clinical research companies in perth

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Participating in a clinical trial knowing that you or someone in the future is going to benefit is a huge gift. Make that choice to make a difference today.

Established in 2012, TrialsWest is one of Australia’s most experienced and successful clinical research centres.

Located in Perth, Western Australia, we partner with the world’s leading pharmaceutical and biotechnology companies to help bring new medicines and vaccines to the world .

CURRENT TRIALS

Contact us to register your interest in participating in a clinical trial.

WHAT PARTICIPANTS SAY ABOUT TRIALSWEST

I participated in an asthma trial in 2021. I cannot speak highly enough of the team at TrialsWest. Naturally, I had concerns for my well-being going into the trial. This apprehension was quickly dispelled as I could see the welfare of participants was the first priority at TrialsWest. This was very reassuring. From pre-trial examination and throughout the trial, every encounter with my TrialsWest Doctor, Nurse and Support Team was meticulous. I never felt alone, and all feedback from me was warmly welcomed. I was consistently monitored and received ongoing communication throughout the trial. Given the opportunity, I would willingly participate in further studies with TrialsWest.

CA - 58 years old Asthma

I have had the good fortune of being chosen as a participant in a trial conducted by TrialsWest, since December 2020. This has involved me undertaking a fairly lengthy trial for 12 months. My experience since the trial started has been one of superb involvement and assistance from the staff at TrialsWest. Instruction, knowledge and assistance is available as required and you are made to feel a part of a very professional and caring organisation. All staff, including Doctors, Nurses and Office Staff, show great knowledge, care and a professional approach to all tasks. I would have no hesitation in recommending TrialsWest.

JR - 71 years old Asthma

My experience at TrialsWest was very professional, caring and friendly. The staff - from the front reception staff; my treating Nurse, Tracey; resident Doctor Val; plus the management team, Michelle and Helen - made me feel more like a friend than just a client. I looked forward to my visits with them andwas sad when it came to an end.

SV - 69 years old COPD

I am about halfway through my trial and have been extremely impressed with how helpful and professional all the staff have been. They all make being there a pleasure and have helped me personally understand and enjoy my time spent with them.

SJ, 68 years old COPD

I have always enjoyed complete confidence in the expertise and professionalism of everybody at WRTS, and later at TrialsWest. I have had the highest regard for the competence and diligence of Peter, Helen, Michelle, Tracey, and Melinda, and it has been a matter of great satisfaction to me to know that the trials I have participated in may have helped others, as well as me, to gain access to more effective medications.

JF, 79 years old COPD

TRIALSWEST IS PROUD TO WORK WITH THESE SPONSORS

WHAT SPONSORS SAY ABOUT TRIALSWEST

It was a privilege to have worked with TrialsWest on the chronic cough study and see first-hand their strong focus on patient care and delivering on study commitments. This was an operationally demanding study and they were able to successfully contribute, both in exceeding their allocation and excellent data quality. Further, their team has always been reliable in regards to meeting DBL, even with extremely tight timelines! We highly value TrialsWest’s strong collaboration with us in bringing clinical trials to Australia and we look forward to our continued partnership in future studies.

The team at TrialsWest can simply be described as professional and from my experience is the ideal clinical trials site to be working with. I approached TrialsWest as a new potential site in a therapeutic area that our company was then naïve to and from our first interaction, it had been nothing but co-operative efforts. From site selection through to budget negotiation and study initiation, the processes adopted by TrialsWest were both practical and efficient, fulfilling all GCP requirements. The team were not only experienced in conducting clinical trials, but were constantly adapting to the ever-changing environment. Our study was scheduled to start in the midst of the COVID crisis but had experienced many hurdles. The flexibility shown by the team to the rapidly changing demands of the study contributed to the site’s targeted recruitment to be achieved within 1 month (from a 12-month recruitment). TrialsWest paves the road for what an ideal institution specializing in clinical trials should be like.

Awareness Through  Research

Call for study enquiries:   +61  8 9448 7376

Clinical Research Australia is a contract research organisation located in Perth, Western Australia.

We specialise in conducting clinical trials on natural treatments to enhance mental and physical well-being

Our Mission Statement

“To provide an efficient, ethical, and high-quality research service that supports the continued growth of the nutraceutical industry and builds trust with consumers."

"We strive to develop personalised, long-lasting, and mutually-beneficial relationships with our trial sponsors, with the goal of contributing to their success.”

All our clinical trials are conducted in accordance with the:

• Guidelines for Good Clinical Practice (CPMP/ICH/135/95)
• National Statement on Ethical Conduct in Human Research
• Declaration of Helsinki
• Australian Code for the Responsible Conduct of Research, 2018

About Our Team

Our Clinical Trials

Our Areas of Expertise

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To be informed about future clinical trials we are conducting, join our mailing list.

Your privacy is assured. We will only contact you when we have new studies commencing and require volunteers.

Paid Clinical Trials

View our clinical trials in Perth below and learn how to contribute to medical research with Linear. Filter our paid clinical trials by age, BMI, gender, other health criteria, and remuneration. The selection process for all our paid clinical trials is easy and follows the same step-by-step process. You may receive a *Screening Reimbursement for applicable studies. Check your eligibility for our Paid Healthy Volunteer and Patient Studies.🤍 = Paid Healthy Volunteer Study and ✚ = Paid Patient Study

Filter trials by

Healthy Participants Contrast Agent Study

3 night stay, 1 phone call

Sep 04th, 09th, 12th

18-45 years old

Healthy adults

Must not have any significant history or current allergies or ongoing medical conditions.

Must not have used more than 5 nicotine products per day in the last 3 months | Must be caucasian

$2085 *with Screening Reimbursement

Healthy Participants The Blood Study

4 night stay, 1 appointment, 1 phone call

18-55 years old

Must not have any significant history or current allergies or ongoing medical conditions | Must have a BMI between 30-32/m2

Non hormonal contraceptive methods required | Must not have used nicotine products in the last 3 months

$2430 *with Screening Reimbursement

Patients The Gout Study

3 Appointments

Starting Soon

18-70 years old

Healthy males and females

Must have a medical diagnosis of Gout for at least 2 years.

Must be willing to limit the use of nicotine containing products during study participation and for at least 7 days post dosing.

Healthy Participants VMS Study

12 night stay

To Be Confirmed

40-65 years old

Healthy females

Must not have any significant history or current allergies or ongoing medical conditions. Must be either post-menopausal or surgically sterile by bilateral oophorectomy

Must be willing to avoid smoking/using tobacco products from screening to the end of the study period

Healthy Participants High Blood Pressure Study

3 day stay, 19 follow up appointments

Various Dates Available

18-65 years old

Must have mild to moderate hypertension with mean sitting systolic blood pressure of >130 and ≤160 mmHg

Must not be a heavy smoker

EOI | Patient Trials

Paid Patient Studies

By Appointment Only

18-85 years old

Males and Females

Must have a diagnosed medical condition

Requirements will differ from study to study

Sorry we currently have no trials available. Please register here.

How linear paid clinical trials work, choose a trial.

Answer a few questions to be directed to suitable trials

Pre-Screening Questionnaire and Phone Call

Find out if you’re eligible

Attend Screening Visit

Attend our world-class facility for screening. Our medical doctors will confirm your eligibility to participate

Participate

Check-In & Check-Out in our world class facility where you will be cared for by our knowledgeable team of medical doctors, nurses, and staff

Follow-up Visit

After your follow-up visit, you are remunerated for participating

Generally, payments are made two weeks after the final follow-up appointment, or as you progress through milestone appointments.

Participant Reviews

Don't listen to us - hear from the people who allow us to do what we do. Our Linear participants!

Why participate with Linear

Healthy participants are paid for their time, but that’s rarely the sole reason for someone becoming a participant. It’s also about doing something for the greater good! Support medical research that can potentially help change and even save lives.

CLINICAL RESEARCH

Home » Research » Clinical Research

LINEAR CLINICAL RESEARCH

Linear Clinical Research Limited is an early phase clinical trials facility; the only one in Western Australia and the most advanced facility of its kind in Australia. Linear was founded by the Harry Perkins Institute of Medical Research in 2010 and built through funds provided by the Western Australian Government.

WHAT ARE CLINICAL TRIALS?

Clinical trials are a vital step in the path to bring new potentially lifesaving medicines to patients. Trials ensure that new treatments are both safe and effective.

ABOUT LINEAR

Linear provides the Perkins with a critical base for clinical trials of new medicines and is an illustration of our commitment to hasten the translation of our basic discoveries at the bench to the bedside.

RESEARCH NEWS & EVENTS

Buckle up as WA’s Premier Truck Show announces HUGE money raised for Cancer Research!

1000 walkers raise over $1.45m for women’s cancer research

“Google map” of ovarian tumours reveals cancer cells control who gets into their neighbourhood

Help wa's best researchers beat the world's toughest diseases..

Perkins North QEII Medical Centre 6 Verdun St Nedlands WA 6009

Get in touch

Perkins South Fiona Stanley Hospital 5 Robin Warren Dr Murdoch WA 6150

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Important information.

All donations of $2 and over are tax deductible in Australia.

Perkins is registered with the Australian Taxation Office as a Deductible Gift Recipient (DGR): Charitable Fundraising Authority No DGR CC20761

We acknowledge the Whadjuk people of the Nyoongar nation, the traditional owners of the lands where our offices are located and pay respects to their elders, past, present and emerging.

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AUSTRALIA'S ORIGINAL

Full service cro, intelligent, clinical trials, early phase, early phase clinical trials.

• Want a CRO with connections to all Phase I units in Australia?
• Need a customised phase I clinical trial in a specific hospital setting, and PK calculations and analyses for bioavailability and bioequivalence studies?
• Datapharm has conducted over 50 phase I clinical trials, and is ready to assist you!
• Do the Phase I clinical trial unit tour!

UP TO 43.5% OFF R&D INCENTIVE

• Are you eligible for up to 43.5% refund on your next Clinical Trial?
• Datapharm Australia is a registered Research Service Provider (RSP) with AusIndustry.  Find out more…
• What are the benefits of using a RSP?
• 43.5% “cash back” benefit now available for eligible foreign companies undertaking R&D in Australia

LATE PHASE CLINICAL STUDIES

• Need phase III clinical trial support in Australia and New Zealand?
• Want to run phase IV post-marketing & observational studies in Oceania?
• Datapharm Australia has well developed clinical trial site networks in various therapeutic areas to get late phase studies running quickly.
• Extending multicentre clinical research studies internationally?

Conducting Wound Healing Clinical Trials in Australia

In Australia, there are more than 450,000 people suffering from chronic wounds each year1. Chronic wounds can have a significant negative impact on the lives of patients and

Conducting Inflammatory Bowel Disease Clinical Trials in Australia Part 2

What to consider when designing an IBD clinical trial Inflammatory Bowel Disease (IBD) is a collective term for two chronic, autoimmune diseases of the gastrointestinal

Conducting Inflammatory Bowel Disease Clinical Trials in Australia Part 1

Inflammatory Bowel Disease (IBD) is a collective term for two chronic, autoimmune diseases of the gastrointestinal tract: ulcerative colitis (UC) and Crohn’s disease (CD). UC

Australia's Original Full Service CRO

Datapharm has earned an enviable reputation for detail and quality through involvement in hundreds of clinical trials in all phases (Phase I to IV) for clients ranging from large international pharmaceutical companies to local and international biotechnology companies, device manufacturers, producers of alternative therapies, private, hospital and university based investigators.

Clinical Trial Services

Datapharm is Australia’s original full service contract research organisation (CRO) providing clinical trial services such as Clinical Trial Site Selection, Regulatory and Site Set-up, Clinical Trial Monitoring Services, Data Management, Statistics, Medical and Scientific Writing, Medical Monitoring and Pharmacovigilance, Quality Control Processes and GCP Auditing.

Clinical Research Therapeutic Expertise

With over 35 years of experience, Datapharm has proudly managed clinical research across all phases and most therapeutic areas for both early phase clinical trials and late phase studies. Datapharm has relationships with some of the best clinical trial Investigators and study sites in Australia and New Zealand. Read more about Datapharm’s clinical trial therapeutic area experience.

Clinical Trial Management Speciality

Our clinical trial Sponsors’ budgets are managed using Project Advantage® and Project Status Invoicing which present project phases by work category against estimated and actual time and cost. As part of our service to you our project managers will work with timelines for data analysis to meet prearranged presentations to client boards or funding agencies. Datapharm Australia CRO clinical trial management services include clinical trial design, preparation of all necessary clinical trial documents, clinical site monitoring, data management, statistical services and medical monitoring and pharmacovigilance.

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What are the advantages of running trials in australia, learn more by downloading the free ebook.

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Patient recruitment and site selection, early phase trials in australia, clinical operations and project management, site management organization (smo), biometrics and data management, virtual clinical trials, real world data, laboratory services, oncology cro services, pharmacometric services, drug development consulting, gmo solutions, liver disease cro services, infectious diseases and vaccines cro services, orphan and rare disease cro services, clinical and regulatory strategy.

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• High quality research, facilities and equipment
• Fast set-up and approval times
• Sponsor can claim R&D cash refund

Australia is a developed nation with the world's top five per capita income and the second-highest human development index globally. It performs strongly in international comparisons of quality of life, health, education, and other measures.

More than one-quarter of Australians are born overseas, and more than 10% of Australians have Asian heritage.

Australia is home to some of the world’s best medical researchers and health professionals and enjoys world-class research infrastructure equal to the US. Clinical trial capability is also of an international standard and the country is well suited to conduct complex trials that are generally focused on indications aligned with the standard of care in developed nations.

With streamlined regulatory requirements and the supportive R&D Government refund of up to 43.5% on clinical research spend, Australia has become a preferred destination for early phase clinical trials.

Importantly Australia also offers alternative recruitment potential to northern hemisphere seasonally related studies.

Novotech has built strong expertise over the years in providing CRO services to biotechnology companies in Australia.

In Australia, biotechnology companies enjoy start-up timelines of around 6 to 8 weeks, from Ethics Committee (EC) submission to Therapeutic Goods Administration (TGA) approval.

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Clinical Research Australia in Australia

Web:   https://clinicalresearch.com.au/

Phone:   +61 8 9448 7376

• Contract research organizations
• Clinical Research Australia

38 Arnisdale Road, Duncraig Western, Australia 6023

About Clinical Research Australia

Clinical Research Australia is a contract research organisation located in Perth, Western Australia. We specialise in conducting clinical trials on natural treatments to enhance mental and physical well-being. Our Mission Statement: “To provide an efficient, ethical, and high-quality research service that supports the continued growth of the nutraceutical industry and builds trust with consumers." "We strive to develop personalised, long-lasting, and mutually-beneficial relationships with our trial sponsors, with the goal of contributing to their success.” All our clinical trials are conducted in accordance with the: Guidelines for Good Clinical Practice (CPMP/ICH/135/95); National Statement on Ethical Conduct in Human Research; Declaration of Helsinki; Australian Code for the Responsible Conduct of Research, 2018.

List of CROs by location

• Bosnia & Herzegovina
• Czech Republic
• Netherlands
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• United Kingdom
• Dominican Republic
• El Salvador
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• United States
• Philippines
• Saudi Arabia
• South Korea
• Turkmenistan
• United Arab Emirates
• Burkina Faso
• Congo, DR of
• Cote d'Ivoire
• Equatorial Guinea
• South Africa
• New Zealand
• Papua New Guinea

Clinical, research Jobs in All Perth WA

Perform a job search.

• Nedlands WA 6009
• West Perth WA 6005
• Murdoch WA 6150
• All Perth WA
• Midland WA 6056
• Inglewood WA 6052

Research Assistant

This is a Full time job

• Advanced biotechnology company
• Exciting opportunity and career development
• Forefront of predictive diagnostics and bio-analytical services

Clinical Psychologist

This is a Part time job

• Be part of a practice that cares about its team members in a wholehearted way
• Less admin, more impact
• Autonomy, flexibility and growth

Research Clinical Trials Assistant

(Senior) Clinical Research Associate

• Remote Work
• Leading CRO
• Additional leave and Bonus

Clinical Research Coordinator

• Join the leading provider of oncology services in Australia!
• Own your development, learn everyday.
• Full-time opportunity available, working Mon-Fri.

Senior Clinical Research Associate

• Principal CRA / Senior CRA / CRA II
• Perth & Adelaide - Fully Remote with Onsite Visits
• Award Winning Training Programmes & Full Lifecycle I-IV Project Scope

Coordinator Clinical Trials

Study Coordinator

• Full Time Salary Range $65,000-$80,000 (dependent on experience)
• Salary Packaging: Up to $15,899 per year plus an entertainment card
• Flexible work hours

Screening Coordinator

• Work across a wide variety of clinical trial studies
• 5 weeks annual leave per year
• Collaborative and supportive team environment

Research Governance Officer

• Partner with our teams to make positive impacts for our children
• Flexible working hours | Work from home options
• Health & wellbeing programs and training opportunities available

Research Nurse

• Up to $18,550 on a range of benefits
• Access to fitness and wellbeing benefits through Fitness Passport
• A healthy work-life balance

Senior Research Officer

• Salary packaging up to 18,550 and staff discount over 370 retail outlets.
• On-site café, free parking and gym onsite.
• Excellent Team Culture

Research Administrator

Intern - Plastics & Human Health (6 Month contract)

This is a Contract/Temp job

• Gain valuable training and experience in philanthropy
• Passionate about fighting fossil-fuel plastic & protecting human health?
• 2x Interns for 6 month fixed contracts. Part time or Full time considered

Chair in Rheumatology and Musculoskeletal Medicine

• Level E plus Clinical loading I 5-year appointment
• Flexible work arrangements I Top 100 University
• Provide leadership and foster excellence in clinical research and teaching

Clinical Solutions Specialist

• Opportunity to join a Global Medical Device Organization
• Enhance Your Clinical Support Skills
• We’ll Support You to Develop Your Career

Biostatistician

• Global CRO with a fantastic reputation
• Office or home based roles available

Industry Internship Project Officer

• Exciting opportunity to assist research students in gaining critical skills.
• Expand connections between research, industry and the wider community.
• World Top 100 University.

Clinical Neuropsychologist/ Clinical Neuropsychologist Registrar

Phd scholarship - digital and mobile technology in the care of older adults.

Manager, Care Information and Analytics

• Permanent full-time opportunity
• Hybrid working flexibility is supported
• Location flexibility - Vic, WA, SA, NSW or QLD

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Listed date, salary estimate, 100 jobs – registered clinical research in perth wa, trial participant trial participant.

• Join our growing army of more than 20,000 clinical trial participants
• Help turn medical innovations into safe, effective treatments
• Open to anyone, including backpackers and international students

(Senior) Clinical Research Associate (Senior) Clinical Research Associate

• Perform site selection, monitoring, and close-out visits
• Administer protocol training and evaluate study site practices
• Bachelor's degree in Life Sciences, 2-4 years monitoring experience

Senior Clinical Research Associate Senior Clinical Research Associate

• Conduct site visits to ensure compliance with protocols and guidelines
• Build strong relationships with investigative sites and study coordinators
• Bachelor's degree in scientific or healthcare field, 2+ years experience

Research Physician Research Physician

• Conduct clinical trials adhering to ICH GCP & study protocols
• Record participant medical histories, perform physical examinations
• Qualified medical doctor with APHRA registration, excellent communication skills

Don't miss out!

We will notify you when new Registered Clinical Research jobs in Perth WA are posted.

Clinical Research Coordinator Clinical Research Coordinator

• Coordinate clinical research activities with research team
• Minimum 2 years experience in clinical research co-ordinator required
• Maintain regulatory compliance and conduct research in accordance with SOPs

Staff Specialist / Physician - Anaesthetist Staff Specialist / Physician - Anaesthetist

• Consultant Anaesthetist providing care to paediatric, adult & obstetric patients
• Mentoring junior staff and nursing, conducting clinical research projects
• Desirable experience in rural and remote Anaesthetic provision
• Coordinate clinical research activities for oncology trials
• Ensure compliance with GCP guidelines and study protocols
• Minimum 2 years experience in nursing, science, or Phase 1 research

Vocationally Registered General Practitioner Vocationally Registered General Practitioner

• Provide holistic medical care in collaboration with multidisciplinary team
• Develop and implement shared care models and resources
• Champion role of General Practitioners in optimal cardiometabolic care

Research Support Officer Research Support Officer

• Support clinical trials activities following Good Clinical Practice standards
• Assist in ethics applications, correspondence, and trial data collection
• Engage with subjects, families, and assist in research publication tasks

Coordinator Clinical Trials Coordinator Clinical Trials

• Coordinate and administer clinical trials and research projects
• Minimum 3 years of clinical trials or research experience required
• Provide support and mentorship to junior staff in the team

Milingimbi Primary and Population Health Manager Milingimbi Primary and Population Health Manager

• Manage all operations of Primary & Population Health Centre
• Implement strategies for clinical services and quality improvement
• Requires 5 years experience in similar role with Aboriginal communities

Research Administrator Research Administrator

• Support research team with administrative tasks and event coordination
• Manage databases, reports, and document preparation for research activities
• Need scientific/health discipline qualifications, academic admin experience

Research Governance Officer Research Governance Officer

• Ensure compliance with research governance framework and regulatory standards
• Support teams in review, approval, and monitoring of clinical research
• Contribute to educational resources and provide advice on ethics

Research Clinical Trials Assistant Research Clinical Trials Assistant

• Support Haematology Research team in conducting clinical trials
• Assist with patient visits, data collection, and trial compliance
• Entry-level role with opportunities for extension and professional development

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Participate in Medical Research  & Get Paid

You're One Step Closer to Advancing Medical Breakthroughs

+ Every trial at Linear requires approval by an independent ethics committee – registered with the Australian Government’s National Health and Medical Research Council (NHMRC)

 + Linear follows regulations and guidelines in accordance with international certification under Good Clinical Practice (GCP) and in accordance with TGA (Australia), FDA (USA), EMA (EU) and Medicines Australia guidelines

 + Every volunteer has to provide consent, go through medical questions specific to the trial, is assessed by a qualified doctor and goes through extensive medical examinations to make sure it is safe for them to participate

 + New drugs and therapies have to go through extensive years of testing before they are tested in clinical trials on humans.

The Importance of Phase 1 Clinical Trials: How You Can Contribute to Medical Advancements

Reasons to Participate in a Clinical Trial with Linear Clinical Research:

Fill out the form to access our paid clinical trials in perth, 1. earn money for your time and involvement by joining our paid clinical trials 2. access potential cutting-edge treatments before they are widely available 3. help advance medical research to develop new treatments 4. gain insights into your health during a comprehensive screen 5. get paid over $500 per night and e njoy our new state-of-the-art facilities during your stay.

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Majority of cancer patients ‘still in remission’ following breakthrough Perth trial

The majority of cancer patients involved in a landmark Perth clinical trial remain in remission years later after a breakthrough treatment that bypasses the need for chemotherapy.

The remarkable development is the result of a eureka moment for Sir Charles Gairdner Hospital consultant haematologist Professor Chan Cheah, who first thought of the treatment while out running in 2016.

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Recognizing the Evolution of Clinical Syndrome Spectrum Progression in Individuals with Single Large-Scale mitochondrial DNA deletion syndromes (SLSMDS)

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Introduction Single large-scale mtDNA deletions (SLSMD) result in Single Large Scale Deletion Syndromes (SLSMDS). SLSMDS presentations have classically been recognized to encompass at least three distinct clinical phenotypes, Pearson Syndrome (PS), Kearns-Sayre Syndrome (KSS), and Chronic Progressive Ophthalmoplegia (CPEO). Methods Facilitated review of electronic medical records, manual charts, and REDCap research databases was performed to complete a retrospective natural history study of 32 SLSMDS participants in a single health system seen between 2002 and 2020. Characteristics evaluated included genetic and clinical laboratory test values, growth parameters, signs and symptoms, demographics, and patient reported outcome measures of fatigue, quality of life, and overall function. Results Detailed cohort characterization highlighted that a recurrent deleted region involving MT-ND5 occurs in 96% of SLSMD subjects regardless of clinical phenotype, which tended to evolve over time. Higher blood heteroplasmy correlated with earlier age of onset. GDF-15 was elevated in all SLSMD subjects. A PS history yielded negative survival prognosis. Furthermore, increased fatigue and decreased quality of life were reported in SLSMD subjects with advancing age. Conclusion Retrospective natural history study of SLSMDS subjects demonstrated the evolution of classically considered PS, KSS, and CPEO clinical presentations within affected individuals, which may inform future clinical trial development.

Competing Interest Statement

RG is a consultant for Minovia Therapeutics and Nurture Genomics. MJF is engaged with several companies involved in mitochondrial disease therapeutic preclinical and/or clinical-stage development. MJF is co-founder and Chief Scientific Advisor of Rarefy Therapeutics LLC; an advisory board member with equity interest in RiboNova Inc.; a scientific advisory board member and paid consultant with Khondrion, and Larimar Therapeutics; has served as a paid consultant for Astellas (formerly MitoBridge), Casma Therapeutics, Cyclerion Therapeutics, Imel Therapeutics, Mayflower, Inc., Minovia Therapeutics, Mission Therapeutics, Myto Therapeutics, NeuroVive Pharmaceutical AB, Precision Biosciences, Primera Therapeutics, Inc., Reneo Therapeutics, Stealth BioTherapeutics, and Vincere Bio; and/or a sponsored research collaborator for Adjuvia Therapeutics, Astellas, Cyclerion Therapeutics, Epirium Bio, Imel Therapeutics, Khondrion, Merck, Minovia Therapeutics, Mission Therapeutics, NeuroVive Pharmaceutical AB, PTC Therapeutics, Reneo Therapeutics, RiboNova, Saol Therapeutics, Standigm, and Stealth BioTherapeutics. MJF also has received royalties from Elsevier and speaker fees from Agios Pharmaceuticals and GenoMind. AG is a paid consultant for Reneo Therapeutics, Cyclerion/Tisento Therapeutics, and UCB Therapeutics. None of the other authors have relevant conflicts of interest to declare.

Funding Statement

This work was supported in part by an investigator-initiated sponsored research award from Minovia Therapeutics (Falk PI) and from the Childrens Hospital of Philadelphia Mitochondrial Medicine Frontier Program.

Author Declarations

I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.

The details of the IRB/oversight body that provided approval or exemption for the research described are given below:

All human participants research was performed per Childrens Hospital of Philadelphia (CHOP) Institutional Review Board approved study #08-6177 (Falk PI).

I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals.

I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).

I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable.

Data Availability

All data produced in the present work are contained in the manuscript

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