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Schiff bases are an important class of organic compounds. The common structural feature of these compounds have the azomethine group with the general formula RHC = N-R1, where R and R1 are alkyl, aryl, cycloalkyl, or heterocyclic groups. Schiff bases have also been shown to exhibit a broad range of biological activities, including antifungal, antibacterial, antimalarial, antiproliferative, anti-inflammatory, antiviral, antipyretic properties and also have some industrial applications. The imine group present in such compounds has been shown to be critical to their biological activities Schiff bases are synthesized by Sterker reaction in which condensation of primary aromatic amines with aryl aldehydes is found to be catalyzed by using mild catalysts in presence of organic solvent. Owing to vast applications of Schiff bases in field of medicine, agriculture and industry; the work presented here was carried out to synthesize indole based Schiff bases. Different substituted anilines and novel-indolic aldehyde are used to synthesize various kinds of imines using green procedure that doesn’t require excess of organic solvents. This eco-friendly reaction has many advantages like economical, medicinal, environmental and with mild reaction conditions, simple work-up yield high products.

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A new series of heterocyclic Schiff bases 2-9 containing indole moiety were synthesized by facile and efficient condensation of indole-3/2/5-carboxaldehyde (1a/1b/1c) with different aromatic and heterocyclic primary amines using conventional and/or microwave irradiation methods. The structures of the obtained compounds were assigned by sophisticated spectroscopic and spectrometric techniques (1D-NMR, 2D-NMR and MS). The synthesized compounds were screened for their cytotoxicity and antibacterial activities. In vitro cytotoxicity screening revealed that compound 5 exhibited moderate activity against KB-3-1 cell line (IC50=57.7 μM) while 5-indolylimino derivative 7 indicated close to the activity (IC50=19.6 μM) in comparison with the positive control (+)-Griseofulvin (IC50=19.2 μM), while the tested compounds 5, 6b, 7 and 9 revealed good or moderate antibacterial activity. In addition, molecular docking study of Schiff bases 2-9 was performed by Molecular Operating Environment (MOE 20...

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In our research novel schiff bases of imides moiety have been synthesized . Novel Schiff base derivatives of imides moiety have been synthesized by multistep reaction . First step involves prepare 2-amino -5-mercapto-1,3,4-thiadiazole (I) by the cyclization of thiosemicarbazide with carbon disulphide and anhydrous sodium carbonate in ethanol as a solvent . Then , compound (I) was reacted with phthalic anhydride in the presence of glacial acetic acid to give 2-(5-mercapto-1,3,4-thiadiazol-2-yl) isoindoline-1,3-dion (II).Compound (II)was heated with ethyl chloracetate in the presence of potassium carbonatproduced ethyl 2- (5-(1,3-dioxoisoindoline -2-yl)-1,3,4-thiadiazole-2-yl thio) acetate (III).The reaction of compound (III) with hydrazine hydrate yielded 2-(5-(1,3-dioxoisoindoline -2-yl)-1,3,4- thiadiazol-jm2-ylthio)acetohydrazide (IV).The fifth step involves reaction of compound (IV) with N,N-dimethyl aminobenzaldehyde to yield N´-(4-(dimethyl amino)benzylidene )-2-(5- (1,3-dioxoisoindoline-2-yl)-1,3,4-thiadiazole-2-yl-thio)acetohydrazide (V).The structures of the newly synthesized compounds were confirmed by physical properties and spectral (FTIR, 1H-NMR)analysis

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In the present study, a series of novel Schiff bases of 5-substituted isatin were synthesized by condensation of imesatin with different aromatic aldehydes. The imesatins were synthesized by reaction of 5-substituted isatin with p-phenylenediamine. The chemical structures of the synthesized compounds were confirmed by means of IR, 1 HNMR, 13 C-NMR, Mass spectroscopy and Elemental analysis. These compounds were screened for antibacterial (Staphylococcus aureus ATCC 9144, Staphylococcus epidermidis ATCC 155, Micrococcus luteus ATCC 4698, Bacillus cereus ATCC 11778, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 2853 and Klebsiella pneumoniae ATCC 11298) and antifungal (Aspergillus niger ATCC 9029 and Aspergillus fumigatus ATCC 46645) activities by paper disc diffusion technique. The minimum inhibitory concentrations (MICs) of the compounds were also determined by agar streak dilution method. Among the synthesized compounds, 3-(4-(4nitrobenzylideneamino)-phenylimino)indoline-...

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