates on bone mineral density after renal transplantation as assessed by bone mineral densitometry
• Evaluation of Feasibility and Performance of Minimally invasive Radioguided Parathyroidectomy in Established Cases of Primary Hyperparathyroidism
• Evaluation of the role of Pneumatic Compression Pump in the management of Post-Mastectomy Lymphedema
• Factors affecting incidence of early postoperative complications
• Three port vs. four ports laparoscopic cholecystectomy- A prospective randomized controlled study
• Focused abdominal sonography in trauma (FAST) in patients with blunt trauma abdomen- A prospective study
• Post cholecystectomy symptoms following laparoscopic cholecystectomy
• Ambulatory Laparoscopic hernia repair: A feasibility study
• Evaluation of early outcomes and quality of life after day care conventional inguinal hernia repair
• Role of centchroman in management of mastalgia and fibroadenoma” – a randomized study
• Relationship of Serum TSH with Thyroid Vascularity assessed at operation.
• Advanced Sentinel lymph Node evaluation in breast and head and neck cancers.
• To study the burden of post – operative surgical site infections in clean and clean contaminated operations.
• To evaluate the role of intra – abdominal pressure as a predictor of abdominal wound dehiscence.
• Dyslipidemia and cardiovascular risk factors in renal transplant recipients
• CMV disease in transplantation (Microbiology)
• Total extra peritoneal hernia repair comparison of space creation by direct telescope vs. balloon dissection- A randomized controlled study
• Standardized mesh repair for inguinal hernia- A pilot study
• To study the feasibility of fast track thyroidectomy
• Post operative surgical site infection in clean and clean contaminated operations
• B hCG expression inpatients with benign and malignant breast diseases
• Prospective Study to evaluate the role of Helicobacter pylori in benign and malignant hepatobiliary disease
• “Mammotome guided biopsy for indeterminate breast lesions following fine needle aspiration cytology
• Radical duct excision for nipple discharge (benign breast disease) – its long term follow up.
• Role of Centchroman in regression of Mastalgia and regression of Fibroadenoma and its correlation to histopathology and estrogen and progesterone receptor.
• Safety and efficacy of autologous stem cells in prevention of amputation in patients with chronic critical limb: a randomized multi-centric study.
• Standardized open mesh repair for primary inguinal hernia – A Pilot Study.
• Role of FDG PET-CT in evaluation of axillary lymph node involvement   in T1 T2 N0 M0 breast cancer in comparison with Sentinel node Biopsy.
• “Evaluation of neo-adjuvant chemotherapy in locally advanced breast cancer” in collaboration with Department of Radiotherapy, Radiology & Pathology.
• “Sentinel lymph node biopsy for locally advanced breast carcinoma after neoadjuvant chemotherapy” in collaboration with Department of Nuclear Medicine, Pathology, and Radiotherapy.

3. Characterization of thymoma using F18 fluorodeoxyglucose positron emission tomography (FDG PET – CT) and its     correlation with histopathology in collaboration with Department of Nuclear Medicine & Pathology. 4. Evaluation of patients with primary mediastinal lymphadenopathy using FDG-PET-CT scan and its correlation with    histopathology – A prospective study in collaboration with Medicine, Nuclear Medicine & pathology. 5. Clinical co-relation of ER, PR, HER2 neu expression and BRCA1 gene mutations in Indian breast cancer patients.

Collaborative Research (Ongoing)   1. Quality of life of live related donors ( Nephrology) 2. Molecular typing and detection of Mupirocin and Methicillin Resistant Staph aureus ( Microbiology) 3. Cytokine Gene Polymorphismin Renal Transplant Patients (Transplant Immunology and Immunogenetics) 4. Outcome after laparoscopic cardiomyotomy – early and late” in collaboration with Department of     Gastroenterology. 5.  Efficacy and feasibility of regional anaesthesia compared to general anaesthesia for totally extraperitoneal      laparoscopic inguinal hernia repair in collaboration with Department of Anaesthesiology. 6. “Breast cancer: local tumour staging by MRI and its impact on therapeutic approach” in collaboration with      Department of Radiodiagnosis & Pathology. 7. “Evaluation of sentinel lymph nodes in patients with early breast cancer using PET scan in collaboration with      Department of Endocrinology, Pathology and Nuclear Medicine 8. Characterization of thymoma using F18 fluorodeoxyglucose positron emission tomography (FDG PET – CT) and its    correlation with histopathology in collaboration with Department of Nuclear Medicine & Pathology. 9. Evaluation of patients with primary mediastinal lymphadenopathy using FDG-PET-CT scan and its correlation with    histopathology – A prospective study in collaboration with Medicine, Nuclear Medicine & pathology.

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Wells Center Newsletter | May 2024

Jackie Maupin May 16, 2024

MMIA celebrates 25 years of inspiring young minds & fueling scientific passion Molecular Medicine in Action (MMIA), hosted annually by the Wells Center, celebrated its 25th anniversary in early March by welcoming 50 new high schoolers to a growing list of more than 1,200 previous participants! MMIA aims to attract more young minds to careers in science and medicine by exposing them to a spectrum of career opportunities from a diverse group of IU experts and providing hands-on learning in a state-of-the-art medical research environment. > Read about this exciting milestone

Fighting Friedreich’s ataxia Mark Payne, MD, has pioneered a promising treatment for Friedreich's ataxia, a degenerative nervous system condition with no present cure. Payne's journey with his drug, CTI-1601, involved extensive collaboration with numerous organizations, partners and colleagues over the last two decades. These efforts have culminated in the treatment's positive Phase 2 clinical trial results with the FDA . > Read more about Payne’s journey

TEAM WELLS UPDATES

Diabetes researchers recognized as IBJ Health Care Heroes Members from the Wells Center’s diabetes research team were honored as 2024 IBJ Health Care Heroes in the Innovations in Health Care category for their incredible efforts leading to the FDA-approval of teplizumaub, a groundbreaking drug that delays the onset of type 1 diabetes.  > Read about this year's honorees

Reason to Dance 2024 Reason to Dance, the annual fundraiser supporting Wells Center research and the Child Life Program at Riley Children's Health, raised $185K at this year's event on March 9, 2024! Representatives from Reason to Dance, Riley Children's Foundation, Riley Children's and the Wells Center gathered for a special check presentation celebrating this incredible achievement on Friday, May 3, 2024.  >  Learn about Reason to Dance  

Welcome to the Wells Center Help us extend a warm welcome and congratulations to the members of Team Wells who have recently joined us or accepted new roles since February 2024:

Adrienne Cantali Ellen Gunn William Hagopian Hemavathy Harikrishnan Ashley Kibbey Keiko Kreklau Bala Yaswanth Kumar Sunnapu Marzieh Nemati Aliee Nguyen Sydney Parrish Abigail Taylor Senthilkumar Thirumurugan Ellie Waechter Eric York

DISCOVERY IN ACTION

Congratulations to Grant and Award Recipients Wells Center members have received a vast number of grants and awards in recent months. A select few are highlighted below.

Simon J. Conway, PhD | “Validate the tamoxifen-inducible Postn-CreERT2-T2A-FLPo transgenic mouse” (Children's Tumor Foundation) / “Barth Syndrome Research Fund” (Riley Children’s Foundation) Carmella Evans-Molina, PhD, MS, MD | “Clinical Trial of Denosumab for Type 1 Diabetes” (City of Hope)

Jamie Felton, MD | “Type I Interferons and B Cell Metabolism as Drivers of Type 1 Diabetes // Diabetes-Docs: Physician-Scientist Career Development Program (DiabDocs)” (Stanford University)

Melissa Fishel, PhD & Mark Kelley, PhD & Steven Rhodes, MD, PhD | “Investigation of redox signaling as a therapeutic target in MPNST” (DOD NRFP - Neurofibromatosis Research Program Funding) Renzhi Han, PhD | “Targeted editing of ASGR1 for cardiovascular diseases” (NIH R01 - National Heart, Lung And Blood Institute) Swetansu K. Hota, MSC, PhD, MTECH | “Dissecting the functions of BAF chromatin remodeling ATPases during cardiogenesis” (American Heart Association Incorporated)  Chandy John, MD, MS | “Severe Malaria And Risk to The Brain (SMART Brain)” (NIH R01 – National Institute of Neurological Disorders and Stroke) Reuben Kapur, PhD | “The Roselynn Turi Fund” (Riley Children’s Foundation) Reuben Kapur, PhD & Ngoc Tung Tran, PhD | “Hypoxia's role in regulating stressed hematopoietic stem cells” (NIH R01 - National Institute Of Diabetes, Digestive & Kidney)

Sarah Marrow, PhD student in the Angus lab | “Young Investigator Award” (Children’s Tumor Foundation)

Mark R. Kelley, PhD | “Tom Wood Lexus Foundation Lexxll” (Riley Children’s Foundation) Chaitra Rao, PhD, MS | “Defining the role of islet-derived extracellular vesicle PD-L1 cargo in type-1 diabetes” (JDRF) Steven D. Rhodes, MD, PhD | “UAB NFCTC Infrastructure Award” (University Of Alabama Birmingham) Emily K. Sims, MD | “Hybrid Closed Loop Therapy for Beta Cell Preservation in New Onset Type 1 Diabetes (CLVer): Extension Study (CLVerEX)” (University Of Minnesota) Mengyao Sun, PhD student in Lei Yang lab | “Deciphering the Cardiac Protective Role of Human IncRNA LIPTER against Doxorubicin-induced Cardiotoxicity” (American Heart Association)

RECENT PUBLICATIONS

• “A novel class of self-complementary AAV vectors with multiple advantages based on cceAAV lacking mutant ITR.” Published in Molecular Therapy Methods & Clinical Development. Contributing IU authors: Junping Zhang, Dylan A. Frabutt, Ning Li, Patrick L. Mulcrone, Anh K Lam, Martin F. Jarrold, Roland W. Herzog, Weidong Xiao 
• “Additional Thoughts on Intrinsic Dysanapsis.” Published in American Journal of Respiratory and Critical Care Medicine. Contributing IU author: Robert S. Tepper
• “Antigen stasis and airway nitrosative stress in human primary ciliary dyskinesia.” Published in American Journal of Physiology-Lung Cellular and Molecular Physiology. Contributing IU authors: Benjamin Gaston, Laura A. Smith, Michael D. Davis, Jessica Saunders, Ivana Daniels, Yi Zhao, Nadzeya Marozkina
• “Approaches to Studying Outcomes in Patients With Congenital Heart Disease With Genetic Syndromes: What Down Syndrome Can Teach Us.” Published in the Journal of the American Heart Association. Contributing IU author: Stephanie M. Ware
• “B cell focused transient immune suppression protocol for efficient AAV readministration to the liver.” Published in Molecular Therapy Methods & Clinical Development. Contributing IU authors: Jyoti Rana, Roland W. Herzog, Maite Muñoz-Melero, Kentaro Yamada, Sandeep R. P. Kumar, Anh K. Lam, David M. Markusic, Dongsheng Duan, Moanaro Biswas
• “Base editing in humanized dystrophic mice.” Published in Molecular Therapy Nucleic Acids. Contributing IU authors: Chen Zhang, Yuan Zhou, Renzhi Han
• “Decreased vascular reactivity associated with increased IL-8 in 6-month-old infants of mothers with pre-eclampsia.” Published in Pediatric Research. Contributing IU authors: Kok Lim Kua, James E. Slaven, Shanique Edwards, David M. Haas, Christina Tiller, Jeffrey Bjerregaard, Laura S. Haneline, Robert S. Tepper
• “Deciphering conundrums of adeno-associated virus liver-directed gene therapy: focus on hemophilia.” Published in Journal of Thrombosis and Haemostasis. Contributing IU author: Radoslaw Kaczmarek 
• “DEFA1A3 DNA gene-dosage regulates the kidney innate immune response during upper urinary tract infection.” Published in Life Science Alliance. Contributing IU authors: Jorge J. Canas, Samuel W. Arregui, Shaobo Zhang, Taylor Knox, Christi Calvert, Vijay Saxena, Andrew L. Schwaderer, David S. Hains
• “Enhancing Leukemia Treatment: The Role of Combined Therapies Based on Amino Acid Starvation.” Published in Cancers. Contributing IU authors: Can Chen, Ji Zhang
• “Hit-and-run epigenome editing durably lowers cholesterol in mice.” Published in Molecular Therapy. Contributing IU author: Renzhi Han
• “Hypertension Increases Susceptibility to Experimental Malaria in Mice.” Published in Function. Contributing IU author: Nathan W. Schmidt
• “Immune tolerance induction by hepatic gene transfer: First-in-human evidence.” Published in Molecular Therapy. Contributing IU authors: Radoslaw Kaczmarek, Roland W. Herzog
• “Impact of the COVID-19 pandemic on social media utilization, influences related to parental vaccine decision making, and opinions on trustworthy social media vaccination campaigns: A qualitative analysis.” Published in Human Vaccines & Immunotherapeutics. Contributing IU authors: Kevin M. Quist, Gregory Zimet
• “Improvements in lung function following vitamin C supplementation to pregnant smokers are associated with buccal DNA methylation at 5 years of age.” Published in Clinical Epigenetics. Contributing IU author: Robert S. Tepper
• “Islet autoantibodies as precision diagnostic tools to characterize heterogeneity in type 1 diabetes: a systematic review.” Published in Communications Medicine. Contributing IU authors: Jamie L. Felton, Gabriela S. F. Monaco, Zeb Saeed, Carmella Evans-Molina, Linda A. DiMeglio, Heba M. Ismail, Emily K. Sims
• “In vitro and In vivo evidence demonstrating chronic absence of Ref-1 Cysteine 65 impacts Ref-1 folding configuration, redox signaling, proliferation and metastasis in pancreatic cancer.” Published in Redox Biology. Contributing IU authors: Mahmut Mijit, Eyram Kpenu, Nayela Chowdhury, Silpa Gampala, Randall Wireman, Sheng Liu, Olivia Babb, Millie M. Georgiadis, Jun Wan, Melissa L. Fishel, Mark R. Kelley
• “In Vivo Analysis of Tissue S-Nitrosothiols in Pediatric Sepsis.” Published in Antioxidants. Contributing IU authors: Daniel T. Cater, Charles Clem, Nadzeya Marozkina, Benjamin Gaston
• “Large-scale falsification of research papers risks public trust in biomedical sciences.” Published in Molecular Therapy. Contributing IU author: Roland W. Herzog
• “New Ref-1/APE1 targeted inhibitors demonstrating improved potency for clinical applications in multiple cancer types.” Published in Pharmacological Research. Contributing IU authors: Silpa Gampala, Randall Wireman, Jacqueline Peil, Sonia Kiran, Dana K. Mitchell, Kylee Brewster, Henry Mang, Andi Masters, Christine Bach, Whitney Smith-Kinnamen, Emma H. Doud, Ratan Rai, Amber L. Mosley, Sara K. Quinney, D. Wade Clapp, Chafiq Hamdouchi, Chi Zhang, Millie M. Georgiadis, Mark R. Kelley, Melissa L. Fishel
• “Novel Echocardiogram Analysis of Cardiac Dysfunction is Associated with Mortality in Pediatric Sepsis.” Published in Shock. Contributing IU authors: Daniel T. Cater, Roberto F. Machado, Benjamin Gaston
• “Precise genome-editing in human diseases: mechanisms, strategies and applications.” Published in Signal Transduction and Targeted Therapy. Contributing IU author: Nathan J. VanDusen
• “Progressive Left Ventricular Remodeling for Predicting Mortality in Children With Dilated Cardiomyopathy: The Pediatric Cardiomyopathy Registry.” Published in the Journal of the American Heart Association. Contributing IU author: Stephanie M. Ware
• “Recommendations for a minimum data set for monitoring gene therapy in hemophilia: communication from the ISTH SSC Working Group on Gene Therapy.” Published in Journal of Thrombosis and Haemostasis. Contributing IU author: Radoslaw Kaczmarek 
• “Regulation of β-cell death by ADP-ribosylhydrolase ARH3 via lipid signaling in insulitis.” Published in Cell Communication and Signaling. Contributing IU authors: Farooq Syed, Carmella Evans-Molina
• “ROCK1 deficiency preserves caveolar compartmentalization of signaling molecules and cell membrane integrity.” Published in FASEB BioAdvances. Contributing IU authors: Jianjian Shi, Lei Wei
• “Spatial Gene-Expression Profiling Unveils Immuno-oncogenic Programs of NF1-Associated Peripheral Nerve Sheath Tumor Progression.” Published in Clinical Cancer Research. Contributing IU authors: Dana K. Mitchell, Breanne Burgess, Emily E. White, Abbi E. Smith, Elizabeth A. Sierra Potchanant, Henry Mang, Brooke E. Hickey, Qingbo Lu, Shaomin Qian, Waylan Bessler, Xiaohong Li, Li Jiang, Kylee Brewster, Constance Temm, Eric A. Albright, Melissa L. Fishel, Steven P. Angus, D Wade Clapp, Steven D. Rhodes
• “Targeting S100A9 Prevents β-Adrenergic Activation-Induced Cardiac Injury.” Published in Inflammation. Contributing IU authors: Ying Liu, Weinian Shou
• “The Ailing β-Cell in Diabetes: Insights From a Trip to the ER: The 2023 Outstanding Scientific Achievement Award Lecture.” Published in Diabetes. Contributing IU author: Carmella Evans-Molina
• “The impact of obesity-induced inflammation on clonal hematopoiesis.” Published in Current Opinion in Hematology. Contributing IU authors: Santhosh Kumar Pasupuleti, Reuben Kapur
• “The NF1+/- Immune Microenvironment: Dueling Roles in Neurofibroma Development and Malignant Transformation.” Published in Cancers. Contributing IU authors: Emily E. White, Steven D. Rhodes
• “Thorough molecular configuration analysis of noncanonical AAV genomes in AAV vector preparations.” Published in Molecular Therapy Methods & Clinical Development. Contributing IU authors: Junping Zhang, Roland W. Herzog, Weidong Xiao

KUDOS AND RECOGNITION

• Congratulations to the following Wells Center graduate students on their recent thesis defenses! Sarah Burns from the Kapur lab presented on March 7, 2024. John Wells from the Ware lab presented on March 11, 2024.
• Congratulations to Wells Center members who received 2024 Cancer Research Day awards and recognition ! Eyram Kpenu from the Kelley lab Rahul Kanumuri from the Kapur lab Erika Dobrota from the Pollok lab Jenna Koenig from the Pollok lab Rada Malko from the Pollok lab
• Caylin Billingsley from the Katzenellenbogen lab has been recognized as a 2024 Elite 50 recipient  
• Naro Biswas, MS, PhD , was featured in a Riley Children’s Foundation “Meet a Riley Researcher” blog. The article highlights her research with the gene and cell therapy group and the career journey that led her to Indiana.
• Carmella Evans-Molina, MD, PhD, MS , was interviewed on DiabetesBio, the monthly podcast of the American Diabetes Association’s flagship research journal Diabetes, to discuss her research and her 2023 Outstanding Scientific Achievement Award.
• David Hains, MD , received the 2024 Mid-Career Award from the American Society of Pediatric Nephrology (ASPN).
• Ben Gaston, MD, was highlighted in a feature by IU Impact about his team's development of a drug formulation that significantly improves lung function by reducing airway inflammation and other symptoms with minimal side effects for patients.
• Roland Herzog, PhD , was presented with the Keith Anliker Supporter of the Year Award at this year's IU Indianapolis Dance Marathon called Jagathon. This year Jagathon raised $307,605 to support Wells Center research and Riley Hospital for Children!
• Roland Herzog, PhD , was presented with the 2024 Exemplary Service Award by the American Society of Gene & Cell Therapy (ASGCT). The award recognizes individuals for their outstanding contributions to ASGCT and their commitment to the Society’s mission to advance knowledge, education, and awareness of gene and cell therapy. Exemplary service may include significant and sustained leadership, expertise, and/or creativity in addressing issues of importance to ASGCT.
• Chandy John, MD, MS , was interviewed by NIH's Fogarty Institute for a Q&A titled, "Finding the connection between malaria and brain development" which was published in the January/February 2024 edition of their Global Health Matters newsletter.
• Reuben Kapur, PhD , was featured in an article by IU Impact about his dedication to advancing treatments for pediatric leukemia through research and the development of novel therapies.
• Mark Kelley, PhD , and Timothy Corson, PhD, were issued a new patent in Europe, "Targeting Ocular Diseases With Novel APE1/REF-1 Inhibitors."
• Mark Payne, MD , recently celebrated positive top-line data and successful completion of the Phase 2 dose exploration study of his drug CTI-1601 for use in patients with Friedreich’s ataxia (FA). The news was announced by the drug’s investment company Larimar Therapeutics, Inc.
• Nathan Schmidt, PhD , was named a 2024 Trustees' Teaching Award winner. Award recipients include faculty who have demonstrated a sustained level of teaching excellence and have completed at least three years of service to IU School of Medicine.

Learn more about the Herman B Wells Center for Pediatric Research Read the February 2024 Newsletter Follow @IUWellsCenter on X

Jackie Maupin

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May 17, 2024

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More leptospirosis cases occur after floods, study shows

by K. W. Wesselink, University of Twente

A recent study, published by researchers at the Faculty of ITC in the International Journal of Health Geographics , has shown that flooding leads to increased leptospirosis cases.

First author, John Ifejube is a recent graduate of the master's program in Spatial Engineering. This publication is a direct result of his thesis on GeoHealth.

Flooding is a climate-related disaster that impacts not only the environment but also the well-being of people. Leptospirosis is a blood infection caused by the bacteria Leptospira. People become infected through interaction with contaminated water or urine.

Infected humans can get headaches, muscle pains, and fevers, but severe forms can lead to kidney failure. More and more studies link the spread of leptospirosis with floods, but it has not been extensively studied, until now.

Master's thesis

For his master's thesis, Ifejube conducted a study on the association between the incidence of leptospirosis and the occurrence of multiple floods in Kerala, India. He found that flooding leads to an increase in leptospirosis cases. His study reveals that flood duration is the most important characteristic of floods that can be used to predict the number of infections. According to his research, severe floods lead to more leptospirosis cases than moderate floods.

He compared leptospirosis cases across three different years in time and space. Specifically, he compared the number of cases in 2018 and 2019, which were years with heavy and moderate flooding respectively, to the number of cases in 2017, a year that did not experience any floods.

For each flood year, he looked at the reported cases three months before, during and three months after the flood. To assess the severity of floods, he determined the population exposed to each flood event using high-resolution satellite images. Finally, he used spatial regression to examine the relationship between post-flood cases and flood extents.

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Things to Do in Lytkarino, Russia - Lytkarino Attractions

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• News & Events

Nursing Research News: April 2024

Each month, the Center for Research and Scholarship at the Frances Payne Bolton School of Nursing sends an internal research newsletter to faculty, staff, students and researchers. A recap is posted here.

Message from the Associate Dean for Research

The National Institutes of Health (NIH), through Deputy Director of Extramural Research, Dr. Mike Lauer, and Director of the NIH Center for Scientific Review, Dr. Noni Byrnes, has announced significant changes to the peer review process and application forms for fellowship applications (e.g., F30, F31, F32, F33, and F99/K00), effective January 25, 2025. 

These changes aim to address concerns raised by the extramural community regarding potential biases in the current fellowship review process. The revisions to the NIH fellowship application and review process are designed to increase the likelihood of identifying the most promising fellowship candidates consistently. 

Key changes include reorganizing and refining the current five scored criteria into three: 

• Candidate’s Goals, Preparedness, and Potential
• Research Training Plan, and
• Commitment to Candidate.

The Center for Research and Scholarship will provide more information about the changes in the fellowship application forms and the review process as it becomes available.

-Ronald Hickman, PhD, RN, ACNP-BC, FNAP, FAAN

Scholarship Awards and Grants

Derry Ann Moritz Scholarship

Colleen Carroll, PhD candidate, is the inaugural recipient of the Derry Ann Moritz Scholarship , which supports PhD candidates at the Frances Payne Bolton School of Nursing whose dissertations focus on topics regarding palliative and end-of-life care.

An oncology palliative care nurse practitioner at University Hospitals Seidman Cancer Center since 2022, Carroll was looking for opportunities to elevate her experience in the field. Last year, she had the opportunity to be the primary author of a medical manuscript. Toward the end of the writing process, she connected with Susan Mazanec, a nurse scientist at University Hospitals Seidman Cancer Center and associate professor at the School of Nursing. Carroll and Mazanec stayed in touch, and Dr. Mazanec ended up recommending Carroll for the Moritz Scholarship. Congratulations, Colleen!

Sigma Spring 2024 Call for Research Grants

The Alpha Mu Chapter of Sigma Global Nursing (STTI) is funding two grants, each up to $1,000: one for student applicants with at least a master's degree in nursing or are enrolled in a nursing doctoral program, and have Sigma membership, and the other grant is open to all STTI members. Allocation of funds is based on the quality of the proposed research, the future promise of the applicant, and the applicant's research budget. Applications from novice researchers who have received no other national research funds are encouraged. Funds for these grants do not cover expenses incurred prior to the funding date, travel, conference registrations, and computer software or hardware. Submission deadline is May 1, 2024. See this "call for grants" document for more details .

Stielau Award for Early-Stage PhD Research

The Joyce M. Stielau Award is available to current PhD candidates at the Frances Payne Bolton School of Nursing. This funding is intended for early-career investigators currently conducting early-stage research. Applicants can request up to $2,000 for funding of their current IRB-approved research. All fields and areas of study will be considered.

The late Joyce M. Stielau was a nurse anesthesiologist, devoted hospital volunteer, philanthropist, and former president of the Greater Cleveland chapter of Mended Hearts, a support group for cardiac patients. A veteran of the United States Air Force, Mrs. Stielau earned her nursing degree from the University of Cincinnati. The foundation named for her and her late husband Herbert supports scholarships and research in the field of nursing, among other important causes. Details about the Stielau Award and how to apply can be found on the School of Nursing website .

Algase Dissertation Award for Eldercare Research

Research funding is available through the Donna Algase Dissertation Award to current PhD candidates at the Frances Payne Bolton School of Nursing. Provided by the generous support of the Donna Algase Dissertation Award Endowed Fund, this award will grant two early career investigators up to $1,350 each for their early-stage research in the field of eldercare.

CWRU alumna Donna L. (Muszynski) Algase (GRS '88, nursing), began her nursing career in pediatric and pediatric intensive care, but found her passion for gerontological nursing and research while completing her bachelor's degree at the University of Toledo.

Widely published on nursing theory, gerontological nursing, and dementia research, Dr. Algase developed her nursing knowledge into an entrepreneurial opportunity and, along with a colleague, began an educational consulting business to deliver in-service and continuing education programs for long-term care facilities. An established authority on end-of-life care and research, she received the Distinguished Alumni Award in 2004.

Details about the Donna Algase Dissertation Award and how to apply can be found on this page of the School of Nursing website.

Research and Scholarly News

Faculty Co-Edit Interprofessional Leadership Textbook 

FPB School of Nursing faculty members Carol Savrin, associate professor, and Jesse Honsky, assistant professor, collaborated to edit Interprofessional Leadership for Nurses: Mastering Knowledge, Skills, and Attitudes for Success, 1st Edition , recently published by Cognella Academic Publishing.

Savrin and Honsky developed this book as a supplementary text for entry-level and advanced nursing courses and programs to help entry-level and advanced nursing students recognize and build on their leadership and teamwork skills. The text integrates knowledge, skills, and attitudes from multiple disciplines, and links students to the American Association of Colleges of Nursing Essentials for nursing education.

The book provides students with salient advice from the field to help them develop into competent and effective healthcare professionals with leadership skills.

Other News and Information

New Name for VA Medical Center

The Louis Stokes Cleveland Department of Veterans Affairs (VA) Medical Center has asked CWRU to now identify the hospital as "VA Northeast Ohio Healthcare System" going forward.

Guidance for working with the VA is on the RADAR Canvas site. The Form 2 for memorandums of understanding between the VA and CWRU has been updated to reflect the new name. Additionally, VA Guidelines have been updated, including information regarding rules for the utilization of an independent physician association (IPA). The current indirect cost (IDC) rate agreement has been extended through June 30, 2025, and is also on the Canvas site.

CWRU Human Research Protection Program Renewed 

CWRU's Human Research Protection Program (CWRU HRPP) recently received a 5-year renewal of its Association for the Accreditation of Human Research Protection Programs (AAHRPP) full accreditation status.

It was originally accredited in 2016, with a renewal in 2019. The CWRU HRPP is responsible for monitoring the rights and welfare of CWRU research participants while ensuring the university’s commitment to high-quality research. AAHRPP, seen as the gold standard of HRPP accreditation, serves to ensure “ethically sound and scientifically valuable research through the accreditation of high-quality human research protection programs.” CWRU’s accreditation is critically important to our researchers’ ability to receive federal and nonfederal funding, as well as to collaborate with other AAHRPP-accredited national and international organizations.

NIH News and Updates

Changes Coming to Applications and Peer Review 

The National Institutes of Health (NIH) is implementing multiple changes that will impact the preparation and peer review of most grant applications submitted for due dates on or after Jan. 25, 2025. Although each of these initiatives have specific goals, they are all meant to simplify, clarify, or ensure greater fairness. NIH has released a guide notice ( NOT-OD-24-084 ) that provides an overview of each change to help the research community contextualize them as details are released over the next few months. 

Where’s the Public Access Policy?

There is a new location for NIH public access policy content and resources . As of March 12, 2024, NIH Public Access Policy content and resources have been consolidated into the NIH Sharing Site.

Recent School of Nursing Publications

Dolansky, M. A., Davey, C. H., & Moore, S. M. (2024). Research and Practice in Quality Improvement and Implementation Science: The Synergy for Change Model. Journal of Nursing Care Quality , 10-1097.

Ruksakulpiwat, S., Thorngthip, S., Niyomyart, A., Benjasirisan, C., Phianhasin, L., Aldossary, H., Ahmed, B. H., & Samai, T. (2024). A Systematic Review of the Application of Artificial Intelligence in Nursing Care: Where Are We, and What’s Next? Journal of Multidisciplinary Healthcare , 1604-1605.