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• v.38(3); 2017 Nov

Enhancing the Clinical Value of Medical Laboratory Testing

The value of medical laboratory testing is often directed to the cost of testing however the clinical benefits of these tests are at least as important. Laboratory testing has an acknowledged widespread role in clinical decision making, and therefore a role in determining clinical outcome. Consequently, the value of laboratory testing should be considered in its role in affecting beneficial actions and outcomes. This includes both the requesting phase of choosing tests which will influence clinical decision making as well as the reporting phase in a way that guides clinical decisions and actions. Clinical decision support systems and software can enhance the value of medical laboratory testing if they are directed toward facilitating those clinical decisions where there is either evidence, or agreed consensus, addressing patient outcomes.

Introduction

Value is often expressed in terms of “quality, clinical efficacy and effectiveness, patient centre-edness, patient satisfaction, timeliness, clinical efficiency, cost effectiveness, productivity affordability and cost”. 1 Laboratory value should ideally be judged in a manner consistent with the main goals of a health system which include disease prevention, early detection, establishing an accurate diagnosis, selecting the right treatment, avoiding delays in treatment, facilitating recovery, reducing disability, preventing relapse or retarding disease progression and reducing the need for long term care. 2 Since laboratory testing can help to guide each of these clinical decision points, 3 these health goals are also the primary goals of laboratory testing.

The often stated claim that 70% of clinical decisions depend on laboratory testing may have been established on little evidence, 4 but the claim is supported by recent surveys of specialist clinicians in Germany and the USA which found 60–70% of clinical decisions were affected by laboratory test results, both in the hospital setting and outside. 5 Furthermore, surveys of evidence based clinical guidelines show that at least 80% of guidelines which are aimed at establishing a diagnosis or managing disease require laboratory testing. 3

The funding of laboratory medicine is typically focused on the cost of testing rather than the clinical value of testing. 6 Laboratory specialists may be entitled to be cynical about cost surveys of laboratory testing because, in the words of Oscar Wilde, a cynic is someone who knows the price of everything and the value of nothing. 7

Defining the Value of Medical Laboratory Testing

Whilst value can be defined as ‘the importance, worth or usefulness or something’, cost is a simple definition and simply ‘the amount that has to be paid for something’. The dependence between cost and value involves the benefit of the product; therefore a cost-benefit relationship can be defined as the amount that has to be paid to gain a financial benefit or ‘profit’ or alternatively a non-financial benefit or one that is difficult to define in purely financial terms, such as ‘quality of life’. Since the goals of healthcare are ultimately defined in improving health outcome, the simplest definition of value in healthcare is ‘health outcome achieved per dollar spent’. 8 I would note that the comparison of health outcome to cost asks us to put a dollar value on someone else’s life and wellbeing, which is at least as problematic as putting a dollar value on your own. It may be appropriate to compare the costs and health outcomes separately, such as (a) the health outcomes associated with obtaining healthcare against the health outcomes when not obtaining that care, and/or (b) the cost of obtaining healthcare against the costs of not obtaining that care. We would then still have the ethical challenges inherent in matching outcome differences with the cost differences. 9

While the value of medical laboratory testing could be regarded as the health benefit compared to cost, we should not neglect the supportive factors for benefit which include technical quality and timeliness. 5 Recent hospital accreditation standards focus heavily on turnaround times for all pathology disciplines in order to reduce length of stay. 10 While we are told, “time is money”, the benefits of efficiency include not only reduced costs but also earlier treatment and therefore improved clinical outcomes. While economic measures such as cost of laboratory testing can be added to the cost of an episode of care, the trade-off between these costs and improved health benefits is much harder to define. Analytical quality (precision and trueness) must also be considered in essential prerequisites of laboratory test value, however the clinical impact of those tests to reflect health and disease (specificity and sensitivity) are better measures of clinical utility. 2

The International Federation of Clinical Chemistry (IFCC) co-sponsored a meeting of world experts in Stockholm during 1999 which aimed at identifying the various strategies used to define quality in laboratory medicine, but also to develop a hierarchy which lists and ranks the preferred strategies for determining quality. 11 The agreed five level hierarchy has since been applied, for example to set allowable quality limits for analytical performance for external quality assurance (proficiency testing). 12 However the hierarchy was rarely applied to non-analytical areas of laboratory quality 13 perhaps suggesting the hierarchy may have been too complex to apply routinely. Fifteen years after the Stockholm meeting, a similar group of experts met in Milan during 2014 and together agreed to simplify the number of levels in the hierarchy from five to three; (a) quality based on clinical outcomes, (b) quality based on biological variation and lastly (c) quality based on state of the art. 14 The Milan meeting also hoped this simplified system would facilitate the broader consideration of laboratory quality beyond the analytical phase, drawing attention to the critical phases before analysis (i.e. test selection and sample processing) 15 as well as those after analysis (i.e. interpretation and clinical action). 16 While the focus of laboratory for many years has been improving analytical quality, Plebani and his co-workers have established that most errors occur in the extra-analytical phases. 17

Clinical Wisdom

According to Berte & Nevalainen, the potential impact of laboratory tests on clinical outcome can be summarised in a sequence of three questions: 18

• Does a laboratory test change the way a clinician thinks about a patient? Then if so:
• Does that change in thinking alter the way the clinician manages the patient? Then if so:
• Does that change in patient management affect clinical outcome (i.e. mortality/morbidity)?

With increasing access to computerised health data, clinicians face a modern challenge in knowing what to do with all this information. Zelany was one of the first to try and define the stages of modern informatics starting from ‘knowing nothing’, and progressing through ‘knowing what it is’, ‘how it happened’, ‘why it is important’ and concluding with ‘what is the best thing to do in response to that importance’. 19 In simpler words; ‘Know Nothing’, ‘Know What’, ‘Know How’, ‘Know Why’, ‘Know Best’. Even in earlier times, author T.S. Eliot may have understood this sequence of importance and relevance when he wrote:

• Where is the Life we have lost in living?
• Where is the wisdom we have lost in knowledge?
• Where is the knowledge we have lost in information? 20

This philosophy of the value of data and information is commonly referred to as the ‘Data-Information-Knowledge-Wisdom (DIKW) framework’ and it is becoming popular across the expanding science of ‘Informatics’ including the sub-discipline of ‘Health Informatics’.

The DIKW framework can be directly applied to the process of interpreting laboratory test results:

Prior to interpretation, a clinician’s initial thoughts are to choose suitable laboratory tests and once the report is received, to think about the clinical significance of the results of those chosen tests. The clinicians ‘Brain to Brain Loop’ was initially defined by Lundberg. 22 More recently Lundberg together with Plebani and Laposata, have reminded us that there are at least two other ‘brains’ that might facilitate the value of laboratory testing i.e. the laboratorian’s brain and the patient’s brain. 23 The laboratorian can assist with appropriate test requesting and interpreting reports. The patient has the ultimate motivation in considering and agreeing to have the tests done in the first place, as well as considering and agreeing to any clinical management consequently indicated by the results of testing.

Patients are often the prime motivators of laboratory testing and have expectations that laboratory testing will relieve (or realise) their anxieties about underlying illness. When clinicians are unsure about the guidelines for screening, it is very likely that patient anxiety or expectation will increase the likelihood of patients being tested regardless of guidelines. 24 General practitioners will admit that the perceived need of the patient for reassurance through testing is seen as an easy, cost- and time-effective strategy during consultation. 25 , 26

The frequency that general practitioners request laboratory tests varies by geographic location, and may be determined by practitioner availability in that area. 27 While the largest variations in requesting are seen with rarely requested tests, 28 common test request rates can also vary by geography: Prostate Specific Antigen (PSA) testing (which is controversial and a cause of patient anxiety) shows large variation in use by geographic location. 29 Variation of clinical behaviour may also reflect differences or gaps in understanding 30 therefore studies on the regional use of laboratory tests potentially provide an excellent base for educational initiatives. 31 Other studies have also found that requesting behaviour is related to clinician experience but not significantly affected clinicians medico-legal attitude to risk taking. 32

There have been numerous strategies proposed to influence laboratory test utilisation. 33 These can be categorised as either (a) restricting access to testing, (b) feedback on the level of testing and/or (c) education regarding guidelines for appropriate testing. On their own, educational programs are generally more effective than a feedback strategy, 34 while restricting access to testing will have various degrees of success depending on the degree of the restriction of access. These strategies are more effective when combined. Conversely, easy access to a bank of tests (test profiles), often defined by laboratories, may have a large effect on regional test use. 35 It is important to note that the incremental cost of some routine tests can be so small, that a restriction in the number of tests per request may not lead to a significant change in the overall cost of testing. 36

Test request influencing strategies are based on the assumption that it is possible to define inappropriate utilisation. With increasing use of laboratory tests since the 1990s, there has been an accompanying exponential increase in the number of published articles auditing test utilisation. 37 Contrary to the widespread expectation that overutilisation is the main problem, a meta-analysis found that 45% of studies found evidence of under-utilisation whereas only 21% found evidence of overutilisation. 38 An example of underutilisation includes lack of diabetes follow-up with HbA1c and urine albumin. The published basis for judging appropriateness of laboratory testing has also shifted from the each author’s opinion on what can be defined as appropriate use, to the use of clinical or organisational guidelines as the basis for defining appropriate test use. 38 It is important to note that many clinical guidelines are based on the subjective consensus of chosen experts rather than truly objective evidence. Achieving consensus on what is an appropriate test request is a significant barrier to improving test utilisation. 39 When test requesting by general practitioners is surveyed and compared to what clinical guidelines would mandate, most general practitioner test requests are not compliant and the main difference is adding other tests not specified in the guidelines. 40 , 41

Quality Framework Applied to Extra-analytical Phases of Laboratory Testing

The Table applies the three ‘Milan’ strategies of defining analytical quality (clinical outcome/biological variation/state of the art) to the extra-analytical phases of laboratory testing.

The Milan hierarchy for analytical quality reconsidered in terms of all phases of laboratory testing.

The baseline for assessing quality is the ‘State of the Art’, where a peer based approach describes the status quo and should be considered the minimum standard of care. Indeed, the medico-legal standard of appropriate care is often defined as following what the ‘reasonable’ practitioner would do in the same clinical circumstance. We generally accept (and hope) that the majority of medical practitioners are reasonable, and the commonest practices are the safest.

The second ‘biological variation’ strategy is a concept that simply states that ‘the allowable analytical variation is less than half the day to day intra-individual biological variation of the patient’. In other words, that the inevitable analytical noise seen during measurement is less than the biological signals we are trying to assess in each patient. If analytical noise is too great, the changes in laboratory results will be mainly due to what is happening in the laboratory rather than what is happening to the patient.

Day to day biological variations in patients also relate to the quality of the extra-analytical phases, but this requires some lateral thought to fully appreciate: when defining reference intervals, the inclusion of the analytical measurement uncertainty together with the biological variations seen within and between individuals literally define the reference limits. Reference limits, defined by the biological variations within and between individuals, have become the most common method to interpret laboratory results. This cannot be underestimated as reference limits are used to determine the abnormality flags shown on a report and also to draw the clinician’s attention to changes presumed to have clinical importance.

How is biological variation, and the ability to reliably define a significant abnormality, related to the pre-analytical requesting phase? In a recent paper, Naugler and Guo introduce a new concept of using the ‘Mean Abnormal Result’ (MAR) rate as a new metric for benchmarking laboratory test requesting. 42 They observe that the MAR rate is typically about 8 to 9% across all laboratory tests requested. When physicians order many tests per request (more than 9 tests in their study), the detection of abnormalities does not increase suggesting diminishing return and waste of effort. The potential use of this metric is not only to restrict the number of tests, but also to define which tests are the most likely to be abnormal in any particular patient. The pre-test likelihood that a test will be abnormal depends on risk and disease prevalence. In our studies we have shown that some clinical indications are more likely to be associated with vitamin B12 deficiency including: ‘vegetarian’/‘macrocytic’/‘confusion’/‘dementia’, while other clinical indications including; ‘check-up’/‘fatigue’/‘tiredness’/‘lethargy’ do not increase the likelihood of an abnormal result. 43

While MAR focuses on the potential value of an abnormality in some clinical situations focused on excluding abnormality, rather than confirming an abnormality, a ‘normal’ result has clinical value. An example is when ruling out organic illness (e.g. phaeochromocytoma) so that a psychiatric diagnosis (e.g. panic disorder) can be made.

Diagnostic errors cause the majority of malpractice claims and are commonly due to either failing to request an appropriate diagnostic test, in about one half of cases, or incorrect diagnostic interpretation, in about one third of cases. 44 – 46 . It is not analytical failures of laboratory testing but extra-analytical failures which ultimately lead to failure of patient follow-up and suboptimal care. 47 We expect that correctly highlighted abnormalities will result in some clinical action. This is precisely why laboratories also set critical phoning limits, to ensure that when a patient’s wellbeing is at extreme risk, the clinician has been made aware of the abnormality in person. While continuing education of clinicians should improve the chance of diagnostic errors occurring, clinical decision support software may also be recruited to improve the requesting and interpretation of laboratory tests.

Guideline-based Clinical Decision Support for Laboratory Test Requesting

Since the value of laboratory testing primarily depends on choosing the appropriate laboratory tests, clinical decision support for laboratory test requesting needs to be focused on the clinical circumstance of each particular patient. As mentioned previously, most clinical guidelines include the appropriate laboratory tests to request in specific clinical circumstances. Several guidelines exist for the appropriate tests used in the management of ‘diabetes’, however many patients aren’t simply diabetic, they may also be: children with type 1 diabetes, or pregnant women with overt or gestational diabetes, or have comorbidities such as obesity, hypertension, dyslipidaemia or renal dysfunction with albuminuria. Each of these demographic and comorbidity factors will influence the appropriateness of laboratory testing. While simplified guidelines are desirable, each patient’s circumstance may not be as simple. Clinical pathway options for each patient may vary according to available resources and patient preferences. Clinician adherence to guidelines requires not only promotion and access to the guidelines, but also positive attitude to guidelines including an agreement on guideline content. 48 How easily a guideline can be directly applied to each of the clinician’s patients will affect the perceived applicability of the guideline.

There is an understanding that certain laboratory tests will affect what will be done to the patient depending on whether the result is normal/high/low. 49 Ideally there should be clear evidence that requesting certain laboratory tests will improve clinical outcome. Clinical guidelines are generally based on the consensus of experts who through the available evidence and/or their experience, are trusted to understand and agree that certain laboratory tests facilitate improved clinical decision making and therefore improve clinical outcome. Often there is little high level evidence and clinical guidelines depend on the eminence of the expert panel more than the evidence. 50

The development of clinical decision support tools based on clinical guidelines depends on the availability of agreed profession based guidelines as well as the tailoring of the advice to the specific circumstances of each patient. Studies are now being conducted that show how clinical decision support rules can improve test utilisation, 51 – 54 however they should ideally also consider the issue of clinical outcome. 55

Clinical Decision Support for Laboratory Test Interpretation

High quality computerised clinical decision support can increase evidence based prescription and decrease primary care prescription costs. 56 Laboratory tests that matter, or have value, are those that produce actionable results that bring a positive outcome benefit for the patient. 57 Therefore, clinical decision support for laboratory test interpretation would not stop at assisting to define health status, but also to actively encourage appropriate clinical follow-up. In fact it can be argued that the accurate definition of health status (e.g. an accurate diagnosis) is not as important as ensuring the appropriate clinical follow-up. An example is in the histological diagnosis of malignancy where the accurate definition of which type of malignancy it is, is not as important as the fact that it was completely excised. Therefore when judging interpretation of pathology reports, an inaccurate report diagnosis that leads to appropriate treatment (as for the true diagnosis) is not as bad as an accurate diagnosis that has not been translated to appropriate clinical follow-up.

Recently, the IFCC working group on interpretative commenting quality assurance (WG-ICQA) published their guideline on assuring the quality of interpretative comments in clinical chemistry. 58 These principles could be translated to all disciplines of laboratory medicine. The optimal interpretation is one that includes both optimal diagnosis as well as optimal follow-up while unsatisfactory or poor comments lead to inadequate or inappropriate follow-up.

What Should Laboratorians be Doing to Enhance the Clinical Value of Testing?

Medical laboratories have been focused on improving and maintaining analytical quality and they will continue to do so using existing quality assurance tools. The clinical value of testing also revolves around the selection of test that will beneficially influence clinical outcome and the interpretation of results so that the reports facilitate beneficial clinical actions. It is a requirement that an advisory service exists that both understands and liaises with clinicians in the selection and interpretation of tests. The fundamental requirement for laboratorians is therefore to nurture and expand the clinical communications of the medical laboratory which include face to face meetings, telephone consultations, newsletters and interpretative comments on reports.

The selection of clinically appropriate tests ideally requires knowledge of clinical purpose and knowledge of the tests available including their strengths and weaknesses. Clinical guidelines for appropriate test use should therefore always have the input of both clinicians and laboratorians. Clinical decision support for test selection should involve both clinicians and laboratorians and they should collaborate in initiatives to improve test selection.

Ensuring that laboratory results are available in a timely manner appropriate to the urgency of clinical decision making is another example of how laboratories can impact clinical outcomes through encouraging liaison on these issues.

Laboratory reports, which are often focused on reporting the results of analysis, should rather focus on facilitating beneficial clinical actions. Rather than wading through the details of analysis, reports should summarise the significant findings, their clinical implication and the possible beneficial clinical actions that might be indicated. Reports should be structured to highlight interpretation and action, particularly those clinical actions such as further testing on the existing sample (reflex testing), or repeat sampling, which the laboratory could help to facilitate.

The value of laboratory testing is primarily related to the ability of these investigations to promote actions that will improve health outcomes. The total cost of healthcare devoted to improving health outcome is a matter for each community while the proportion of cost attributable to laboratory testing depends on its contribution to promoting beneficial outcome. While collecting the evidence for these beneficial impacts has become a recent concern, the facts that laboratory tests affect clinical decision making and laboratory tests are included in clinical guidelines is undeniable. Enhancing the value of medical laboratory testing primarily relates to supporting each clinicians’ ability to request and interpret laboratory testing in a way that facilitates clinical decisions that improve health outcome.

This review was originally presented as the David Curnow Plenary Lecture at the Australasian Association of Clinical Biochemists Annual Scientific Meeting, held in conjunction with the Australian Institute of Medical Scientists, Brisbane, 13th September 2016.

Competing Interests: None declared.

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Yale Medicine Thesis Digital Library

Starting with the Yale School of Medicine (YSM) graduating class of 2002, the Cushing/Whitney Medical Library and YSM Office of Student Research have collaborated on the Yale Medicine Thesis Digital Library (YMTDL) project, publishing the digitized full text of medical student theses on the web as a valuable byproduct of Yale student research efforts. The digital thesis deposit has been a graduation requirement since 2006. Starting in 2012, alumni of the Yale School of Medicine were invited to participate in the YMTDL project by granting scanning and hosting permission to the Cushing/Whitney Medical Library, which digitized the Library’s print copy of their thesis or dissertation. A grant from the Arcadia Fund in 2017 provided the means for digitizing over 1,000 additional theses. IF YOU ARE A MEMBER OF THE YALE COMMUNITY AND NEED ACCESS TO A THESIS RESTRICTED TO THE YALE NETWORK, PLEASE MAKE SURE YOUR VPN (VIRTUAL PRIVATE NETWORK) IS ON.

Theses/Dissertations from 2024 2024

Refractory Neurogenic Cough Management: The Non-Inferiority Of Soluble Steroids To Particulate Suspensions For Superior Laryngeal Nerve Blocks , Hisham Abdou

Percutaneous Management Of Pelvic Fluid Collections: A 10-Year Series , Chidumebi Alim

Behavioral Outcomes In Patients With Metopic Craniosynostosis: Relationship With Radiographic Severity , Mariana Almeida

Ventilator Weaning Parameters Revisited: A Traditional Analysis And A Test Of Artificial Intelligence To Predict Successful Extubation , John James Andrews

Developing Precision Genome Editors: Peptide Nucleic Acids Modulate Crispr Cas9 To Treat Autosomal Dominant Disease , Jem Atillasoy

Radiology Education For U.s. Medical Students In 2024: A State-Of-The-Art Analysis , Ryan Bahar

Out-Of-Pocket Spending On Medications For Diabetes In The United States , Baylee Bakkila

Imaging Markers Of Microstructural Development In Neonatal Brains And The Impact Of Postnatal Pathologies , Pratheek Sai Bobba

A Needs Assessment For Rural Health Education In United States Medical Schools , Kailey Carlson

Racial Disparities In Behavioral Crisis Care: Investigating Restraint Patterns In Emergency Departments , Erika Chang-Sing

Social Determinants Of Health & Barriers To Care In Diabetic Retinopathy Patients Lost To Follow-Up , Thomas Chang

Association Between Fine Particulate Matter And Eczema: A Cross-Sectional Study Of The All Of Us Research Program And The Center For Air, Climate, And Energy Solutions , Gloria Chen

Predictors Of Adverse Outcomes Following Surgical Intervention For Cervical Spondylotic Myelopathy , Samuel Craft

Genetic Contributions To Thoracic Aortic Disease , Ellelan Arega Degife

Actigraphy And Symptom Changes With A Social Rhythm Intervention In Young Persons With Mood Disorders , Gabriela De Queiroz Campos

Incidence Of Pathologic Nodal Disease In Clinically Node Negative, Microinvasive/t1a Breast Cancers , Pranammya Dey

Spinal Infections: Pathophysiology, Diagnosis, Prevention, And Management , Meera Madhav Dhodapkar

Childen's Reentry To School After Psychiatric Hospitalization: A Qualitative Study , Madeline Digiovanni

Bringing Large Language Models To Ophthalmology: Domain-Specific Ontologies And Evidence Attribution , Aidan Gilson

Surgical Personalities: A Cultural History Of Early 20th Century American Plastic Surgery , Joshua Zev Glahn

Implications Of Acute Brain Injury Following Transcatheter Aortic Valve Replacement , Daniel Grubman

Latent Health Status Trajectory Modelling In Patients With Symptomatic Peripheral Artery Disease , Scott Grubman

The Human Claustrum Tracks Slow Waves During Sleep , Brett Gu

Patient Perceptions Of Machine Learning-Enabled Digital Mental Health , Clara Zhang Guo

Variables Affecting The 90-Day Overall Reimbursement Of Four Common Orthopaedic Procedures , Scott Joseph Halperin

The Evolving Landscape Of Academic Plastic Surgery: Understanding And Shaping Future Directions In Diversity, Equity, And Inclusion , Sacha C. Hauc

Association Of Vigorous Physical Activity With Psychiatric Disorders And Participation In Treatment , John L. Havlik

Long-Term Natural History Of Ush2a-Retinopathy , Michael Heyang

Clinical Decision Support For Emergency Department-Initiated Buprenorphine For Opioid Use Disorder , Wesley Holland

Applying Deep Learning To Derive Noninvasive Imaging Biomarkers For High-Risk Phenotypes Of Prostate Cancer , Sajid Hossain

The Hardships Of Healthcare Among People With Lived Experiences Of Homelessness In New Haven, Ct , Brandon James Hudik

Outcomes Of Peripheral Vascular Interventions In Patients Treated With Factor Xa Inhibitors , Joshua Joseph Huttler

Janus Kinase Inhibition In Granuloma Annulare: Two Single-Arm, Open-Label Clinical Trials , Erica Hwang

Medicaid Coverage For Undocumented Children In Connecticut: A Political History , Chinye Ijeli

Population Attributable Fraction Of Reproductive Factors In Triple Negative Breast Cancer By Race , Rachel Jaber Chehayeb

Evaluation Of Gastroesophageal Reflux And Hiatal Hernia As Risk Factors For Lobectomy Complications , Michael Kaminski

Health-Related Social Needs Before And After Critical Illness Among Medicare Beneficiaries , Tamar A. Kaminski

Effects Of Thoracic Endovascular Aortic Repair On Cardiac Function At Rest , Nabeel Kassam

Conditioned Hallucinations By Illness Stage In Individuals With First Episode Schizophrenia, Chronic Schizophrenia, And Clinical High Risk For Psychosis , Adam King

The Choroid Plexus Links Innate Immunity To Dysregulation Of Csf Homeostasis In Diverse Forms Of Hydrocephalus , Emre Kiziltug

Health Status Changes After Stenting For Stroke Prevention In Carotid Artery Stenosis , Jonathan Kluger

Rare And Undiagnosed Liver Diseases: New Insights From Genomic And Single Cell Transcriptomic Analyses , Chigoziri Konkwo

“Teen Health” Empowers Informed Contraception Decision-Making In Adolescents And Young Adults , Christina Lepore

Barriers To Mental Health Care In Us Military Veterans , Connor Lewis

Barriers To Methadone For Hiv Prevention Among People Who Inject Drugs In Kazakhstan , Amanda Rachel Liberman

Unheard Voices: The Burden Of Ischemia With No Obstructive Coronary Artery Disease In Women , Marah Maayah

Partial And Total Tonsillectomy For Pediatric Sleep-Disordered Breathing: The Role Of The Cas-15 , Jacob Garn Mabey

Association Between Insurance, Access To Care, And Outcomes For Patients With Uveal Melanoma In The United States , Victoria Anne Marks

Urinary Vegf And Cell-Free Dna As Non-Invasive Biomarkers For Diabetic Retinopathy Screening , Mitchelle Matesva

Pain Management In Facial Trauma: A Narrative Review , Hunter Mccurdy

Meningioma Relational Database Curation Using A Pacs-Integrated Tool For Collection Of Clinical And Imaging Features , Ryan Mclean

Colonoscopy Withdrawal Time And Dysplasia Detection In Patients With Inflammatory Bowel Disease , Chandler Julianne Mcmillan

Cerebral Arachnoid Cysts Are Radiographic Harbingers Of Epigenetics Defects In Neurodevelopment , Kedous Mekbib

Regulation And Payment Of New Medical Technologies , Osman Waseem Moneer

Permanent Pacemaker Implantation After Tricuspid Valve Repair Surgery , Alyssa Morrison

Non-Invasive Epidermal Proteome-Based Subclassification Of Psoriasis And Eczema And Identification Of Treatment Relevant Biomarkers , Michael Murphy

Ballistic And Explosive Orthopaedic Trauma Epidemiology And Outcomes In A Global Population , Jamieson M. O'marr

Dermatologic Infectious Complications And Mimickers In Cancer Patients On Oncologic Therapy , Jolanta Pach

Distressed Community Index In Patients Undergoing Carotid Endarterectomy In Medicare-Linked Vqi Registry , Carmen Pajarillo

Preoperative Psychosocial Risk Burden Among Patients Undergoing Major Thoracic And Abdominal Surgery , Emily Park

Volumetric Assessment Of Imaging Response In The Pnoc Pediatric Glioma Clinical Trials , Divya Ramakrishnan

Racial And Sex Disparities In Adult Reconstructive Airway Surgery Outcomes: An Acs Nsqip Analysis , Tagan Rohrbaugh

A School-Based Study Of The Prevalence Of Rheumatic Heart Disease In Bali, Indonesia , Alysha Rose

Outcomes Following Hypofractionated Radiotherapy For Patients With Thoracic Tumors In Predominantly Central Locations , Alexander Sasse

Healthcare Expenditure On Atrial Fibrillation In The United States: The Medical Expenditure Panel Survey 2016-2021 , Claudia See

A Cost-Effectiveness Analysis Of Oropharyngeal Cancer Post-Treatment Surveillance Practices , Rema Shah

Machine Learning And Risk Prediction Tools In Neurosurgery: A Rapid Review , Josiah Sherman

Maternal And Donor Human Milk Support Robust Intestinal Epithelial Growth And Differentiation In A Fetal Intestinal Organoid Model , Lauren Smith

Constructing A Fetal Human Liver Atlas: Insights Into Liver Development , Zihan Su

Somatic Mutations In Aging, Paroxysmal Nocturnal Hemoglobinuria, And Myeloid Neoplasms , Tho Tran

Illness Perception And The Impact Of A Definitive Diagnosis On Women With Ischemia And No Obstructive Coronary Artery Disease: A Qualitative Study , Leslie Yingzhijie Tseng

Advances In Keratin 17 As A Cancer Biomarker: A Systematic Review , Robert Tseng

Regionalization Strategy To Optimize Inpatient Bed Utilization And Reduce Emergency Department Crowding , Ragini Luthra Vaidya

Survival Outcomes In T3 Laryngeal Cancer Based On Staging Features At Diagnosis , Vickie Jiaying Wang

Analysis Of Revertant Mosaicism And Cellular Competition In Ichthyosis With Confetti , Diana Yanez

A Hero's Journey: Experiences Using A Therapeutic Comicbook In A Children’s Psychiatric Inpatient Unit , Idil Yazgan

Prevalence Of Metabolic Comorbidities And Viral Infections In Monoclonal Gammopathy , Mansen Yu

Automated Detection Of Recurrent Gastrointestinal Bleeding Using Large Language Models , Neil Zheng

Vascular Risk Factor Treatment And Control For Stroke Prevention , Tianna Zhou

Theses/Dissertations from 2023 2023

Radiomics: A Methodological Guide And Its Applications To Acute Ischemic Stroke , Emily Avery

Characterization Of Cutaneous Immune-Related Adverse Events Due To Immune Checkpoint Inhibitors , Annika Belzer

An Investigation Of Novel Point Of Care 1-Tesla Mri Of Infants’ Brains In The Neonatal Icu , Elisa Rachel Berson

Understanding Perceptions Of New-Onset Type 1 Diabetes Education In A Pediatric Tertiary Care Center , Gabriel BetancurVelez

Effectiveness Of Acitretin For Skin Cancer Prevention In Immunosuppressed And Non-Immunosuppressed Patients , Shaman Bhullar

Adherence To Tumor Board Recommendations In Patients With Hepatocellular Carcinoma , Yueming Cao

Clinical Trials Related To The Spine & Shoulder/elbow: Rates, Predictors, & Reasons For Termination , Dennis Louis Caruana

Improving Delivery Of Immunomodulator Mpla With Biodegradable Nanoparticles , Jungsoo Chang

Sex Differences In Patients With Deep Vein Thrombosis , Shin Mei Chan

Incorporating Genomic Analysis In The Clinical Practice Of Hepatology , David Hun Chung

Emergency Medicine Resident Perceptions Of A Medical Wilderness Adventure Race (medwar) , Lake Crawford

Surgical Outcomes Following Posterior Spinal Fusion For Adolescent Idiopathic Scoliosis , Wyatt Benajmin David

Representing Cells As Sentences Enables Natural Language Processing For Single Cell Transcriptomics , Rahul M. Dhodapkar

Life Vs. Liberty And The Pursuit Of Happiness: Short-Term Involuntary Commitment Laws In All 50 US States , Sofia Dibich

Healthcare Disparities In Preoperative Risk Management For Total Joint Arthroplasty , Chloe Connolly Dlott

Toll-Like Receptors 2/4 Directly Co-Stimulate Arginase-1 Induction Critical For Macrophage-Mediated Renal Tubule Regeneration , Natnael Beyene Doilicho

Associations Of Atopic Dermatitis With Neuropsychiatric Comorbidities , Ryan Fan

International Academic Partnerships In Orthopaedic Surgery , Michael Jesse Flores

Young Adults With Adhd And Their Involvement In Online Communities: A Qualitative Study , Callie Marie Ginapp

Becoming A Doctor, Becoming A Monster: Medical Socialization And Desensitization In Nazi Germany And 21st Century USA , SimoneElise Stern Hasselmo

Comparative Efficacy Of Pharmacological Interventions For Borderline Personality Disorder: A Network Meta-Analysis , Olivia Dixon Herrington

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Join us for our upcoming information sessions via Zoom. All sessions are at 4pm Pacific Time. Registration required; sign up for a session today.  The MS Program Application Deadline is March 15th, annually.

November 7, 2024 December 5, 2024 January 2, 2025 February 6, 2025 

Graduate Curriculum

To complete the program at least thirty-eight credits are required, of which nine are thesis credits. The program requires a minimum of 2 years for completion.

Pathways and Areas of Research

DLMP combines the sophisticated testing and informatics capabilities of fully accredited clinical laboratories with the resources of an academic institution in its delivery of clinical and anatomical pathology services. The DLMP MS program admits students with undergraduate Bachelor of Science (BS) or in some cases, Bachelor of Arts degrees if basic science courses have been completed. The MS program serves students with BS degrees in Medical Laboratory Science (MLS) and also students with standard BS degrees in a biological field such as Biology, Biochemistry, etc. Within the field of Laboratory Medicine itself, there are several pathways that a MS student, particularly a student with an MLS undergraduate degree, might identify as an area for further education and training while in the MS program. In these instances, the MS student may seek to identify a pathway (and thesis mentor) in the first two quarters of the program. Selection of a specific pathway helps focus the student in a specialty area. The following six pathways are available for in-depth study:

• Blood Bank/Transfusion Service
• Chemistry/Immunology
• Hematology/Coagulation
• Microbiology/Virology
• Genetics/Molecular Diagnostics
• Informatics

Pathway focus is optional and dependent on what the student wants to accomplish in the MS Program. In addition to these pathways, many DLMP faculty have active, funded research programs on infectious, neurodegenerative, gastrointestinal, and renal and genetic diseases, including cancer. Thus, for some MS students, for example those with standard BS degrees, their area of focus might align with these research areas and faculty mentors. Faculty members and their research interests can be found on the DLMP Faculty page.

Core Requirements for All Pathways

• BIOST 511 Medical Biometry I (4)
• LAB M 502 Laboratory Medicine Grand Rounds (3 total, 1 per quarter)
• LAB M 510 Laboratory Medicine Research Conference (3 total, 1 per quarter)
• LAB M 520 Organization and Management in Laboratory Medicine (3)
• LAB M 555 Critical Thinking and Research Design in Laboratory Medicine (2)
• LAB M 601 Laboratory Medicine Internship in Teaching (3)
• LAB M 700 Master's Thesis in Laboratory Medicine (9)

Career and Research Opportunities

A Master of Science degree in Laboratory Medicine & Pathology provides opportunities to work in the health profession including: laboratory management, administration, research, global health, consultation, education and industry. Graduates of our two-year program currently work for public, private and non-profit health agencies, educational institutions, the military, and the pharmaceutical industry.

MS Program Admission Requirements For All Applicants

• BS degree in Medical Laboratory Science, or
• Other BS degree in Chemistry, Microbiology, Biology, etc. or
• BA degree in the biological sciences or has basic science courses complete
• Unofficial transcripts submitted from all colleges/universities that you have attended. Please visit this link to learn about when to submit official transcripts
• Achievement of a 3.0 grade point average in the last 90 graded quarter credits or the last 60 graded semester credits

English language proficiency (ELP) is required for graduate study at the University of Washington. Therefore, every applicant whose native language is not English must demonstrate English language proficiency. Please see this link for details on the 5 ways proficiency can be demonstrated

• Three letters of recommendation from relevant professionals
• Please provide a bullet point list of the different research experiences you have had, indicate their duration, and provide a very brief description.These experiences may include summer research internships, academic year research, post-baccalaureate, and/or work-related experiences. Please include your total years of research experience at the end of the list. (1500 character limit)
• What are your future goals, and why is obtaining an MS in Laboratory Medicine necessary to achieve them? (1000 character limit)
• What pathways are you interested in specifically? Outline which faculty and research subjects that interest you in particular. (1500 character limit)
• What do you expect to be challenging about graduate school? What strategies would you use to manage these challenges? (1500 character limit)
• Is there any information pertinent to your application that you would like to add that was not covered in the previous questions? (1000 character limit)

Additional requirements for medical laboratory scientists (MLS/MT) or medical laboratory technicians (MLT) or with significant experience in a clinical laboratory:

Certification as a medical laboratory scientist in one's country of origin i.e., MLS or equivalent, or as an MLT or equivalent, or as a specialist in a clinical laboratory field is strongly recommended. Individuals not certified as an MLS in the United States are encouraged to seek ASCPi certification.

Additional suggestions for students with an undergraduate degree in a scientific field such as chemistry, microbiology or biology:

Ideal applicants will have significant research experience of approximately one year of work in a research laboratory.

Application Process

All prospective applicants must submit a complete application by March 15th for autumn admission. Eligible candidates may be invited for an in-person or video interview.

See the UW Graduate School Admission page for admission forms and procedures.

Academic Advising and Contact Information

If you need information about the program, please email at [email protected] with questions or to schedule an advising appointment via in-person, Zoom, email, or phone.

Graduate Program Department of Laboratory Medicine & Pathology Box 357110 1959 NE Pacific Street, NW120 Seattle, WA 98195-7110 Tel: 206.598.2162 [email protected]

Home > FACULTIES > Pathology > PATHOL-ETD

Pathology Theses and Dissertations

This collection contains theses and dissertations from the Department of Pathology, collected from the Scholarship@Western Electronic Thesis and Dissertation Repository

Theses/Dissertations from 2024 2024

The role of gut microbiome on the immunogenicity of immune hot neuroblastoma tumours , Hasti Gholami

Theses/Dissertations from 2023 2023

Investigation of Novel Pan-RAF Inhibitors in Anaplastic Thyroid Cancer , Sarah EB Ryan

Theses/Dissertations from 2022 2022

Evaluating the utility of S100A7 in identifying oral dysplastic lesions that will progress to oral squamous cell carcinoma , Jeff Soparlo

Theses/Dissertations from 2021 2021

Investigating The Impact Of The COVID-19 Pandemic On Maternal Perceived Stress, Postpartum Depressive Symptoms, And Pregnancy Outcomes In London, Ontario: A One Health Approach , Mei Yuan

Theses/Dissertations from 2020 2020

Evidence of an Antigen Presenting Cell Phenotype in Granular Cell Tumours , Benjamin J W A Rogala

Theses/Dissertations from 2019 2019

Junctophilin-2 Protects Cardiomyocytes against Palmitate-induced Injury , Xiaoyun Ji

Evaluating the Utility of Protein Biomarker, S100A7, and Diagnostic Test, Straticyte, in Predicting the Progression of Oral Dysplasia , Lachlan McLean

Alpha-Synuclein Toxicity is Caused by Mitochondrial Dysfunction , Michael G. Tauro

Theses/Dissertations from 2018 2018

Non-Cancerous Abnormalities That Could Mimic Prostate Cancer Like Signal in Multi-Parametric MRI Images , Mena Gaed

Mitochondrial permeability regulates cardiac endothelial cell necroptosis and cardiac allograft rejection , Ingrid Gan

Kallikrein-Related Peptidases are Dysregulated in Pleomorphic Adenoma , Matthew D. Morrison

Increased Mitochondrial Calpain-1 Is an Important Mechanism Contributing to Mitochondrial ROS Generation in Cardiac Diseases , Rui Ni

Elucidating mechanisms of innate and acquired resistance to PI3Ka inhibition in head and neck squamous cell carcinoma , Kara M. Ruicci

The Effects of Child Restraint System Use and Motor Vehicle Collision Severity on Injury Patterns and Severity in Children 8 Years Old and Younger. , Peyton A. Schroeder

Role of Long Noncoding RNAs in Diabetic Complications , Anu Alice Thomas

Effect of Estrogen and Glucocorticoid Signaling on Th2 cells – Implications for Severe Asthma , Meerah Vijeyakumaran

Theses/Dissertations from 2017 2017

CRISPR Screen for Identification of Kinases that Mediate Prostate Cancer Cell Invasion , Hamad Aldhafeeri

Immunological Impact of CLI-095 on Dendritic Cell Maturation and Hypoxia-re-oxygenation induced inflammatory injury , Hajed Obaid Alharbi

ERK5 Expression in Brain Tumours , Reem Ansari

Expression of Human Tissue Kallikreins (KLKs) in Polymorphous Low Grade Adenocarcinoma (PLGA) , Jacqueline M. Cox

A Clinico-Pathological Study of the Structural and Functional Changes in the Retina and Optic Nerve Following Diabetic Retinopathy Treatments , Richard Filek

Mechanisms underlying chemotherapy-induced vascular proliferation in ovarian cancer , Zeynep Gülsüm Kahramanoğlu

The Effect of Glucocorticosteroids on Th2 cells , Tharsan Kanagalingam

Hsp90 and its Co-chaperones Modify TDP-43 Localization, Aggregation, and Toxicity , Lilian T. Lin

Characterization of Hemangioma-initiating Stem Cells , Natalie Montwill

Postnatal β1 Integrin Deficiency in Pancreatic Beta-Cells Impairs Function and Survival , Jason E. Peart

Up-regulation of junctophilin-2 prevents ER stress and apoptosis in hypoxia/reoxygenation-stimulated H9c2 cells , Zijun Su

Theses/Dissertations from 2016 2016

Body and Organ Measurements in Infants and Neonates: An Autopsy Study , Audrey-Ann M. Evetts

The Long Non-coding RNA Malat1 Regulates Inflammatory Cytokine Production in Chronic Diabetic Complications , Andrew D. Gordon

Expression of Kallikrein-Related Peptidases (KLKs) in Adenoid Cystic Carcinoma , Zachary R. Kerr

Mechanisms regulating stem cell phenotype in infantile hemangioma , Niamh Richmond

Etiology of Motor Vehicle Collision Fatalities in Urban and Rural Canada , James R. Roos

Identification of a Nuclear Localization Signal (NLS) within the Pleckstrin Homology (PH) domain of Rho Guanine Nucleotide Exchange Factor (RGNEF) , Michael V. Tavolieri

Development and Performance Evaluation of an Antibody-Based Technology for Detection of E. coli O157 in Meat Samples and Its Potential Evolution Using Antibody Engineering , Yadira Tejeda Saldaña

Regulation of Phosphatase and Tensin Homolog Expression and Activity by Transforming Growth-Factor Beta in the Trabecular Meshwork Cells: Implications for Primary Open Angle Glaucoma , Nikoleta Tellios

Theses/Dissertations from 2015 2015

Phase II Clinical Trial of Concurrent Neoadjuvant Chemotherapy With Radiotherapy in Locally Advanced Breast Cancer , Muriel Brackstone

Expression Of Human Kallikrein Protein And mRNA In Maxillofacial Cysts And Tumours , Karl Kevin Cuddy

Chromatin Structure and Differential Accessibility of Homologous Human Mitotic Metaphase Chromosomes , Wahab A. Khan

β-adrenergic receptor-dependent and -independent effects of propranolol in infantile hemangioma , Jina J.Y. Kum

CD4+ T-cell Mediated Microvascular Endothelial Cell Death and Chronic Cardiac Allograft Rejection Involves Necroptosis , Cecilia YT Kwok

Epithelial to mesenchymal transition in the metastatic progression of gastroenteropancreatic neuroendocrine tumours , Stephanie Mok

Protective Effect of Modified Human Fibroblast Growth Factor on Diabetic Nephropathy , Ana M. Pena Diaz

Diabetic Bone Marrow & Stem Cell Dysfunction , Meghan A. Piccinin

Investigation of Pancreatic β-Cell Insulin Receptor Regulation of β-Cell Growth, Function, and Survival Via a Temporal Conditional Knockout , Liangyi Zhou

Theses/Dissertations from 2014 2014

The Role Of The RNA-Binding Protein Rho Guanine Nucleotide Exchange Factor In The Cellular Stress Response , Kevin WH Cheung

Exposure to Environmental Contaminants and Stress as Determinants of Health in Three Communities: Walpole Island and Attawapiskat First Nations and Naivasha, Kenya , Deirdre Phaedra Henley

miRNA Regulation of Programmed Cell Death-1 in T Cells: Potential Prognostic and Therapeutic Markers in Melanoma , Nathan J. Johnston

Cell Death Regulates Injury and Inflammation During Renal Allograft Transplantation , Arthur Lau

Role of SIRT1 in Vascular Complications of Diabetes , Rokhsana Mortuza

RIPK3 Regulates Microvascular Endothelial Cell Necroptosis and Cardiac Allograft Rejection , Alexander William Pavlosky

The Role of Integrins in Support of Pancreatic Function, Survival and Maturation , Matthew Riopel

Polycomb Repressive Complex 2 Regulates miR-200b in Retinal Endothelial Cells: Possible Implications in Diabetic Retinopathy , Michael A. Ruiz

Association of Head and Cervical Injuries in Pediatric Occupants Involved in Motor Vehicle Collisions , Shayan Shekari

Development of Non-Covalent Functionalization of Carbon Nanotubes for siRNA Delivery , King Sun Siu

The Expression and Potential Significance of Human Kallikreins 6, 7, 8, 10, 13, and 14 in the Epithelium of Selected Odontogenic Cysts and Tumors of Variably Aggressive Biological Behaviour , Rebecca Woodford

Theses/Dissertations from 2013 2013

Targeted siRNA Delivery Methods for RNAi-Based Therapies , Di Chen

Elucidating the Role of Menin During Islet Cell Development in the Human Fetal Pancreas , Jessica L. Dubrick

Vascular Stem Cells in Diabetic Complications , Emily C. Keats

Theses/Dissertations from 2012 2012

Immunohistochemical Studies of Expression and Correlation of Osteopontin, CD44, and Integrin αVβ3 in Selected Benign and Malignant Salivary Gland Tumours , Tommy Fok

The role of non-canonical Wnt/planar cell polarity signalling in breast cancer progression , Connor D. MacMillan

Elucidating the Function of Transplanted Islets of Langerhans and Predicting Their Ability to Reverse Diabetes , Andrew R. Pepper

Role of ERK5 in Diabetic Vascular Complications , Yuexiu Wu

Regulation of NK cell-mediated tubular epithelial cell death and kidney ischemia-reperfusion injury by the NKR-P1B receptor and Clr-b , James Yip

Theses/Dissertations from 2011 2011

A Model System for Rapid Identification and Functional Testing of Genes Involved in Early Breast Cancer Progression , Lesley H. Souter

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Value of Clinical Laboratory Services in Health Care

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This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.

• ASCLS Position Paper

Introduction Clinical laboratory professionals and the services they provide contribute to maximizing the effective delivery of care in today's complex healthcare system. Appropriate utilization of clinical laboratory services enhances the ability of clinicians to make evidence-based diagnostic and therapeutic decisions for their patients using the optimal level of resources and minimizing overall healthcare expenditures. Clinical laboratory services are the most cost effective, least invasive source of objective health information in disease prevention and diagnosis, improving patient outcomes, assuring patient safety, and fulfilling essential public health surveillance functions. Thus, clinical laboratory professionals and the services they provide are essential in providing care that is safe, effective, patient-centered, timely, efficient, and equitable.

Background Within the United States, laboratories are certified by the Centers for Medicare and Medicaid Services (CMS) under the CLIA (Clinical Laboratory Improvement Amendments) program. The hundreds of thousands of certified laboratories registered under CLIA are responsible for performing billions of laboratory tests annually. As the healthcare delivery system continues to evolve and more individuals seek healthcare, the role of clinical laboratory services will become increasingly more vital. Clinical laboratory testing will continue to be a significant component of the healthcare market, due to factors such as the continued improvements in technology, the development of new tests which are more specific to certain diseases, an aging patient population, and expanded consumer access to healthcare. As a result, clinical laboratory information will continue to have a major impact on evidence-based, decision-making strategies utilized in healthcare and public health.

Rationale Impacting diagnosis, …

• © Copyright 2013 American Society for Clinical Laboratory Science Inc. All rights reserved.

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Graduate Degree

Clinical laboratory sciences - master of science, college of natural science, biomedical laboratory diagnostics program, graduate study.

The graduate program in clinical laboratory sciences leads to the Master of Science degree. The program emphasizes the multidisciplinary nature of the laboratory sciences, encourages research that crosses traditional laboratory disciplines, and promotes innovative thinking. The curriculum is customized to the student's interests and to supporting the project each student identifies. Students may conduct research projects with both resident and adjunct faculty.

In addition to meeting the requirements of the university and of the College of Natural Science, students must meet the requirements specified below.

• Completion of 16 credits of biological science including one semester of microbiology.
• Completion of 16 credits of chemistry including organic chemistry and/or biochemistry.
• Completion of 3 credits of statistics.
• Submit official transcripts.
• Submit three letters of recommendation on official letterhead paper from professional references such as supervisors, professors, or project leaders, people who have overseen your work and can speak to your ability to think critically, work independently, and succeed in graduate work. The letter must include the recommender's credentials and contact information.
• Submit a letter of intent or purpose statement that addresses why you want to enter graduate education, including career goals and educational goals. Highlight exceptional achievements or explain low performance or withdrawal from undergraduate courses.
• Submit a brief resume.
• Submit General Record Examination (GRE) scores. The GRE exam score can be waived in lieu of a professional credential.
• Submit scores from the Test of English as a Foreign Language (TOEFL) if English is not the first language.

A total of 30 credits is required for the degree under either Plan A (with thesis) or Plan B (without thesis).  The student's program of study must be approved by the student's academic advisor.

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UDL Thesis Publication 2024 Seminar

• Published on September 11, 2024

UDL Thesis Publication 2024: A Global Platform for Urban Design Innovation

The Urban Design Lab (UDL) is excited to host the UDL Thesis Publication Seminar 2024 on September 14-15, gathering top design minds from around the world. This prestigious event will showcase 40 outstanding thesis projects from graduate and undergraduate students, highlighting groundbreaking research and innovative design solutions in urban design, landscape architecture, and planning.

Curating the Best in Urban Design The UDL Thesis Publication creates a unique opportunity for students to share their visionary work on contemporary urban challenges, with the best projects being published in an ISBN-assigned book. The selected theses will contribute to global discussions on topics such as sustainability, urban regeneration, mobility, and heritage conservation.

Themes and Scope The 2024 publication covers four major themes:

Urban Renewal: Focusing on conservation, revitalization, and heritage revival. Urban Landscapes: Managing the natural and built environments in urban settings. Urban Management: Exploring physical, social, economic, and infrastructure management. Urban Networks: Addressing connectivity, transit, and mobility within and between urban areas. These themes present innovative solutions to critical issues faced by cities globally, ensuring the publication's relevance for academics and professionals alike.

Meet the Experts The UDL Thesis Seminar 2024 is graced by an exceptional group of seminar panelists and jurors:

Seminar Panel Members:

Rajeev Bhakat (Founding Partner - Studio CoDe, India) Master of Architecture, University of Pennsylvania Ujan Ghosh (Urban Designer, Upalghosh Associates, India) Master of Architecture & City Planning, University of Pennsylvania Mansi Kataria (Creative Head, i.e. Design, India) Masters in Architecture (Urban Design), School of Planning & Architecture, Delhi Oormi Kapadia (Founding Partner, PLURAL, India) M.Arch, Urban Design, The University of Texas at Austin Publication Jury Members:

Peter Hasdell (Associate Dean, The Hong Kong Polytechnic University, China) Architect & Urban Designer, University of Sydney & Architectural Association, London Daniel Feldman (Founder and CEO, ZITA, Colombia) Urban Designer, Harvard Graduate School of Design Stefan Lengen (Associate Professor, The Bartlett School of Architecture, London, UK) DipArch UCL ARB RIBA, Architecture, The Bartlett School of Architecture Fabiano Lemes (Associate Professor in Urbanism, Politecnico di Milano, Italy) PhD, Universitat Politècnica de Catalunya- UPC, Barcelona Mohammed Fekry (Professor, Effat University, Jeddah, Saudi Arabia) Doctor of Philosophy (Ph.D.), Cairo University, Egypt Clara Reutter (Assistant Professor, Landscape Design, RMIT University, Australia) Master of Architecture, Pontifical Catholic University of Chile Zeina ElZein (Assistant Professor, Helwan University, Egypt) Doctor of Philosophy (Ph.D.), Helwan University, Cairo Evan Shieh (Assistant Professor, New York Institute of Technology, USA) Master of Architecture in Urban Design, Harvard University GSD These esteemed professionals bring their vast experience to evaluate the thesis projects, ensuring the event is a rich learning experience for participants and attendees.

Why Attend? This seminar is a must-attend for anyone passionate about urban design. It offers opportunities to learn from global experts, discover emerging trends, and network with professionals who are shaping the future of cities. Whether you are a student, academic, or professional, this event promises to provide valuable insights into the latest in urban design research and practice.

Register Now Be part of the UDL Thesis Seminar 2024 by registering today! Don't miss the chance to explore innovative solutions to urban challenges and connect with leaders in the field. Download the Book of Abstracts to preview the selected projects.

Join us on September 14-15, 2024, and witness the future of urban design unfold!

REGISTER NOW!

Download the information related to this event here.

This event was submitted by an ArchDaily user. If you'd like to submit an event, please use our "Submit a Event" form. The views expressed in announcements submitted by ArchDaily users do not necessarily reflect the views of ArchDaily.

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