importance of related literature in research

Why is it important to do a literature review in research?

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 “A substantive, thorough, sophisticated literature review is a precondition for doing substantive, thorough, sophisticated research”. Boote and Baile 2005

Authors of manuscripts treat writing a literature review as a routine work or a mere formality. But a seasoned one knows the purpose and importance of a well-written literature review.  Since it is one of the basic needs for researches at any level, they have to be done vigilantly. Only then the reader will know that the basics of research have not been neglected.

The aim of any literature review is to summarize and synthesize the arguments and ideas of existing knowledge in a particular field without adding any new contributions.   Being built on existing knowledge they help the researcher to even turn the wheels of the topic of research.  It is possible only with profound knowledge of what is wrong in the existing findings in detail to overpower them.  For other researches, the literature review gives the direction to be headed for its success. 

The common perception of literature review and reality:

As per the common belief, literature reviews are only a summary of the sources related to the research. And many authors of scientific manuscripts believe that they are only surveys of what are the researches are done on the chosen topic.  But on the contrary, it uses published information from pertinent and relevant sources like

• Scholarly books
• Scientific papers
• Latest studies in the field
• Established school of thoughts
• Relevant articles from renowned scientific journals

and many more for a field of study or theory or a particular problem to do the following:

• Summarize into a brief account of all information
• Synthesize the information by restructuring and reorganizing
• Critical evaluation of a concept or a school of thought or ideas
• Familiarize the authors to the extent of knowledge in the particular field
• Encapsulate
• Compare & contrast

By doing the above on the relevant information, it provides the reader of the scientific manuscript with the following for a better understanding of it:

• It establishes the authors’  in-depth understanding and knowledge of their field subject
• It gives the background of the research
• Portrays the scientific manuscript plan of examining the research result
• Illuminates on how the knowledge has changed within the field
• Highlights what has already been done in a particular field
• Information of the generally accepted facts, emerging and current state of the topic of research
• Identifies the research gap that is still unexplored or under-researched fields
• Demonstrates how the research fits within a larger field of study
• Provides an overview of the sources explored during the research of a particular topic

Importance of literature review in research:

The importance of literature review in scientific manuscripts can be condensed into an analytical feature to enable the multifold reach of its significance.  It adds value to the legitimacy of the research in many ways:

• Provides the interpretation of existing literature in light of updated developments in the field to help in establishing the consistency in knowledge and relevancy of existing materials
• It helps in calculating the impact of the latest information in the field by mapping their progress of knowledge.
• It brings out the dialects of contradictions between various thoughts within the field to establish facts
• The research gaps scrutinized initially are further explored to establish the latest facts of theories to add value to the field
• Indicates the current research place in the schema of a particular field
• Provides information for relevancy and coherency to check the research
• Apart from elucidating the continuance of knowledge, it also points out areas that require further investigation and thus aid as a starting point of any future research
• Justifies the research and sets up the research question
• Sets up a theoretical framework comprising the concepts and theories of the research upon which its success can be judged
• Helps to adopt a more appropriate methodology for the research by examining the strengths and weaknesses of existing research in the same field
• Increases the significance of the results by comparing it with the existing literature
• Provides a point of reference by writing the findings in the scientific manuscript
• Helps to get the due credit from the audience for having done the fact-finding and fact-checking mission in the scientific manuscripts
• The more the reference of relevant sources of it could increase more of its trustworthiness with the readers
• Helps to prevent plagiarism by tailoring and uniquely tweaking the scientific manuscript not to repeat other’s original idea
• By preventing plagiarism , it saves the scientific manuscript from rejection and thus also saves a lot of time and money
• Helps to evaluate, condense and synthesize gist in the author’s own words to sharpen the research focus
• Helps to compare and contrast to  show the originality and uniqueness of the research than that of the existing other researches
• Rationalizes the need for conducting the particular research in a specified field
• Helps to collect data accurately for allowing any new methodology of research than the existing ones
• Enables the readers of the manuscript to answer the following questions of its readers for its better chances for publication
• What do the researchers know?
• What do they not know?
• Is the scientific manuscript reliable and trustworthy?
• What are the knowledge gaps of the researcher?

22. It helps the readers to identify the following for further reading of the scientific manuscript:

• What has been already established, discredited and accepted in the particular field of research
• Areas of controversy and conflicts among different schools of thought
• Unsolved problems and issues in the connected field of research
• The emerging trends and approaches
• How the research extends, builds upon and leaves behind from the previous research

A profound literature review with many relevant sources of reference will enhance the chances of the scientific manuscript publication in renowned and reputed scientific journals .

References:

http://www.math.montana.edu/jobo/phdprep/phd6.pdf

journal Publishing services  |  Scientific Editing Services  |  Medical Writing Services  |  scientific research writing service  |  Scientific communication services

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A Guide to Literature Reviews

Importance of a good literature review.

• Conducting the Literature Review
• Structure and Writing Style
• Types of Literature Reviews
• Citation Management Software This link opens in a new window
• Acknowledgements

A literature review is not only a summary of key sources, but  has an organizational pattern which combines both summary and synthesis, often within specific conceptual categories . A summary is a recap of the important information of the source, but a synthesis is a re-organization, or a reshuffling, of that information in a way that informs how you are planning to investigate a research problem. The analytical features of a literature review might:

• Give a new interpretation of old material or combine new with old interpretations,
• Trace the intellectual progression of the field, including major debates,
• Depending on the situation, evaluate the sources and advise the reader on the most pertinent or relevant research, or
• Usually in the conclusion of a literature review, identify where gaps exist in how a problem has been researched to date.

The purpose of a literature review is to:

• Place each work in the context of its contribution to understanding the research problem being studied.
• Describe the relationship of each work to the others under consideration.
• Identify new ways to interpret prior research.
• Reveal any gaps that exist in the literature.
• Resolve conflicts amongst seemingly contradictory previous studies.
• Identify areas of prior scholarship to prevent duplication of effort.
• Point the way in fulfilling a need for additional research.
• Locate your own research within the context of existing literature [very important].
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Literature reviews, what is a literature review, learning more about how to do a literature review.

• Planning the Review
• The Research Question
• Choosing Where to Search
• Organizing the Review
• Writing the Review

A literature review is a review and synthesis of existing research on a topic or research question. A literature review is meant to analyze the scholarly literature, make connections across writings and identify strengths, weaknesses, trends, and missing conversations. A literature review should address different aspects of a topic as it relates to your research question. A literature review goes beyond a description or summary of the literature you have read. 

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Conducting a literature review: why do a literature review, why do a literature review.

• How To Find "The Literature"
• Found it -- Now What?

Besides the obvious reason for students -- because it is assigned! -- a literature review helps you explore the research that has come before you, to see how your research question has (or has not) already been addressed.

You identify:

• core research in the field
• experts in the subject area
• methodology you may want to use (or avoid)
• gaps in knowledge -- or where your research would fit in

It Also Helps You:

• Publish and share your findings
• Justify requests for grants and other funding
• Identify best practices to inform practice
• Set wider context for a program evaluation
• Compile information to support community organizing

Great brief overview, from NCSU

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Literature Review: Purpose of a Literature Review

• Literature Review
• Purpose of a Literature Review
• Work in Progress
• Compiling & Writing
• Books, Articles, & Web Pages
• Types of Literature Reviews
• Departmental Differences
• Citation Styles & Plagiarism
• Know the Difference! Systematic Review vs. Literature Review

The purpose of a literature review is to:

• Provide a foundation of knowledge on a topic
• Identify areas of prior scholarship to prevent duplication and give credit to other researchers
• Identify inconstancies: gaps in research, conflicts in previous studies, open questions left from other research
• Identify the need for additional research (justifying your research)
• Identify the relationship of works in the context of their contribution to the topic and other works
• Place your own research within the context of existing literature, making a case for why further study is needed.

Videos & Tutorials

VIDEO: What is the role of a literature review in research? What's it mean to "review" the literature? Get the big picture of what to expect as part of the process. This video is published under a Creative Commons 3.0 BY-NC-SA US license. License, credits, and contact information can be found here: https://www.lib.ncsu.edu/tutorials/litreview/

Elements in a Literature Review

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How to Write Review of Related Literature (RRL) in Research

A review of related literature (a.k.a RRL in research) is a comprehensive review of the existing literature pertaining to a specific topic or research question. An effective review provides the reader with an organized analysis and synthesis of the existing knowledge about a subject. With the increasing amount of new information being disseminated every day, conducting a review of related literature is becoming more difficult and the purpose of review of related literature is clearer than ever.  

All new knowledge is necessarily based on previously known information, and every new scientific study must be conducted and reported in the context of previous studies. This makes a review of related literature essential for research, and although it may be tedious work at times , most researchers will complete many such reviews of varying depths during their career. So, why exactly is a review of related literature important?    

Table of Contents

Why a review of related literature in research is important  

Before thinking how to do reviews of related literature , it is necessary to understand its importance. Although the purpose of a review of related literature varies depending on the discipline and how it will be used, its importance is never in question. Here are some ways in which a review can be crucial.  

• Identify gaps in the knowledge – This is the primary purpose of a review of related literature (often called RRL in research ). To create new knowledge, you must first determine what knowledge may be missing. This also helps to identify the scope of your study.  
• Avoid duplication of research efforts – Not only will a review of related literature indicate gaps in the existing research, but it will also lead you away from duplicating research that has already been done and thus save precious resources.  
• Provide an overview of disparate and interdisciplinary research areas – Researchers cannot possibly know everything related to their disciplines. Therefore, it is very helpful to have access to a review of related literature already written and published.  
• Highlight researcher’s familiarity with their topic 1  – A strong review of related literature in a study strengthens readers’ confidence in that study and that researcher.

Tips on how to write a review of related literature in research

Given that you will probably need to produce a number of these at some point, here are a few general tips on how to write an effective review of related literature 2 .

• Define your topic, audience, and purpose: You will be spending a lot of time with this review, so choose a topic that is interesting to you. While deciding what to write in a review of related literature , think about who you expect to read the review – researchers in your discipline, other scientists, the general public – and tailor the language to the audience. Also, think about the purpose of your review of related literature .  
• Conduct a comprehensive literature search: While writing your review of related literature , emphasize more recent works but don’t forget to include some older publications as well. Cast a wide net, as you may find some interesting and relevant literature in unexpected databases or library corners. Don’t forget to search for recent conference papers.
• Review the identified articles and take notes: It is a good idea to take notes in a way such that individual items in your notes can be moved around when you organize them. For example, index cards are great tools for this. Write each individual idea on a separate card along with the source. The cards can then be easily grouped and organized.  
• Determine how to organize your review: A review of related literature should not be merely a listing of descriptions. It should be organized by some criterion, such as chronologically or thematically.  
• Be critical and objective: Don’t just report the findings of other studies in your review of related literature . Challenge the methodology, find errors in the analysis, question the conclusions. Use what you find to improve your research. However, do not insert your opinions into the review of related literature. Remain objective and open-minded.  
• Structure your review logically: Guide the reader through the information. The structure will depend on the function of the review of related literature. Creating an outline prior to writing the RRL in research is a good way to ensure the presented information flows well.  

As you read more extensively in your discipline, you will notice that the review of related literature appears in various forms in different places. For example, when you read an article about an experimental study, you will typically see a literature review or a RRL in research , in the introduction that includes brief descriptions of similar studies. In longer research studies and dissertations, especially in the social sciences, the review of related literature will typically be a separate chapter and include more information on methodologies and theory building. In addition, stand-alone review articles will be published that are extremely useful to researchers.  

The review of relevant literature or often abbreviated as, RRL in research , is an important communication tool that can be used in many forms for many purposes. It is a tool that all researchers should befriend.  

• University of North Carolina at Chapel Hill Writing Center. Literature Reviews.  https://writingcenter.unc.edu/tips-and-tools/literature-reviews/  [Accessed September 8, 2022]
• Pautasso M. Ten simple rules for writing a literature review. PLoS Comput Biol. 2013, 9. doi: 10.1371/journal.pcbi.1003149.

Q:  Is research complete without a review of related literature?

A research project is usually considered incomplete without a proper review of related literature. The review of related literature is a crucial component of any research project as it provides context for the research question, identifies gaps in existing literature, and ensures novelty by avoiding duplication. It also helps inform research design and supports arguments, highlights the significance of a study, and demonstrates your knowledge an expertise.

Q: What is difference between RRL and RRS?

The key difference between an RRL and an RRS lies in their focus and scope. An RRL or review of related literature examines a broad range of literature, including theoretical frameworks, concepts, and empirical studies, to establish the context and significance of the research topic. On the other hand, an RRS or review of research studies specifically focuses on analyzing and summarizing previous research studies within a specific research domain to gain insights into methodologies, findings, and gaps in the existing body of knowledge. While there may be some overlap between the two, they serve distinct purposes and cover different aspects of the research process.

Q: Does review of related literature improve accuracy and validity of research?

Yes, a comprehensive review of related literature (RRL) plays a vital role in improving the accuracy and validity of research. It helps authors gain a deeper understanding and offers different perspectives on the research topic. RRL can help you identify research gaps, dictate the selection of appropriate research methodologies, enhance theoretical frameworks, avoid biases and errors, and even provide support for research design and interpretation. By building upon and critically engaging with existing related literature, researchers can ensure their work is rigorous, reliable, and contributes meaningfully to their field of study.

R Discovery is a literature search and research reading platform that accelerates your research discovery journey by keeping you updated on the latest, most relevant scholarly content. With 250M+ research articles sourced from trusted aggregators like CrossRef, Unpaywall, PubMed, PubMed Central, Open Alex and top publishing houses like Springer Nature, JAMA, IOP, Taylor & Francis, NEJM, BMJ, Karger, SAGE, Emerald Publishing and more, R Discovery puts a world of research at your fingertips.  

Try R Discovery Prime FREE for 1 week or upgrade at just US$72 a year to access premium features that let you listen to research on the go, read in your language, collaborate with peers, auto sync with reference managers, and much more. Choose a simpler, smarter way to find and read research – Download the app and start your free 7-day trial today !  

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Reviewing literature for research: Doing it the right way

Shital amin poojary.

Department of Dermatology, K J Somaiya Medical College, Mumbai, Maharashtra, India

Jimish Deepak Bagadia

In an era of information overload, it is important to know how to obtain the required information and also to ensure that it is reliable information. Hence, it is essential to understand how to perform a systematic literature search. This article focuses on reliable literature sources and how to make optimum use of these in dermatology and venereology.

INTRODUCTION

A thorough review of literature is not only essential for selecting research topics, but also enables the right applicability of a research project. Most importantly, a good literature search is the cornerstone of practice of evidence based medicine. Today, everything is available at the click of a mouse or at the tip of the fingertips (or the stylus). Google is often the Go-To search website, the supposed answer to all questions in the universe. However, the deluge of information available comes with its own set of problems; how much of it is actually reliable information? How much are the search results that the search string threw up actually relevant? Did we actually find what we were looking for? Lack of a systematic approach can lead to a literature review ending up as a time-consuming and at times frustrating process. Hence, whether it is for research projects, theses/dissertations, case studies/reports or mere wish to obtain information; knowing where to look, and more importantly, how to look, is of prime importance today.

Literature search

Fink has defined research literature review as a “systematic, explicit and reproducible method for identifying, evaluating, and synthesizing the existing body of completed and recorded work produced by researchers, scholars and practitioners.”[ 1 ]

Review of research literature can be summarized into a seven step process: (i) Selecting research questions/purpose of the literature review (ii) Selecting your sources (iii) Choosing search terms (iv) Running your search (v) Applying practical screening criteria (vi) Applying methodological screening criteria/quality appraisal (vii) Synthesizing the results.[ 1 ]

This article will primarily concentrate on refining techniques of literature search.

Sources for literature search are enumerated in Table 1 .

Sources for literature search

PubMed is currently the most widely used among these as it contains over 23 million citations for biomedical literature and has been made available free by National Center for Biotechnology Information (NCBI), U.S. National Library of Medicine. However, the availability of free full text articles depends on the sources. Use of options such as advanced search, medical subject headings (MeSH) terms, free full text, PubMed tutorials, and single citation matcher makes the database extremely user-friendly [ Figure 1 ]. It can also be accessed on the go through mobiles using “PubMed Mobile.” One can also create own account in NCBI to save searches and to use certain PubMed tools.

PubMed home page showing location of different tools which can be used for an efficient literature search

Tips for efficient use of PubMed search:[ 2 , 3 , 4 ]

Use of field and Boolean operators

When one searches using key words, all articles containing the words show up, many of which may not be related to the topic. Hence, the use of operators while searching makes the search more specific and less cumbersome. Operators are of two types: Field operators and Boolean operators, the latter enabling us to combine more than one concept, thereby making the search highly accurate. A few key operators that can be used in PubMed are shown in Tables ​ Tables2 2 and ​ and3 3 and illustrated in Figures ​ Figures2 2 and ​ and3 3 .

Field operators used in PubMed search

Boolean operators used in PubMed search

PubMed search results page showing articles on donovanosis using the field operator [TIAB]; it shows all articles which have the keyword “donovanosis” in either title or abstract of the article

PubMed search using Boolean operators ‘AND’, ‘NOT’; To search for articles on treatment of lepra reaction other than steroids, after clicking the option ‘Advanced search’ on the home page, one can build the search using ‘AND’ option for treatment and ‘NOT’ option for steroids to omit articles on steroid treatment in lepra reaction

Use of medical subject headings terms

These are very specific and standardized terms used by indexers to describe every article in PubMed and are added to the record of every article. A search using MeSH will show all articles about the topic (or keywords), but will not show articles only containing these keywords (these articles may be about an entirely different topic, but still may contain your keywords in another context in any part of the article). This will make your search more specific. Within the topic, specific subheadings can be added to the search builder to refine your search [ Figure 4 ]. For example, MeSH terms for treatment are therapy and therapeutics.

PubMed search using medical subject headings (MeSH) terms for management of gonorrhea. Click on MeSH database ( Figure 1 ) →In the MeSH search box type gonorrhea and click search. Under the MeSH term gonorrhea, there will be a list of subheadings; therapy, prevention and control, click the relevant check boxes and add to search builder →Click on search →All articles on therapy, prevention and control of gonorrhea will be displayed. Below the subheadings, there are two options: (1) Restrict to medical subject headings (MeSH) major topic and (2) do not include MeSH terms found below this term in the MeSH hierarchy. These can be used to further refine the search results so that only articles which are majorly about treatment of gonorrhea will be displayed

Two additional options can be used to further refine MeSH searches. These are located below the subheadings for a MeSH term: (1) Restrict to MeSH major topic; checking this box will retrieve articles which are majorly about the search term and are therefore, more focused and (2) Do not include MeSH terms found below this term in the MeSH hierarchy. This option will again give you more focused articles as it excludes the lower specific terms [ Figure 4 ].

Similar feature is available with Cochrane library (also called MeSH), EMBASE (known as EMTREE) and PsycINFO (Thesaurus of Psychological Index Terms).

Saving your searches

Any search that one has performed can be saved by using the ‘Send to’ option and can be saved as a simple word file [ Figure 5 ]. Alternatively, the ‘Save Search’ button (just below the search box) can be used. However, it is essential to set up an NCBI account and log in to NCBI for this. One can even choose to have E-mail updates of new articles in the topic of interest.

Saving PubMed searches. A simple option is to click on the dropdown box next to ‘Send to’ option and then choose among the options. It can be saved as a text or word file by choosing ‘File’ option. Another option is the “Save search” option below the search box but this will require logging into your National Center for Biotechnology Information account. This however allows you to set up alerts for E-mail updates for new articles

Single citation matcher

This is another important tool that helps to find the genuine original source of a particular research work (when few details are known about the title/author/publication date/place/journal) and cite the reference in the most correct manner [ Figure 6 ].

Single citation matcher: Click on “Single citation matcher” on PubMed Home page. Type available details of the required reference in the boxes to get the required citation

Full text articles

In any search clicking on the link “free full text” (if present) gives you free access to the article. In some instances, though the published article may not be available free, the author manuscript may be available free of charge. Furthermore, PubMed Central articles are available free of charge.

Managing filters

Filters can be used to refine a search according to type of article required or subjects of research. One can specify the type of article required such as clinical trial, reviews, free full text; these options are available on a typical search results page. Further specialized filters are available under “manage filters:” e.g., articles confined to certain age groups (properties option), “Links” to other databases, article specific to particular journals, etc. However, one needs to have an NCBI account and log in to access this option [ Figure 7 ].

Managing filters. Simple filters are available on the ‘search results’ page. One can choose type of article, e.g., clinical trial, reviews etc. Further options are available in the “Manage filters” option, but this requires logging into National Center for Biotechnology Information account

The Cochrane library

Although reviews are available in PubMed, for systematic reviews and meta-analysis, Cochrane library is a much better resource. The Cochrane library is a collection of full length systematic reviews, which can be accessed for free in India, thanks to Indian Council of Medical Research renewing the license up to 2016, benefitting users all over India. It is immensely helpful in finding detailed high quality research work done in a particular field/topic [ Figure 8 ].

Cochrane library is a useful resource for reliable, systematic reviews. One can choose the type of reviews required, including trials

An important tool that must be used while searching for research work is screening. Screening helps to improve the accuracy of search results. It is of two types: (1) Practical: To identify a broad range of potentially useful studies. Examples: Date of publication (last 5 years only; gives you most recent updates), participants or subjects (humans above 18 years), publication language (English only) (2) methodological: To identify best available studies (for example, excluding studies not involving control group or studies with only randomized control trials).

Selecting the right quality of literature is the key to successful research literature review. The quality can be estimated by what is known as “The Evidence Pyramid.” The level of evidence of references obtained from the aforementioned search tools are depicted in Figure 9 . Systematic reviews obtained from Cochrane library constitute level 1 evidence.

Evidence pyramid: Depicting the level of evidence of references obtained from the aforementioned search tools

Thus, a systematic literature review can help not only in setting up the basis of a good research with optimal use of available information, but also in practice of evidence-based medicine.

Source of Support: Nil.

Conflict of Interest: None declared.

Literature Review - what is a Literature Review, why it is important and how it is done

What are literature reviews, goals of literature reviews, types of literature reviews, about this guide/licence.

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 What is a literature review? "A literature review is an account of what has been published on a topic by accredited scholars and researchers. In writing the literature review, your purpose is to convey to your reader what knowledge and ideas have been established on a topic, and what their strengths and weaknesses are. As a piece of writing, the literature review must be defined by a guiding concept (e.g., your research objective, the problem or issue you are discussing, or your argumentative thesis). It is not just a descriptive list of the material available, or a set of summaries. " - Quote from Taylor, D. (n.d) "The literature review: A few tips on conducting it"

Source NC State University Libraries. This video is published under a Creative Commons 3.0 BY-NC-SA US license.

What are the goals of creating a Literature Review?

• To develop a theory or evaluate an existing theory
• To summarize the historical or existing state of a research topic
• Identify a problem in a field of research 

- Baumeister, R.F. & Leary, M.R. (1997). "Writing narrative literature reviews," Review of General Psychology , 1(3), 311-320.

When do you need to write a Literature Review?

• When writing a prospectus or a thesis/dissertation
• When writing a research paper
• When writing a grant proposal

In all these cases you need to dedicate a chapter in these works to showcase what have been written about your research topic and to point out how your own research will shed a new light into these body of scholarship.

Literature reviews are also written as standalone articles as a way to survey a particular research topic in-depth. This type of literature reviews look at a topic from a historical perspective to see how the understanding of the topic have change through time.

What kinds of literature reviews are written?

• Narrative Review: The purpose of this type of review is to describe the current state of the research on a specific topic/research and to offer a critical analysis of the literature reviewed. Studies are grouped by research/theoretical categories, and themes and trends, strengths and weakness, and gaps are identified. The review ends with a conclusion section which summarizes the findings regarding the state of the research of the specific study, the gaps identify and if applicable, explains how the author's research will address gaps identify in the review and expand the knowledge on the topic reviewed.
• Book review essays/ Historiographical review essays : This is a type of review that focus on a small set of research books on a particular topic " to locate these books within current scholarship, critical methodologies, and approaches" in the field. - LARR
• Systematic review : "The authors of a systematic review use a specific procedure to search the research literature, select the studies to include in their review, and critically evaluate the studies they find." (p. 139). Nelson, L.K. (2013). Research in Communication Sciences and Disorders . San Diego, CA: Plural Publishing.
• Meta-analysis : "Meta-analysis is a method of reviewing research findings in a quantitative fashion by transforming the data from individual studies into what is called an effect size and then pooling and analyzing this information. The basic goal in meta-analysis is to explain why different outcomes have occurred in different studies." (p. 197). Roberts, M.C. & Ilardi, S.S. (2003). Handbook of Research Methods in Clinical Psychology . Malden, MA: Blackwell Pub.
• Meta-synthesis : "Qualitative meta-synthesis is a type of qualitative study that uses as data the findings from other qualitative studies linked by the same or related topic." (p.312). Zimmer, L. (2006). "Qualitative meta-synthesis: A question of dialoguing with texts," Journal of Advanced Nursing , 53(3), 311-318.

Guide adapted from "Literature Review" , a guide developed by Marisol Ramos used under CC BY 4.0 /modified from original.

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Chapter 1: Introduction

Learning objectives.

At the conclusion of this chapter, you will be able to:

• Identify the purpose of the literature review in  the research process
• Distinguish between different types of literature reviews

1.1 What is a Literature Review?

Pick up nearly any book on research methods and you will find a description of a literature review.  At a basic level, the term implies a survey of factual or nonfiction books, articles, and other documents published on a particular subject.  Definitions may be similar across the disciplines, with new types and definitions continuing to emerge.  Generally speaking, a literature review is a:

• “comprehensive background of the literature within the interested topic area…” ( O’Gorman & MacIntosh, 2015, p. 31 ).
• “critical component of the research process that provides an in-depth analysis of recently published research findings in specifically identified areas of interest.” ( House, 2018, p. 109 ).
• “written document that presents a logically argued case founded on a comprehensive understanding of the current state of knowledge about a topic of study” ( Machi & McEvoy,  2012, p. 4 ).

As a foundation for knowledge advancement in every discipline, it is an important element of any research project.  At the graduate or doctoral level, the literature review is an essential feature of thesis and dissertation, as well as grant proposal writing.  That is to say, “A substantive, thorough, sophisticated literature review is a precondition for doing substantive, thorough, sophisticated research…A researcher cannot perform significant research without first understanding the literature in the field.” ( Boote & Beile, 2005, p. 3 ).  It is by this means, that a researcher demonstrates familiarity with a body of knowledge and thereby establishes credibility with a reader.  An advanced-level literature review shows how prior research is linked to a new project, summarizing and synthesizing what is known while identifying gaps in the knowledge base, facilitating theory development, closing areas where enough research already exists, and uncovering areas where more research is needed. ( Webster & Watson, 2002, p. xiii )

A graduate-level literature review is a compilation of the most significant previously published research on your topic. Unlike an annotated bibliography or a research paper you may have written as an undergraduate, your literature review will outline, evaluate and synthesize relevant research and relate those sources to your own thesis or research question. It is much more than a summary of all the related literature.

It is a type of writing that demonstrate the importance of your research by defining the main ideas and the relationship between them. A good literature review lays the foundation for the importance of your stated problem and research question.

Literature reviews:

• define a concept
• map the research terrain or scope
• systemize relationships between concepts
• identify gaps in the literature ( Rocco & Plathotnik, 2009, p. 128 )

The purpose of a literature review is to demonstrate that your research question  is meaningful. Additionally, you may review the literature of different disciplines to find deeper meaning and understanding of your topic. It is especially important to consider other disciplines when you do not find much on your topic in one discipline. You will need to search the cognate literature before claiming there is “little previous research” on your topic.

Well developed literature reviews involve numerous steps and activities. The literature review is an iterative process because you will do at least two of them: a preliminary search to learn what has been published in your area and whether there is sufficient support in the literature for moving ahead with your subject. After this first exploration, you will conduct a deeper dive into the literature to learn everything you can about the topic and its related issues.

Literature Review Tutorial

1.2 Literature Review Basics

An effective literature review must:

• Methodologically analyze and synthesize quality literature on a topic
• Provide a firm foundation to a topic or research area
• Provide a firm foundation for the selection of a research methodology
• Demonstrate that the proposed research contributes something new to the overall body of knowledge of advances the research field’s knowledge base. ( Levy & Ellis, 2006 ).

All literature reviews, whether they are qualitative, quantitative or both, will at some point:

• Introduce the topic and define its key terms
• Establish the importance of the topic
• Provide an overview of the amount of available literature and its types (for example: theoretical, statistical, speculative)
• Identify gaps in the literature
• Point out consistent finding across studies
• Arrive at a synthesis that organizes what is known about a topic
• Discusses possible implications and directions for future research

1.3 Types of Literature Reviews

There are many different types of literature reviews, however there are some shared characteristics or features.  Remember a comprehensive literature review is, at its most fundamental level, an original work based on an extensive critical examination and synthesis of the relevant literature on a topic. As a study of the research on a particular topic, it is arranged by key themes or findings, which may lead up to or link to the  research question.  In some cases, the research question will drive the type of literature review that is undertaken.

The following section includes brief descriptions of the terms used to describe different literature review types with examples of each.   The included citations are open access, Creative Commons licensed or copyright-restricted.

1.3.1 Types of Review

1.3.1.1 conceptual.

Guided by an understanding of basic issues rather than a research methodology. You are looking for key factors, concepts or variables and the presumed relationship between them. The goal of the conceptual literature review is to categorize and describe concepts relevant to your study or topic and outline a relationship between them. You will include relevant theory and empirical research.

Examples of a Conceptual Review:

• Education : The formality of learning science in everyday life: A conceptual literature review. ( Dohn, 2010 ).
• Education : Are we asking the right questions? A conceptual review of the educational development literature in higher education. ( Amundsen & Wilson, 2012 ).

1.3.1.2 Empirical

An empirical literature review collects, creates, arranges, and analyzes numeric data reflecting the frequency of themes, topics, authors and/or methods found in existing literature. Empirical literature reviews present their summaries in quantifiable terms using descriptive and inferential statistics.

Examples of an Empirical Review:

• Nursing : False-positive findings in Cochrane meta-analyses with and without application of trial sequential analysis: An empirical review. ( Imberger, Thorlund, Gluud, & Wettersley, 2016 ).
• Education : Impediments of e-learning adoption in higher learning institutions of Tanzania: An empirical review ( Mwakyusa & Mwalyagile, 2016 ).

1.3.1.3 Exploratory

Unlike a synoptic literature review, the purpose here is to provide a broad approach to the topic area. The aim is breadth rather than depth and to get a general feel for the size of the topic area. A graduate student might do an exploratory review of the literature before beginning a synoptic, or more comprehensive one.

Examples of an Exploratory Review:

• Education : University research management: An exploratory literature review. ( Schuetzenmeister, 2010 ).
• Education : An exploratory review of design principles in constructivist gaming learning environments. ( Rosario & Widmeyer, 2009 ).

1.3.1.4 Focused

A type of literature review limited to a single aspect of previous research, such as methodology. A focused literature review generally will describe the implications of choosing a particular element of past research, such as methodology in terms of data collection, analysis and interpretation.

Examples of a Focused Review:

• Nursing : Clinical inertia in the management of type 2 diabetes mellitus: A focused literature review. ( Khunti, Davies, & Khunti, 2015 ).
• Education : Language awareness: Genre awareness-a focused review of the literature. ( Stainton, 1992 ).

1.3.1.5 Integrative

Critiques past research and draws overall conclusions from the body of literature at a specified point in time. Reviews, critiques, and synthesizes representative literature on a topic in an integrated way. Most integrative reviews are intended to address mature topics or  emerging topics. May require the author to adopt a guiding theory, a set of competing models, or a point of view about a topic.  For more description of integrative reviews, see Whittemore & Knafl (2005).

Examples of an Integrative Review:

• Nursing : Interprofessional teamwork and collaboration between community health workers and healthcare teams: An integrative review. ( Franklin,  Bernhardt, Lopez, Long-Middleton, & Davis, 2015 ).
• Education : Exploring the gap between teacher certification and permanent employment in Ontario: An integrative literature review. ( Brock & Ryan, 2016 ).

1.3.1.6 Meta-analysis

A subset of a  systematic review, that takes findings from several studies on the same subject and analyzes them using standardized statistical procedures to pool together data. Integrates findings from a large body of quantitative findings to enhance understanding, draw conclusions, and detect patterns and relationships. Gather data from many different, independent studies that look at the same research question and assess similar outcome measures. Data is combined and re-analyzed, providing a greater statistical power than any single study alone. It’s important to note that not every systematic review includes a meta-analysis but a meta-analysis can’t exist without a systematic review of the literature.

Examples of a Meta-Analysis:

• Education : Efficacy of the cooperative learning method on mathematics achievement and attitude: A meta-analysis research. ( Capar & Tarim, 2015 ).
• Nursing : A meta-analysis of the effects of non-traditional teaching methods on the critical thinking abilities of nursing students. ( Lee, Lee, Gong, Bae, & Choi, 2016 ).
• Education : Gender differences in student attitudes toward science: A meta-analysis of the literature from 1970 to 1991. ( Weinburgh, 1995 ).

1.3.1.7 Narrative/Traditional

An overview of research on a particular topic that critiques and summarizes a body of literature. Typically broad in focus. Relevant past research is selected and synthesized into a coherent discussion. Methodologies, findings and limits of the existing body of knowledge are discussed in narrative form. Sometimes also referred to as a traditional literature review. Requires a sufficiently focused research question. The process may be subject to bias that supports the researcher’s own work.

Examples of a Narrative/Traditional Review:

• Nursing : Family carers providing support to a person dying in the home setting: A narrative literature review. ( Morris, King, Turner, & Payne, 2015 ).
• Education : Adventure education and Outward Bound: Out-of-class experiences that make a lasting difference. ( Hattie, Marsh, Neill, & Richards, 1997 ).
• Education : Good quality discussion is necessary but not sufficient in asynchronous tuition: A brief narrative review of the literature. ( Fear & Erikson-Brown, 2014 ).
• Nursing : Outcomes of physician job satisfaction: A narrative review, implications, and directions for future research. ( Williams & Skinner, 2003 ).

1.3.1.8 Realist

Aspecific type of literature review that is theory-driven and interpretative and is intended to explain the outcomes of a complex intervention program(s).

Examples of a Realist Review:

• Nursing : Lean thinking in healthcare: A realist review of the literature. ( Mazzacato, Savage, Brommels, 2010 ).
• Education : Unravelling quality culture in higher education: A realist review. ( Bendermacher, Egbrink, Wolfhagen, & Dolmans, 2017 ).

1.3.1.9 Scoping

Tend to be non-systematic and focus on breadth of coverage conducted on a topic rather than depth. Utilize a wide range of materials; may not evaluate the quality of the studies as much as count the number. One means of understanding existing literature. Aims to identify nature and extent of research; preliminary assessment of size and scope of available research on topic. May include research in progress.

Examples of a Scoping Review:

• Nursing : Organizational interventions improving access to community-based primary health care for vulnerable populations: A scoping review. ( Khanassov, Pluye, Descoteaux, Haggerty,  Russell, Gunn, & Levesque, 2016 ).
• Education : Interdisciplinary doctoral research supervision: A scoping review. ( Vanstone, Hibbert, Kinsella, McKenzie, Pitman, & Lingard, 2013 ).
• Nursing : A scoping review of the literature on the abolition of user fees in health care services in Africa. ( Ridde, & Morestin, 2011 ).

1.3.1.10 Synoptic

Unlike an exploratory review, the purpose is to provide a concise but accurate overview of all material that appears to be relevant to a chosen topic. Both content and methodological material is included. The review should aim to be both descriptive and evaluative. Summarizes previous studies while also showing how the body of literature could be extended and improved in terms of content and method by identifying gaps.

Examples of a Synoptic Review:

• Education : Theoretical framework for educational assessment: A synoptic review. ( Ghaicha, 2016 ).
• Education : School effects research: A synoptic review of past efforts and some suggestions for the future. ( Cuttance, 1981 ).

1.3.1.11 Systematic Review

A rigorous review that follows a strict methodology designed with a presupposed selection of literature reviewed.  Undertaken to clarify the state of existing research, the evidence, and possible implications that can be drawn from that.  Using comprehensive and exhaustive searching of the published and unpublished literature, searching various databases, reports, and grey literature.  Transparent and reproducible in reporting details of time frame, search and methods to minimize bias.  Must include a team of at least 2-3 and includes the critical appraisal of the literature.  For more description of systematic reviews, including links to protocols, checklists, workflow processes, and structure see “ A Young Researcher’s Guide to a Systematic Review “.

Examples of a Systematic Review:

• Education : The potentials of using cloud computing in schools: A systematic literature review ( Hartmann, Braae, Pedersen, & Khalid, 2017 )
• Nursing : Is butter back? A systematic review and meta-analysis of butter consumption and risk of cardiovascular disease, diabetes, and total mortality. ( Pimpin, Wu, Haskelberg, Del Gobbo, & Mozaffarian, 2016 ).
• Education : The use of research to improve professional practice: a systematic review of the literature. ( Hemsley-Brown & Sharp, 2003 ).
• Nursing : Using computers to self-manage type 2 diabetes. ( Pal, Eastwood, Michie, Farmer, Barnard, Peacock, Wood, Inniss, & Murray, 2013 ).

1.3.1.12 Umbrella/Overview of Reviews

Compiles evidence from multiple systematic reviews into one document. Focuses on broad condition or problem for which there are competing interventions and highlights reviews that address those interventions and their effects. Often used in recommendations for practice.

Examples of an Umbrella/Overview Review:

• Education : Reflective practice in healthcare education: An umbrella review. ( Fragknos, 2016 ).
• Nursing : Systematic reviews of psychosocial interventions for autism: an umbrella review. ( Seida, Ospina, Karkhaneh, Hartling, Smith, & Clark, 2009 ).

For a brief discussion see “ Not all literature reviews are the same ” (Thomson, 2013).

1.4 Why do a Literature Review?

The purpose of the literature review is the same regardless of the topic or research method. It tests your own research question against what is already known about the subject.

1.4.1 First – It’s part of the whole. Omission of a literature review chapter or section in a graduate-level project represents a serious void or absence of critical element in the research process.

The outcome of your review is expected to demonstrate that you:

• can systematically explore the research in your topic area
• can read and critically analyze the literature in your discipline and then use it appropriately to advance your own work
• have sufficient knowledge in the topic to undertake further investigation

1.4.2 Second – It’s good for you!

• You improve your skills as a researcher
• You become familiar with the discourse of your discipline and learn how to be a scholar in your field
• You learn through writing your ideas and finding your voice in your subject area
• You define, redefine and clarify your research question for yourself in the process

1.4.3 Third – It’s good for your reader. Your reader expects you to have done the hard work of gathering, evaluating and synthesizes the literature.  When you do a literature review you:

• Set the context for the topic and present its significance
• Identify what’s important to know about your topic – including individual material, prior research, publications, organizations and authors.
• Demonstrate relationships among prior research
• Establish limitations of existing knowledge
• Analyze trends in the topic’s treatment and gaps in the literature

1.4.4 Why do a literature review?

• To locate gaps in the literature of your discipline
• To avoid reinventing the wheel
• To carry on where others have already been
• To identify other people working in the same field
• To increase your breadth of knowledge in your subject area
• To find the seminal works in your field
• To provide intellectual context for your own work
• To acknowledge opposing viewpoints
• To put your work in perspective
• To demonstrate you can discover and retrieve previous work in the area

1.5 Common Literature Review Errors

Graduate-level literature reviews are more than a summary of the publications you find on a topic.  As you have seen in this brief introduction, literature reviews are a very specific type of research, analysis, and writing.  We will explore these topics more in the next chapters.  Some things to keep in mind as you begin your own research and writing are ways to avoid the most common errors seen in the first attempt at a literature review.  For a quick review of some of the pitfalls and challenges a new researcher faces when he/she begins work, see “ Get Ready: Academic Writing, General Pitfalls and (oh yes) Getting Started! ”.

As you begin your own graduate-level literature review, try to avoid these common mistakes:

• Accepts another researcher’s finding as valid without evaluating methodology and data
• Contrary findings and alternative interpretations are not considered or mentioned
• Findings are not clearly related to one’s own study, or findings are too general
• Insufficient time allowed to define best search strategies and writing
• Isolated statistical results are simply reported rather than synthesizing the results
• Problems with selecting and using most relevant keywords, subject headings and descriptors
• Relies too heavily on secondary sources
• Search methods are not recorded or reported for transparency
• Summarizes rather than synthesizes articles

In conclusion, the purpose of a literature review is three-fold:

• to survey the current state of knowledge or evidence in the area of inquiry,
• to identify key authors, articles, theories, and findings in that area, and
• to identify gaps in knowledge in that research area.

A literature review is commonly done today using computerized keyword searches in online databases, often working with a trained librarian or information expert. Keywords can be combined using the Boolean operators, “and”, “or” and sometimes “not”  to narrow down or expand the search results. Once a list of articles is generated from the keyword and subject heading search, the researcher must then manually browse through each title and abstract, to determine the suitability of that article before a full-text article is obtained for the research question.

Literature reviews should be reasonably complete, and not restricted to a few journals, a few years, or a specific methodology or research design. Reviewed articles may be summarized in the form of tables, and can be further structured using organizing frameworks such as a concept matrix.

A well-conducted literature review should indicate whether the initial research questions have already been addressed in the literature, whether there are newer or more interesting research questions available, and whether the original research questions should be modified or changed in light of findings of the literature review.

The review can also provide some intuitions or potential answers to the questions of interest and/or help identify theories that have previously been used to address similar questions and may provide evidence to inform policy or decision-making. ( Bhattacherjee, 2012 ).

Read Abstract 1.  Refer to Types of Literature Reviews.  What type of literature review do you think this study is and why?  See the Answer Key for the correct response.

Nursing : To describe evidence of international literature on the safe care of the hospitalised child after the World Alliance for Patient Safety and list contributions of the general theoretical framework of patient safety for paediatric nursing.

An integrative literature review between 2004 and 2015 using the databases PubMed, Cumulative Index of Nursing and Allied Health Literature (CINAHL), Scopus, Web of Science and Wiley Online Library, and the descriptors Safety or Patient safety, Hospitalised child, Paediatric nursing, and Nursing care.

Thirty-two articles were analysed, most of which were from North American, with a descriptive approach. The quality of the recorded information in the medical records, the use of checklists, and the training of health workers contribute to safe care in paediatric nursing and improve the medication process and partnerships with parents.

General information available on patient safety should be incorporated in paediatric nursing care. ( Wegner, Silva, Peres, Bandeira, Frantz, Botene, & Predebon, 2017 ).

Read Abstract 2.  Refer to Types of Literature Reviews.  What type of lit review do you think this study is and why?  See the Answer Key for the correct response.

Education : The focus of this paper centers around timing associated with early childhood education programs and interventions using meta-analytic methods. At any given assessment age, a child’s current age equals starting age, plus duration of program, plus years since program ended. Variability in assessment ages across the studies should enable everyone to identify the separate effects of all three time-related components. The project is a meta-analysis of evaluation studies of early childhood education programs conducted in the United States and its territories between 1960 and 2007. The population of interest is children enrolled in early childhood education programs between the ages of 0 and 5 and their control-group counterparts. Since the data come from a meta-analysis, the population for this study is drawn from many different studies with diverse samples. Given the preliminary nature of their analysis, the authors cannot offer conclusions at this point. ( Duncan, Leak, Li, Magnuson, Schindler, & Yoshikawa, 2011 ).

Test Yourself

See Answer Key for the correct responses.

The purpose of a graduate-level literature review is to summarize in as many words as possible everything that is known about my topic.

A literature review is significant because in the process of doing one, the researcher learns to read and critically assess the literature of a discipline and then uses it appropriately to advance his/her own research.

Read the following abstract and choose the correct type of literature review it represents.

Nursing: E-cigarette use has become increasingly popular, especially among the young. Its long-term influence upon health is unknown. Aim of this review has been to present the current state of knowledge about the impact of e-cigarette use on health, with an emphasis on Central and Eastern Europe. During the preparation of this narrative review, the literature on e-cigarettes available within the network PubMed was retrieved and examined. In the final review, 64 research papers were included. We specifically assessed the construction and operation of the e-cigarette as well as the chemical composition of the e-liquid; the impact that vapor arising from the use of e-cigarette explored in experimental models in vitro; and short-term effects of use of e-cigarettes on users’ health. Among the substances inhaled by the e-smoker, there are several harmful products, such as: formaldehyde, acetaldehyde, acroleine, propanal, nicotine, acetone, o-methyl-benzaldehyde, carcinogenic nitrosamines. Results from experimental animal studies indicate the negative impact of e-cigarette exposure on test models, such as ascytotoxicity, oxidative stress, inflammation, airway hyper reactivity, airway remodeling, mucin production, apoptosis, and emphysematous changes. The short-term impact of e-cigarettes on human health has been studied mostly in experimental setting. Available evidence shows that the use of e-cigarettes may result in acute lung function responses (e.g., increase in impedance, peripheral airway flow resistance) and induce oxidative stress. Based on the current available evidence, e-cigarette use is associated with harmful biologic responses, although it may be less harmful than traditional cigarettes. (J ankowski, Brożek, Lawson, Skoczyński, & Zejda, 2017 ).

• Meta-analysis
• Exploratory

Education: In this review, Mary Vorsino writes that she is interested in keeping the potential influences of women pragmatists of Dewey’s day in mind while presenting modern feminist re readings of Dewey. She wishes to construct a narrowly-focused and succinct literature review of thinkers who have donned a feminist lens to analyze Dewey’s approaches to education, learning, and democracy and to employ Dewey’s works in theorizing on gender and education and on gender in society. This article first explores Dewey as both an ally and a problematic figure in feminist literature and then investigates the broader sphere of feminist pragmatism and two central themes within it: (1) valuing diversity, and diverse experiences; and (2) problematizing fixed truths. ( Vorsino, 2015 ).

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• Writing Tips

What is the Purpose of a Literature Review?

4-minute read

• 23rd October 2023

If you’re writing a research paper or dissertation , then you’ll most likely need to include a comprehensive literature review . In this post, we’ll review the purpose of literature reviews, why they are so significant, and the specific elements to include in one. Literature reviews can:

1. Provide a foundation for current research.

2. Define key concepts and theories.

3. Demonstrate critical evaluation.

4. Show how research and methodologies have evolved.

5. Identify gaps in existing research.

6. Support your argument.

Keep reading to enter the exciting world of literature reviews!

What is a Literature Review?

A literature review is a critical summary and evaluation of the existing research (e.g., academic journal articles and books) on a specific topic. It is typically included as a separate section or chapter of a research paper or dissertation, serving as a contextual framework for a study. Literature reviews can vary in length depending on the subject and nature of the study, with most being about equal length to other sections or chapters included in the paper. Essentially, the literature review highlights previous studies in the context of your research and summarizes your insights in a structured, organized format. Next, let’s look at the overall purpose of a literature review.

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Literature reviews are considered an integral part of research across most academic subjects and fields. The primary purpose of a literature review in your study is to:

Provide a Foundation for Current Research

Since the literature review provides a comprehensive evaluation of the existing research, it serves as a solid foundation for your current study. It’s a way to contextualize your work and show how your research fits into the broader landscape of your specific area of study.  

Define Key Concepts and Theories

The literature review highlights the central theories and concepts that have arisen from previous research on your chosen topic. It gives your readers a more thorough understanding of the background of your study and why your research is particularly significant .

Demonstrate Critical Evaluation 

A comprehensive literature review shows your ability to critically analyze and evaluate a broad range of source material. And since you’re considering and acknowledging the contribution of key scholars alongside your own, it establishes your own credibility and knowledge.

Show How Research and Methodologies Have Evolved

Another purpose of literature reviews is to provide a historical perspective and demonstrate how research and methodologies have changed over time, especially as data collection methods and technology have advanced. And studying past methodologies allows you, as the researcher, to understand what did and did not work and apply that knowledge to your own research.  

Identify Gaps in Existing Research

Besides discussing current research and methodologies, the literature review should also address areas that are lacking in the existing literature. This helps further demonstrate the relevance of your own research by explaining why your study is necessary to fill the gaps.

Support Your Argument

A good literature review should provide evidence that supports your research questions and hypothesis. For example, your study may show that your research supports existing theories or builds on them in some way. Referencing previous related studies shows your work is grounded in established research and will ultimately be a contribution to the field.  

Literature Review Editing Services 

Ensure your literature review is polished and ready for submission by having it professionally proofread and edited by our expert team. Our literature review editing services will help your research stand out and make an impact. Not convinced yet? Send in your free sample today and see for yourself! 

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Matada Research

Understanding the importance of a literature review in research

• March 29, 2023

Gerald Naepi

When conducting research, a literature review plays a crucial role as it provides an overview of the existing literature related to a specific topic. Its main objective is to identify the gaps in the current knowledge and provide direction for future research. This article delves into the purpose and structure of a literature review, along with the various types of literature reviews typically employed in research. By familiarising themselves with the different types of literature reviews and their unique features, researchers can determine which review type would best suit their research question and help them achieve their desired results.

Purpose of a literature review in research

The primary goal of a literature review in research is to offer a comprehensive overview of the relevant research within a given area. A well-executed literature review should provide readers with a clear understanding of the theoretical and empirical contributions made in the field, while also highlighting areas that require further exploration or investigation. Additionally, literature reviews help researchers identify gaps in existing knowledge that can lead to new hypotheses or questions for future study.

When conducting a literature review, researchers should pay close attention to key themes and topics covered by previous studies, including the approaches used to answer specific questions or address particular issues. This ensures that any conclusions drawn by the researcher are supported by established evidence and build on prior work in the field. Moreover, when synthesising information from multiple studies, researchers should aim to identify conflicting opinions or discrepancies in the literature and draw implications for further study. Through this process, a comprehensive literature review can provide invaluable insights into the current state of research and inform future studies.

Literature review format

The format of a literature review in research typically consists of the following elements:

Introduction: The introduction is an important part of a literature review, as it gives the reader a sense of what to expect. It should start with a clear statement of the research question or objective, so that the reader understands what the review is trying to achieve. It’s also important to explain why the topic is important, so that the reader understands the relevance of the review. Finally, the introduction should give the reader an overview of the structure and organisation of the review, so that they can easily navigate through the rest of the content.

Search Strategy: The search strategy should be comprehensive, focused, and systematic. It involves selecting appropriate databases, developing effective search terms, and utilizing other sources to collect information. To begin, the researcher needs to determine the most relevant databases to search. Depending on the topic, discipline, and research question, different databases may be more suitable. Some commonly used databases are PubMed, Scopus, Web of Science, and Google Scholar. Once the databases are selected, the researcher can develop a set of search terms that accurately reflect the topic and research question. These search terms can be a combination of keywords and subject headings. Other sources of information may include reference lists, grey literature, conference proceedings, and experts in the field. These sources can provide additional insights and help to ensure a comprehensive search.

The search strategy should be documented in detail to enable replication and transparency. This documentation should include the databases searched, search terms used, search dates, and any filters or limits applied. By having a clear and systematic search strategy, the researcher can ensure that they have identified all relevant literature and that the research findings are reliable and valid.

Inclusion and Exclusion Criteria: Inclusion criteria refer to the characteristics that a study must have to be included in the review, while exclusion criteria refer to the characteristics that disqualify a study from being included. The inclusion and exclusion criteria may vary depending on the research question, but generally, they should be clearly defined and stated in the methods section of the review. Common criteria include study design, population, intervention or exposure, and outcome measures. For example, a systematic review on the effectiveness of a particular drug for a specific condition may include only randomized controlled trials (RCTs) with a minimum sample size of 50 participants, and exclude non-randomized studies or studies with a high risk of bias.

Defining clear inclusion and exclusion criteria is crucial in ensuring that the studies included in the review are relevant, appropriate, and of high quality. It also helps to minimize bias and enhance the validity of the review’s findings. Additionally, transparent reporting of inclusion and exclusion criteria allows readers to assess the rigor of the review process and the generalizability of the findings to their own context.

Methodology: The methodology section typically involves outlining the procedures and techniques employed to collect relevant data and information, including any data extraction forms that were used. Additionally, this section may also include information about the process of data extraction, such as how the data was collected, coded, and analysed. Furthermore, it is essential to include a description of the quality assessment process used to ensure that the extracted data was reliable and valid. This may involve explaining the criteria used to evaluate the quality of the studies, as well as any potential biases or limitations that were taken into consideration. By providing a thorough description of the methodology, readers will be able to assess the rigor of the research and better understand the context and implications of the findings.

Results: The results section summarises the main outcomes and findings of the review process, including the key themes, concepts, and trends identified in the literature. The results section provides a clear and concise description of the analysed data and should be presented in a logical and organized manner to make it easy for readers to understand. The results section of a literature review provides an overview of the evidence and information obtained from the analysed sources and explains how the findings support or challenge the research question or hypothesis. It is essential to ensure that the results are presented accurately, and any limitations or weaknesses of the study are acknowledged to provide a transparent and objective review of the literature.

Discussion: The discussion section of a literature review in research is an important component that provides a critical analysis of the literature reviewed in the study. This section allows the researcher to present their findings and interpretations of the literature, as well as to draw conclusions about the research question or problem being investigated. In the discussion section, the researcher will typically summarise the key findings of the literature review and then discuss these findings in relation to the research question or problem. The discussion section may also identify gaps in the literature and suggest areas for further research, as well as discuss the implications of the findings for theory, practice, or policy. Ultimately, the discussion section of a literature review should provide a comprehensive and insightful analysis of the literature reviewed, which contributes to the overall understanding of the research question or problem at hand.

Conclusion: The conclusion section in a literature review summarises the key findings and implications of the reviewed studies. It is the final part of the literature review that brings together all the main points and themes discussed in the previous sections. In this section, the researcher should provide a critical evaluation of the reviewed literature, highlighting the strengths and limitations of the studies, and how they relate to the research question or problem. The conclusion section should also address any gaps or inconsistencies in the existing literature and suggest future research directions. Furthermore, it should provide a clear and concise summary of the main findings and their significance for the field of study.

References: The reference section provides a comprehensive list of all the sources that have been cited in the literature review, including books, journal articles, reports, and other relevant materials. The purpose of the reference section is to give credit to the authors whose work has been used to support the arguments and ideas presented in the paper. Additionally, the reference section allows readers to locate and retrieve the sources that have been cited, which can help them further explore the topic or verify the accuracy of the information presented. The reference section is typically organized in alphabetical order by the last name of the first author of each source, and it includes all of the necessary bibliographic information such as the title of the work, the name of the journal or book, the date of publication, and the page numbers

Download our literature review template

Types of literature review in research

Literature reviews in research can be conducted for a variety of reasons, including to gain a comprehensive understanding of a topic, to identify research gaps, or to support the development of research proposals.

Here are the different types of literature reviews in research:

• Narrative Literature Review: A narrative literature review is an overview of the literature on a specific topic or research question that does not follow a structured or systematic approach. It is a qualitative review that summarizes and synthesizes the findings from different studies.
• Systematic Literature Review: A systematic literature review is a rigorous and structured approach to reviewing literature that involves a comprehensive search strategy, inclusion/exclusion criteria, and critical appraisal of the quality of evidence. It involves a meta-analysis and quantitative synthesis of data from multiple studies.
• Meta-analysis: A meta-analysis is a quantitative review of the literature that involves statistical analysis of the data from multiple studies. It combines the results of different studies to produce an overall estimate of the effect size of a particular intervention or treatment.
• Scoping Review: A scoping review is a type of literature review that aims to map the existing literature on a topic, identify research gaps, and provide an overview of the evidence. It is useful when the research question is broad or unclear.
• Rapid Review: A rapid review is a type of systematic review that uses streamlined methods to quickly and efficiently review the literature. It is useful when there is a time constraint or when there is a need to update a previous review.
• Umbrella Review: An umbrella review is a type of systematic review that synthesizes the findings of multiple systematic reviews on a particular topic. It provides a higher level of evidence by combining the findings from multiple studies.
• Critical Review: A critical review involves the evaluation and analysis of the strengths and weaknesses of the literature on a particular topic. It assesses the quality, credibility, and relevance of the literature and identifies research gaps.

Literature review example:

A literature review can play a crucial role in connecting with qualitative talanoa research. Talanoa is a research approach that emphasises collaboration, dialogue, and relationships within Pacific communities. Conducting a thorough literature review can help researchers to identify existing knowledge and gaps in ta specific field. This can inform the design of Talanoa research that centers on community engagement and dialogue. By reviewing literature that focuses on Pacific cultures, histories, and knowledge systems, researchers can develop a deeper understanding of the context and values of the community they are working with. This can help to build trust and establish meaningful relationships between researchers and community members.

An example of a literature review is our social research on Pacific peoples’ concerns about COVID-19, titled “The $7 cabbage dilemma: Pacific peoples’ experiences and New Zealand’s COVID-19 response.pdf” The objective of our study was to investigate how the COVID-19 pandemic impacted the wellbeing of Pacific peoples in New Zealand. To accomplish this, we conducted a comprehensive literature review of existing research on Pacific peoples’ urban climate change, health, economy, and housing in New Zealand. Through our talanoa-based research, we discovered that many Pacific peoples were worried about the cost of living, access to healthcare, support for parents, and affordable healthy food options, which were all connected to the broader themes of urban climate change, health, economy, and housing that we had identified in our literature review.

In conclusion, a literature review is an essential component of research as it helps to identify gaps in existing knowledge, provide direction for future research and support or challenge research questions or hypotheses. The purpose of a literature review is to offer a comprehensive overview of the relevant research within a given area, identify key themes and topics, and synthesize information from multiple studies. Researchers need to pay attention to the different types of literature reviews and their unique features when conducting literature reviews to determine which review type would best suit their research question and help them achieve their desired results. A well-structured literature review should include an introduction, search strategy, inclusion and exclusion criteria, methodology and results sections. A well-executed literature review ensures that the research findings are reliable and valid and provides invaluable insights into the current state of research to inform future studies.

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Frequently asked questions

What is the purpose of a literature review.

There are several reasons to conduct a literature review at the beginning of a research project:

• To familiarize yourself with the current state of knowledge on your topic
• To ensure that you’re not just repeating what others have already done
• To identify gaps in knowledge and unresolved problems that your research can address
• To develop your theoretical framework and methodology
• To provide an overview of the key findings and debates on the topic

Writing the literature review shows your reader how your work relates to existing research and what new insights it will contribute.

Frequently asked questions: Academic writing

A rhetorical tautology is the repetition of an idea of concept using different words.

Rhetorical tautologies occur when additional words are used to convey a meaning that has already been expressed or implied. For example, the phrase “armed gunman” is a tautology because a “gunman” is by definition “armed.”

A logical tautology is a statement that is always true because it includes all logical possibilities.

Logical tautologies often take the form of “either/or” statements (e.g., “It will rain, or it will not rain”) or employ circular reasoning (e.g., “she is untrustworthy because she can’t be trusted”).

You may have seen both “appendices” or “appendixes” as pluralizations of “ appendix .” Either spelling can be used, but “appendices” is more common (including in APA Style ). Consistency is key here: make sure you use the same spelling throughout your paper.

The purpose of a lab report is to demonstrate your understanding of the scientific method with a hands-on lab experiment. Course instructors will often provide you with an experimental design and procedure. Your task is to write up how you actually performed the experiment and evaluate the outcome.

In contrast, a research paper requires you to independently develop an original argument. It involves more in-depth research and interpretation of sources and data.

A lab report is usually shorter than a research paper.

The sections of a lab report can vary between scientific fields and course requirements, but it usually contains the following:

• Title: expresses the topic of your study
• Abstract: summarizes your research aims, methods, results, and conclusions
• Introduction: establishes the context needed to understand the topic
• Method: describes the materials and procedures used in the experiment
• Results: reports all descriptive and inferential statistical analyses
• Discussion: interprets and evaluates results and identifies limitations
• Conclusion: sums up the main findings of your experiment
• References: list of all sources cited using a specific style (e.g. APA)
• Appendices: contains lengthy materials, procedures, tables or figures

A lab report conveys the aim, methods, results, and conclusions of a scientific experiment . Lab reports are commonly assigned in science, technology, engineering, and mathematics (STEM) fields.

The abstract is the very last thing you write. You should only write it after your research is complete, so that you can accurately summarize the entirety of your thesis , dissertation or research paper .

If you’ve gone over the word limit set for your assignment, shorten your sentences and cut repetition and redundancy during the editing process. If you use a lot of long quotes , consider shortening them to just the essentials.

If you need to remove a lot of words, you may have to cut certain passages. Remember that everything in the text should be there to support your argument; look for any information that’s not essential to your point and remove it.

To make this process easier and faster, you can use a paraphrasing tool . With this tool, you can rewrite your text to make it simpler and shorter. If that’s not enough, you can copy-paste your paraphrased text into the summarizer . This tool will distill your text to its core message.

Revising, proofreading, and editing are different stages of the writing process .

• Revising is making structural and logical changes to your text—reformulating arguments and reordering information.
• Editing refers to making more local changes to things like sentence structure and phrasing to make sure your meaning is conveyed clearly and concisely.
• Proofreading involves looking at the text closely, line by line, to spot any typos and issues with consistency and correct them.

The literature review usually comes near the beginning of your thesis or dissertation . After the introduction , it grounds your research in a scholarly field and leads directly to your theoretical framework or methodology .

A literature review is a survey of scholarly sources (such as books, journal articles, and theses) related to a specific topic or research question .

It is often written as part of a thesis, dissertation , or research paper , in order to situate your work in relation to existing knowledge.

Avoid citing sources in your abstract . There are two reasons for this:

• The abstract should focus on your original research, not on the work of others.
• The abstract should be self-contained and fully understandable without reference to other sources.

There are some circumstances where you might need to mention other sources in an abstract: for example, if your research responds directly to another study or focuses on the work of a single theorist. In general, though, don’t include citations unless absolutely necessary.

An abstract is a concise summary of an academic text (such as a journal article or dissertation ). It serves two main purposes:

• To help potential readers determine the relevance of your paper for their own research.
• To communicate your key findings to those who don’t have time to read the whole paper.

Abstracts are often indexed along with keywords on academic databases, so they make your work more easily findable. Since the abstract is the first thing any reader sees, it’s important that it clearly and accurately summarizes the contents of your paper.

In a scientific paper, the methodology always comes after the introduction and before the results , discussion and conclusion . The same basic structure also applies to a thesis, dissertation , or research proposal .

Depending on the length and type of document, you might also include a literature review or theoretical framework before the methodology.

Whether you’re publishing a blog, submitting a research paper , or even just writing an important email, there are a few techniques you can use to make sure it’s error-free:

• Take a break : Set your work aside for at least a few hours so that you can look at it with fresh eyes.
• Proofread a printout : Staring at a screen for too long can cause fatigue – sit down with a pen and paper to check the final version.
• Use digital shortcuts : Take note of any recurring mistakes (for example, misspelling a particular word, switching between US and UK English , or inconsistently capitalizing a term), and use Find and Replace to fix it throughout the document.

If you want to be confident that an important text is error-free, it might be worth choosing a professional proofreading service instead.

Editing and proofreading are different steps in the process of revising a text.

Editing comes first, and can involve major changes to content, structure and language. The first stages of editing are often done by authors themselves, while a professional editor makes the final improvements to grammar and style (for example, by improving sentence structure and word choice ).

Proofreading is the final stage of checking a text before it is published or shared. It focuses on correcting minor errors and inconsistencies (for example, in punctuation and capitalization ). Proofreaders often also check for formatting issues, especially in print publishing.

The cost of proofreading depends on the type and length of text, the turnaround time, and the level of services required. Most proofreading companies charge per word or page, while freelancers sometimes charge an hourly rate.

For proofreading alone, which involves only basic corrections of typos and formatting mistakes, you might pay as little as $0.01 per word, but in many cases, your text will also require some level of editing , which costs slightly more.

It’s often possible to purchase combined proofreading and editing services and calculate the price in advance based on your requirements.

There are many different routes to becoming a professional proofreader or editor. The necessary qualifications depend on the field – to be an academic or scientific proofreader, for example, you will need at least a university degree in a relevant subject.

For most proofreading jobs, experience and demonstrated skills are more important than specific qualifications. Often your skills will be tested as part of the application process.

To learn practical proofreading skills, you can choose to take a course with a professional organization such as the Society for Editors and Proofreaders . Alternatively, you can apply to companies that offer specialized on-the-job training programmes, such as the Scribbr Academy .

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• Open access
• Published: 06 September 2024

A scoping review of health literacy in rare disorders: key issues and research directions

• Una Stenberg   ORCID: orcid.org/0000-0002-6007-8630 1 , 2 ,
• Lydia Westfal 1 ,
• Andreas Dybesland Rosenberger 3 ,
• Kristin Ørstavik 4 ,
• Maria Flink 5 ,
• Heidi Holmen 6 ,
• Silje Systad 7 ,
• Karl Fredrik Westermann 2 &
• Gry Velvin 8  

Orphanet Journal of Rare Diseases volume  19 , Article number:  328 ( 2024 ) Cite this article

Metrics details

The ability to find, understand, appraise and utilise health information is crucial among individuals living with rare disorders. The aim of this study was to give a comprehensive overview of the literature on health literacy in adult persons with rare disorders.

We applied a scoping review methodology and performed a systematic search in 2021 in bibliographic databases. Searches were conducted in Medline (Ovid), Embase (Ovid), PsycInfo (Ovid), CINAHL (ebsco), and ERIC (Ovid). References were sorted and evaluated for inclusion using EndNote and Covidence. This review was guided by the question “What are the characteristics of research on health literacy in rare disorders?”

The database searches yielded 75 eligible reports. A total of 6223 individuals with rare disorders were represented alongside 1707 caregivers. The reports in this review have included study participants representing a total of 80 different rare disorders with unique ORPHA and ICD-10 codes. The results revealed that persons with rare disorders often exhibit gaps in health literacy through a lack of knowledge and access to information related to self-management, their own diagnosis and health, as well as daily coping and social rights. In addition, the importance of aid and information from healthcare personnel and the significance of getting social support from others in the same situation were accentuated.

This review emphasizes the importance of reinforcing health literacy among persons with rare disorders through peer support and education. This is the first review to give a comprehensive and state-of-the-art overview of literature investigating health literacy among persons with rare disorders and offers a basis for further research.

Introduction

In Europe, a disorder is considered rare when it affects less than 1:2000 individuals [ 1 ]. According to current calculations, more than 7000 different rare disorders have been identified. However, it is plausible that the actual number may be as high as 10,000 [ 2 ]. Although each rare disorder affects a limited quantity of individuals, it is estimated that the combined prevalence of all rare diseases is 3,5–5,9% [ 3 ]. Accordingly, up to 36 million people residing in the European Union are living with a rare disease [ 4 ]. Out of the total rare disorders, 72% have a genetic aetiology, and 70% have childhood onset [ 3 ]. Whilst there is a large clinical diversity between the rare disorders, they tend to have some aspects in common; they are known for being chronic, complicated, mostly degenerating, and often disabling [ 5 ].

Persons with rare disorders face some unique challenges in accessing information on their diagnosis, which may lead to issues in making beneficial health choices regarding treatment and care [ 6 ]. A key issue with rare disorders is the lack of research in the field [ 7 , 8 ]. Insufficient evidence and knowledge on rare diseases in general pose challenges both for professionals and people with these diseases [ 8 ]. Due to healthcare professionals’ limited understanding of their rare disorder in general, as well as a lack of information provided, persons with rare disorders often need to search for health-related information themselves [ 6 ]. A systematic review published in 2017 aimed to provide an overview of adults` shared experience of living with a rare disorder, found that in 12 out of 21 reports, persons with rare disorders reported progressively becoming “experts” on their own diagnosis [ 9 ]. In some cases, those living with rare disorders possess more information about the condition than the healthcare professionals they encounter [ 10 ].

Healthcare systems are increasingly challenging to navigate [ 11 ]. Simultaneously, the healthcare services share prospective aims of prioritising digitization, enabling more home-based care, promoting shared decision-making, and ensuring equitable access to services [ 5 , 12 , 13 ]. Managing one’s health while dealing with a rare disorder and the responsibility of seeking information can be especially demanding due to the challenging standards set by the healthcare system [ 6 ].

Increased participation and responsibility for one’s own health impose a demand on the individual to have adequate health literacy. Health literacy pertains to individuals’ ability to manage the complex health requirements of today’s society and make informed decisions regarding health [ 14 ]. This includes understanding the factors that affect one’s health, addressing health challenges, and making appropriate health choices. There is a lack of consensus on the definition of health literacy, and multiple interpretations have been made [ 14 ]. A review by Sørensen et al. [ 15 ] identified as many as 17 different definitions of health literacy and created a working definition of health literacy by considering the contents of each interpretation. The inclusive definition according to Sørensen et al. is stated as follows:

“Health literacy is linked to literacy and entails people’s knowledge , motivation and competencies to access , understand , appraise , and apply health information in order to make judgments and take decisions in everyday life concerning healthcare , disease prevention and health promotion to maintain or improve quality of life during the life course.” (ref p. 3).

Along with the comprehensive definition, Sørensen et al. developed an integrated model of health literacy [ 15 ]. The model has been widely used to understand the complex interaction between individual skills and abilities related to health literacy, social and environmental factors, and health outcomes. The core elements of the model are four cognitive competencies; to access, understand, appraise, and apply health-related information. These four competencies allow a person to manoeuvre three identified domains on the health spectrum: healthcare, disease prevention, and health promotion. The model suggests that an individual’s ability to access and use health information is determined by their own skills, motivation, and knowledge as well as the social and environmental context they reside within. These conditions, accordingly, affect individuals’ ability to address their health and ultimately impact their health outcomes.

Sorensen’s model emphasises that components such as empowerment, health outcomes, and health behaviour are interlaced and connected to an individual’s health literacy. Enhancing the level of health literacy allows individuals to become more empowered and take charge of their health, participate in health-promoting behaviours, and gradually attain improved health outcomes [ 15 ]. Thus, participation and empowerment can give persons with rare disorders enhanced control over their own health and treatment, and increased involvement in decision-making processes that concern their health. This may lead to better health outcomes and elevated health-related quality of life, which remain crucial as persons with rare disorders report lower quality of life compared to those with more common chronic conditions [ 16 ]. They can feel stigmatised and marginalised in the healthcare system, and it can be challenging to find psychosocial support. Examining how to increase health literacy and empowerment for persons with rare disorders can therefore be an important and relevant direction for further research. Health literacy of individuals with rare disorders is an emerging field of research, and the literature is based on a wide range of study methodologies [ 7 , 8 ]. Hence, this scoping review aims to give a comprehensive overview of empirical reports (from primary research studies) investigating health literacy among persons with rare disorders as reported in the international literature, by identifying characteristics of definitions, study populations, methods and interventions.

Study design and research questions

The scoping review process described by Arksey and O`Malley [ 17 ] aims to: “(…) map rapidly the key concepts underpinning a research area and the main sources and types of evidence available and can be undertaken as a stand-alone project in their own right , especially where an area is complex or has not been reviewed comprehensively before. ” A scoping review methodology is also suitable for examining the extent, range, variety, and characteristics of evidence on a topic, but also to identify research gaps. This scoping review was conducted according to the five-stage framework by Arksey and O`Malley [ 17 ], enhanced by Levac [ 18 ] and Daudt [ 19 ] and reported according to the PRISMA Extension for Scoping Reviews [ 20 ] (shown in Additional file 1 ). A protocol for this review is available on request.

The aim of this review was to identify the characteristics of research on health literacy in rare disorders. The specific research questions were:

What are the characteristics of study populations?

When and where have reports on health literacy been carried out?

What are the characteristics of research questions used to investigate health literacy?

What are the characteristics of methods used to investigate health literacy?

What are the characteristics of assessment tools used to measure health literacy?

What are the characteristics of interventions that have been described in the reports?

How is health literacy defined or described in the reports?

How is access to health information and support for individuals with rare disorders described the reports?

Overarching participatory approach

The study group in this scoping review included one co-researcher, one with experiential knowledge trained in research methods, several experienced healthcare professionals in the field of rare disorders, working in clinical practice (specialized health care), and experienced researchers in health literacy and scoping review methodology. All members have been involved in all stages of the review process.

Eligibility criteria

This scoping review included primary research reports that investigated health literacy in adults with rare disorders. Reports were included if they had investigated the individual`s capacities, skills and motivation to make judgements and decisions in everyday life concerning healthcare, disease prevention and health promotion in persons with a rare disorder. While being 18 years of age or older was set as a search criterion, reports that included both adults and persons below 18 were not excluded. Empirical reports in English and Scandinavian languages published in peer-reviewed journals were included. All study designs were included. Dissertations, reports published in abstract form only, editorials, commentaries and duplicates were excluded.

Systematic searches

In the first stage, research questions were developed by the study group in a highly iterative process. We agreed to apply a broad variety of synonyms, conducting many and extensive pilot searches and simultaneously enhancing the search strategy, and clarify the criteria for inclusion and exclusion of reports. A senior academic librarian, in close collaboration with the first author, developed a systematic literature search using MeSH-terms and free search terms combining a comprehensive set of synonyms and terms for health literacy and rare disorders. Both the librarian and the researchers in the study group had experience with previous literature searches in the field of rare disorders. The literature searches complied with the PICO principles and applied a combination of “OR” within groups and “AND” between groups. Searches were conducted in Medline (Ovid), Embase (Ovid), PsycInfo (Ovid), CINAHL (ebsco), and ERIC (Ovid) for publications between 2010 and 2021. No other sources for literature were searched for this review. The complete search strategy is displayed in Additional file 2 .

Selection of publications

All titles and abstracts were reviewed by the first author (US) and one of the co-authors independently using the systematic review software Covidence (Veritas Health Innovation). Disagreements and conflicts were resolved through discussion with a third review author.

Data extraction

All data from the included reports were extracted according to study characteristics, participant characteristics included ORPHA and ICD-codes, description of interventions, methods, assessment tools, definitions and understanding of health literacy was collected using data extraction forms and reported separately for each study in evidence summaries (Supplementary Material 4 – 9 : Tables 2–6). A full reference list of included reports is presented in Additional file 3 . Extracted data is presented in a descriptive manner using text, tables and figures. All members of the study group participated in the data extraction. We did not attempt to contact the authors in this review process.

The search of the online databases resulted in 5999 reports when duplicates were removed. From these, 5794 were excluded because they did not fulfil the inclusion criteria. A total of 177 reports were downloaded in full text and read by two authors. Of these, 102 reports were excluded, leaving 75 to undergo analysis in this review (Fig. 1). All the included reports were in English language.

Prisma flow diagram

Characteristics of study populations

A total of 6223 persons with a rare disorder and 1707 caregivers were represented in the 75 included reports. About 70% of the reports were based on data from samples with less than 100 participants. About 15% of the reports were based on samples with more than 200 participants. Of the included participants in the reports, about 60% were female. Of the reports that reported the mean age of the participants, approximately 75% of the participants were between 30 and 50 years of age. About 15% of the reports had participants with a mean age over 55 years, and eleven reports had participants with a mean age under 25 years.

The reports in this review have included study participants representing a total of 80 different rare disorders with unique ORPHA and ICD-10 codes. A detailed description of diagnoses is given in Table 1 (Additional file 4 ). Five of the reports included participants across rare disorders but did not specify what type of disorders. Most of the rare disorders had been investigated in one or two reports, but a few disorders were investigated in several reports: different types of Hemophilia were investigated in 24/75 reports, Cystic Fibrosis in 14/75 reports, Huntington’s disease in 7/75 reports, Scleroderma in 4/75 reports and Myotonic dystrophy type 1, Neurofibromatosis type 1 and Spina bifida in 3/75 reports.

Where and when have reports on health literacy been carried out?

Of the 75 included reports, 21 were conducted in the USA, 11 in Canada and eight in the UK (see Table 2 for details in Additional file 9 ). The included reports were published between 2010 and 2021, 54/75 after 2016.

Characteristics of research questions

The research questions most frequently investigated among the included reports were related to assessments of experienced knowledge and different health- and/or psychosocial outcomes (31/75). The second most investigated research questions (27/75) were about persons with rare disorders’ views, experiences and understanding of their own condition, care, health information, management, transition process or peer support (see Table 6 for details in Additional file 8 ). In addition, 16 reports were conducted to evaluate an intervention aimed to improve or strengthen participants` knowledge, health literacy or coping, and therefore included in this review.

Characteristics of methodological design

Of the included reports, 28/75 applied a quantitative cross-sectional design to explore characteristics of patient groups in terms of knowledge and disease-related variables. Among the cross-sectional reports, both digital and paper-based surveys were used, and some gathered data through medical charts or personal interviews. In addition, fourteen reports applied an experimental design investigating either the feasibility or effects of specific interventions, mainly to increase knowledge or health literacy. Among the qualitative designs (28/75), individual interviews were frequently applied, less so focus groups. Most of the qualitative reports aimed to explore experiences and gain insight into the views of persons who are living with a rare disorder, for example, needs of information and support, barriers to care and communication with health care providers. To present the qualitative results, a thematic analysis approach was most frequently applied. A minority of reports (5/75) reported a mixed or multi-method approach, combining interviews and surveys (see Table 3 for more details, Additional file 5 ).

Characteristics of assessment tools

Five of the assessment tools measured health literacy specifically. However, 23 standardized assessment tools aimed to assess important aspects relevant to health literacy, such as self-management skills, coping and medication adherence. Table 4 provides an overview of the standardised assessment tools used to measure health outcomes (Additional file 6 ). Quality of life was the outcome assessed most frequently (10/75) and was most commonly assessed with SF36 (4/75). Seven reports examined anxiety levels, while six estimated depression. Hospital Anxiety and Depression Scale (HAD) was the most commonly utilized tool to assess anxiety and depression (3/75). Correspondingly, 27 study-specific assessment tools sought to achieve outcomes closely related to health literacy, including health information-seeking patterns, medication information sources and knowledge, attitude and behaviour towards their condition. For a more detailed review of study-specific assessment tools, see Table 5 (Additional file 7 ).

Characteristics of interventions

A total of 16/75 of the reports included interventions. Each intervention originated from a distinct study and had diverse characteristics in terms of study design, objectives, intended recipients, implementation settings, and delivery personnel, including healthcare professionals and peers. Additional information regarding this is provided in Table 6 (Additional file 8 ). The interventions encompassed both face-to-face approaches, such as individual sessions [ 21 , 22 , 23 , 24 , 25 , 26 , 27 ] and group-based patient education [ 22 , 26 , 28 , 29 , 30 , 31 , 32 , 33 , 34 ], and written information/online training [ 29 , 31 , 35 , 36 , 37 ]. The interventions took place in a variety of settings, including hospitals, clinics, and online platforms. The common thread between the interventions is that they all share the objective of enhancing patient outcomes and experiences through education, support, and empowerment. For example, they aim to improve knowledge, health literacy, and self-treatment skills, as well as to promote treatment adherence and reduce interruptions in care. In 9/16 interventions, the primary aim was to improve knowledge or understanding of the patient’s particular health condition or treatment. These nine interventions applied various components such as audiovisual materials, individualised training courses, or booklets. Out of those nine interventions, six demonstrated a significant ( p  < 0.05) improvement in knowledge of the targeted health condition or treatment [ 21 , 25 , 28 , 32 , 36 , 37 ].

Out of all interventions, 5/16 aimed predominantly at reducing psychiatric symptoms, such as depression, anxiety, and somatic symptom severity. Several interventions displayed positive effects on mental health, including improvements in emotional health, coping strategies, and quality of life [ 22 , 26 , 28 , 29 , 32 , 33 , 35 ]. Examples of such interventions included group counselling and group mindfulness training. The interventions were evaluated using methods such as self-report questionnaires, physiological measures, and clinical assessments. The outcomes measured included improvements in physical health, mental health, quality of life, and social support.

Description of health literacy

Only 6/75 reports described in the introduction how they defined health literacy [ 21 , 38 , 39 , 40 , 41 , 42 ]. Five of these reports were based on the understanding and definition of health literacy as the cognitive and social skills that determine the motivation and ability of individuals to gain access to, understand and use information in ways that promote and maintain good health (WHO). One of the reports defined health literacy as “the patients’ skills on reading, listening, analysing decisions making and applying these skills to the situation related to health monitoring and coordination for strategy plan in term of health promotion” [ 42 ].

Access to health information and support

Most of the reports included in this review investigated knowledge or understanding of one’s own health and diagnosis, and access to health information. Persons with rare disorders commonly lack information about:

Own diagnosis and health [ 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 ].

Self-management and daily coping [ 6 , 10 , 54 , 59 , 60 , 61 , 62 , 63 ].

Medication, treatment options and research-based recommendations [ 6 , 10 , 28 , 51 , 64 , 65 , 66 , 67 ].

Peer and professional support [ 53 , 54 , 55 ].

Clinical trials and research [ 53 , 54 , 55 ].

Sexual knowledge [ 68 , 69 , 70 , 71 ].

Behaviour and attitude [ 28 , 72 , 73 ].

Social rights [ 28 , 60 ].

Pregnancy and childbirth [ 51 , 60 ].

Ageing [ 71 ].

Navigation and coordination [ 23 ].

The most important sources of health information summarized among the included reports were physicians, the internet, patient organizations and spouse/partner [ 74 , 75 , 76 ]. Transitions in life can be challenging and generate new needs for information and care. Three of the reports investigated the transition process from paediatric to adult services [ 23 , 77 , 78 ]. Persons with rare disorders and their family caregivers call for health information on various aspects of the disease burden including medical research and treatment, coping strategies, management, symptoms and general knowledge about the disease [ 57 , 63 ].

Only a few reports investigated how persons with rare disorders are navigating in healthcare and their experiences of healthcare services. These reports found that many persons with rare disorders feel let down by the system- and lack trust in the standards of health care [ 54 , 79 , 80 , 81 ]. Several reports described the frustration among persons with rare disorders because of a lack of knowledge about diagnosis and medication by healthcare professionals [ 54 , 56 , 59 , 62 , 73 , 81 , 82 ] and concerns about poor communication and information provision [ 83 ].

Some of the reports described the experiences of persons with rare disorders concerning limited access to peer- and professional support, like specialized care, treatment plans and access to peer groups [ 34 , 53 , 61 , 62 , 84 , 85 , 86 ]. Persons with rare disorders missed the engagement in health care to assist in their management of the disease [ 85 ], and one report claimed that hospital visits could be reduced with more information [ 52 ].

Several reports have investigated peer support [ 6 , 22 , 28 , 44 , 50 , 81 , 82 , 87 , 88 , 89 ]. Persons with rare disorders who connected and interacted with fellow individuals with rare disorders reported great improvements in overall health, disease severity, motivation to take care of health, emotional well-being and satisfaction with their primary treating physician [ 66 , 69 ].

This scoping review identified 75 reports presenting data on rare disorders and aspects of health literacy, thereby providing valuable insight into the characteristics of research in the field of health literacy in individuals with rare disorders. A total of 6223 individuals with rare disorders and 1707 caregivers were included, and 80 different rare disorders were represented. Most of the studies were published after 2016, and were conducted in the USA, Canada and UK. The most frequently investigated research questions were related to different health- and psychosocial outcomes, understanding of own condition, health information and support, or concerning evaluation of an intervention. The reports used a variety of research methodologies, including qualitative, quantitative, and mixed methods approaches. Cross-sectional designs were frequently employed to depict patient characteristics, knowledge and health-related variables, and qualitative designs were commonly used to capture the perspectives of persons living with rare disorders. In total 23 standardized assessment tools and 27 study-specific assessment used in the reports. Only five assessment tools measured health literacy specifically. Some of the reports also assessed interventions to improve elements such as knowledge, health literacy and coping strategies. These interventions encompassed both face-to-face approaches, such as individual sessions and group-based patient education.

Only six reports had described how they defined health literacy. Five of these reports were based on the understanding and WHO-definition of health literacy as the cognitive and social skills that determine the motivation and ability of individuals to gain access to, understand and use information in ways that promote and maintain good health (WHO). Concerning access to health information and support, the results revealed that individuals with rare disorders often exhibit gaps in knowledge and access to information related to self-management, their own diagnosis and health, as well as daily coping and social rights. In addition, the importance of aid and information from healthcare personnel and the significance of getting social support from others in the same situation were accentuated.

A recurring issue identified among the reports was that individuals with rare disorders consistently encounter challenges in accessing information on their own health and diagnosis, self-managing and coping [ 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 ]. This observation has been established in previous research and can sometimes be ascribed to a lack of knowledge among healthcare personnel [ 6 , 9 , 10 ]. The understanding and appraisal of health information could pose difficulties since the information available on rare conditions often is complex and contains medical terminology that is challenging to comprehend. This particularly applies to those with cognitive impairments, which pertains to 44% of the rare disease population [ 90 ]. More than 7000 rare disorders are identified, and only 80 of these disorders are represented in this review. More than 50% of the included reports have included study participants with Haemophilia, Cystic Fibrosis and Huntington’s disease, which means that a range of different rare disorders have not been included in health literacy research. A majority of the interventions in this study focused on increasing knowledge and understanding of one’s own health and treatment. Acquiring the skills to apply health knowledge to everyday life efficiently can profoundly impact health outcomes and is especially important when it comes to self-management, such as adherence to medication and treatment [ 15 , 91 , 92 , 93 , 94 , 95 ].

Another possible challenge related to access to information and support is the often-large geographical distances between persons with rare disorders. This may result in difficulties when it comes to meeting or participating in peer-support groups in person [ 96 ]. Peer interactions appear particularly important in this population [ 6 , 53 , 54 , 55 ], and several of the perceived benefits of the interventions in this review were associated with the recognition, acceptance and companionship encountered within peer-support groups [ 16 , 28 , 32 , 35 ]. Interestingly, none of the included reports explored the potential benefits of online peer support, which has been found to be an effective supplement to in-person meetings in people with other disorders.

While there is reason to believe that health literacy has a significant impact on health outcomes, only one of the included reports investigated this possible correlation, finding that individuals who possessed adequate health literacy displayed more favourable health-related outcomes [ 38 ]. In that report, the authors observed that individuals who possessed adequate health literacy displayed more favourable health-related outcomes. None of the included reports explored health literacy across various types of rare disorders. One prominent finding across the reviewed reports is the shortage of accessible health information specifically targeted towards individuals with rare conditions. There is a need to investigate if there are structural or social barriers that limit access to information and support for the population. Furthermore, it would be valuable to examine the underlying factors that impact health literacy in persons with rare disorders, including the association between health literacy and socio-demographic variables, health status, self-efficacy and health-related quality of life. Another potential research topic could be to evaluate the success of interventions aiming at improving health literacy in persons with rare disorders and their caregivers.

To the best of our knowledge, only four previous reports have explicitly aimed to examine the levels of health literacy in persons with rare disorders [ 38 , 39 , 40 , 42 ]. Furthermore, the data does not provide enough information to say anything about relatives’ health literacy. Enhancing health literacy is known to be an enabler for improved empowerment and participation, which is associated with positive health outcomes [ 13 , 94 ]. Empowerment is especially important in the field of rare disorders, due to the unique challenges of low prevalence, limited knowledge and expertise, and compromised quality of life [ 94 ].

To achieve a better understanding of health literacy in rare disorders, we could benefit from the incorporation of different perspectives, including those of persons with rare disorders, their family members and healthcare providers. We need future research on how different dimensions of health literacy, and interventions aiming to strengthen health literacy, influence health outcomes according to health care, disease prevention and health promotion. We need to achieve a deeper understanding of how the personal determinants of health literacy, such as individual skills and motivation, interact with situational determinants, such as social and environmental factors, to shape health outcomes. To properly address the executive challenges faced by persons with rare disorders we need a greater understanding of health literacy in rare disorders [ 28 ]. The integrated model of health literacy [ 15 ] can serve as a tool to point us in the right direction when designing future research projects.

The strength of our work lies in providing a comprehensive overview of the reported findings from research on health literacy in rare disorders. We conducted an up-to-date systematic search in five databases without restrictions. Despite using an array of synonyms in database searches to maximise the identification of relevant reports, the search terms used are not exhaustive. Hence, some reports may not have been detected. To reduce the risk of selection bias, two authors independently assessed the abstracts and reports in full text according to the a priori eligibility criteria. Further, in line with the scoping review framework, we have not evaluated the methodological quality or risk of bias among the included reports. This may be seen as a limitation; however, the purpose of scoping reviews is to give an overview of the available research literature, characterise a research area and pinpoint gaps in knowledge that should be addressed in future systematic reviews.

This review has important implications for practice. Healthcare does not offer curative treatment options for most rare disorders, and several reports suggest the development of consensus recommendations for care. To optimise health and secure continuity of care several reports included in this review recommend formalisation of the transition process through the courses of illness and life. Moreover, the results reveal that some of the key challenges for persons with rare disorders are related to important aspects of health literacy, such as accessing, understanding, and applying health information. Our findings indicate a need for strengthened health literacy in the rare disease population, that could be accomplished by developing health communication strategies tailored to the needs and preferences of persons with rare conditions. Healthcare personnel can play a significant role in enhancing health literacy, which is an additional implication for practice. Health care personnel can achieve this by offering clear and understandable health-related information and encouraging an active dialogue between patients and professionals. Another way for healthcare personnel to assist persons with rare disorders is by offering them the support needed to accept, cope, and effectively manage their condition [ 97 ].

This scoping review consists of 75 reports presenting data on rare disorders and aspects of health literacy, thereby providing valuable insight into the characteristics of research in the field of health literacy in individuals with rare disorders. In total, 6223 individuals with rare disorders and 1707 caregivers were included, and 80 different rare disorders were represented. Most of the studies were published after 2016, and were conducted in the USA, Canada and UK.

The findings of this scoping review demonstrate that persons with rare disorders experience considerable gaps in knowledge and information, particularly in relation to their own diagnosis and health, treatment options, self-management and coping strategies. Moreover, the lack of diagnosis-specific knowledge and limited information provided by healthcare professionals are identified as a common concern among persons with rare disorders. Access to, and understanding, health information is key aspects of health literacy. Therefore, our results imply a need for increased awareness regarding the state of health literacy among individuals with rare disorders. The points of view expressed in this review offer valuable perspectives that can help health personnel in outlining the communicative strategy when caring for individuals with rare disorders.

This review provides a solid understanding block for future research into the emerging field of health literacy in rare disorders, by examining the challenges that persons with rare conditions encounter. Moreover, the findings enable us to develop a better understanding of the care and support persons with a rare disorder and their family members require.

These results pave the way for future research that looks to improve the healthcare experience of those with rare disorders and their caretakers and shed light on the importance of empowering the rare disease population through peer support, participation, education and increased health literacy. Future reports in this field are necessary to develop strategies and interventions that improve health literacy and enhance health outcomes and the quality of life for individuals with rare disorders.

Data availability

All data generated or analysed during this review are included in this published article (and its additional files).

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Acknowledgements

The authors want to thank leaders and colleagues. A special thank goes to librarian Hilde Iren Flaatten who has conducted systematic searches after literature and Anne Siri Albrigtsen for important contributions to this review. Several of the authors are members of Euro-NMD.

This work received funding from Norwegian National Advisory Unit on Rare Disorders. In addition the work was performed as part of regular activities at Frambu Resource Centre for Rare Disorders and Norwegian National Advisory Unit on Learning and Mastery in Health, Oslo University Hospital.

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Una Stenberg & Lydia Westfal

Norwegian National Advisory Unit on Learning and Mastery in Health, Oslo University Hospital, Postboks 4959 Nydalen, Oslo, 0424, Norway

Una Stenberg & Karl Fredrik Westermann

National Neuromuscular Centre Norway, University Hospital of North-Norway, Hansine Hansens vei 37, Tromsø, 9019, Norway

Andreas Dybesland Rosenberger

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Kristin Ørstavik

Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solnavägen 1, Solna, 171 77, Sweden

Maria Flink

Oslo Metropolitan University, Postbox 4, St. Olavs place, Oslo, N-0130, Norway

Heidi Holmen

National Centre for Rare Epilepsy-Related Disorders, Department of Rare Disorders, Division of Paediatric and Adolescent Medicine, Oslo University Hospital, Postboks, 4950 Nydalen, 0424, Oslo, Norway

Silje Systad

TRS Resource Centre for Rare Diseases, Sunnaas Rehabilitation Hospital, Bjørnemyrveien 11, 1453, Bjørnemyr, Norway

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All the authors (US, GV, SS, KØ, KFW, HH, ADR, MF) except LW have contributed in the conception, design and analysis of data and interpretation of data. US has led all the phases of the review, and LW has contributed in the analysis and interpretation of data, and in writing the manuscript. All authors have read and approved the final manuscript.

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Stenberg, U., Westfal, L., Dybesland Rosenberger, A. et al. A scoping review of health literacy in rare disorders: key issues and research directions. Orphanet J Rare Dis 19 , 328 (2024). https://doi.org/10.1186/s13023-024-03332-5

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Research trends on nanomaterials in triple negative breast cancer (TNBC): a bibliometric analysis from 2010 to 2024

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• Hongyi Liang 1   na1 ,
• Guoliang Yin 1   na1 ,
• Dandan Feng 1 ,
• Hanhan Chen 2 ,
• Xiaofei Liu 2 &
• Jingwei Li 2  

Breast cancer (BC) is an important cause of cancer-related death in the world. As a subtype of BC with the worst prognosis, triple-negative breast cancer (TNBC) is a serious threat to human life and health. In recent years, there has been an increasing amount of research aimed at designing and developing nanomaterials for the diagnosis and treatment of TNBC. The purpose of this study was to comprehensively evaluate the current status and trend of the application of nanomaterials in TNBC through bibliometric analysis. Studies focusing on nanomaterials and cancer were searched from the Web of Science core collection (WOSCC) database, and relevant literature meeting the inclusion criteria was selected for inclusion in the study. VOSviewer and CiteSpace were used to perform bibliometric and visual analysis of the included publications. A total of 2338 studies were included. Annual publications have increased from 2010 to 2024. China, the United States and India were the leading countries in the field, accounting for 66.1%, 11.5% and 7.2% of publications, respectively. The Chinese Academy of Sciences and Li Yaping were the most influential institutions and authors, respectively. Journal of Controlled Release was considered the most productive journal. Cancer Research was considered to be the most co-cited journal. Drug delivery and anti-cancer mechanisms related to nanomaterials were considered to be the most widely studied aspects, and green synthesis and anti-cancer mechanisms were also recent research hotspots. In this study, the characteristics of publications were summarized, and the most influential countries, institutions, authors, journals, hot spots and trends in the application of nanomaterials in cancer were identified. These findings provide valuable insights into the current state and future direction of this dynamic field.

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This work was supported by the National Natural Science Foundation of China (General Program, No. 82374452).

Author information

Hongyi Liang and Guoliang Yin contributed equally to this work.

Authors and Affiliations

Shandong University of Traditional Chinese Medicine, Jinan, Shandong, 250014, China

Hongyi Liang, Guoliang Yin & Dandan Feng

Affiliated Hospital of Shandong University of Traditional Chinese Medicine, No. 16369 Jingshi Road, Jinan, Shandong, 250014, China

Hanhan Chen, Xiaofei Liu & Jingwei Li

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H.L. and G.Y. conceived the idea and designed the manuscript. D.F. drew the figures. H.L. prepared the original draft of the manuscript. H.C., X.L., and J.L. revised the manuscript. J.L. supervised and gave the final approval of the manuscript.

Corresponding author

Correspondence to Jingwei Li .

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Liang, H., Yin, G., Feng, D. et al. Research trends on nanomaterials in triple negative breast cancer (TNBC): a bibliometric analysis from 2010 to 2024. Drug Deliv. and Transl. Res. (2024). https://doi.org/10.1007/s13346-024-01704-9

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Accepted : 26 August 2024

Published : 06 September 2024

DOI : https://doi.org/10.1007/s13346-024-01704-9

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