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122 The Best Genetics Research Topics For Projects

genetics research topics

The study of genetics takes place across different levels of the education system in academic facilities all around the world. It is an academic discipline that seeks to explain the mechanism of heredity and genes in living organisms. First discovered back in the 1850s, the study of genetics has come a pretty long way, and it plays such an immense role in our everyday lives. Therefore, when you are assigned a genetics research paper, you should pick a topic that is not only interesting to you but one that you understand well.

Choosing Research Topics in Genetics

Even for the most knowledgeable person in the room, choosing a genetics topic for research papers can be, at times, a hectic experience. So we put together a list of some of the most exciting top in genetics to make the endeavor easier for you. However, note, while all the topics we’ve listed below will enable you to write a unique genetic project, remember what you choose can make or break your paper. So again, select a topic that you are both interested and knowledgeable on, and that has plenty of research materials to use. Without further ado, check out the topics below.

Interesting Genetics Topics for your Next Research Paper

  • Genes and DNA: write a beginners’ guide to genetics and its applications
  • Factors that contribute or/and cause genetic mutations
  • Genetics and obesity, what do you need to know?
  • Describe RNA information
  • Is there a possibility of the genetic code being confidential?
  • Are there any living cells present in the gene?
  • Cancer and genetics
  • Describe the role of genetics in the fight against Alzheimer’s disease
  • What is the gene
  • Is there a link between genetics and Parkinson’s disease? Explain your answer.
  • Replacement of genes and artificial chromosomes
  • Explain genetic grounds for obesity
  • Development and disease; how can genetics dissect the developing process
  • Analyzing gene expression – RNA
  • Gene interaction; eye development
  • Advances and developments in nanotechnology to enable therapeutic methods for the treatment of HIV and AIDS.
  • Isolating and identifying the cancer treatment activity of special organic metal compounds.
  • Analyzing the characteristics in certain human genes that can withstand heavy metals.
  • A detailed analysis of genotypes that is both sensitive and able to endure heavy metals.
  • Isolating special growth-inducing bacteria that can assist crops during heavy metal damage and identifying lipid directing molecules for escalating heavy metal endurance in plants.

Hot and Controversial Topics in Genetics

  • Is there a link between genetics and homosexuality? Explain your answer
  • Is it ethical and morally upright to grow human organs
  • Can DNA changes beat aging
  • The history and development of human cloning science
  • How addictive substances alter our genes
  • Are genetically modified foods safe for human and animal consumption?
  • Is depression a genetically based condition?
  • Genetic diagnosis of the fetus
  • Genetic analysis of the DNA structure
  • What impact does cloning have on future generations?
  • What is the link between genetics and autism?
  • Can artificial insemination have any sort of genetic impact on a person?
  • The advancements in genetic research and the bioethics that come with them.
  • Is human organ farming a possibility today?
  • Can genetics allow us to design and build a human to our specifications?
  • Is it ethical to try and tamper with human genetics in any way?

Molecular Genetics Topics

  • Molecular techniques: How to analyze DNA(including genomes), RNA as well as proteins
  • Stem cells describe their potential and shortcomings
  • Describe molecular and genome evolution
  • Describe DNA as the agent of heredity
  • Explain the power of targeted mutagenesis
  • Bacteria as a genetic system
  • Explain how genetic factors increase cancer susceptibility
  • Outline and describe recent advances in molecular cancer genetics
  • Does our DNA sequencing have space for more?
  • Terminal illness and DNA.
  • Does our DNA determine our body structure?
  • What more can we possibly discover about DNA?

Genetic Engineering Topics

  • Define gene editing, and outline key gene-editing technologies, explaining their impact on genetic engineering
  • The essential role the human microbiome plays in preventing diseases
  • The principles of genetic engineering
  • Project on different types of cloning
  • What is whole genome sequencing
  • Explain existing studies on DNA-modified organisms
  • How cloning can impact medicine
  • Does our genetics hold the key to disease prevention?
  • Can our genetics make us resistant to certain bacteria and viruses?
  • Why our genetics plays a role in chronic degenerative diseases.
  • Is it possible to create an organism in a controlled environment with genetic engineering?
  • Would cloning lead to new advancements in genetic research?
  • Is there a possibility to enhance human DNA?
  • Why do we share DNA with so many other animals on the planet?
  • Is our DNA still evolving or have reached our biological limit?
  • Can human DNA be manipulated on a molecular or atomic level?
  • Do we know everything there is to know about our DNA, or is there more?

Controversial Human Genetic Topics

  • Who owns the rights to the human genome
  • Is it legal for parents to order genetically perfect children
  • is genetic testing necessary
  • What is your stand on artificial insemination vs. ordinary pregnancy
  • Do biotech companies have the right to patent human genes
  • Define the scope of the accuracy of genetic testing
  • Perks of human genetic engineering
  • Write about gene replacement and its relationship to artificial chromosomes.
  • Analyzing DNA and cloning
  • DNA isolation and nanotechnology methods to achieve it.
  • Genotyping of African citizens.
  • Greatly mutating Y-STRs and the isolated study of their genetic variation.
  • The analytical finding of indels and their genetic diversity.

DNA Research Paper Topics

The role and research of DNA are so impactful today that it has a significant effect on our daily lives today. From health care to medication and ethics, over the last few decades, our knowledge of DNA has experienced a lot of growth. A lot has been discovered from the research of DNA and genetics.

Therefore, writing a good research paper on DNA is quite the task today. Choosing the right topic can make things a lot easier and interesting for writing your paper. Also, make sure that you have reliable resources before you begin with your paper.

  • Can we possibly identify and extract dinosaur DNA?
  • Is the possibility of cloning just around the corner?
  • Is there a connection between the way we behave and our genetic sequence?
  • DNA research and the environment we live in.
  • Does our DNA sequencing have something to do with our allergies?
  • The connection between hereditary diseases and our DNA.
  • The new perspectives and complications that DNA can give us.
  • Is DNA the reason all don’t have similar looks?
  • How complex human DNA is.
  • Is there any sort of connection between our DNA and cancer susceptibility and resistance?
  • What components of our DNA affect our decision-making and personality?
  • Is it possible to create DNA from scratch under the right conditions?
  • Why is carbon such a big factor in DNA composition?
  • Why is RNA something to consider in viral research and its impact on human DNA?
  • Can we detect defects in a person’s DNA before they are born?

Genetics Topics For Presentation

The subject of genetics can be quite broad and complex. However, choosing a topic that you are familiar with and is unique can be beneficial to your presentation. Genetics plays an important part in biology and has an effect on everyone, from our personal lives to our professional careers.

Below are some topics you can use to set up a great genetics presentation. It helps to pick a topic that you find engaging and have a good understanding of. This helps by making your presentation clear and concise.

  • Can we create an artificial gene that’s made up of synthetic chromosomes?
  • Is cloning the next step in genetic research and engineering?
  • The complexity and significance of genetic mutation.
  • The unlimited potential and advantages of human genetics.
  • What can the analysis of an individual’s DNA tell us about their genetics?
  • Is it necessary to conduct any form of genetic testing?
  • Is it ethical to possibly own a patent to patent genes?
  • How accurate are the results of a genetics test?
  • Can hereditary conditions be isolated and eliminated with genetic research?
  • Can genetically modified food have an impact on our genetics?
  • Can genetics have a role to play in an individual’s sexuality?
  • The advantages of further genetic research.
  • The pros and cons of genetic engineering.
  • The genetic impact of terminal and neurological diseases.

Biotechnology Topics For Research Papers

As we all know, the combination of biology and technology is a great subject. Biotechnology still offers many opportunities for eager minds to make innovations. Biotechnology has a significant role in the development of modern technology.

Below you can find some interesting topics to use in your next biotechnology research paper. Make sure that your sources are reliable and engage both you and the reader.

  • Settlements that promote sustainable energy technology maintenance.
  • Producing ethanol through molasses emission treatment.
  • Evapotranspiration and its different processes.
  • Circular biotechnology and its widespread framework.
  • Understanding the genes responsible for flora response to harsh conditions.
  • Molecule signaling in plants responding to dehydration and increased sodium.
  • The genetic improvement of plant capabilities in major crop yielding.
  • Pharmacogenomics on cancer treatment medication.
  • Pharmacogenomics on hypertension treating medication.
  • The uses of nanotechnology in genotyping.
  • How we can quickly detect and identify food-connected pathogens using molecular-based technology.
  • The impact of processing technology both new and traditional on bacteria cultures linked to Aspalathus linearis.
  • A detailed analysis of adequate and renewable sorghum sources for bioethanol manufacturing in South Africa.
  • A detailed analysis of cancer treatment agents represented as special quinone compounds.
  • Understanding the targeted administering of embelin to cancerous cells.

Tips for Writing an Interesting Genetics Research Paper

All the genetics research topics above are excellent, and if utilized well, could help you come up with a killer research paper. However, a good genetics research paper goes beyond the topic. Therefore, besides choosing a topic, you are most interested in, and one with sufficient research materials ensure you

Fully Understand the Research Paper Format

You may write on the most interesting genetics topics and have a well-thought-out set of ideas, but if your work is not arranged in an engaging and readable manner, your professor is likely to dismiss it, without looking at what you’ve written. That is the last thing you need as a person seeking to score excellent grades. Therefore, before you even put pen to paper, understand what research format is required.

Keep in mind that part of understanding the paper’s format is knowing what words to use and not to use. You can contact our trustful masters to get qualified assistance.

Research Thoroughly and Create an Outline

Whichever genetics research paper topics you decide to go with, the key to having excellent results is appropriately researching it. Therefore, embark on a journey to understand your genetics research paper topic by thoroughly studying it using resources from your school’s library and the internet.

Ensure you create an outline so that you can note all the useful genetic project ideas down. A research paper outline will help ensure that you don’t forget even one important point. It also enables you to organize your thoughts. That way, writing them down in the actual genetics research paper becomes smooth sailing. In other words, a genetics project outline is more like a sketch of the paper.

Other than the outline, it pays to have an excellent research strategy. In other words, instead of looking for information on any random source you come across, it would be wise to have a step-by-step process of looking for the research information.

For instance, you could start by reading your notes to see what they have to say about the topic you’ve chosen. Next, visit your school’s library, go through any books related to your genetics research paper topic to see whether the information on your notes is correct and for additional information on the topic. Note, you can visit the library either physically or via your school’s website. Lastly, browse educational sites such as Google Scholar, for additional information. This way, you’ll start your work with a bunch of excellent genetics project ideas, and at the same time, you’ll have enjoyed every step of the research process.

Get Down to Work

Now turn the genetics project ideas on your outline into a genetics research paper full of useful and factual information.

There is no denying writing a genetics research paper is one of the hardest parts of your studies. But with the above genetics topics and writing tips to guide you, it should be a tad easier. Good luck!

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119 Genetics Research Topics You Must Know About

genetics research topics

Put simply, Genetics is the study of genes and hereditary traits in living organisms. Knowledge in this field has gone up over time, and this is proportional to the amount of research.

Right from the DNA structure discovery, a lot more has come out into the open. There are so many genetics research topics to choose from because of the wide scope of research done in recent years.

Genetics is so dear to us since it helps us understand our genes and hereditary traits. In this guide, you will get to understand this subject more and get several topic suggestions that you can consider when looking for interesting genetics topics.

Writing a paper on genetics is quite intriguing nowadays. Remember that because there are so many topics in genetics, choosing the right one is crucial. It will help you cut down on research time and the technicality of selecting content for the topic. Thus, it would matter a lot if you confirmed whether or not the topic you’re choosing has relevant sources in plenty.

What Is Genetics?

Before we even go deeper into genetics topics for research papers, it is essential to have a basic understanding of what the subject entails.

Genetics is a branch of Biology to start with. It is mainly focused on the study of genetic variation, hereditary traits, and genes.

Genetics has relations with several other subjects, including biotechnology, medicine, and agriculture. In Genetics, we study how genes act on the cell and how they’re transmitted from a parent to the offspring. In modern Genetics, the emphasis is more on DNA, which is the chemical substance found in genes. Remember that Genetics cut across animals, insects, and plants – basically any living organism there is.

Tips On How To Write A Decent Research Paper On Genetics

When planning to choose genetics topics, you should also make time and learn how to research. After all, this is the only way you can gather the information that will help you come up with the content for the paper. Here are some tips that can bail you out whenever you feel stuck:

Choosing the topic, nonetheless, is not an easy thing for many students. There are just so many options present, and often, you get spoilt for choice. But note that this is an integral stage/process that you have to complete. Do proper research on the topic and choose the kind of information that you’d like to apply.

Choose a topic that has enough sources academically. Also, choosing interesting topics in genetics is a flex that can help you during the writing process.

On the web, there’s a myriad of information that often can become deceiving. Amateurs try their luck to put together several pieces of information in a bid to try and convince you that they are the authority on the subject. Many students become gullible to such tricks and end up writing poorly in Genetics.

Resist the temptation to look for an easy way of gaining sources/information. You have to take your time and dig up information from credible resources. Otherwise, you’ll look like a clown in front of your professor with laughable Genetics content.

Also, it is quite important that you check when your sources were updated or published. It is preferred and advised that you use recent sources that have gone under satisfactory research and assessment.

Also, add a few words to each on what you’re planning to discuss.Now, here are some of the top genetics paper topics that can provide ideas on what to write about.

Good Ideas For Genetics Topics

Here are some brilliant ideas that you can use as research paper topics in the Genetics field:

  • Is the knowledge of Genetics ahead of replication and research?
  • What would superman’s genetics be like?
  • DNA molecules and 3D printing – How does it work?
  • How come people living in mountainous regions can withstand high altitudes?
  • How to cross genes in distinct animals.
  • Does gene-crossing really help to improve breeds or animals?
  • The human body’s biggest intriguing genetic contradictions
  • Are we still far away from achieving clones?
  • How close are we to fully cloning human beings?
  • Can genetics really help scientists to secure various treatments?
  • Gene’s regulation – more details on how they can be regulated.
  • Genetic engineering and its functioning.
  • What are some of the most fascinating facts in the field of Genetics?
  • Can you decipher genetic code?
  • Cancer vaccines and whether or not they really work.
  • Revealing the genetic pathways that control how proteins are made in a bacterial cell.
  • How food affects the human body’s response to and connection with certain plants’ and animals’ DNA.

Hot Topics In Genetics

In this list are some of the topics that raise a lot of attention and interest from the masses. Choose the one that you’d be interested in:

  • The question of death: Why do men die before women?
  • Has human DNA changed since the evolution process?
  • How much can DNA really change?
  • How much percentage of genes from the father goes to the child?
  • Does the mother have a higher percentage of genes transferred to the child?
  • Is every person unique in terms of their genes?
  • How does genetics make some of us alike?
  • Is there a relationship between diets and genetics?
  • Does human DNA resemble any other animal’s DNA?
  • Sleep and how long you will live on earth: Are they really related?
  • Does genetics or a healthy lifestyle dictate how long you’ll live?
  • Is genetics the secret to long life on earth?
  • How much does genetics affect your life’s quality?
  • The question on ageing: Does genetics have a role to play?
  • Can one push away certain diseases just by passing a genetic test?
  • Is mental illness continuous through genes?
  • The relationship between Parkinson’s, Alzheimer’s and the DNA.

Molecular Genetics Topics

Here is a list of topics to help you get a better understanding of Molecular genetics:

  • Mutation of genes and constancy.
  • What can we learn more about viruses, bacteria, and multicellular organisms?
  • A study on molecular genetics: What does it involve?
  • The changing of genetics in bacteria.
  • What is the elucidation of the chemical nature of a gene?
  • Prokaryotes genetics: Why does this take a centre stage in the genetics of microorganisms?
  • Cell study: How this complex assessment has progressed.
  • What tools can scientists wield in cell study?
  • A look into the DNA of viruses.
  • What can the COVID-19 virus help us to understand about genetics?
  • Examining molecular genetics through chemical properties.
  • Examining molecular genetics through physical properties.
  • Is there a way you can store genetic information?
  • Is there any distinction between molecular levels and subcellular levels?
  • Variability and inheritance: What you need to note about living things at the molecular level.
  • The research and study on molecular genetics: Key takeaways.
  • What scientists can do within the confines of molecular genetics?
  • Molecular genetics research and experiments: What you need to know.
  • What is molecular genetics, and how can you learn about it?

Human Genetics Research Topics

Human genetics is an interesting field that has in-depth content. Some topics here will jog your brain and invoke curiosity in you. However, if you have difficulty writing a scientific thesis , you can always contact us for help.

  • Can you extend your life by up to 100% just by gaining more understanding of the structure of DNA?
  • What programming can you do with the help of DNA?
  • Production of neurotransmitters and hormones through DNA.
  • Is there something that you can change in the human body?
  • What is already predetermined in the human body?
  • Do genes capture and secure information on someone’s mentality?
  • Vaccines and their effect on the DNA.
  • What’s the likelihood that a majority of people on earth have similar DNA?
  • Breaking of the myostatin gene: What impact does it have on the human body?
  • Is obesity passed genetically?
  • What are the odds of someone being overweight when the rest of his lineage is obese?
  • A better understanding of the relationship between genetics and human metabolism.
  • The truths and myths engulfing human metabolism and genetics.
  • Genetic tests on sports performance: What you need to know.
  • An insight on human genetics.
  • Is there any way that you can prevent diseases that are transmitted genetically?
  • What are some of the diseases that can be passed from one generation to the next through genetics?
  • Genetic tests conducted on a person’s country of origin: Are they really accurate?
  • Is it possible to confirm someone’s country of origin just by analyzing their genes?

Current Topics in Genetics

A list to help you choose from all the most relevant topics:

  • DNA-altering experiments: How are scientists conducting them?
  • How important is it to educate kids about genetics while they’re still in early learning institutions?
  • A look into the genetics of men and women: What are the variations?
  • Successes and failures in the study of genetics so far.
  • What does the future of genetics compare to the current state?
  • Are there any TV series or science fiction films that showcase the future of genetics?
  • Some of the most famous myths today are about genetics.
  • Is there a relationship between genetics and homosexuality?
  • Does intelligence pass through generations?
  • What impact does genetics hold on human intelligence?
  • Do saliva and hair contain any genetic data?
  • What impact does genetics have on criminality?
  • Is it possible that most criminals inherit the trait through genetics?
  • Drug addiction and alcohol use: How close can you relate it to genetics?
  • DNA changes in animals, humans, and plants: What is the trigger?
  • Can you extend life through medication?
  • Are there any available remedies that extend a person’s life genetically?
  • Who can study genetics?
  • Is genetics only relevant to scientists?
  • The current approach to genetics study: How has it changed since ancient times?

Controversial Genetics Topics

Last, but definitely not least, are some controversial topics in genetics. These are topics that have gone through debate and have faced criticism all around. Here are some you can write a research paper about:

  • Gene therapy: Some of the ethical issues surrounding it.
  • The genetic engineering of animals: What questions have people raised about it?
  • The controversy around epigenetics.
  • The human evolution process and how it relates to genetics.
  • Gene editing and the numerous controversies around it.
  • The question on same-sex relations and genetics.
  • The use of personal genetic information in tackling forensic cases.
  • Gene doping in sports: What you need to know.
  • Gene patenting: Is it even possible?
  • Should gene testing be compulsory?
  • Genetic-based therapies and the cloud of controversy around them.
  • The dangers and opportunities that lie in genetic engineering.
  • GMOs and their impact on the health and welfare of humans.
  • At what stage in the control of human genetics do we stop to be human?
  • Food science and GMO.
  • The fight against GMOs: Why is it such a hot topic?
  • The pros and cons of genetic testing.
  • The debates around eugenics and genetics.
  • Labelling of foods with GMO: Should it be mandatory?
  • What really are the concerns around the use of GMOs?
  • The Supreme Court decision on the patent placed on gene discoveries.
  • The ethical issues surrounding nurses and genomic healthcare.
  • Cloning controversial issues.
  • Religion and genetics.
  • Behavior learning theories are pegged on genetics.
  • Countries’ war on GMOs.
  • Studies on genetic disorders.

Get Professional Help Online

Now that we have looked at the best rated topics in genetics, from interesting to controversial topics genetics, you have a clue on what to choose. These titles should serve as an example of what to select.

Nonetheless, if you need help with a thesis, we are available to offer professional and affordable thesis writing services . Our high quality college and university assignment assistance are available to all students online at a cheap rate. Get a sample to check on request and let us give you a hand when you need it most.

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Research Topics & Ideas

Biotechnology and Genetic Engineering

Research topics and ideas about biotechnology and genetic engineering

If you’re just starting out exploring biotechnology-related topics for your dissertation, thesis or research project, you’ve come to the right place. In this post, we’ll help kickstart your research topic ideation process by providing a hearty list of research topics and ideas , including examples from recent studies.

PS – This is just the start…

We know it’s exciting to run through a list of research topics, but please keep in mind that this list is just a starting point . To develop a suitable research topic, you’ll need to identify a clear and convincing research gap , and a viable plan  to fill that gap.

If this sounds foreign to you, check out our free research topic webinar that explores how to find and refine a high-quality research topic, from scratch. Alternatively, if you’d like hands-on help, consider our 1-on-1 coaching service .

Research topic idea mega list

Biotechnology Research Topic Ideas

Below you’ll find a list of biotech and genetic engineering-related research topics ideas. These are intentionally broad and generic , so keep in mind that you will need to refine them a little. Nevertheless, they should inspire some ideas for your project.

  • Developing CRISPR-Cas9 gene editing techniques for treating inherited blood disorders.
  • The use of biotechnology in developing drought-resistant crop varieties.
  • The role of genetic engineering in enhancing biofuel production efficiency.
  • Investigating the potential of stem cell therapy in regenerative medicine for spinal cord injuries.
  • Developing gene therapy approaches for the treatment of rare genetic diseases.
  • The application of biotechnology in creating biodegradable plastics from plant materials.
  • The use of gene editing to enhance nutritional content in staple crops.
  • Investigating the potential of microbiome engineering in treating gastrointestinal diseases.
  • The role of genetic engineering in vaccine development, with a focus on mRNA vaccines.
  • Biotechnological approaches to combat antibiotic-resistant bacteria.
  • Developing genetically engineered organisms for bioremediation of polluted environments.
  • The use of gene editing to create hypoallergenic food products.
  • Investigating the role of epigenetics in cancer development and therapy.
  • The application of biotechnology in developing rapid diagnostic tools for infectious diseases.
  • Genetic engineering for the production of synthetic spider silk for industrial use.
  • Biotechnological strategies for improving animal health and productivity in agriculture.
  • The use of gene editing in creating organ donor animals compatible with human transplantation.
  • Developing algae-based bioreactors for carbon capture and biofuel production.
  • The role of biotechnology in enhancing the shelf life and quality of fresh produce.
  • Investigating the ethics and social implications of human gene editing technologies.
  • The use of CRISPR technology in creating models for neurodegenerative diseases.
  • Biotechnological approaches for the production of high-value pharmaceutical compounds.
  • The application of genetic engineering in developing pest-resistant crops.
  • Investigating the potential of gene therapy in treating autoimmune diseases.
  • Developing biotechnological methods for producing environmentally friendly dyes.

Research topic evaluator

Biotech & GE Research Topic Ideas (Continued)

  • The use of genetic engineering in enhancing the efficiency of photosynthesis in plants.
  • Biotechnological innovations in creating sustainable aquaculture practices.
  • The role of biotechnology in developing non-invasive prenatal genetic testing methods.
  • Genetic engineering for the development of novel enzymes for industrial applications.
  • Investigating the potential of xenotransplantation in addressing organ donor shortages.
  • The use of biotechnology in creating personalised cancer vaccines.
  • Developing gene editing tools for combating invasive species in ecosystems.
  • Biotechnological strategies for improving the nutritional quality of plant-based proteins.
  • The application of genetic engineering in enhancing the production of renewable energy sources.
  • Investigating the role of biotechnology in creating advanced wound care materials.
  • The use of CRISPR for targeted gene activation in regenerative medicine.
  • Biotechnological approaches to enhancing the sensory qualities of plant-based meat alternatives.
  • Genetic engineering for improving the efficiency of water use in agriculture.
  • The role of biotechnology in developing treatments for rare metabolic disorders.
  • Investigating the use of gene therapy in age-related macular degeneration.
  • The application of genetic engineering in developing allergen-free nuts.
  • Biotechnological innovations in the production of sustainable and eco-friendly textiles.
  • The use of gene editing in studying and treating sleep disorders.
  • Developing biotechnological solutions for the management of plastic waste.
  • The role of genetic engineering in enhancing the production of essential vitamins in crops.
  • Biotechnological approaches to the treatment of chronic pain conditions.
  • The use of gene therapy in treating muscular dystrophy.
  • Investigating the potential of biotechnology in reversing environmental degradation.
  • The application of genetic engineering in improving the shelf life of vaccines.
  • Biotechnological strategies for enhancing the efficiency of mineral extraction in mining.

Recent Biotech & GE-Related Studies

While the ideas we’ve presented above are a decent starting point for finding a research topic in biotech, they are fairly generic and non-specific. So, it helps to look at actual studies in the biotech space to see how this all comes together in practice.

Below, we’ve included a selection of recent studies to help refine your thinking. These are actual studies,  so they can provide some useful insight as to what a research topic looks like in practice.

  • Genetic modifications associated with sustainability aspects for sustainable developments (Sharma et al., 2022)
  • Review On: Impact of Genetic Engineering in Biotic Stresses Resistance Crop Breeding (Abebe & Tafa, 2022)
  • Biorisk assessment of genetic engineering — lessons learned from teaching interdisciplinary courses on responsible conduct in the life sciences (Himmel et al., 2022)
  • Genetic Engineering Technologies for Improving Crop Yield and Quality (Ye et al., 2022)
  • Legal Aspects of Genetically Modified Food Product Safety for Health in Indonesia (Khamdi, 2022)
  • Innovative Teaching Practice and Exploration of Genetic Engineering Experiment (Jebur, 2022)
  • Efficient Bacterial Genome Engineering throughout the Central Dogma Using the Dual-Selection Marker tetAOPT (Bayer et al., 2022)
  • Gene engineering: its positive and negative effects (Makrushina & Klitsenko, 2022)
  • Advances of genetic engineering in streptococci and enterococci (Kurushima & Tomita, 2022)
  • Genetic Engineering of Immune Evasive Stem Cell-Derived Islets (Sackett et al., 2022)
  • Establishment of High-Efficiency Screening System for Gene Deletion in Fusarium venenatum TB01 (Tong et al., 2022)
  • Prospects of chloroplast metabolic engineering for developing nutrient-dense food crops (Tanwar et al., 2022)
  • Genetic research: legal and ethical aspects (Rustambekov et al., 2023). Non-transgenic Gene Modulation via Spray Delivery of Nucleic Acid/Peptide Complexes into Plant Nuclei and Chloroplasts (Thagun et al., 2022)
  • The role of genetic breeding in food security: A review (Sam et al., 2022). Biotechnology: use of available carbon sources on the planet to generate alternatives energy (Junior et al., 2022)
  • Biotechnology and biodiversity for the sustainable development of our society (Jaime, 2023) Role Of Biotechnology in Agriculture (Shringarpure, 2022)
  • Plants That Can be Used as Plant-Based Edible Vaccines; Current Situation and Recent Developments (İsmail, 2022)

As you can see, these research topics are a lot more focused than the generic topic ideas we presented earlier. So, in order for you to develop a high-quality research topic, you’ll need to get specific and laser-focused on a specific context with specific variables of interest.  In the video below, we explore some other important things you’ll need to consider when crafting your research topic.

Get 1-On-1 Help

If you’re still unsure about how to find a quality research topic, check out our Research Topic Kickstarter service, which is the perfect starting point for developing a unique, well-justified research topic.

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Research Topics

The Center for Genetic Medicine’s faculty members represent 33 departments or programs across three Northwestern University schools and three Feinberg-affiliated healthcare institutions. Faculty use genetics and molecular genetic approaches to understand biological processes for a diverse range of practical and clinical applications.

Select a topic below to learn more and see a list of faculty associated with that type of research. For a full list of Center for Genetic Medicine members, visit our Members section .

  Animal Models of Human Disease

Using genetic approaches with model organisms to investigate cellular and physiological processes can lead to improved approaches for detection, prevention and treatment of human diseases.

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  Bioinformatics & Statistics

Bioinformatics, a discipline that unites biology, computer science, statistical methods, and information technology, helps researchers understand how genes or parts of genes relate to other genes, and how genes interact to form networks. These studies provide insight to normal cellular functions and how these functions are disturbed by disease. Statistics is central to genetic approaches, providing quantitative support for biological observations, and statistical genetics is heavily used by laboratories performing gene and trait mapping, sequencing and genotyping, epidemiology, population genetics and risk analysis.

  Cancer Genetics and Genomics

Cancer begins with genetic changes, or mutations, that disrupt normal regulation of cell proliferation, survival and death. Inherited genetic changes contribute to the most common cancers, like breast and colon cancer, and genetic testing can help identify risks for disease. Tumors also develop additional genetic changes, or somatic mutations, that promote cancer growth and tumor metastases. These genetic changes can be readily defined through DNA and RNA sequencing. Genetic changes within a tumor can be used to develop and guide treatment options.

  Cardiovascular Genetics

Cardiovascular disease is one of the leading causes of death in the US, and the risk of  cardiovascular disease is highly dependent inherited genetic changes. The most common forms of heart disease including heart failure, arrhythmias, and vascular disease are under heritable genetic changes. We work to identify and understand the functions of genes that affect the risk of developing cardiovascular disease, as well as to understand the function of genes involved in the normal and pathological development of the heart.

  Clinical and Therapeutics

Using genetic data identifies pathways for developing new therapies and applying existing therapies. DNA sequencing and epigenetic profiling of tumors helps define the precise defects responsible for cancer progression. We use genetic signals to validate pathways for therapy development.  We are using gene editing methods to correct genetic defects. These novel strategies are used to treat patients at Northwestern Memorial Hospital and the Ann & Robert H. Lurie Children's Hospital of Chicago.

  Development

The genomic blueprint of a single fertilized egg directs the formation of the entire organism. To understand the cellular processes that allow cells to create organs and whole animals from this blueprint, we use genetic approaches to investigate the development of model organisms and humans. Induced pluripotent stem cells can be readily generated from skin, blood or urine cells and used to mirror human developmental processes. These studies help us define how genes coordinate normal human development and the changes that occur in diseases, with the goal of improving detection, prevention and treatment of human disease.

  Epigenetics/Chromatin Structure/Gene Expression

Abnormal gene expression underlies many diseases, including cancer and cardiovascular diseases. We investigate how gene expression is regulated by chromatin structure and other regulators to understand abnormal gene expression in disease, and to learn how to manipulate gene expression for therapeutic purposes.

  Gene Editing/Gene Therapy

Gene editing tools like CRISPR/Cas can be used to directly alter the DNA code. This tool is being used to generate cell and animal models of human diseases and disease processes. Gene therapy is being used to treat human disease conditions.

  Genetic Counseling

As part of training in genetic counseling, each student completes a thesis project. These projects examine all aspects of genetic counseling ranging from family-based studies to mechanisms of genetic action. With the expansion of genetic testing, genetic counselors are now conducting research on outcomes, cost effectiveness, and quality improvement.

  Genetic Determinants of Cellular Biology

Genetic mutations ultimately change the functionality of the cells in which they are found. Mutations in genes encoding nuclear, cytoplasmic and extracellular matrix protein lead to many different human diseases, ranging from neurological and developmental disorders to cancer and heart disease. Using induced pluripotent stem cell and gene-editing technologies, it is now possible to generate and study nearly every human genetic disorder. Having cellular models of disease is necessary to develop new treatments.

  Immunology

Many immunological diseases, such as Rheumatoid arthritis, Lupus, scleroderma, and others have a genetic basis. We work to understand how genetic changes and misregulation contribute to immunological diseases, and use genetic approaches to investigate how the immune system functions.

  Infectious Disease/Microbiome

The susceptibility and/or pathological consequences of many infectious diseases have a genetic basis. We investigate how human genes interact with infectious diseases, and use genetic approaches to determine the interactions between pathogens and the host. Genetic tools, including deep sequencing, are most commonly used to define the microbiome as it undergoes adaptation and maladaptation to its host environment.

  Neuroscience

We work to understand how genes contribute to neurological diseases, and use genetic approaches to investigate how the nervous system functions. Epilepsy, movement disorders, and dementia are heritable and under genetic influence. Neuromuscular diseases including muscular dystrophies and myopathies arise from primary mutations and research in genetic correction is moving into human trials and drug approvals.

  Population Genetics/Epidemiology

Genetic data is increasingly available from large human populations and is advancing the population-level understanding of genetic risk. Northwestern participates in All-Of-US, which aims to build a cohort of one million citizens to expand genetic knowledge of human diseases. Race and ancestry have genetic determinants and genetic polymorphisms can help mark disease risks better than other markers of race/ancestry. We use epidemiology and population genetics to investigate the genetic basis of disease, and to assess how genetic diseases affect subgroups within broader populations.

  Reproduction

Research is examining how germ cells are specified. We study the broad range of biology required to transmit genetic information from one generation to another, and how to facilitate the process of reproduction when difficulties arise or to avoid passing on mutant genes.

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50 ideas to change science: Genetics

6 October 2010

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(Image: Hybrid Medical Animation/SPL)

Read more: 50 ideas to change science forever

After the genome, it’s time for the next level: the interactome and phenome. Expect biotech wizardry and a stream of Jurassic Park headlines along the way

The 1000 Genomes Project

A catalogue of human variation

The mapping of the human genome, largely completed 10 years ago, was a remarkable feat. But if genomics is to fulfil its potential, for example in combating disease, we need to know how much DNA sequences vary between individuals.

Within the next few years we should do. The 1000 Genomes Project, a private-public consortium established in 2008, aims to create a detailed map of human genetic variation. Pilot projects involving 885 people were completed in June this year and identified about 16 million DNA variations, half of them not previously identified. That suggests there may be around 60 million such variations to be found.

The full project, analysing the genomes of 2500 people from 27 populations across the world, is now under way. The growing dataset is freely available online at www.1000genomes.org .

Palaeogenetics

DNA blueprints from the past

Until recently, we thought it would be impossible to decode the genetic blueprint of an extinct organism. In May this year, though, an international team published the full genome of a Neanderthal ( Science , vol 328, p 710 ). What changed?

Faster and cheaper DNA sequencing, mainly. Processing thousands or millions of sequences at once has allowed palaeogeneticists to piece together damaged DNA and discard degraded sections. They can also pull out the 5 per cent from a fossil sample that actually belongs to an ancient species, rather than subsequent bacterial contamination, by matching it up with DNA from a related, extant species. In the past five years, this has delivered genomes for several iconic species including a 40,000-year-old cave bear, a mammoth and now a Neanderthal.

What does this tell us? A lot about our own family tree, for a start. The idea that ancient DNA sequences could be used to revive long-extinct beasts à la Jurassic Park is more fanciful, but we should never say never .

Interactomes

Mapping cellular complexity

Proteins and RNAs, the molecules encoded by genes, rarely act in isolation. Some proteins associate with other proteins, either to regulate them or to form larger cellular machines. Others perform specific tasks by binding to particular DNA sequences, or linking themselves tightly to RNA molecules.

Throughout the 20th century, this incredibly dense web of interactions – dubbed the “interactome” in allusion to the genome – remained impenetrable. In the last decade, however, complete genome-sequence information and increasingly powerful bioinformatic tools have allowed us to generate and analyse draft interactome maps both for humans and for other model organisms.

Although still far from complete, these maps are poised to serve as scaffolds for newly sophisticated models of how cells operate. Since many human diseases can be explained by perturbations of molecular interactions within cells, interactomes will drastically change how we think about human health, and how we set about designing drugs and preventive measures to counter illness. Marc Vidal

Marc Vidal is a professor of genetics at Harvard Medical School and director of the Center for Cancer Systems Biology (CCSB) at the Dana-Farber Cancer Institute in Boston

There’s more to life than genomes

If we want truly to understand the living world, the genome won’t do. We need to get to grips with the “phenome”: the sum total of all traits, from genes to behaviour, that make up a living thing.

If you think that sounds tough, you’d be right. Think about your own phenome. There are obvious traits such as eye colour, height and facial features. Then there are more intangible things such as your metabolic rate, personality, susceptibility to Alzheimer’s disease, and trillions of others. All of these came about through the interaction of your genome and your environment, starting from the moment you were conceived.

That complexity perhaps explains why there is as yet no “human phenome project”, though such a thing was first mooted in 2003. But smaller-scale projects such as the Mouse Phenome Database are now springing up. From personalised medicine to our understanding of evolution, science will be the beneficiary.

DNA origami

Life as a template          

The stuff of life is sticky: put the right DNA base pairs together and they bond like Velcro. Take long single strands of DNA and throw in some shorter synthesised strands, and the bonds on the short strands can pull the long strands into specific shapes and hold them all together.

This “DNA origami” technique is one of the most promising of many ways to make molecules self-assemble into 3D structures. It has been used to make a bewildering variety of objects, from toothed gears to 3D boxes with a lock-and-key mechanism. Ultimately, the hope is to use such boxes for drug delivery, and to exploit the folding and unfolding of biomolecules to make nanoscale computer components.

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Genetics research articles from across Nature Portfolio

Genetics research is the scientific discipline concerned with the study of the role of genes in traits such as the development of disease. It has a key role in identifying potential targets for therapeutic intervention and also in understanding genetically based variations in response to therapeutic interventions.

research project ideas for genetics

Deciphering the genetic architecture of pain intensity

Chronic pain is common, with more than one in five adult Americans reporting having pain daily or on most days. A multi-ancestry genomic analysis in 598,339 military veterans in the USA identifies 126 genetic variants associated with pain intensity, highlights shared genetic risk with substance use and psychiatric disorders, and reveals enrichment in GABAergic neurons as a key molecular contributor to experiencing pain.

Latest Research and Reviews

research project ideas for genetics

Whole genome sequencing identifies associations for nonsyndromic sagittal craniosynostosis with the intergenic region of BMP2 and noncoding RNA gene LINC01428

  • Anthony M. Musolf
  • Cristina M. Justice
  • Simeon A. Boyadjiev

research project ideas for genetics

Evaluation of 100 Dutch cases with 16p11.2 deletion and duplication syndromes; from clinical manifestations towards personalized treatment options

  • Lotte Kleinendorst
  • Mieke M. van Haelst

research project ideas for genetics

Combined approaches, including long-read sequencing, address the diagnostic challenge of HYDIN in primary ciliary dyskinesia

  • Andrew Fleming
  • Miranda Galey
  • Deborah J. Morris-Rosendahl

research project ideas for genetics

Genomic spectrum of actionable alterations in serial cell free DNA (cfDNA) analysis of patients with metastatic breast cancer

  • Jennifer C. Keenan
  • Neelima Vidula

research project ideas for genetics

Next-generation sequencing of host genetics risk factors associated with COVID-19 severity and long-COVID in Colombian population

  • Mariana Angulo-Aguado
  • Juan Camilo Carrillo-Martinez
  • Oscar Ortega-Recalde

research project ideas for genetics

Genetic associations of risk behaviours and educational achievement

A genetic study that explores the relationship between risk behaviours engagement in adolescents and educational achievement. This study found that risk behaviours were phenotypically associated with educational achievement at age 16, even after adjusting for confounders.

  • Michelle Arellano Spano
  • Tim T. Morris
  • Amanda Hughes

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Guidance on use of race, ethnicity, and geographic origin as proxies for genetic ancestry groups in biomedical publications.

  • W. Gregory Feero
  • Robert D. Steiner
  • Kirsten Bibbins-Domingo

research project ideas for genetics

Optimizing genetic testing strategies for congenital anomalies in Iran

  • Daniel G. Calame

Comment on: “Somatic CAG repeat instability in intermediate alleles of the HTT gene and its potential association with a clinical phenotype” by Ruiz de Sabando et al.

  • Magdalena Mroczek

research project ideas for genetics

Rare diseases: challenges and opportunities for research and public health

Rare diseases remain a formidable public health challenge. The key to unlocking breakthroughs in diagnosis and treatment is fostering dynamic international partnerships and streamlined data sharing. The empowerment of patient advocacy groups is essential, as they are pivotal in driving innovative research and elevating health-care standards for these often under-represented conditions.

  • Domenica Taruscio
  • William A. Gahl

research project ideas for genetics

Comparison of karyotype scoring guidelines for evaluating karyotype complexity in chronic lymphocytic leukemia

  • Matthew R. Avenarius
  • Cecelia R. Miller

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Current Clinical Studies

Researchers at the National Human Genome Research Institute (NHGRI) are working with patients and families to better understand of how genes can cause or influence diseases and develop new and more effective diagnostics and treatments.

Value of Clinical Studies

Clinical studies give us a better understanding of how genes can cause or influence diseases. NHGRI researchers are working with patients, and with families with a history of inherited diseases, to learn more about the genetic components of common and rare disorders, and to develop new and more effective tests and treatments.

Deciding whether to participate in a clinical study is an important and personal process. Some reasons people choose to participate include:

  • Participants in clinical studies help current and future generations. Through these studies, researchers develop new diagnostic tests, more effective treatments, and better ways of managing diseases with genetic components.
  • Participants in studies are actively involved in understanding their disorder and current research.
  • Participants in some studies gain access to new tests and treatments before they are widely available.

Featured Clinical Studies

ADHD Genetic Research Study | NHGRI

Metabolism, Infection and Immunity (MINI) Section

The MINI section aims to define the relationship between infection, immunity and clinical decline in individuals with mitochondrial disease.

COVID-19 MINI

Other Clinical Studies

The following are conducted by NHGRI researchers. For eligibility requirements and contact information, visit the study on clinicaltrials.gov.

Last updated: January 12, 2023

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60 Interesting Genetic Engineering Topics for Your Next Research Paper

Genetic Engineering Topics

Genetics engineering is one of the popular areas of study today. The discipline was discovered back in 1850 and seeks to analyze the systems of heredity and genes in different species. Therefore, when your professor gives you assignments prompts, it is important to start by picking the right genetics topics for research papers.

However, many students find selecting the best genetics project ideas difficult. So, if you find yourself staring at a blank page for hours, you are not alone. But we are here to help!

To get you started on the right path, we have listed 60 hot genetic engineering topics for your research paper. Furthermore, we have provided you with pro tips for crafting A-rated research papers.

The Best Molecular Genetics Topic Ideas

  • Stem cells: What are their potential and shortcomings?
  • A closer look at the genome evolution.
  • The molecular techniques of analyzing DNA and RNA.
  • Evaluating the power of mutagenesis.
  • DNA as an agent of heredity: A comprehensive analysis.
  • Bacteria and genetics.
  • Genetics: How does it increase the risk of cancer?
  • Contemporary issues in genetic engineering public policy.
  • Molecular cancer genetics: What are the latest advances?

Interesting Genetics Topics

  • What are the main applications of genetics today?
  • Discuss the main causes of genetic mutations.
  • What is the link between genetics and obesity?
  • RNA information.
  • Do we have living cells in genes? Explain.
  • Explain the role of genetics in the fight against Alhzeimer’s disease.
  • An evaluation of genes replacement with artificial chromosomes.
  • Genetics and depression: Are they linked?
  • What are the impacts of genetics on future generations?
  • What is the link between Parkinson’s disease and genetics?
  • Can DNA changes help to beat aging?
  • Discuss the morality of growing human organs.
  • Genetics and homosexuality: Are they linked?
  • A closer look at the history of human cloning.
  • How do addictive substances impact our genes?

Top Genetics Topics for Presentation

  • Should genetic engineering be legalized?
  • What are the principles of genetic engineering?
  • Analyzing the impact of cloning on modern medicine.
  • A review of the latest studies on genetically modified organisms.
  • Do we really need genetics testing?
  • Artificial inseminations vs normal conception: What are your thoughts?
  • Should parents be allowed to order genetically perfect children?
  • A close look at the accuracy in genetic engineering.
  • Should biotech firms be allowed to patent human genes?
  • What are the pros and cons of genetic engineering?
  • How does genetic engineering impact our relationships?
  • Genetic engineering and the sale of human organisms.
  • Ethics of genetic engineering: Should we support cloning of dead people?
  • How is genetic engineering presented in the media today?
  • Should researchers be obliged to share the benefits and burden of their work on genetic engineering?

Hot Topics on Genetics Engineering

  • Are genetically modified foods safe for human consumption?
  • Analyzing the philosophical issues of genetic engineering.
  • Should the US government invest in genetic engineering?
  • Impact of social media on genetically modified organisms discussions.
  • Should using genetically modified foods to fight hunger be allowed?
  • Comparing the genetic engineering policies of the US and UK.
  • Cloning pets: Is it ethically right?
  • Does cloning increase or limit biological diversity?
  • The comprehensive analysis of the 2001 George W. Bush speech on cloning.
  • Discuss the five main ethical dilemmas of genetic cloning.
  • Whole-genome sequencing.
  • Evaluating the top three gene-editing technologies.
  • How does human microbiome work in preventing diseases?
  • Genomic hybridization for enhanced fruits production.
  • A closer look at CCR5 Delta 32 Genetic Mutation.
  • The pros and cons of studies on biological dark matter.
  • Biotic mutation for enhanced bone density.
  • Using genetic mutation to eliminate sickle cell anemia.
  • How does IVF help to prevent babies from inheriting genetic defects?
  • Using genetic engineering to address the problem of genetic engineering.
  • What is the future of cloning?

Special Tips for Writing a Great Research Paper

Once you have selected the preferred genetics topic for research papers, your journey to creating an A-rated paper has just started. Here are some useful tips to help you craft the best research paper on genetic engineering.

  • Research on your selected topic comprehensively. This will help you to develop the right research questions and identify key points to discuss on the paper. Make sure to also capture the counter-arguments on the selected topic.
  • Develop a good paper structure. Once you have picked the best research ideas, you need to craft a good structure so that the paper looks coherent and enjoyable to read. The format will help you to know what point to discuss at any part of the paper.
  • Make sure to read other genetic engineering research papers to understand how experts did it. Here, you can borrow the structure and enrich your arguments from the discussions by other scholars.
  • Proofread your work well. Even if you have the best genetics research topics and a good paper, but fail to proofread it well, there is a danger of scoring poor grade. So, make sure to proofread your work well to identify and correct errors, incomplete sentences, and flow. You can ask a professional to proofread and edit your paper , to ensure that your work is mistake-free.

When you are faced with a genetic engineering assignment, it is important to look at it holistically. So, start by identifying the most interesting genetic topics and use a good structure to craft the best paper.

No time to deal with upcoming assignment? Don’t worry – our geeks can help! Enter promo “ mygeek20 ” and get a 20% discount off your next writing assignment!

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13 Cancer Research and Passion Project Ideas for High School Students

research project ideas for genetics

By Alex Yang

Graduate student at Southern Methodist University

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By Soha Aslam

Principal Nuclear Engineer

8 minute read

Cancer research addresses one of the most devastating and widespread diseases that affects millions of people worldwide. Cancer is a complex group of diseases and ongoing research is essential to better understand its underlying causes, develop innovative treatments, and improve early detection methods. This research not only saves lives by advancing our ability to diagnose and treat cancer more effectively but also improves our knowledge of the fundamental workings of cellular biology, allowing for breakthroughs in fields beyond just cancer research.

Cancer research can be a particularly exciting field if you already have an interest in STEM. Although high school courses like AP Biology may provide an introduction to cancer, you don’t have to wait until college to dive deeper into the topic. A cancer research passion project can be a great way to learn on your own.

Finding the Right Cancer Research Passion Project For You

Even within the topic of cancer research there are many different directions you can go with your project. For example, you could focus your research on a specific kind of cancer and its nuances. You could also focus on different aspects of cancer research, like investigating what may cause cancer, how to treat cancer, how to detect cancer, and how cancers develop over time. Try to focus on one of these specific areas as opposed to doing a project about cancer as a whole. A more targeted approach will make it easier for you to do research and organize your findings.

13 Cancer Research Passion Project Ideas

1. on top of genetics - epigenetics in cancer.

Mutations within a cell are a driving force in cancer; however, it is not the only way a cell could become malignant. In this project, you will explore how epigenetic modifications (ie. DNA methylation or DNA oxidations) can facilitate cancer cell survival. This project could be conducted in multiple ways: a scientific blog, a review article, a brief video, or a podcast.

Idea by cancer research mentor Alejandra

2. Cancer deep dive

Different types of cancer, and even different subtypes, have drastically different outcomes. For example, patients with HPV-mediated cancers are more sensitized to radiation, meaning lower doses of treatment may be equally effective as higher doses but with fewer side effects. In this project, students can pick a specific type of cancer and do a deep-dive on the mutation that causes the cancer, the treatment, and current/future therapies.

Idea by cancer research mentor Kendra

3. How can RNA be used to treat cancer? 

One class of new cancer therapies uses RNA molecules to specifically target cancer cells. In this project, you will explore RNA therapies currently in use. After learning about these therapies, you will then come up with a new target or approach for the use of an RNA therapy in treating cancer or another disease of your choice. Your findings can be summarized in a scientific paper or presentation.

Idea by cancer research mentor Rebecca

4. Essentiality of genes in pancreatic cancer 

Certain genes are essential for all cancer cells to survive. However, some genes are only essential in certain cell type contexts. To figure out how to kill cancer cells of certain cell types, we can use publicly available data on the Broad Institute's Cancer Cell Line Dependency Map database . This database shows which genes are essential across thousands of cancer cell lines. For example, if you look at pancreatic cancer specifically, you can identify genes that are important for cell survival only in the pancreatic cancer context. Look at other cancers and learn about the genes that are essential for the cancer’s survival and present your findings.

Idea by cancer research mentor Lauren

5. Designing a novel CAR T cell therapy 

Chimeric antigen receptor (CAR) T cells are immune cells genetically engineered to attack specific proteins implicated in cancer, autoimmune diseases, or viral infections. This project will challenge students to design a CAR T cell therapy for their disease of interest by 1) reviewing literature on antigen(s) specific to their chosen disease; 2) learning basics of T cell biology and genetic engineering; and 3) writing a research proposal to assess the safety and efficacy of their designer T cell therapy.

Idea by cancer research mentor Josh

6. Investigating the role of a particular gene in the development of breast cancer. 

Breast cancer is a leading cause of cancer-related deaths in women, and understanding what causes its development is crucial for developing more effective treatments. In this project, you will investigate the role of a particular gene in the development of breast cancer, using online databases and other sources to collect data on the expression of the selected gene in normal and cancerous breast tissue. This project could involve the following steps: 1. Research the function of the selected gene and its potential role in cancer development. 2. Use online databases and other sources to collect data on the expression of the selected gene in normal and cancerous breast tissue. 3. Use bioinformatics tools to analyze the data and determine if the selected gene is differentially expressed in cancerous tissue. 4. Analyze the data and interpret the results, and write a scientific report summarizing the findings and their implications.

Idea by cancer research mentor Chanelle

Create a research project tailored to your interests and your schedule

Polygence pairs you with an expert mentor in your area of passion. Together, you work to create a high quality research project that is uniquely your own. We also offer options to explore multiple topics, or to showcase your final product!

7. Personalized disease markers

Cancer is a personalized disease - no two patients will have exactly the same cancer. This problem makes cancer difficult to treat and cure. Modern cancer research looks for disease markers specific to certain patients that may make them respond better to certain treatments. In this project, you can choose a cancer type and review the different markers known to inform patient treatment outcomes.

Idea by cancer research mentor Sarah

8. Dormant cancer cells

Cancer cells undergo a process called dormancy to evade immune surveillance, by which cancer cells are not actively undergoing the cell cycle process, allowing them to remain "asleep" within a patient's body. The major problem with dormant cancer cells is that once they "wake up", they spread quickly to other parts of the body and are resistant to treatment. Explore and learn about the concept of dormancy.

9. Understanding how cells in the tumor affect tumor growth 

When researchers evaluate the cells present in a tumor, there are generally two main classes: cells that help the tumor grow (pro-tumor) and those that try to destroy the tumor (anti-tumor). As we start to learn more about which cell types are present in the tumor, we start to understand how the tumor evades our bodies natural defenses. These insights can also be used to develop new treatment strategies for patients with cancer. Writing a literature review on this topic will provide you with a thorough understanding of many aspects of immunology and gives you the opportunity to publish your research in a journal .

Idea by cancer research mentor Xanne

10. Cancer health disparities 

Unfortunately, many studies have shown that race and gender can affect the level of care cancer patients receive which ultimately affects their survival chances. In this project, you can research a specific area of disparity and its effects on cancer patients and the treatment they receive. Next, you can propose a strategy to overcome the disparity using knowledge of cancer medicine and public health policy.

11. Decreasing risk of getting cancer

While there are many factors predisposing a person to getting cancer, it is important to share the ways we can work to control being exposed to certain risk factors. Students can explore these risk factors to prepare a review article, presentation, or community event to educate the next generation about how limiting factors such as sun exposure, poor diet, alcohol use, and getting genetic testing early if your family has a history of cancer, can decrease your risks of getting certain cancers.

Idea by cancer research mentor Carly

12. Exploring the connections between cancer, organ transplantation and pregnancy

For years, scientists have been trying to solve problems related to organ transplantation and cancer. When a patient receives a much-needed organ from a donor, the immune system can recognize the organ as foreign and attack it. However, when a patient develops cancerous cells, the immune system can fail to recognize that the cells don't belong, allowing the cancer to spread. Yet, during pregnancy, a mother is able to carry a fetus for 9 months even though half of its genetic material is not shared by the mother. Can cancer and pregnancy help us solve some of the challenges related to organ transplantation? Explore this question and share your findings.

Idea by cancer research mentor Amber  

13. Exploring nuclear physics and radiation detection for cancer therapy

Last but not least, nuclear physics plays a pivotal role in cancer treatment, with applications like radiology, boron neutron capture therapy (BNCT), and the use of radioisotopes for diagnosis and treatment. Here are some project ideas in this realm: 

Radiology and Cancer Imaging: Radiology, a branch of medical science that uses ionizing radiation, is a powerful tool for cancer diagnosis. Explore the various imaging techniques like X-rays, CT scans, and MRI that utilize radiation to detect and visualize tumors. Investigate the advancements in radiology technology and how it aids in early cancer detection and treatment planning.

Boron Neutron Capture Therapy (BNCT): BNCT is a cutting-edge cancer therapy that involves targeting tumor cells with boron-10-loaded compounds and irradiating them with thermal neutrons. This technique results in the release of high-energy alpha particles, specifically damaging cancer cells while sparing healthy tissue. Delve into the principles of BNCT, its potential applications, and the latest research in this field. Share your insights through a detailed report or a presentation.

Radioisotopes in Cancer Treatment: Radioisotopes are radioactive forms of elements that can be used in various cancer treatments. Investigate how radioisotopes like iodine-131, yttrium-90, and others are employed for targeted cancer therapy, such as radioiodine therapy for thyroid cancer. Explore the mechanisms, benefits, and challenges associated with using radioisotopes in cancer treatment. You can present your findings through a research paper, presentation, or even an educational video or podcasts.

By venturing into nuclear physics and radiation detection for cancer therapy, you can contribute to the understanding and advancement of non-invasive cancer treatments and diagnostics, making a significant impact in the field of oncology. 

Idea by nuclear physicist research mentor Soha

How to Showcase Your Cancer Research Passion Project

After you’ve done the hard work of researching cancer, you should also dedicate time towards deciding how you want to showcase your project . There are many unique ways that you can showcase a project. Specifically for cancer research, you could write a research paper or do a literature review, or you could try to execute something more creative like a presentation with graphics or a podcast. The decision is up to you, but be sure that with whatever showcasing method that you choose, make sure that the hard work and effort that you put into your research comes through. 

Examples of Cancer Research Passion Projects Completed by Polygence Students

Cancer research is a popular topic for Polygence students, and we wanted to showcase some of the great work that our students have done in the field!

Natalie’s project was a research paper she wrote about immunotherapies for breast cancer, which affects around 1 in 3 women.

Dnyanada did research into melanoma, a type of skin cancer, and a specific immunotherapy called Nivolumab. Dnyanada found through her research that patients who were treated with Nivolumab had specific gene expressions that could reveal whether the treatment was affecting the patient positively or negatively. Dnyanada then used machine learning models to predict whether certain patients would have a positive or negative response to Nivolumab.

Shravan worked on a project designing a CRISPR-Cas9n genetic therapy for Lynch syndrome (hereditary non-polyposis colorectal cancer). Shravan was able to present his project at Polygence’s 8th Symposium of Rising Scholars , and also created a series of blog posts, as well as a research paper to submit to journals.

Arif worked on a project modeling Boron Neutron Capture Therapy (BNCT) using an open source modeling tool called OpenMC. CT relies on the selective accumulation of boron-10 within tumor cells, followed by irradiation with thermal neutrons. Arif's modeling efforts likely encompass the detailed calculations of neutron flux, the behavior of boron-10 under irradiation, and the subsequent release of high-energy alpha particles within the tumor. 

Complete a Cancer Related Research Project With Polygence

In this article, we covered how to pick the right cancer research project for you, shared some project ideas, and discussed best practices for how to showcase your project.

If you’re interested and inspired by cancer research and you’re interested in diving deeper, Polygence’s programs are a great place to start. You’ll be able to meet virtually one-on-one with a biology/cancer research mentor who can help you learn new concepts and brainstorm with you on how to showcase your passion project.

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A Paper on the Relationship Between the Most Significant Breast Cancer Susceptibility Proteins, Aldehydes, and Prostate Cancer

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Get Matched with a Mentor

Interested in doing one of these exciting research projects? Click below to get matched with one of our expert mentors!

Genetic Literacy Project

Robots with poison guns target weeds and offer an alternative to some herbicides

research project ideas for genetics

The plants we eat have bitter enemies on all sides.

Can robots with poison guns help them?

“Aggressive weeds, insects, and fungi are just some of the obstacles,” says Ingeborg Klingen. She is head of research at the Norwegian Institute of Bioeconomy Research (NIBIO).

Precision is key when applying poison, a skill that the AX-1 robot is being trained in.

“We have taught the robot AX-1 to compare weeds with pictures of weeds,” says Brevik.

It can do this with artificial intelligence.

The robot can then browse through the album and compare while it drives on the field.

“If it’s a weed, the robot gets ready,” he says.

In an instant, it releases a poison droplet, small as a grape seed, precisely targeting the weed.

“Our robot ensures the poison is accurately deployed onto the weed,” Brevik assures.

“It’s great that agriculture gets robots like this. It means we can use much less herbicides while the plants we eat grow better,” researcher Klingen says.

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research project ideas for genetics

Ding receives Michelson Prize for advancing human immunology

research project ideas for genetics

Siyuan Ding , an assistant professor of molecular microbiology at Washington University School of Medicine in St. Louis, has received a Michelson Prize: Next Generation Grant from the Michelson Medical Research Foundation and the Human Immunome Project. The grants are awarded annually to innovative early-career scientists advancing human immunology, vaccine discovery and immunotherapy research for major global diseases.

Ding uses innovative approaches to develop vaccines for infectious diarrhea, a leading cause of death among children worldwide.

Read more on the School of Medicine website .

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Hidden serial numbers for guns, dietary supplements among CC Science Symposium topics

research project ideas for genetics

Clandestine serial numbers, cloning an enzyme for a potential future dietary supplement and the health of rural versus urban streams for aquatic invertebrates were among topics covered Wednesday at the 10th annual Columbia College Science Symposium.

Students filled Brouder Science Center with posters representing their research, explaining it to the dozens of visitors who approached.

More than 50 student research projects were represented.

Nicholas Pouk, a senior in forensic science and biology from St. Peters, was receiving a lot of attention for his project, "Using carbon dot nanocomposites towards a clandestine serial number stamping method."

Carbon dots are a biological marker that can be melted into a type of plastic and applied to items to be marked, Pouk explained.

He envisions it being used to serial numbers on firearms that aren't visible without using a specific wavelength of ultraviolet light.

Law enforcement can be supplied with the location on the firearm of the serial number and the wavelength needed to view it, he said.

It can be used as an anti-counterfeit method for bank notes, he said.

"It's also cheap and simple," Pouk said, noting another benefit.

He has a job lined up after graduation as a necropsy technician with Alta Sciences in Columbia.

Kristin Kelly, A Columbia senior in biology did her research on cloning malate dehygrogenase.

"It's an important enzyme," Kelly said.

The protein that results could be used as a dietary supplement, she said.

"It's kind of like a vitamin," she said.

She's' enrolled in the biomedical sciences master's degree program at the University of Missouri, where she will study the immune system's effects on cardiac performance after a heart attack.

Her research won the symposium's Top Research Proposal award.

Nick Grabner, an Asland senior in biology, won the Department of Natural Sciences, Mathematics and Computer Science Award. He also was the keynote speaker at the symposium.

His researched looked at the health of invertebrates and water quality in urban and rural streams.

The urban stream is Flat Branch Creek in downtown Columbia and the rural stream is Turkey Creek, between Columbia and Ashland, one of the creeks in the Three Creeks Conservation Area .

Water quality was better in Turkey Creek, based on measures including oxygen and Ph levels.

"Alkalinity was high and it had lower phosphates," Grabner said of Turkey Creek.

The invertebrate information was inconclusive, he said. There were more invertebrates in Flat Branch Creek, but a bigger variety in Turkey Creek.

Adrienne Mason, a senior in forensic chemistry from Searcy, Arkansas, presented her research on the reliability of eyewitness evidence.

It has been established previously that eyewitness evidence is not at all reliable and has resulted in many wrongful convictions, Mason said. Groups like The Innocence Project has worked to reverse many convictions using DNA evidence.

In her research, she staged a disruption in a classroom. A woman entered the room and loudly chastised the instructor for not meeting deadlines, then left.

"They overall did best on hair color," Mason said. "They scored lower on height and clothing."

There were 25 students in the class, but two were eliminated. One declined to participate and the other knew the intruder personally.

"This field needs more research," Mason said.

Columbia College biology professor Brad Sharf said the symposium is a good opportunity for students to present their research to a wide audience.

"It gives the student the ability to present their data," Sharf said. "It's something that's really important in the science field."

Roger McKinney is the Tribune's education reporter. You can reach him at [email protected] or 573-815-1719. He's on X at @rmckinney9.

ScienceDaily

Cockayne syndrome: New insights into cellular DNA repair mechanism

Cockayne syndrome is a severe autosomal recessive disorder caused by defective DNA repair mechanisms. People with the disease have much reduced life expectancy and suffer from facial deformities; growth failure; neurological, cognitive, and sensory impairments; bone, joint, and muscle deformities; kidney problems; and premature aging. Like xeroderma pigmentosum (XP), Cockayne syndrome (CS) is a disease where elements of nucleotide excision repair (NER) do not work properly. The purpose of this repair mechanism is to remove DNA damage caused by ultraviolet (UV) light, chemicals, and various other environmental factors.

Researchers from the group of biochemist Professor Julian Stingele from LMU's Gene Center Munich have now uncovered important details about the role of the CSB/ERCC6 and CSA/ERCC8 genes involved in Cockayne syndrome. These genes encode two enzymes associated with DNA repair. The results of their work have been published in the journal Nature Cell Biology . "Our data point to a new, previously unknown function of these two genes and their gene products in the repair of covalent DNA-protein interactions in the course of transcription," reports Stingele, referring to the cytotoxic, biologically undesirable crosslinking of proteins to DNA.

An obstacle for transcription

In collaboration with researchers from the University of Cambridge, the scientists demonstrated that DNA-protein crosslinks present a physical obstacle to further transcription. Arresting transcription brings CS proteins to the blockade sites. "Our results indicate that CSB and CSA then initiate the transcription-coupled repair of the toxic DNA-protein crosslinks," says Stingele. "This previously unrecognized cellular function of CS proteins leads to the marking of the DNA damage -- and thence to its enzymatic breakdown."

The study also revealed that this newly discovered function of CS proteins works independently of classic TC-NER (transcription-coupled nucleotide excision repair) enzymes, which are deployed, among other things, for repairing DNA damage caused by UV light -- and the absence of which leads to xeroderma pigmentosum. "The fact that CS proteins have additional functions is noteworthy. This discovery could help to explain the pathological differences between xeroderma pigmentosum and Cockayne syndrome," says Stingele. CS is a more severe and more multifaceted disorder than XP, with complex and incompletely understood causes. As their next step, Stingele's research group plans to decode the exact process of CS-protein-mediated repair.

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Materials provided by Ludwig-Maximilians-Universität München . Note: Content may be edited for style and length.

Journal Reference :

  • Christopher J. Carnie, Aleida C. Acampora, Aldo S. Bader, Chimeg Erdenebat, Shubo Zhao, Elnatan Bitensky, Diana van den Heuvel, Avital Parnas, Vipul Gupta, Giuseppina D’Alessandro, Matylda Sczaniecka-Clift, Pedro Weickert, Fatih Aygenli, Maximilian J. Götz, Jacqueline Cordes, Isabel Esain-Garcia, Larry Melidis, Annelotte P. Wondergem, Simon Lam, Maria S. Robles, Shankar Balasubramanian, Sheera Adar, Martijn S. Luijsterburg, Stephen P. Jackson, Julian Stingele. Transcription-coupled repair of DNA–protein cross-links depends on CSA and CSB . Nature Cell Biology , 2024; DOI: 10.1038/s41556-024-01391-1

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    The Division of Genetic and Genomic Medicine maintains an active basic science and clinical research program. Our laboratory research program focuses on discovering the underlying causes of genetic diseases, understanding the clinical implications of mutations in genes and development of novel approaches for treatment of genetic disorders.

  11. DNA Day Activity Ideas

    List of Activities. DNA Day Essay Contest from ASHG. American Society of Human Genetics (ASHG) DNA Day essay contest is open to students in grades 9-12 worldwide and asks students to examine, question, and reflect on important concepts in genetics. The submission site is closed and winners will be announced on DNA Day ( Tuesday, April 25, 2024 ).

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  27. Ding receives Michelson Prize for advancing human immunology

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  28. Science symposium highlights Columbia College student research

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