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COMMENTS

  1. Exploring DNA Damage and Repair Mechanisms: A Review with Computational Insights

    This comprehensive review paper consolidates research efforts, focusing on DNA repair mechanisms, computational research methods, and associated databases. Our work is a valuable resource for scientists and researchers engaged in computational DNA research, offering the latest insights into DNA-related proteins, diseases, and cutting-edge ...

  2. Mechanisms of DNA damage, repair and mutagenesis

    The 2015 Nobel Prize in Chemistry to Drs. Lindahl, Modrich and Sancar highlights the importance of mechanisms of DNA damage and repair and their implications for human health. In this review we will discuss the details of various types and mechanisms of DNA damage and the compensatory repair and tolerance pathways.

  3. Platelet-Rich Plasma: New Performance Understandings and Therapeutic

    Abstract. Emerging autologous cellular therapies that utilize platelet-rich plasma (PRP) applications have the potential to play adjunctive roles in a variety of regenerative medicine treatment plans. There is a global unmet need for tissue repair strategies to treat musculoskeletal (MSK) and spinal disorders, osteoarthritis (OA), and patients ...

  4. DNA Repair

    DNA Repair (DNAREP) is a journal focusing on DNA repair and cellular responses to DNA damage.DNA Repair publishes articles on genetic, cellular, biochemical, structural and molecular aspects of DNA repair. The journal welcomes articles describing databases, methods and new technologies supporting research on DNA repair and responses to DNA damage.

  5. DNA damage and repair

    DNA damage and repair articles from across Nature Portfolio. Atom; ... Research Highlights 24 Jun 2024 Nature Chemical Biology. Volume: 20, P: 796. APOBEC3 upregulation drives gemcitabine resistance.

  6. DNA damage repair: historical perspectives, mechanistic ...

    The Journey of DNA repair machinery system discovery. In recent years, the availability of high-quality data on DNA from in vivo and in vitro research reported in the literature, as well as ...

  7. Exploring DNA Damage and Repair Mechanisms: A Review with ...

    DNA repair mechanisms play a pivotal role in safeguarding genetic integrity and preventing the onset of these ailments. Over the past decade, substantial progress and pivotal discoveries have been achieved in DNA damage and repair. This comprehensive review paper consolidates research efforts, focusing on DNA repair mechanisms, computational ...

  8. Revolutionizing DNA repair research and cancer therapy with ...

    All organisms possess molecular mechanisms that govern DNA repair and associated DNA damage response (DDR) processes. Owing to their relevance to human disease, most notably cancer, these ...

  9. Maintenance management: Literature review and directions

    Abstract. Purpose - The purpose of this paper is to review the literature on maintenance management and. suggest possible gaps from the point of view of researchers and practitioners. Design ...

  10. Critical step found in DNA repair, cellular aging

    Now, research led by scientists at Harvard Medical School (HMS) reveals a critical step in a molecular chain of events that allows cells to mend their broken DNA. The findings, to be published March 24 in Science, offer a critical insight into how and why the body's ability to fix DNA dwindles over time and point to a previously unknown role ...

  11. Structural Mechanisms of DNA Replication, Repair, and Recombination

    DNA processing involves multiple biochemical steps requiring far more functions than can be easily incorporated into a single protein. Consequently, replication, repair, and recombination are performed by multiprotein assemblies. Remarkably, there is growing evidence that these processes share many common features. The enzymes active in replicating DNA during S phase are needed to synthesize ...

  12. (PDF) Repair and Rehabilitation of RCC Structures

    Content may be subject to copyright. Repair and Rehabilitation of RCC Structures. Rathod Ravinder, A.Vittalaiah and Akula Prakash. 1,2,3 Assistant Professor GRIET, Bachupally Hyderabad ...

  13. Systematic literature review of repair shops: focus on sustainability

    Generally known in the research community as 'repair shops', they aim to pool all the resources needed to repair defective equipment provided by different production sites. This paper aims to provide a comprehensive overview of repair shops and to present opportunities for future research with a focus on the circular economy context ...

  14. Research and Write Effectively: Dissertation, Thesis, Term paper

    Research and Write Effectively: Dissertation, Thesis, Term paper . Working on a doctoral dissertation, a master's thesis, a senior capstone, or an undergraduate term paper? Meet with a subject librarian to refine your research question, design a literature review search, learn about research methods, and connect to tools for qualitative and ...

  15. Neurorehabilitation and Neural Repair: Sage Journals

    Neurorehabilitation & Neural Repair (NNR) offers innovative and reliable reports relevant to functional recovery from neural injury and long term neurologic care. The journal's unique focus is evidence-based basic and clinical practice and research. NNR deals with the management and fundamental mechanisms of functional recovery from conditions such as stroke, multiple sclerosis, Alzheimer's ...

  16. Creating Effective Research Paper Titles: A Step-by-Step Guide for

    Keep these tips in mind when creating your research paper title. Write the title after you've written your paper in abstract. Include all of your paper's essential terms. Keep it short and to the point, about 16 words or fewer is best. Avoid using jargon or abbreviations that will not be understandable by the general reader.

  17. Postoperative outcomes that matter to patients ...

    Research Paper. Postoperative outcomes that matter to patients undergoing inguinal hernia repair: A qualitative study. Author links open overlay panel Anders Gram-Hanssen MD, ... The patients' main motive for seeking surgical repair of their inguinal hernia was the expectation of elimination or reduction of physical limitations and pain relief ...

  18. PDF Review Paper on Repair, Rehabilitation and Retrofitting of R ...

    This review paper presents an experimental study of Repair, Rehabilitation and Retrofitting of R.C.C Structures. Reinforced cement concrete (RCC) as a construction material has come into use for the last one century. In India RCC has been used extensively in the last 50-60 years.

  19. DdrC, a unique DNA repair factor from D. radiodurans, senses and

    Introduction. The bacterium Deinococcus radiodurans, along with other species of the Deinococcus genus, are distinguished for their ability to survive high doses of DNA-damaging agents, such as UV-C radiation, ionizing radiation, and desiccation (1, 2).Several factors have been proposed to contribute to the DNA-damage resistance phenotype. Most notably is the atypically high intracellular ...

  20. Understanding nucleotide excision repair and its roles in ...

    The versatile nucleotide excision repair (NER) pathway removes helix-distorting DNA damage in a multistep 'cut and patch'-type reaction. Two damage detection subpathways exist: global genomic NER ...

  21. Transcatheter Valve Repair in Heart Failure with Moderate to Severe

    A total of 505 patients underwent randomization: 250 were assigned to the device group and 255 to the control group. At 24 months, the rate of first or recurrent hospitalization for heart failure ...

  22. Advancing Uterine Regenerative Therapies with Endometrial Organoids

    They recently published a paper in the journal Theranostics. It focuses on how endometrial organoids serve as a reservoir of functional mitochondria for uterine repair. Their research findings suggest that endometrial organoid-originating mitochondria might be key players to mediate uterine repair resulting in fertility enhancement by ...

  23. Abiraterone, Olaparib, or Abiraterone + Olaparib in First-Line

    AbstractPurpose:. Deleterious germline/somatic homologous recombination repair mutations (HRRm) are present in ∼25% of patients with metastatic castration-resistant prostate cancer (mCRPC). Preclinically, poly(ADP-ribose) polymerase (PARP) inhibition demonstrated synergism with androgen receptor pathway (ARP)-targeted therapy. This trial evaluated the efficacy of ARP inhibitor versus PARP ...

  24. Rotator cuff tears: An evidence based approach

    Abstract. Lesions of the rotator cuff (RC) are a common occurrence affecting millions of people across all parts of the globe. RC tears are also rampantly prevalent with an age-dependent increase in numbers. Other associated factors include a history of trauma, limb dominance, contralateral shoulder, smoking-status, hypercholesterolemia ...

  25. Transcatheter Repair versus Mitral-Valve Surgery for Secondary Mitral

    A total of 210 patients underwent randomization. The mean (±SD) age of the patients was 70.5±7.9 years, 39.9% were women, and the mean left ventricular ejection fraction was 43.0±11.7%.

  26. Research team receives ASME Outstanding Paper Award

    This year's "Outstanding Paper Award" from the American Society of Mechanical Engineers (ASME) goes to a research team from our institute. This was announced during the 18th International Conference on Energy Sustainability in Anaheim, USA. The award aims to promote high quality research in the field of energy sustainability recognising papers for their originality, impact, clarity and elegance.

  27. How to Choose a Credit Repair Company in 2024

    Complete the application: Provide your personal information, like your name, address, and date of birth.; Select a service level: Choose a service type based on your needs and affordability.Many ...

  28. Guides: CWP: The Modern NBA: Researching the White Paper

    The research you do for your white paper will require that you identify a specific problem, seek popular culture sources to help define the problem, its history, its significance and impact for people affected by it. You will then delve into academic and grey literature to learn about the way scholars and others with professional expertise ...

  29. Exploring DNA Damage and Repair Mechanisms: A Review with ...

    This comprehensive review paper consolidates research efforts, focusing on DNA repair mechanisms, computational research methods, and associated databases. Our work is a valuable resource for scientists and researchers engaged in computational DNA research, offering the latest insights into DNA-related proteins, diseases, and cutting-edge ...

  30. The physics behind the most annoying thing that could ever happen to

    Scientists have figured out what type of paper is the most prone to cut skin. Kaare Jensen, associate professor of physics at the Technical University of Denmark, explains.